| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ritam Chatterjee, Sujata La. Genomic insult oriented mitochondrial instability and proliferative hindrance in the bone marrow of aplastic mice including stem/progenitor population. Pathology, research and practice. vol 215. issue 4. 2019-06-11. PMID:30683472. |
to gain deep knowledge about the molecular mechanisms of the hematopoietic disruption, cytotoxicity assay, dna damage measurement, apoptosis study, replicative senescence analysis, redox balance study, mitochondrial membrane potential change assessment, flowcytometric expressional analysis of p21, p53, atm, chk-2, necdin, gfi-1, c-myc, ku-80 and sod-2 were done with marrow hematopoietic stem/ progenitor cells (hspcs). |
2019-06-11 |
2023-08-13 |
mouse |
| Natalia Pawłowska, Agnieszka Gornowicz, Anna Bielawska, Arkadiusz Surażyński, Anna Szymanowska, Robert Czarnomysy, Krzysztof Bielawsk. The molecular mechanism of anticancer action of novel octahydropyrazino[2,1-a:5,4-a']diisoquinoline derivatives in human gastric cancer cells. Investigational new drugs. vol 36. issue 6. 2019-06-10. PMID:29549610. |
confocal microscopy bioimaging was used to demonstrate the expression of pivotal proteins engaged in apoptosis (caspase-8, caspase-3, p53) and cell signaling (akt, erk1/2). |
2019-06-10 |
2023-08-13 |
human |
| Ioannis K Rizos, James N Tsoporis, Ioannis K Toumpoulis, Vasileios Salpeas, Shehla Izhar, Angelos G Rigopoulos, Eleftherios A Sakadakis, Thomas G Parke. Antiapoptotic Effect of β1 Blockers in Ascending Thoracic Aortic Smooth Muscle Cells: The Role of HSP70 Expression. Journal of cardiovascular pharmacology. vol 72. issue 2. 2019-06-10. PMID:29738368. |
in vitro, metoprolol treatment of hypoxic rat avsmcs increased nitric oxide (no) production, induced heat shock factor 1 transport to the nucleus, upregulated hsp70, decreased p53 phosphorylation and attenuated apoptosis. |
2019-06-10 |
2023-08-13 |
human |
| Sakhawat Ali, Muhammad Tahir, Aamir Ali Khan, Xue Chai Chen, Ma Ling, Yinghui Huan. Cisplatin Synergistically Enhances Antitumor Potency of Conditionally Replicating Adenovirus via p53 Dependent or Independent Pathways in Human Lung Carcinoma. International journal of molecular sciences. vol 20. issue 5. 2019-06-10. PMID:30841620. |
in conclusion, cisplatin synergistically increased the tumor-killing of crad by (1) increasing crad transduction via enhanced car expression and (2) increasing p53 dependent or independent apoptosis of lung cancer cell lines. |
2019-06-10 |
2023-08-13 |
human |
| Ulyana Boyarskikh, Sergey Pintus, Nikita Mandrik, Daria Stelmashenko, Ilya Kiselev, Ivan Evshin, Ruslan Sharipov, Philip Stegmaier, Fedor Kolpakov, Maxim Filipenko, Alexander Ke. Computational master-regulator search reveals mTOR and PI3K pathways responsible for low sensitivity of NCI-H292 and A427 lung cancer cell lines to cytotoxic action of p53 activator Nutlin-3. BMC medical genomics. vol 11. issue Suppl 1. 2019-06-07. PMID:29504919. |
small molecule nutlin-3 reactivates p53 in cancer cells by interacting with the complex between p53 and its repressor mdm-2 and causing an increase in cancer cell apoptosis. |
2019-06-07 |
2023-08-13 |
Not clear |
| Jian-Yang Chen, Xungang Tan, Zheng-Hua Wang, Yun-Zhang Liu, Jian-Feng Zhou, Xiao-Zhi Rong, Ling Lu, Yun L. The ribosome biogenesis protein Esf1 is essential for pharyngeal cartilage formation in zebrafish. The FEBS journal. vol 285. issue 18. 2019-06-07. PMID:30073783. |
we also show strong upregulation of p53 signaling as well as apoptosis, and poor proliferation in mutants. |
