| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xu-Na Wang, Kui-Yang Wang, Xue-Song Zhang, Chao Yang, Xue-Ying L. 4-Hydroxybenzoic acid (4-HBA) enhances the sensitivity of human breast cancer cells to adriamycin as a specific HDAC6 inhibitor by promoting HIPK2/p53 pathway. Biochemical and biophysical research communications. vol 504. issue 4. 2019-05-28. PMID:30217455. |
4-hba significantly promoted the anticancer effect of adm on apoptosis induction, as evidenced by the increased expressions of caspase-3 and parp cleavage, which was associated with the promotion p53 and homeodomain interacting protein kinase-2 (hipk2) expressions in adm-resistant breast cancer cells. |
2019-05-28 |
2023-08-13 |
human |
| Qing Zhang, Xiao-Feng Zhan. Hyperoside decreases the apoptosis and autophagy rates of osteoblast MC3T3‑E1 cells by regulating TNF‑like weak inducer of apoptosis and the p38mitogen activated protein kinase pathway. Molecular medicine reports. vol 19. issue 1. 2019-05-28. PMID:30387825. |
expression levels of apoptosis‑associated genes, including caspase‑3, apoptosis regulator bax, apoptosis regulator bcl‑2 and cellular tumor antigen p53, in addition to autophagy‑associated genes, including beclin1 and microtubule‑associated protein light chain 3 conversion lc3‑ii/i, were measured using reverse transcription‑quantitative polymerase chain reaction and western blotting. |
2019-05-28 |
2023-08-13 |
Not clear |
| Geng-Qiang Ling, Xian-Feng Li, Xu-Hui Lei, Zhen-Yu Wang, Dong-Ying Ma, Yue-Na Wang, Wei Y. c‑Jun N‑terminal kinase inhibition attenuates early brain injury induced neuronal apoptosis via decreasing p53 phosphorylation and mitochondrial apoptotic pathway activation in subarachnoid hemorrhage rats. Molecular medicine reports. vol 19. issue 1. 2019-05-28. PMID:30431087. |
c‑jun n‑terminal kinase inhibition attenuates early brain injury induced neuronal apoptosis via decreasing p53 phosphorylation and mitochondrial apoptotic pathway activation in subarachnoid hemorrhage rats. |
2019-05-28 |
2023-08-13 |
rat |
| Geng-Qiang Ling, Xian-Feng Li, Xu-Hui Lei, Zhen-Yu Wang, Dong-Ying Ma, Yue-Na Wang, Wei Y. c‑Jun N‑terminal kinase inhibition attenuates early brain injury induced neuronal apoptosis via decreasing p53 phosphorylation and mitochondrial apoptotic pathway activation in subarachnoid hemorrhage rats. Molecular medicine reports. vol 19. issue 1. 2019-05-28. PMID:30431087. |
the present study aimed to explore whether the role of jnk1 is associated with tumor protein p53 (p53), which is one of the most important factor that triggers cell apoptosis. |
2019-05-28 |
2023-08-13 |
rat |
| Geng-Qiang Ling, Xian-Feng Li, Xu-Hui Lei, Zhen-Yu Wang, Dong-Ying Ma, Yue-Na Wang, Wei Y. c‑Jun N‑terminal kinase inhibition attenuates early brain injury induced neuronal apoptosis via decreasing p53 phosphorylation and mitochondrial apoptotic pathway activation in subarachnoid hemorrhage rats. Molecular medicine reports. vol 19. issue 1. 2019-05-28. PMID:30431087. |
the interruption of ebi‑induced neuronal apoptosis may originate from a decrease in the level of p53 phosphorylation and deactivation of the downstream mitochondrial apoptotic pathway. |
2019-05-28 |
2023-08-13 |
rat |
| Shang-Ze Li, Jian-Wei Ren, Jing Fei, Xiao-Dong Zhang, Run-Lei D. Cordycepin induces Bax‑dependent apoptosis in colorectal cancer cells. Molecular medicine reports. vol 19. issue 2. 2019-05-28. PMID:30535479. |
to investigate the molecular mechanisms of cordycepin against colon cancer and in driving apoptosis, p53 and bcl‑2‑like protein 4‑null (bax‑/‑) colon cancer hct116 cell lines were used. |
2019-05-28 |
2023-08-13 |
human |
| Ruirui Yang, Jianmei Chen, Li Wang, Aijing Den. LncRNA BANCR participates in polycystic ovary syndrome by promoting cell apoptosis. Molecular medicine reports. vol 19. issue 3. 2019-05-24. PMID:30592281. |
