| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Tian Liu, Fang Wang, Patrick LePochat, Jung-A A Woo, Mohammed Zaheen Bukhari, Kyung Woo Hong, Courtney Trotter, David E Kan. Cofilin-mediated Neuronal Apoptosis via p53 Translocation and PLD1 Regulation. Scientific reports. vol 7. issue 1. 2019-06-24. PMID:28912445. |
in this study, we show that activated cofilin (s3a) preferentially forms a complex with p53 and promotes its mitochondrial and nuclear localization, resulting in transcription of p53-responsive genes and promotion of apoptosis. |
2019-06-24 |
2023-08-13 |
mouse |
| Tian Liu, Fang Wang, Patrick LePochat, Jung-A A Woo, Mohammed Zaheen Bukhari, Kyung Woo Hong, Courtney Trotter, David E Kan. Cofilin-mediated Neuronal Apoptosis via p53 Translocation and PLD1 Regulation. Scientific reports. vol 7. issue 1. 2019-06-24. PMID:28912445. |
finally, activated cofilin is unable to induce apoptosis in cells genetically lacking p53. |
2019-06-24 |
2023-08-13 |
mouse |
| Tian Liu, Fang Wang, Patrick LePochat, Jung-A A Woo, Mohammed Zaheen Bukhari, Kyung Woo Hong, Courtney Trotter, David E Kan. Cofilin-mediated Neuronal Apoptosis via p53 Translocation and PLD1 Regulation. Scientific reports. vol 7. issue 1. 2019-06-24. PMID:28912445. |
these findings taken together indicate that cofilin coopts and requires the nuclear and mitochondrial pro-apoptotic p53 program to induce and execute apoptosis, while pld1 functions in a regulatory multi-brake capacity in this pathway. |
2019-06-24 |
2023-08-13 |
mouse |
| A Lindemann, H Takahashi, A A Patel, A A Osman, J N Myer. Targeting the DNA Damage Response in OSCC with TP53 Mutations. Journal of dental research. vol 97. issue 6. 2019-06-24. PMID:29489434. |
the dna damage stabilizes p53 in part via the dna damage signaling pathway that involves sensor kinases, including atm and atr and effector kinases, such as chk1/2 and wee1, which leads to posttranscriptional regulation of a variety of genes involved in dna repair, cell cycle control, apoptosis, and senescence. |
2019-06-24 |
2023-08-13 |
human |
| Ziling Fang, Bo Cao, Jun-Ming Liao, Jun Deng, Kevin D Plummer, Peng Liao, Tao Liu, Wensheng Zhang, Kun Zhang, Li Li, David Margolin, Shelya X Zeng, Jianping Xiong, Hua L. SPIN1 promotes tumorigenesis by blocking the uL18 (universal large ribosomal subunit protein 18)-MDM2-p53 pathway in human cancer. eLife. vol 7. 2019-06-24. PMID:29547122. |
spin1 ablation activates p53, suppresses cell growth, reduces clonogenic ability, and induces apoptosis of human cancer cells. |
2019-06-24 |
2023-08-13 |
human |
| Toshiyuki Yano, Koki Abe, Masaya Tanno, Takayuki Miki, Atsushi Kuno, Tetsuji Miura, Charles Steenberge. Does p53 Inhibition Suppress Myocardial Ischemia-Reperfusion Injury? Journal of cardiovascular pharmacology and therapeutics. vol 23. issue 4. 2019-06-24. PMID:29554809. |
p53 is well known as a regulator of apoptosis and autophagy. |
2019-06-24 |
2023-08-13 |
mouse |
| Xianping Dai, Feng Geng, Mengshun Li, Ming Li. Tripartite motif‑containing 11 regulates the proliferation and apoptosis of breast cancer cells. Oncology reports. vol 41. issue 4. 2019-06-24. PMID:30816511. |
downregulation of trim11 in mcf‑7 and mda‑mb‑231 cells inhibited cell proliferation and promoted cell apoptosis, accompanied by increased phosphatase and tensin homolog deleted on chromosome 10 (pten), p53 and bcl‑2‑associated x protein, and decreased b‑cell lymphoma 2, phosphorylated c‑jun n‑terminal kinase 1/2 (p‑jnk1/2) and phosphorylated extracellular signal‑regulated kinases 1/2 (p‑erk1/2), whereas the overexpression of trim11 completely reversed these effects. |
2019-06-24 |
