| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yutian Zhang, Diying Li, Zhuo Wang, Wanting Zang, Pan Rao, Yunxiang Liang, Yuxia Me. Alpha-terpineol affects synthesis and antitumor activity of triterpenoids from Antrodia cinnamomea mycelia in solid-state culture. Food & function. vol 9. issue 12. 2019-04-03. PMID:30474680. |
several related proteins involved in the mitochondrial pathway of apoptosis (p53, bax, caspase-3) did not show expression upregulation by acts-e, suggesting that apoptosis induction occurred through a p53-independent process. |
2019-04-03 |
2023-08-13 |
Not clear |
| Xiaoyan He, Mayinur Maimaiti, Yan Jiao, Xuegang Meng, Hongyan L. Sinomenine Induces G1-Phase Cell Cycle Arrest and Apoptosis in Malignant Glioma Cells Via Downregulation of Sirtuin 1 and Induction of p53 Acetylation. Technology in cancer research & treatment. vol 17. 2019-04-01. PMID:29756546. |
sinomenine induces g1-phase cell cycle arrest and apoptosis in malignant glioma cells via downregulation of sirtuin 1 and induction of p53 acetylation. |
2019-04-01 |
2023-08-13 |
Not clear |
| Xiuna Sun, Mengqi Jia, Wei Sun, Lu Feng, Chundong Gu, Taihua W. Functional role of RBM10 in lung adenocarcinoma proliferation. International journal of oncology. vol 54. issue 2. 2019-04-01. PMID:30483773. |
we found that rbm10 protein was overexpressed in lung adenocarcinoma cells and tissues, and it reduced p53 expression (as detected by immunofluorescence assay and western blot analysis) in a549 cells and inhibited apoptosis (as shown by flow cytometric assay). |
2019-04-01 |
2023-08-13 |
Not clear |
| Yu-Chen Lin, Ze-Ren Shen, Xiao-Hui Song, Xin Liu, Ke Ya. Comparative transcriptomic analysis reveals adriamycin-induced apoptosis via p53 signaling pathway in retinal pigment epithelial cells. Journal of Zhejiang University. Science. B. vol 19. issue 12. 2019-04-01. PMID:30507074. |
comparative transcriptomic analysis reveals adriamycin-induced apoptosis via p53 signaling pathway in retinal pigment epithelial cells. |
2019-04-01 |
2023-08-13 |
Not clear |
| Mengjie Sun, Hui Song, Yuting Ye, Qianqian Yang, Xiaodong Xu, Xiaodong Zhu, Jiong Zhang, Shaolin Shi, Jinquan Wang, Zhihong Li. Differential toxicities of triptolide to immortalized podocytes and the podocytes in vivo. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 109. 2019-04-01. PMID:30551497. |
we found that treatment of tp at 10 ng/ml, a concentration that is routinely used for podocyte protection, was sufficient to activate pro-apoptotic signaling of mapk p38, p53 and bax and induced apoptosis in cultured podocytes; and higher concentrations of tp exacerbated the p38, p53 and bax activations and apoptosis. |
2019-04-01 |
2023-08-13 |
mouse |
| Yann Guéguen, Alice Bontemps, Teni G Ebrahimia. Adaptive responses to low doses of radiation or chemicals: their cellular and molecular mechanisms. Cellular and molecular life sciences : CMLS. vol 76. issue 7. 2019-03-29. PMID:30535789. |
they include dna damage repair (p53, atm, parp pathways), antioxidant response (nrf2 pathway), immune/inflammatory response (nf-κb pathway), cell survival/death pathway (apoptosis), endoplasmic response to stress (upr response), and other cytoprotective processes including autophagy, cell cycle regulation, and the unfolded protein response. |
2019-03-29 |
2023-08-13 |
Not clear |
| Bin Li, Peng Chen, Jialin Wang, Linxia Wang, Mingzhi Ren, Ruisan Zhang, Jianjun H. MicroRNA-1254 exerts oncogenic effects by directly targeting RASSF9 in human breast cancer. International journal of oncology. vol 53. issue 5. 2019-03-28. PMID:30132526. |
taken together, these results demonstrate that mir-1254 accelerates breast cancer cell growth by activating the akt signaling pathway and suppresses apoptosis by inhibiting p53 expression through the targeting of rassf9. |
2019-03-28 |
2023-08-13 |
human |
| Noor Atatreh, Mohammad A Ghattas, Sanaa K Bardaweel, Sara Al Rawashdeh, Mohammad Al Sorkh. Identification of new inhibitors of Mdm2-p53 interaction via pharmacophore and structure-based virtual screening. Drug design, development and therapy. vol 12. 2019-03-26. PMID:30464405. |
the tumor suppressor protein p53 plays an important role in preventing tumor formation and progression through its involvement in cell division control and initiation of apoptosis. |
2019-03-26 |