kgn cells were also transfected with a bancr expression vector, after which, cell proliferation, apoptosis and the expression levels of pro‑apoptotic b‑cell lymphoma 2‑associated x protein (bax) and p53 were detected by cell counting kit‑8 assay, mtt assay and western blotting, respectively. |
2019-05-24 |
2023-08-13 |
human |
| Ruirui Yang, Jianmei Chen, Li Wang, Aijing Den. LncRNA BANCR participates in polycystic ovary syndrome by promoting cell apoptosis. Molecular medicine reports. vol 19. issue 3. 2019-05-24. PMID:30592281. |
transfection with the bancr expression vector significantly inhibited proliferation and promoted apoptosis of kgn cells, and significantly promoted the expression levels of pro‑apoptotic bax and p53. |
2019-05-24 |
2023-08-13 |
human |
| Ruirui Yang, Jianmei Chen, Li Wang, Aijing Den. LncRNA BANCR participates in polycystic ovary syndrome by promoting cell apoptosis. Molecular medicine reports. vol 19. issue 3. 2019-05-24. PMID:30592281. |
therefore, it may be concluded that lncrna bancr participates in pcos by promoting cell apoptosis through the upregulation of bax and p53. |
2019-05-24 |
2023-08-13 |
human |
| Aldo F Clemente-Soto, Enrique Salas-Vidal, Cesar Milan-Pacheco, Jessica Nayelli Sánchez-Carranza, Oscar Peralta-Zaragoza, Leticia González-May. Quercetin induces G2 phase arrest and apoptosis with the activation of p53 in an E6 expression‑independent manner in HPV‑positive human cervical cancer‑derived cells. Molecular medicine reports. vol 19. issue 3. 2019-05-24. PMID:30664221. |
quercetin induces g2 phase arrest and apoptosis with the activation of p53 in an e6 expression‑independent manner in hpv‑positive human cervical cancer‑derived cells. |
2019-05-24 |
2023-08-13 |
human |
| Aldo F Clemente-Soto, Enrique Salas-Vidal, Cesar Milan-Pacheco, Jessica Nayelli Sánchez-Carranza, Oscar Peralta-Zaragoza, Leticia González-May. Quercetin induces G2 phase arrest and apoptosis with the activation of p53 in an E6 expression‑independent manner in HPV‑positive human cervical cancer‑derived cells. Molecular medicine reports. vol 19. issue 3. 2019-05-24. PMID:30664221. |
therefore, these cells are deficient in the processes regulated by p53, including apoptosis, damaged dna repair, and the cell cycle. |
2019-05-24 |
2023-08-13 |
human |
| Aldo F Clemente-Soto, Enrique Salas-Vidal, Cesar Milan-Pacheco, Jessica Nayelli Sánchez-Carranza, Oscar Peralta-Zaragoza, Leticia González-May. Quercetin induces G2 phase arrest and apoptosis with the activation of p53 in an E6 expression‑independent manner in HPV‑positive human cervical cancer‑derived cells. Molecular medicine reports. vol 19. issue 3. 2019-05-24. PMID:30664221. |
in the present study, it was demonstrated that quercetin induced g2 phase cell cycle arrest and apoptosis in both hela and siha cells, accompanied by an increase of p53 and its nuclear signal. |
2019-05-24 |
2023-08-13 |
human |
| Svetlana Demyanenko, Anatoly Uzdensk. Profiling of Signaling Proteins in Penumbra After Focal Photothrombotic Infarct in the Rat Brain Cortex. Molecular neurobiology. vol 54. issue 9. 2019-05-23. PMID:27771897. |
these included over-expression of proteins initiating, regulating, or executing various apoptosis stages (caspases, smac/diablo, bcl-10, phosphatidylserine receptor (psr), prostate apoptosis response 4 (par4), e2f1, p75, p38, jnk, p53, growth arrest and dna damage inducible protein 153 (gadd153), glutamate decarboxylases (gad65/67), nmdar2a, c-myc) and antiapoptotic proteins (bcl-x, p63, mdm2, p21waf-1, erk1/2, erk5, map kinase-activated protein kinase-2 (makapk2), pkcα, pkcβ, pkcμ, raf1, protein phosphatases 1α and map kinase phosphatase-1 (mkp-1), neural precursor cell expressed, developmentally down-regulated 8 (nedd8), estrogen and egf receptors, calmodulin, camkiiα, camkiv, amyloid precursor protein (app), nicastrin). |
