| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ji Geng, Xiao Yuan, Mingzhen Wei, Junchao Wu, Zheng-Hong Qi. The diverse role of TIGAR in cellular homeostasis and cancer. Free radical research. vol 52. issue 11-12. 2019-04-29. PMID:30284488. |
tp53-induced glycolysis and apoptosis regulator (tigar) is a p53 target protein that plays critical roles in glycolysis and redox balance. |
2019-04-29 |
2023-08-13 |
Not clear |
| Øyvind H Hald, Lotte Olsen, Gabriel Gallo-Oller, Lotta Helena Maria Elfman, Cecilie Løkke, Per Kogner, Baldur Sveinbjörnsson, Trond Flægstad, John Inge Johnsen, Christer Einvi. Inhibitors of ribosome biogenesis repress the growth of MYCN-amplified neuroblastoma. Oncogene. vol 38. issue 15. 2019-04-29. PMID:30542116. |
treatment of neuroblastoma cells with quarfloxin or cx-5461, two small molecule inhibitors of rna polymerase i, suppressed mycn expression, induced dna damage, and activated p53 followed by cell cycle arrest or apoptosis. |
2019-04-29 |
2023-08-13 |
mouse |
| C Cai, H Zhang, Y Ou, Y Jiang, D Zhong, H Qi, Q Dan. Saikosaponin-d suppresses cell growth in renal cell carcinoma through EGFR/p38 signaling pathway. Neoplasma. vol 64. issue 4. 2019-04-25. PMID:28485157. |
analysis by flow cytometry revealed that rcc cell proliferation inhibitory effect of ssd was achieved by inducing apoptosis and cell cycle arrest at g0/g1 phase via up-regulation of p53. |
2019-04-25 |
2023-08-13 |
human |
| Mahmoud A Ali, Hassan Abu Damir, Naheed Amir, E A Adeghate, Salim Bastaki, David Murphy, Abdu Ade. Effects of long-term dehydration on oxidative stress, apoptotic markers and neuropeptides in the gastric mucosa of the dromedary camel. Molecular and cellular biochemistry. vol 455. issue 1-2. 2019-04-25. PMID:30478677. |
dehydration caused significant increase in apoptotic markers; tumor necrosis factor α, caspases 8 and 3, bcl-x1 and tgfβ whereas caspase 9, p53, beclin 1, and parp1 showed no significant change between the three groups indicating that apoptosis was initiated by the extrinsic pathway. |
2019-04-25 |
2023-08-13 |
Not clear |
| Chao Wang, Lu Yang, Yuhuan Hu, Jiansheng Zhu, Rong Xia, Yongquan Yu, Jiemiao Shen, Zhan Zhang, Shou-Lin Wan. Isoliquiritigenin as an antioxidant phytochemical ameliorates the developmental anomalies of zebrafish induced by 2,2',4,4'-tetrabromodiphenyl ether. The Science of the total environment. vol 666. 2019-04-24. PMID:30802654. |
besides, isl ameliorated excessive ros accumulation, and exaggerated the expressions of apoptosis-related genes p53, bcl-2, caspase 3 and caspase 9 induced by bde47, suggesting that isl protected zebrafish from the developmental toxicity of bde47 by inactivation of programmed apoptosis and activation of antioxidant signaling pathways. |
2019-04-24 |
2023-08-13 |
zebrafish |
| Shun Li, Long-Feng Lu, Shu-Bo Liu, Can Zhang, Zhuo-Cong Li, Xiao-Yu Zhou, Yong-An Zhan. Spring viraemia of carp virus modulates p53 expression using two distinct mechanisms. PLoS pathogens. vol 15. issue 3. 2019-04-24. PMID:30925159. |
p53, which regulates cell-cycle arrest and apoptosis, is a crucial target for viruses to release cells from cell-cycle checkpoints or to protect cells from apoptosis for their own benefit. |
2019-04-24 |
2023-08-13 |
Not clear |
| S X Wu, X Y Ren, Y L Pan, D D Guan, S Liu, X Y Zou, C G Shi, Y Z Li, Y Z Zhan. Effects of ALA-PDT on HPV16-immortalized cervical epithelial cell. Neoplasma. vol 64. issue 2. 2019-04-23. PMID:28043143. |
annexin v-fitc/pi staining showed a significant dose-dependent induction of apoptosis by ala-pdt in h8 cells, associated with accumulation of the tumor suppressor protein p53 and the cyclin-dependent kinase inhibitor p21. |
