| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Na Ma, Hai-Xia Zhao, Qian Chen, Gui-Fang Han, Zhen-Cai Liu, Ding Yuan, Chang-Cheng Zhan. [Protective effect of Wuzi Yanzong recipe on testicular DNA damage and apoptosis in natural ageing rats]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 43. issue 8. 2019-07-16. PMID:29751716. |
all the above results suggest that wuzi yanzong recipe could protect the germ cell in testicular tissues of natural ageing rates from dna damage and apoptosis, and the mechanism may be associated with regulating p53 signaling pathway. |
2019-07-16 |
2023-08-13 |
rat |
| Tavina L Offutt, Pek U Ieong, Özlem Demir, Rommie E Amar. Dynamics and Molecular Mechanisms of p53 Transcriptional Activation. Biochemistry. vol 57. issue 46. 2019-07-16. PMID:30388364. |
the "guardian of the genome", p53, functions as a tumor suppressor that responds to cell stressors such as dna damage, hypoxia, and tumor formation by inducing cell-cycle arrest, senescence, or apoptosis. |
2019-07-16 |
2023-08-13 |
human |
| Jessica Neville Little, Noelle D Dwye. p53 deletion rescues lethal microcephaly in a mouse model with neural stem cell abscission defects. Human molecular genetics. vol 28. issue 3. 2019-07-15. PMID:30304535. |
by making double mutants with the pro-apoptotic genes bax and trp53 (p53), we find that p53-dependent apoptosis of cortical nscs accounts for most of the microcephaly, but that there is a significant apoptosis-independent contribution as well. |
2019-07-15 |
2023-08-13 |
mouse |
| Mohamed M Zeweil, Kadry M Sadek, Nabil M Taha, Yasser El-Sayed, Sherif Menshaw. Graviola attenuates DMBA-induced breast cancer possibly through augmenting apoptosis and antioxidant pathway and downregulating estrogen receptors. Environmental science and pollution research international. vol 26. issue 15. 2019-07-11. PMID:30924043. |
nevertheless, administration of dmba and graviola especially dmba+g37 induced apoptosis through at least 1.5-fold in gene expression levels of pro-apoptotic genes: bcl2-associated x protein (bax), tumor suppressor gene (p53), and cysteinyl-aspartic acid-protease-3 (caspase-3). |
2019-07-11 |
2023-08-13 |
rat |
| Marwa M Abu-Serie, Esmail M El-Fakharan. Efficiency of novel nanocombinations of bovine milk proteins (lactoperoxidase and lactoferrin) for combating different human cancer cell lines. Scientific reports. vol 7. issue 1. 2019-07-09. PMID:29196676. |
additionally, significant alterations in the expression of well characterized cellular proliferation and apoptosis guards (nf-κb, bcl-2 and p53) in these nps-treated cancer cells compared to 5-fluorouracil (5-fu) treated cells. |
2019-07-09 |
2023-08-13 |
human |
| Ping Wang, Han Bao, Xiao-Peng Zhang, Feng Liu, Wei Wan. Regulation of Tip60-dependent p53 acetylation in cell fate decision. FEBS letters. vol 593. issue 1. 2019-07-09. PMID:30414319. |
for severe damage, p53 is acetylated at lysine 120 (k120) by tip60 to trigger apoptosis by inducing puma, and its concentration increases to high levels. |
2019-07-09 |
2023-08-13 |
Not clear |
| Artur Zajkowicz, Małgorzata Krześniak, Agnieszka Gdowicz-Kłosok, Barbara Łasut, Marek Rusi. PIM2 survival kinase is upregulated in a p53-dependent manner in cells treated with camptothecin or co-treated with actinomycin D and nutlin-3a. Archives of biochemistry and biophysics. vol 655. 2019-07-08. PMID:30096294. |
the p53 protein is an inducer of apoptosis, acting as a transcriptional regulator of apoptotic genes. |
2019-07-08 |
2023-08-13 |
Not clear |
