| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xiaobing Yu, Shuo Zhang, Dewei Zhao, Xiuzhi Zhang, Chongjun Xia, Tienan Wang, Meng Zhang, Tao Liu, Wei Huang, Baolin W. SIRT1 inhibits apoptosis in in vivo and in vitro models of spinal cord injury via microRNA-494. International journal of molecular medicine. vol 43. issue 4. 2019-07-30. PMID:30816451. |
administration of a sirt1 agonist reduced the effects of mir‑494 overexpression on cell apoptosis in an sci model, whereas treatment with a p53 agonist reduced the effects of mir‑494 knockdown on cell apoptosis in an sci model. |
2019-07-30 |
2023-08-13 |
rat |
| Xiaobing Yu, Shuo Zhang, Dewei Zhao, Xiuzhi Zhang, Chongjun Xia, Tienan Wang, Meng Zhang, Tao Liu, Wei Huang, Baolin W. SIRT1 inhibits apoptosis in in vivo and in vitro models of spinal cord injury via microRNA-494. International journal of molecular medicine. vol 43. issue 4. 2019-07-30. PMID:30816451. |
together, these findings suggested that sirt1 may inhibit apoptosis of sci in vivo and in vitro through the p53 signaling pathway, whereas mir‑494 suppressed sirt1 and induced apoptosis. |
2019-07-30 |
2023-08-13 |
rat |
| Yu Qi Qiao, Chen Wen Cai, Jun Shen, Qing Zheng, Zhi Hua Ra. Circular RNA expression alterations in colon tissues of Crohn's disease patients. Molecular medicine reports. vol 19. issue 5. 2019-07-30. PMID:30896837. |
furthermore, kyoto encyclopaedia of genes and genomes pathway analysis predicted that hsa‑circrna‑102685 potentially participated in apoptosis, and in the toll‑like receptor and p53 signalling pathways. |
2019-07-30 |
2023-08-13 |
Not clear |
| Mona Diab-Assaf, Josiane Semaan, Marwan El-Sabban, Soad K Al Jaouni, Rania Azar, Mohammad Amjad Kamal, Steve Harake. Inhibition of Proliferation and Induction of Apoptosis by Thymoquinone via Modulation of TGF Family, p53, p21 and Bcl-2α in Leukemic Cells. Anti-cancer agents in medicinal chemistry. vol 18. issue 2. 2019-07-29. PMID:28901264. |
inhibition of proliferation and induction of apoptosis by thymoquinone via modulation of tgf family, p53, p21 and bcl-2α in leukemic cells. |
2019-07-29 |
2023-08-13 |
human |
| Xue Zhu, Ke Wang, Kai Zhang, Yi Pan, Fanfan Zhou, Ling Zh. Polyphyllin I Induces Cell Cycle Arrest and Cell Apoptosis in Human Retinoblastoma Y-79 Cells through Targeting p53. Anti-cancer agents in medicinal chemistry. vol 18. issue 6. 2019-07-29. PMID:29308745. |
polyphyllin i induces cell cycle arrest and cell apoptosis in human retinoblastoma y-79 cells through targeting p53. |
2019-07-29 |
2023-08-13 |
human |
| Liang Zhang, Zhenyu Wang, Jie Zhang, Xiaomao Luo, Qian Du, Lingling Chang, Xiaomin Zhao, Yong Huang, Dewen Ton. Porcine parvovirus infection impairs progesterone production in luteal cells through mitogen-activated protein kinases, p53, and mitochondria-mediated apoptosis. Biology of reproduction. vol 98. issue 4. 2019-07-29. PMID:29360968. |
porcine parvovirus infection impairs progesterone production in luteal cells through mitogen-activated protein kinases, p53, and mitochondria-mediated apoptosis. |
2019-07-29 |
2023-08-13 |
Not clear |
| Liang Zhang, Zhenyu Wang, Jie Zhang, Xiaomao Luo, Qian Du, Lingling Chang, Xiaomin Zhao, Yong Huang, Dewen Ton. Porcine parvovirus infection impairs progesterone production in luteal cells through mitogen-activated protein kinases, p53, and mitochondria-mediated apoptosis. Biology of reproduction. vol 98. issue 4. 2019-07-29. PMID:29360968. |
pretreatment with p38 mapk inhibitor (sb203580) suppressed ppv-induced p53 accumulation and translocation, slcs apoptosis, and progesterone production reduction. |
2019-07-29 |
2023-08-13 |
Not clear |