2019-04-23 |
2023-08-13 |
human |
| Ming-Cheng Yang, Cheng Peng, Hua Huang, Lei Yang, Xiang-Hong He, Wei Huang, Hai-Lei Cui, Gu He, Bo Ha. Organocatalytic Asymmetric Synthesis of Spiro-oxindole Piperidine Derivatives That Reduce Cancer Cell Proliferation by Inhibiting MDM2-p53 Interaction. Organic letters. vol 19. issue 24. 2019-04-18. PMID:29210587. |
mechanistic studies suggest that the most potent compound 9e can directly interfere with mdm2-p53 interactions and elevate protein levels of p53 and p21, thereby inducing cell cycle arrest and mitochondrial apoptosis. |
2019-04-18 |
2023-08-13 |
Not clear |
| Marie Ménard, Clélia Costechareyre, Gabriel Ichim, Jonathan Blachier, David Neves, Loraine Jarrosson-Wuilleme, Reinhard Depping, Jan Koster, Pierre Saintigny, Patrick Mehlen, Servane Tauszig-Delamasur. Hey1- and p53-dependent TrkC proapoptotic activity controls neuroblastoma growth. PLoS biology. vol 16. issue 5. 2019-04-18. PMID:29750782. |
p53 transcriptionally regulates the expression of trkc-kf cytoplasmic and mitochondrial interactors cofactor of breast cancer 1 (cobra1) and b cell lymphoma 2-associated x (bax), which will subsequently trigger the intrinsic pathway of apoptosis. |
2019-04-18 |
2023-08-13 |
mouse |
| A Štern, A Rotter, M Novak, M Filipič, B Žegur. Genotoxic effects of the cyanobacterial pentapeptide nodularin in HepG2 cells. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 124. 2019-04-18. PMID:30562542. |
moreover changes in the expression of selected genes from the p53 pathway, involved in the response to dna damage (p53, gadd45α, cdkn1a, mdm2), apoptosis (bax, bcl2) and oxidative stress (gpx1, gsr, gclc, cat, sod1) were determined using qpcr. |
2019-04-18 |
2023-08-13 |
human |
| Hongbing Fu, Changming Wang, Dejun Yang, Ziran Wei, Jiapeng Xu, Zunqi Hu, Yu Zhang, Weimin Wang, Ronglin Yan, Qingping Ca. Curcumin regulates proliferation, autophagy, and apoptosis in gastric cancer cells by affecting PI3K and P53 signaling. Journal of cellular physiology. vol 233. issue 6. 2019-04-15. PMID:28926094. |
curcumin regulates proliferation, autophagy, and apoptosis in gastric cancer cells by affecting pi3k and p53 signaling. |
2019-04-15 |
2023-08-13 |
Not clear |
| Hwani Ryu, Ky-Youb Nam, Jae Sung Kim, Sang-Gu Hwang, Jie-Young Song, Jiyeon Ah. The small molecule AU14022 promotes colorectal cancer cell death via p53-mediated G2/M-phase arrest and mitochondria-mediated apoptosis. Journal of cellular physiology. vol 233. issue 6. 2019-04-15. PMID:29030986. |
to identify small molecules that induce apoptosis via increased p53 transcriptional activity, we used a novel in-house library containing 96 small-molecule compounds. |
2019-04-15 |
2023-08-13 |
mouse |
| Hwani Ryu, Ky-Youb Nam, Jae Sung Kim, Sang-Gu Hwang, Jie-Young Song, Jiyeon Ah. The small molecule AU14022 promotes colorectal cancer cell death via p53-mediated G2/M-phase arrest and mitochondria-mediated apoptosis. Journal of cellular physiology. vol 233. issue 6. 2019-04-15. PMID:29030986. |
treatment with au14022 increased p53 protein expression, p53 ser15 phosphorylation, p53-mediated expression of downstream target genes, and apoptosis in p53-wild-type hct116 human colon cancer cells, but not in p53-knockout hct116 cells. |
2019-04-15 |
2023-08-13 |
mouse |
| Zhengzheng Duan, Ping Ping, Guishuan Wang, Xiansheng Zhang, Fei Su. Imsnc761 and DDX6 synergistically suppress cell proliferation and promote apoptosis via p53 in testicular embryonal carcinoma cells. Bioscience reports. vol 38. issue 4. 2019-04-15. PMID:29769412. |