2019-06-07 |
2023-08-13 |
zebrafish |
| Anneleen Steels, Adriaan Verhelle, Olivier Zwaenepoel, Jan Getteman. Intracellular displacement of p53 using transactivation domain (p53 TAD) specific nanobodies. mAbs. vol 10. issue 7. 2019-06-07. PMID:30111239. |
via a complex interplay between both transcription-dependent and - independent functions of p53, the cell will go through transient cell cycle arrest, cellular senescence or apoptosis. |
2019-06-07 |
2023-08-13 |
Not clear |
| Hamidreza Javadi, Abbas Sahebghadam Lotfi, Saman Hosseinkhani, Hossein Mehrani, Jafar Amani, Zahra Soheila Soheili, Zahra Hojati, Mehdi Kamal. The combinational effect of E6/E7 siRNA and anti-miR-182 on apoptosis induction in HPV16-positive cervical cells. Artificial cells, nanomedicine, and biotechnology. vol 46. issue sup2. 2019-06-05. PMID:29873516. |
in the present research, we assumed that reducing the amounts of e6 and e7 oncoproteins by a specific sirna sequence and recovering p53 and rb proteins, along with the recovery of the foxo1 protein by applying anti-mir-182, would increase apoptosis and reduce proliferation rate in cancer cells. |
2019-06-05 |
2023-08-13 |
Not clear |
| Xingang Xu, Ying Xu, Qi Zhang, Feng Yang, Zheng Yin, Lixiang Wang, Qinfan L. Porcine epidemic diarrhea virus infections induce apoptosis in Vero cells via a reactive oxygen species (ROS)/p53, but not p38 MAPK and SAPK/JNK signalling pathways. Veterinary microbiology. vol 232. 2019-06-05. PMID:31030832. |
ros and p53 play key roles in regulating many kinds of cell process during viral infection, however, the exact function in pedv-induced apoptosis remains unclear. |
2019-06-05 |
2023-08-13 |
Not clear |
| Xingang Xu, Ying Xu, Qi Zhang, Feng Yang, Zheng Yin, Lixiang Wang, Qinfan L. Porcine epidemic diarrhea virus infections induce apoptosis in Vero cells via a reactive oxygen species (ROS)/p53, but not p38 MAPK and SAPK/JNK signalling pathways. Veterinary microbiology. vol 232. 2019-06-05. PMID:31030832. |
treatment with the p53 inhibitor pft-α could significantly inhibit pedv-induced apoptosis. |
2019-06-05 |
2023-08-13 |
Not clear |
| Xingang Xu, Ying Xu, Qi Zhang, Feng Yang, Zheng Yin, Lixiang Wang, Qinfan L. Porcine epidemic diarrhea virus infections induce apoptosis in Vero cells via a reactive oxygen species (ROS)/p53, but not p38 MAPK and SAPK/JNK signalling pathways. Veterinary microbiology. vol 232. 2019-06-05. PMID:31030832. |
moreover, further inhibition tests were established to prove that p53 was regulated by ros in pedv-induced apoptosis. |
2019-06-05 |
2023-08-13 |
Not clear |
| Xingang Xu, Ying Xu, Qi Zhang, Feng Yang, Zheng Yin, Lixiang Wang, Qinfan L. Porcine epidemic diarrhea virus infections induce apoptosis in Vero cells via a reactive oxygen species (ROS)/p53, but not p38 MAPK and SAPK/JNK signalling pathways. Veterinary microbiology. vol 232. 2019-06-05. PMID:31030832. |
taken together, the results of this study demonstrate that activated p53 and accumulated ros participated in pedv-induced apoptosis and p53 could be regulated by ros during pedv infection. |
2019-06-05 |
2023-08-13 |
Not clear |
| Chae-Ok Yun, Priyanshu Bhargava, Youjin Na, Jung-Sun Lee, Jihoon Ryu, Sunil C Kaul, Renu Wadhw. Relevance of mortalin to cancer cell stemness and cancer therapy. Scientific reports. vol 7. 2019-06-04. PMID:28165047. |
enriched in a large variety of cancers, it has been shown to contribute to the process of carcinogenesis by multiple ways including inactivation of tumor suppressor p53 protein, deregulation of apoptosis and activation of emt signaling. |