2023-08-13 |
Not clear |
| Min Quan, Shunai Liu, Li Zhou, Shenghu Feng, Yu Zhang, Jun Chen. Hepatitis C virus nonstructural 5A protein inhibits the starvation‑induced apoptosis of hepatoblastoma cells by increasing Beclin 1 expression. Oncology reports. vol 41. issue 5. 2019-06-24. PMID:30896822. |
furthermore, it was confirmed that beclin 1 expression by ns5a was involved in the negative regulation of starvation‑induced liver cancer apoptosis, which was accompanied by reduced p53 and apoptosis regulator bax expression, as well as decreased caspase‑3/-7 activation. |
2019-06-24 |
2023-08-13 |
Not clear |
| Sijing Li, Fenbo Ma, Xiangchao Pang, Bin Tang, Lijun Li. Synthesis of chondroitin sulfate magnesium for osteoarthritis treatment. Carbohydrate polymers. vol 212. 2019-06-20. PMID:30832871. |
furthermore, significant upregulation of bcl-2 mrna expression and downregulation of the expression of apoptosis related gene p53 were observed. |
2019-06-20 |
2023-08-13 |
Not clear |
| Nanashara C de Carvalho, Sara P Neves, Rosane B Dias, Ludmila de F Valverde, Caroline B S Sales, Clarissa A G Rocha, Milena B P Soares, Edjane R Dos Santos, Regina M M Oliveira, Rose M Carlos, Paulo C L Nogueira, Daniel P Bezerr. A novel ruthenium complex with xanthoxylin induces S-phase arrest and causes ERK1/2-mediated apoptosis in HepG2 cells through a p53-independent pathway. Cell death & disease. vol 9. issue 2. 2019-06-18. PMID:29362398. |
in contrast, pretreatment with a p53 inhibitor (cyclic pifithrin-α) did not prevent rcx-induced apoptosis, indicating the activation of a p53-independent apoptosis pathway. |
2019-06-18 |
2023-08-13 |
mouse |
| Junlian Gu, Shudong Wang, Hua Guo, Yi Tan, Yaqin Liang, Anyun Feng, Qiuju Liu, Chendil Damodaran, Zhiguo Zhang, Bradley B Keller, Chi Zhang, Lu Ca. Inhibition of p53 prevents diabetic cardiomyopathy by preventing early-stage apoptosis and cell senescence, reduced glycolysis, and impaired angiogenesis. Cell death & disease. vol 9. issue 2. 2019-06-18. PMID:29362483. |
inhibition of p53 prevents diabetic cardiomyopathy by preventing early-stage apoptosis and cell senescence, reduced glycolysis, and impaired angiogenesis. |
2019-06-18 |
2023-08-13 |
mouse |
| Junlian Gu, Shudong Wang, Hua Guo, Yi Tan, Yaqin Liang, Anyun Feng, Qiuju Liu, Chendil Damodaran, Zhiguo Zhang, Bradley B Keller, Chi Zhang, Lu Ca. Inhibition of p53 prevents diabetic cardiomyopathy by preventing early-stage apoptosis and cell senescence, reduced glycolysis, and impaired angiogenesis. Cell death & disease. vol 9. issue 2. 2019-06-18. PMID:29362483. |
mechanistically, the inhibition of p53 prevented the cardiac apoptosis during early-stage diabetes (0.5 month), attenuated diabetes-induced cell senescence (3 and 6 months), and improved both glycolytic and angiogenic defects by increasing hypoxia-induced factor (hif)-1α protein stability and upregulating hif-1α transcription of specific target genes at 3 and 6 months after diabetes. |
2019-06-18 |
2023-08-13 |
mouse |
| Qiming Shen, Haoyou Wang, Lin Zhan. Effect of exogenous p51a gene on the growth and chemo sensitivity of human lung adenocarcinoma cell lines. Artificial cells, nanomedicine, and biotechnology. vol 46. issue sup3. 2019-06-18. PMID:30095026. |
the dysfunction of p53-mediated apoptosis is the key to tumorigenesis, so most gene therapy programs concentrate on improving the expressing level of wild-type p53 in tumour cells. |
2019-06-18 |
2023-08-13 |
human |
| Hector Katifelis, Anna Lyberopoulou, Iuliia Mukha, Nadiia Vityuk, Gallina Grodzyuk, George E Theodoropoulos, Efstathios P Efstathopoulos, Maria Gazoul. Ag/Au bimetallic nanoparticles induce apoptosis in human cancer cell lines via P53, CASPASE-3 and BAX/BCL-2 pathways. Artificial cells, nanomedicine, and biotechnology. vol 46. issue sup3. 2019-06-18. PMID:30371113. |