| Sahar Yarahmadi, Zohreh Abdolvahabi, Zahra Hesari, Masoumeh Tavakoli-Yaraki, Zeynab Yousefi, Parvaneh Seiri, Saman Hosseinkhani, Mitra Nourbakhs. Inhibition of sirtuin 1 deacetylase by miR-211-5p provides a mechanism for the induction of cell death in breast cancer cells. Gene. vol 711. 2019-07-29. PMID:31220581. |
up-regulation of mir-211-5p was also followed by a significant decline in the acetylation status of p53 which was associated with remarkable decreased cell viability and induction of apoptosis in breast cancer cells. |
2019-07-29 |
2023-08-13 |
Not clear |
| Xiaoxiao Fan, Shuai Li, Zhenlong Wu, Zhaolai Dai, Ju Li, Xiaolong Wang, Guoyao W. Glycine supplementation to breast-fed piglets attenuates post-weaning jejunal epithelial apoptosis: a functional role of CHOP signaling. Amino acids. vol 51. issue 3. 2019-07-24. PMID:30483907. |
among the proteins related to apoptosis, abundances of chop and p53 were reduced, whereas those of bcl-2 and bcl-xl were enhanced in the jejunum of 100-200% glycine-supplemented piglets. |
2019-07-24 |
2023-08-13 |
Not clear |
| Pat P Ongusaha, Hyung-Gu Kim, Sarah A Boswell, Anne J Ridley, Channing J Der, G Paolo Dotto, Young-Bum Kim, Stuart A Aaronson, Sam W Le. Retraction Notice to: RhoE Is a Pro-Survival p53 Target Gene that Inhibits ROCK I-Mediated Apoptosis in Response to Genotoxic Stress. Current biology : CB. vol 29. issue 12. 2019-07-23. PMID:31211968. |
retraction notice to: rhoe is a pro-survival p53 target gene that inhibits rock i-mediated apoptosis in response to genotoxic stress. |
2019-07-23 |
2023-08-13 |
Not clear |
| Marcel Tuppi, Sebastian Kehrloesser, Daniel W Coutandin, Valerio Rossi, Laura M Luh, Alexander Strubel, Katharina Hötte, Meike Hoffmeister, Birgit Schäfer, Tiago De Oliveira, Florian Greten, Ernst H K Stelzer, Stefan Knapp, Massimo De Felici, Christian Behrends, Francesca Gioia Klinger, Volker Dötsc. Oocyte DNA damage quality control requires consecutive interplay of CHK2 and CK1 to activate p63. Nature structural & molecular biology. vol 25. issue 3. 2019-07-22. PMID:29483652. |
loss of the primordial follicle reserve is the most important cause of poi, with the p53 family member p63 being responsible for dna-damage-induced apoptosis of resting oocytes. |
2019-07-22 |
2023-08-13 |
mouse |
| Erdinç Turk, Fatih Mehmet Kandemir, Serkan Yildirim, Cuneyt Caglayan, Sefa Kucukler, Muslum Kuz. Protective Effect of Hesperidin on Sodium Arsenite-Induced Nephrotoxicity and Hepatotoxicity in Rats. Biological trace element research. vol 189. issue 1. 2019-07-22. PMID:30066062. |
furthermore, sa caused inflammation, apoptosis, and oxidative dna damage by increasing tumor necrosis factor-α (tnf-α), nuclear factor kappa b (nf-κb), interleukin-1β (il-1β), cysteine aspartate-specific protease-3 (caspase-3), and 8-hydroxy-2'-deoxyguanosine (8-ohdg) levels in the kidney and liver tissues and by increasing liver p53 and kidney interleukin-6 (il-6) expressions. |
2019-07-22 |
2023-08-13 |
rat |
| Jiangtao Pu, Xiaojun Tang, Xiang Zhuang, Zhi Hu, Kaiming He, Yunfei Wu, Tianyang Da. Matrine induces apoptosis via targeting CCR7 and enhances the effect of anticancer drugs in non-small cell lung cancer in vitro. Innate immunity. vol 24. issue 7. 2019-07-22. PMID:30236029. |
the results showed that matrine (≥10 μm) caused a significant inhibition on cell viability and 10 and 100 μm matrine induced cell apoptosis via influencing p53, bax, casp3, and bcl-2 expressions in a549 cells. |
2019-07-22 |
2023-08-13 |
Not clear |
| Ma Yanchun, Wang Yi, Wang Lu, Qian Yu, Yang Jian, Kong Pengzhou, Yan Ting, Li Hongyi, Wang Fang, Cheng Xiaolong, Cui Yongpin. Triptolide prevents proliferation and migration of Esophageal Squamous Cell Cancer via MAPK/ERK signaling pathway. European journal of pharmacology. vol 851. 2019-07-22. PMID:30779917. |