imsnc761 and ddx6 synergistically suppress cell proliferation and promote apoptosis via p53 in testicular embryonal carcinoma cells. |
2019-04-15 |
2023-08-13 |
Not clear |
| Zhengzheng Duan, Ping Ping, Guishuan Wang, Xiansheng Zhang, Fei Su. Imsnc761 and DDX6 synergistically suppress cell proliferation and promote apoptosis via p53 in testicular embryonal carcinoma cells. Bioscience reports. vol 38. issue 4. 2019-04-15. PMID:29769412. |
in the present study, we found that imsnc761 could interact with dead-box helicase 6 (ddx6) to induce ntera-2 (nt2 (testicular embryonal carcinoma cell)) cell apoptosis and proliferation inhibition via the p53 pathway. |
2019-04-15 |
2023-08-13 |
Not clear |
| Lin Sang, Qian-Jin Fang, Xing-Bo Zha. A research on the protein expression of p53, p16, and MDM2 in endometriosis. Medicine. vol 98. issue 14. 2019-04-15. PMID:30946310. |
this study aims to examine the expression of p53, p16, and murine double minute 2 (mdm2) protein in normal endometrium and endometriosis, in order to discuss the role of p53, p16, and mdm2 protein and apoptosis in the pathogenesis and development of endometriosis, and provide a theoretical basis for clinical diagnosis and treatment.the immunohistochemical streptavidin-biotin peroxidase method was used to detect the expression of p53, p16, and mdm2 in tissue samples obtained from 30 women with pathologically confirmed ovarian endometriosis and 29 women with pathologically confirmed normal endometrium. |
2019-04-15 |
2023-08-13 |
Not clear |
| Lin Sang, Qian-Jin Fang, Xing-Bo Zha. A research on the protein expression of p53, p16, and MDM2 in endometriosis. Medicine. vol 98. issue 14. 2019-04-15. PMID:30946310. |
the relationship between p53, p16, and mdm2 expression and apoptosis was analyzed.in normal endometrium, the positive rate of p53 in the secretory phase was higher than that in the proliferative phase (p < .05). |
2019-04-15 |
2023-08-13 |
Not clear |
| Lin Sang, Qian-Jin Fang, Xing-Bo Zha. A research on the protein expression of p53, p16, and MDM2 in endometriosis. Medicine. vol 98. issue 14. 2019-04-15. PMID:30946310. |
furthermore, the expression of p16 and mdm2 might not be relevant in the endometriosis (r = 0.404, p > .05).as important apoptosis regulatory genes, p53, p16, and mdm2 might be involved in the pathogenesis and development of endometriosis. |
2019-04-15 |
2023-08-13 |
Not clear |
| Liyan Tang, Bo Zhao, Hui Zhang, Qiao Du, Jiang Zhu, Zhijiang Zhao, Ce Chen, Cheng Luo, Qiyuan Kang, Wenbing Yuan, Shaohua Bian, Hang Bi, Huimin Sun, Yingyi L. Regulation of nonylphenol-induced reproductive toxicity in mouse spermatogonia cells by miR-361-3p. Molecular reproduction and development. vol 84. issue 12. 2019-04-11. PMID:29024157. |
klln encodes a transcription factor that directly regulates the expression of tp73 (transcriptionally active p73), whose encoded protein can up-regulate the expression of puma (p53 upregulated modulator of apoptosis). |
2019-04-11 |
2023-08-13 |
mouse |
| Jizong Li, Li Mao, Wenliang Li, Fei Hao, Chunyan Zhong, Xing Zhu, Xinqin Ji, Leilei Yang, Wenwen Zhang, Maojun Liu, Jieyuan Jian. Analysis of microRNAs Expression Profiles in Madin-Darby Bovine Kidney Cells Infected With Caprine Parainfluenza Virus Type 3. Frontiers in cellular and infection microbiology. vol 8. 2019-04-10. PMID:29651410. |
functional annotation analysis showed these up- and downregulated target genes were mainly involved in mapk signaling pathway, jak-stat signaling pathway, toll-like receptor signaling pathway, p53 signaling pathway, focal adhesion, nf-kappa b signaling pathway, and apoptosis, et al. |
2019-04-10 |
2023-08-13 |
cattle |