2019-05-23 |
2023-08-13 |
rat |
| Ziyun Gao, Junqi Shan, Bishi Wang, Luxin Qiao, Dexi Chen, Yulin Zhan. DRAM Is Involved in Regulating Nucleoside Analog-Induced Neuronal Autophagy in a p53-Independent Manner. Molecular neurobiology. vol 55. issue 3. 2019-05-23. PMID:28265856. |
p53 played a role in the regulation of na-induced neuronal apoptosis, but its role in na-associated neuronal autophagy was uncertain. |
2019-05-23 |
2023-08-13 |
mouse |
| Simin Mirakhor Samani, Tahmineh Ezazi Bojnordi, Manijeh Zarghampour, Sobhan Merat, Daniel F Foulad. Expression of p53, Bcl-2 and Bax in endometrial carcinoma, endometrial hyperplasia and normal endometrium: a histopathological study. Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology. vol 38. issue 7. 2019-05-23. PMID:29560769. |
the p53, bcl-2 and bax are the three major genes that regulate apoptosis. |
2019-05-23 |
2023-08-13 |
human |
| Xiaolong Gu, Zhi Wang, Jian Gao, Dandan Han, Limei Zhang, Peng Chen, Guangjian Luo, Bo Ha. SIRT1 suppresses p53-dependent apoptosis by modulation of p21 in osteoblast-like MC3T3-E1 cells exposed to fluoride. Toxicology in vitro : an international journal published in association with BIBRA. vol 57. 2019-05-23. PMID:30738887. |
results showed that there was a promotion in apoptosis rate, intracellular ros levels, the ratio of bax/bcl-2, protein expression (cyt c, caspase-3, p53, ac-p53 and p21) and blockage of s phase after cells were exposed to naf. |
2019-05-23 |
2023-08-13 |
Not clear |
| Ana Gabriela Silva, Caio Fabio Baeta Lopes, Clóvis Gomes Carvalho Júnior, Ralph Gruppi Thomé, Hélio Batista Dos Santos, Rui Reis, Rosy Iara Maciel de Azambuja Ribeir. WIN55,212-2 induces caspase-independent apoptosis on human glioblastoma cells by regulating HSP70, p53 and Cathepsin D. Toxicology in vitro : an international journal published in association with BIBRA. vol 57. 2019-05-23. PMID:30776504. |
win55,212-2 induces caspase-independent apoptosis on human glioblastoma cells by regulating hsp70, p53 and cathepsin d. despite the standard approaches to treat the highly aggressive and invasive glioblastoma (gbm), it remains incurable. |
2019-05-23 |
2023-08-13 |
human |
| Mariko Takami, Christina Cunha, Shinichiro Motohashi, Toshinori Nakayama, Makio Iwashim. TGF-β suppresses RasGRP1 expression and supports regulatory T cell resistance against p53-induced CD28-dependent T-cell apoptosis. European journal of immunology. vol 48. issue 12. 2019-05-22. PMID:30298904. |
we previously reported a form of activation-induced cell death, which is dependent on p53 (p53-induced cd28-dependent t-cell apoptosis, pica). |
2019-05-22 |
2023-08-13 |
mouse |
| Yi-Ying Wu, Chin-Tung Hsieh, Ying-Ming Chiu, Shen-Chieh Chou, Jung-Ta Kao, Dong-Chen Shieh, Yi-Ju Le. GSK-3 inhibitors enhance TRAIL-mediated apoptosis in human gastric adenocarcinoma cells. PloS one. vol 13. issue 12. 2019-05-22. PMID:30557366. |
adding p53 sirna can downregulate gsk-3 inhibitor-related sensitization to trail-induced apoptosis and caspase-3 activity. |
2019-05-22 |
2023-08-13 |
human |
| Chongshan Dai, Giuseppe D Ciccotosto, Roberto Cappai, Yang Wang, Shusheng Tang, Daniel Hoyer, Elena K Schneider, Tony Velkov, Xilong Xia. Rapamycin Confers Neuroprotection against Colistin-Induced Oxidative Stress, Mitochondria Dysfunction, and Apoptosis through the Activation of Autophagy and mTOR/Akt/CREB Signaling Pathways. ACS chemical neuroscience. vol 9. issue 4. 2019-05-21. PMID:29257864. |
moreover, rapamycin pretreatment protected against colistin-induced mitochondrial dysfunction, caspase activation, and subsequent apoptosis by up-regulating autophagy and activating the akt/creb, ngf, and nrf2 pathways, while inhibiting p53 signaling. |
2019-05-21 |
2023-08-13 |
mouse |