| Ji Soo Park, Yong Joo Park, Ha Ryong Kim, Kyu Hyuck Chun. Polyhexamethylene guanidine phosphate-induced ROS-mediated DNA damage caused cell cycle arrest and apoptosis in lung epithelial cells. The Journal of toxicological sciences. vol 44. issue 6. 2019-07-08. PMID:31168028. |
interestingly, p53 was activated by phmg-p treatment and p53 knockdown suppressed phmg-p-induced apoptosis and cell cycle arrest. |
2019-07-08 |
2023-08-13 |
human |
| Yinxing Ma, Licia Silveri, John LaCava, Svetlana Dokudovskay. Tumor suppressor NPRL2 induces ROS production and DNA damage response. Scientific reports. vol 7. issue 1. 2019-07-03. PMID:29127423. |
these events are accompanied by phosphorylation of p53, activation of a dna-damage response and cell cycle arrest in g1 phase, followed by apoptosis. |
2019-07-03 |
2023-08-13 |
Not clear |
| Qing Xie, Shuai Wang, Yue Zhao, Zhenchao Zhang, Chuan Qin, Xianjun Yan. MicroRNA-216a suppresses the proliferation and migration of human breast cancer cells via the Wnt/β-catenin signaling pathway. Oncology reports. vol 41. issue 5. 2019-07-03. PMID:30864744. |
microrna-216a overexpression led to a decrease in cell proliferation and migration, as well as increases in apoptosis, caspase-3/8 activities, bax expression and p53 protein expression in mcf-7 cells. |
2019-07-03 |
2023-08-13 |
human |
| Yu-Ling Wu, Jui-Chih Chang, Wei-Yong Lin, Chien-Chun Li, Mingli Hsieh, Haw-Wen Chen, Tsu-Shing Wang, Chin-San Liu, Kai-Li Li. Treatment with Caffeic Acid and Resveratrol Alleviates Oxidative Stress Induced Neurotoxicity in Cell and Drosophila Models of Spinocerebellar Ataxia Type3. Scientific reports. vol 7. issue 1. 2019-07-01. PMID:28912527. |
blockade of nf-κb activation annulled the protective effects of ca and res on apoptosis, ros, and p53 activation in tbh-treated sk-n-sh-mjd78 cells, which suggests the importance of restoring nf-κb activity by ca and res. |
2019-07-01 |
2023-08-13 |
drosophila_melanogaster |
| Omar M Alaufi, Abdulwahab Noorwali, Fatheya Zahran, Ahmed M Al-Abd, Safia Al-Atta. Cytotoxicity of thymoquinone alone or in combination with cisplatin (CDDP) against oral squamous cell carcinoma in vitro. Scientific reports. vol 7. issue 1. 2019-07-01. PMID:29030590. |
finally, apoptosis induction results were confirmed by the change in the expression levels of p53, bcl-2 and caspase-9 proteins in both umscc-14c and oec cells. |
2019-07-01 |
2023-08-13 |
human |
| Guangyu Zhou, Xiaofei Zhang, Wanning Wang, Wenlong Zhang, Huaying Wang, Guangda Xi. Both Peripheral Blood and Urinary miR-195-5p, miR-192-3p, miR-328-5p and Their Target Genes PPM1A, RAB1A and BRSK1 May Be Potential Biomarkers for Membranous Nephropathy. Medical science monitor : international medical journal of experimental and clinical research. vol 25. 2019-07-01. PMID:30865617. |
results a total of 1246 degs were identified from pbmcs samples, among them upregulated ccl5 was found to be involved in the chemokine signaling pathway, and bax was found to be apoptosis related; while downregulated ppm1a and cdk1 were associated with the mapk signaling pathway and the p53 signaling pathway, respectively. |
2019-07-01 |
2023-08-13 |
Not clear |
| Farnam Azad, Vahid Nejati, Ali Shalizar-Jalali, Gholamreza Najafi, Fatemeh Rahman. Antioxidant and anti-apoptotic effects of royal jelly against nicotine-induced testicular injury in mice. Environmental toxicology. vol 34. issue 6. 2019-07-01. PMID:30896085. |
in addition, the mitochondria-dependent apoptosis was investigated by assessing the bcl-2, p53, and caspase-3 mrna levels expression by reverse transcription-pcr (rt-pcr). |
2019-07-01 |
2023-08-13 |
mouse |