2019-06-04 |
2023-08-13 |
Not clear |
| Muhammad Riaz Khan, Ihtisham Bukhari, Ranjha Khan, Hafiz Muhammad Jafar Hussain, Mian Wu, Rick Francis Thorne, Jinming Li, Guangzhi Li. TP53LNC-DB, the database of lncRNAs in the p53 signalling network. Database : the journal of biological databases and curation. vol 2019. 2019-06-04. PMID:30624647. |
the tp53 gene product, p53, is a pleiotropic transcription factor induced by stress, which functions to promote cell cycle arrest, apoptosis and senescence. |
2019-06-04 |
2023-08-13 |
Not clear |
| Naheed Ahmad, Abhay K Sharma, Seema Sharma, Imran Khan, Dhananjay K Sharma, Ayesha Shamsi, T R Santhosh Kumar, Mahendra Seerv. Biosynthesized composites of Au-Ag nanoparticles using Trapa peel extract induced ROS-mediated p53 independent apoptosis in cancer cells. Drug and chemical toxicology. vol 42. issue 1. 2019-06-03. PMID:29842822. |
biosynthesized composites of au-ag nanoparticles using trapa peel extract induced ros-mediated p53 independent apoptosis in cancer cells. |
2019-06-03 |
2023-08-13 |
Not clear |
| Ji-Hye Kim, Dahee Kim, Suk Joon Cho, Kwan-Young Jung, Jong-Hoon Kim, Jun Mi Lee, Hee Jung Jung, Kwang Rok Ki. Identification of a novel SIRT7 inhibitor as anticancer drug candidate. Biochemical and biophysical research communications. vol 508. issue 2. 2019-06-03. PMID:30503501. |
p53, a tumor suppressor, induces apoptosis or cell cycle arrest and is stabilized by acetylation. |
2019-06-03 |
2023-08-13 |
Not clear |
| Young-Sun Lee, Dae-Hee Lee, Haroon A Choudry, David L Bartlett, Yong J Le. Ferroptosis-Induced Endoplasmic Reticulum Stress: Cross-talk between Ferroptosis and Apoptosis. Molecular cancer research : MCR. vol 16. issue 7. 2019-05-29. PMID:29592897. |
chop (c/ebp homologous protein) signaling pathway-mediated p53-independent puma (p53 upregulated modulator of apoptosis) expression is involved in the synergistic interaction between ferroptosis and apoptosis. |
2019-05-29 |
2023-08-13 |
Not clear |
| Ce Li, Lutao Du, Yidan Ren, Xiaoyan Liu, Qinlian Jiao, Donghai Cui, Mingxin Wen, Chuanxin Wang, Guangwei Wei, Yunshan Wang, Aiguo Ji, Qin Wan. SKP2 promotes breast cancer tumorigenesis and radiation tolerance through PDCD4 ubiquitination. Journal of experimental & clinical cancer research : CR. vol 38. issue 1. 2019-05-29. PMID:30760284. |
programmed cell death protein 4 (pdcd4) is a tumor suppressor gene that plays a role in cell apoptosis and dna-damage response via interacting with eukaryotic initiation factor-4a (eif4a) and p53. |
2019-05-29 |
2023-08-13 |
Not clear |
| Polina Vikhreva, Gerry Melino, Ivano Ameli. p73 Alternative Splicing: Exploring a Biological Role for the C-Terminal Isoforms. Journal of molecular biology. vol 430. issue 13. 2019-05-28. PMID:29733853. |
similarly to p53, following dna damage, p73 is stabilized and activated and controls expression of target genes that are involved in the regulation of cycle arrest and apoptosis. |
2019-05-28 |
2023-08-13 |
Not clear |
| Souvik Roy, Sritama Banerjee, Tania Chakrabort. Vanadium quercetin complex attenuates mammary cancer by regulating the P53, Akt/mTOR pathway and downregulates cellular proliferation correlated with increased apoptotic events. Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine. vol 31. issue 4. 2019-05-28. PMID:29855745. |
in vitro studies established that the complex upregulated the expressions of p53, caspase 3 and 9, whereas down regulating akt, mtor and vegf expressions and also induced apoptosis and dna fragmentation in a dose dependent manner. |
2019-05-28 |
2023-08-13 |
human |