ag/au bimetallic nanoparticles induce apoptosis in human cancer cell lines via p53, caspase-3 and bax/bcl-2 pathways. |
2019-06-18 |
2023-08-13 |
human |
| Qi Cheng, Deng Ning, Jin Chen, Xue Li, Xiao-Ping Chen, Li Jian. SIX1 and DACH1 influence the proliferation and apoptosis of hepatocellular carcinoma through regulating p53. Cancer biology & therapy. vol 19. issue 5. 2019-06-17. PMID:29333942. |
six1 and dach1 influence the proliferation and apoptosis of hepatocellular carcinoma through regulating p53. |
2019-06-17 |
2023-08-13 |
mouse |
| Yalu Zhou, Ricardo E Perez, Lei Duan, Carl G Mak. DZNep represses Bcl-2 expression and modulates apoptosis sensitivity in response to Nutlin-3a. Cancer biology & therapy. vol 19. issue 6. 2019-06-17. PMID:29394130. |
wild-type p53 expressing hct116 colon cancer cells were resistant to apoptosis in response to the mdm2 antagonist nutlin-3a. |
2019-06-17 |
2023-08-13 |
Not clear |
| Waleed Minzel, Avanthika Venkatachalam, Avner Fink, Eric Hung, Guy Brachya, Ido Burstain, Maya Shaham, Amitai Rivlin, Itay Omer, Adar Zinger, Shlomo Elias, Eitan Winter, Paul E Erdman, Robert W Sullivan, Leah Fung, Frank Mercurio, Dansu Li, Joseph Vacca, Nathali Kaushansky, Liran Shlush, Moshe Oren, Ross Levine, Eli Pikarsky, Irit Snir-Alkalay, Yinon Ben-Neria. Small Molecules Co-targeting CKIα and the Transcriptional Kinases CDK7/9 Control AML in Preclinical Models. Cell. vol 175. issue 1. 2019-06-17. PMID:30146162. |
we show that blocking ckiα together with cdk7 and/or cdk9 synergistically stabilize p53, deprive leukemia cells of survival and proliferation-maintaining se-driven oncogenes, and induce apoptosis. |
2019-06-17 |
2023-08-13 |
mouse |
| Yanze Li, Kenji Kokura, Toshiaki Inou. Stabilization of P/CAF, as a ubiquitin ligase toward MDM2, suppresses mitotic cell death through p53-p21 activation in HCT116 cells with SIRT2 suppression. Biochemical and biophysical research communications. vol 508. issue 1. 2019-06-13. PMID:30482390. |
we previously reported that the suppression of sirt2, an nad + -dependent protein deacetylases, induces p53 accumulation via degradation of p300 and the subsequent mdm2 degradation, eventually leading to apoptosis in hela cells. |
2019-06-13 |
2023-08-13 |
Not clear |
| Yanze Li, Kenji Kokura, Toshiaki Inou. Stabilization of P/CAF, as a ubiquitin ligase toward MDM2, suppresses mitotic cell death through p53-p21 activation in HCT116 cells with SIRT2 suppression. Biochemical and biophysical research communications. vol 508. issue 1. 2019-06-13. PMID:30482390. |
the present study identified a novel pathway of p53 accumulation by sirt2 suppression in hct116(p53+/+) cells in which sirt2 suppression led to escape from mitotic cell death caused by spindle assembly checkpoint activation induced by microtubule inhibitors such as nocodazole but not apoptosis or g1 or g2 arrest. |
2019-06-13 |
2023-08-13 |
Not clear |
| Jiwon Baeka, Hyun-Soo Rohb, Chang-Ik Choi, Kwan-Hyuck Baekb, Ki Hyun Ki. Raphanus sativus Sprout Causes Selective Cytotoxic Effect on p53-Deficient Human Lung Cancer Cells in vitro. Natural product communications. vol 12. issue 2. 2019-06-11. PMID:30428220. |
the meoh extract decreased the viability of p53-deleted human lung cancer cells (h1299 and calu-6) by inducing apoptosis; this effect, however, did not occur for wild-type p53 cancer cells (a549), for cells expressing a p53 mutant lacking the c terminus (h1264), or for . |
2019-06-11 |
2023-08-13 |
human |