in addition, we revealed that triptolide regulates cell apoptosis and metastasis by p53 and mitogen-activated protein kinases/extracellular signal-regulated kinase (mapk/erk) signaling pathway, respectively. |
2019-07-22 |
2023-08-13 |
mouse |
| Bing Wu, Heyuan Wang, Lenign Zhang, Chenglin Sun, Hang Li, Chunyan Jiang, Xiaodong Li. High expression of RAD18 in glioma induces radiotherapy resistance via down-regulating P53 expression. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 112. 2019-07-22. PMID:30798132. |
furthermore, cell growth promotion and cell apoptosis inhibition induced by rad18 up-regulation were impaired when p53 expression was up-regulated under radiation condition. |
2019-07-22 |
2023-08-13 |
Not clear |
| V A Zuev, A S Dyatlova, N S Lin'kova, T V Kvetnay. Expression of Aβ42, τ-Protein, p16, p53 in Buccal Epithelium: Prospects for Use in the Diagnostics of Alzheimer's Disease and Rate of Aging. Bulletin of experimental biology and medicine. vol 166. issue 5. 2019-07-22. PMID:30903490. |
in addition, increased synthesis of proteins of cell aging and apoptosis p16 (by 6-10 times) and p53 (by 2-3 times) was observed in patients in comparison with age-matched persons without neuropathology. |
2019-07-22 |
2023-08-13 |
Not clear |
| Yao Liu, Xiaohui Wang, Guan Wang, Yushang Yang, Yong Yuan, Liang Ouyan. The past, present and future of potential small-molecule drugs targeting p53-MDM2/MDMX for cancer therapy. European journal of medicinal chemistry. vol 176. 2019-07-22. PMID:31100649. |
the p53 gene, a well-known tumor suppressor gene, plays a crucial role in cell cycle regulation, dna repair, cell differentiation, and apoptosis. |
2019-07-22 |
2023-08-13 |
Not clear |
| Yong Guo, Yi Li, Fang-Fang Wang, Bing Xiang, Xiao-Ou Huang, Hong-Bing Ma, Yu-Ping Gon. The combination of Nutlin-3 and Tanshinone IIA promotes synergistic cytotoxicity in acute leukemic cells expressing wild-type p53 by co-regulating MDM2-P53 and the AKT/mTOR pathway. The international journal of biochemistry & cell biology. vol 106. 2019-07-18. PMID:30389549. |
mdm2 inhibitors that activate p53 and induce apoptosis are currently being developed for potential treatment of acute leukemia. |
2019-07-18 |
2023-08-13 |
mouse |
| Yong Guo, Yi Li, Fang-Fang Wang, Bing Xiang, Xiao-Ou Huang, Hong-Bing Ma, Yu-Ping Gon. The combination of Nutlin-3 and Tanshinone IIA promotes synergistic cytotoxicity in acute leukemic cells expressing wild-type p53 by co-regulating MDM2-P53 and the AKT/mTOR pathway. The international journal of biochemistry & cell biology. vol 106. 2019-07-18. PMID:30389549. |
here, we report that the combination of nutlin-3 and tanshinone iia synergistically induces cytotoxicity, cell cycle arrest, apoptosis, and autophagic cell death, thereby imparting anti-leukemia effect in an acute leukemia cell line with wild-type p53 by effectively activating p53, inhibiting the akt/mtor pathway, and activating the raf/mek pathway. |
2019-07-18 |
2023-08-13 |
mouse |
| W J Smiles, D M Camer. The guardian of the genome p53 regulates exercise-induced mitochondrial plasticity beyond organelle biogenesis. Acta physiologica (Oxford, England). vol 222. issue 3. 2019-07-16. PMID:29178461. |
specifically, via its role(s) as a tumour suppressor, p53 intimately surveys cellular dna damage, in particular mitochondrial dna (mtdna), to ensure that the mitochondrial network is carefully monitored and cell viability is upheld, because aberrant mtdna damage leads to apoptosis and widespread cellular perturbations. |
2019-07-16 |
2023-08-13 |
human |