| Mi Liu, Weiming Ai, Limei Sun, Fang Fang, Xuedong Wang, Shaobo Chen, Huili Wan. Triclosan-induced liver injury in zebrafish (Danio rerio) via regulating MAPK/p53 signaling pathway. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. vol 222. 2019-07-01. PMID:31048017. |
the significant up-regulation of mapk and p53 at both mrna and protein levels proved that tcs-induced hepatocyte apoptosis was closely related to activating the mapk/p53 signaling pathway. |
2019-07-01 |
2023-08-13 |
zebrafish |
| Maria J Kowzun, William J Rifkin, Zachary M Borab, Trevor Ellison, Marc A Soares, Stelios C Wilson, Philip Lotfi, Amey Bandekar, Stavroula Sofou, Pierre B Saadeh, Daniel J Ceradin. Topical inhibition of PUMA signaling mitigates radiation injury. Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society. vol 26. issue 6. 2019-06-27. PMID:30155987. |
in this study, we attempted to mitigate the effects of irradiation on skin using a novel transcutaneous topical delivery system to locally inhibit p53 up-regulated modulator of apoptosis (puma) gene expression with small interfering rna (sirna). |
2019-06-27 |
2023-08-13 |
mouse |
| Julieta Saba, Juan Turati, Delia Ramírez, Lila Carniglia, Daniela Durand, Mercedes Lasaga, Carla Carus. Astrocyte truncated tropomyosin receptor kinase B mediates brain-derived neurotrophic factor anti-apoptotic effect leading to neuroprotection. Journal of neurochemistry. vol 146. issue 6. 2019-06-26. PMID:29851427. |
we found that bdnf increased astrocyte viability, preventing apoptosis induced by serum deprivation by decreasing active caspase 3 and p53 expression. |
2019-06-26 |
2023-08-13 |
Not clear |
| Ying-Yan Fang, Peng Zeng, Na Qu, Lin-Na Ning, Jiang Chu, Teng Zhang, Xin-Wen Zhou, Qing Tia. Evidence of altered depression and dementia-related proteins in the brains of young rats after ovariectomy. Journal of neurochemistry. vol 146. issue 6. 2019-06-26. PMID:29939407. |
a link between neuronal loss and apoptosis was suggested, as evidenced by increases in adenylate kinase 2 (ak2), b-cell lymphoma 2 associated x (bax), cleaved caspase 3, and phosphorylated p53 and decreases in huntingtin-interacting protein k, hexokinase, and phosphorylated b-cell lymphoma 2 (bcl-2), and apoptosis might be triggered by endoplasmic reticulum stress (probed by increased glucose-regulated protein 78 (grp78), cleaved caspase 12, phosphorylated protein kinase r (pkr)-like endoplasmic reticulum kinase, inositol-requiring enzyme-1 and activating transcription factor 6), and mitochondrial dysfunction (probed by increased cytochrome c and cleaved caspase 3 and decreased sideroflexin-1 (sfxn1) and nadh dehydrogenase (ubiquinone) 1 α subcomplex 11 (ndufa11)). |
2019-06-26 |
2023-08-13 |
rat |
| Tian Liu, Fang Wang, Patrick LePochat, Jung-A A Woo, Mohammed Zaheen Bukhari, Kyung Woo Hong, Courtney Trotter, David E Kan. Cofilin-mediated Neuronal Apoptosis via p53 Translocation and PLD1 Regulation. Scientific reports. vol 7. issue 1. 2019-06-24. PMID:28912445. |
cofilin-mediated neuronal apoptosis via p53 translocation and pld1 regulation. |
2019-06-24 |
2023-08-13 |
mouse |
| Tian Liu, Fang Wang, Patrick LePochat, Jung-A A Woo, Mohammed Zaheen Bukhari, Kyung Woo Hong, Courtney Trotter, David E Kan. Cofilin-mediated Neuronal Apoptosis via p53 Translocation and PLD1 Regulation. Scientific reports. vol 7. issue 1. 2019-06-24. PMID:28912445. |
while the p53 apoptotic pathway has clearly been associated with aβ deposits and neuronal apoptosis, the critical upstream factors contributing to p53 activation in ad are not well understood. |
2019-06-24 |
2023-08-13 |
mouse |