2023-08-13 |
Not clear |
| Ibrahim Malami, Ahmad B Abdu. Involvement of the uridine cytidine kinase 2 enzyme in cancer cell death: A molecular crosstalk between the enzyme and cellular apoptosis induction. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 109. 2019-03-26. PMID:30551402. |
in this present review, we propose the probable molecular crosstalk involving uck2 protein and cancer cell death through cell cycle arrest and triggering of apoptosis involving proteins, mdm2 and the subsequent activation of p53. |
2019-03-26 |
2023-08-13 |
Not clear |
| Stefanie Klenke, Sebastian Eul, Jürgen Peters, Till Neumann, Michael Adamzik, Ulrich H Fre. Circulating miR-192 is a prognostic marker in patients with ischemic cardiomyopathy. Future cardiology. vol 14. issue 4. 2019-03-25. PMID:29927310. |
ischemic cardiomyopathy (icm) is characterized by accumulation of p53 causing apoptosis of cardiomyocytes and resulting in upregulation of mirna (mir)-192, which plays an important role in the development of heart failure after acute myocardial infarction. |
2019-03-25 |
2023-08-13 |
Not clear |
| Farideh Hosseini, Mohammad Reza Sam, Nasrollah Jabbari, Hossein Mozdaran. Modulating Survivin as a Radioresistant Factor, Caspase-3, and Apoptosis by Omega-3 Docosahexaenoic Acid Sensitizes Mutant-p53 Colorectal Cancer Cells to γ-Irradiation. Cancer biotherapy & radiopharmaceuticals. vol 33. issue 9. 2019-03-21. PMID:30395490. |
thus, the search for safe compounds that modulate survivin expression and induce apoptosis irrespective of p53 status may potentiate the efficacy of radiotherapy in mutant-p53 crc cells. |
2019-03-21 |
2023-08-13 |
human |
| Alfonso Lavado, Jun Young Park, Joshua Paré, David Finkelstein, Haitao Pan, Beisi Xu, Yiping Fan, Ram Parikshan Kumar, Geoffrey Neale, Young Don Kwak, Peter J McKinnon, Randy L Johnson, Xinwei Ca. The Hippo Pathway Prevents YAP/TAZ-Driven Hypertranscription and Controls Neural Progenitor Number. Developmental cell. vol 47. issue 5. 2019-03-21. PMID:30523785. |
following a transient increase in proliferation, however, hypertranscription in neural progenitors triggers replication stress, dna damage, and p53 activation, resulting in massive apoptosis. |
2019-03-21 |
2023-08-13 |
mouse |
| Jiaomei Li, Kelei Li, Jinlong Gao, Xiaofei Guo, Mengqing Lu, Zihao Li, Duo L. Maternal exposure to an n-3 polyunsaturated fatty acid diet decreases mammary cancer risk of female offspring in adulthood. Food & function. vol 9. issue 11. 2019-03-20. PMID:30327803. |
in line with these changes, maternal exposure to fo promoted the expression of long noncoding rna (lncrna) in p53 and apoptosis signaling pathways and inhibited that in nf-κb and jak-stat signaling pathways, while fso promoted the expression of lncrna in p53 signaling pathways and inhibited that in nf-κb, jak-stat and mapk signaling pathways. |
2019-03-20 |
2023-08-13 |
mouse |
| Qiong Shi, Yawen Wang, Wenjing Dong, Erqun Song, Yang Son. Polychlorinated biphenyl quinone-induced signaling transition from autophagy to apoptosis is regulated by HMGB1 and p53 in human hepatoma HepG2 cells. Toxicology letters. vol 306. 2019-03-18. PMID:30742880. |
polychlorinated biphenyl quinone-induced signaling transition from autophagy to apoptosis is regulated by hmgb1 and p53 in human hepatoma hepg2 cells. |
2019-03-18 |
2023-08-13 |
human |
| Qiong Shi, Yawen Wang, Wenjing Dong, Erqun Song, Yang Son. Polychlorinated biphenyl quinone-induced signaling transition from autophagy to apoptosis is regulated by HMGB1 and p53 in human hepatoma HepG2 cells. Toxicology letters. vol 306. 2019-03-18. PMID:30742880. |
hmgb1 and p53 both serve as transcription factors that play crucial roles in the regulation of pcb29-pq-induced autophagy and apoptosis. |
2019-03-18 |
2023-08-13 |
human |
| Qiong Shi, Yawen Wang, Wenjing Dong, Erqun Song, Yang Son. Polychlorinated biphenyl quinone-induced signaling transition from autophagy to apoptosis is regulated by HMGB1 and p53 in human hepatoma HepG2 cells. Toxicology letters. vol 306. 2019-03-18. PMID:30742880. |
interestingly, hmgb1 rather than p53 plays a primary role in 5 μm of pcb29-pq-induced autophagy in the nucleus; however, p53 promoted apoptosis to a great extent in the cytosol at the dose of 15 μm pcb29-pq. |
2019-03-18 |
2023-08-13 |
human |
| Qiong Shi, Yawen Wang, Wenjing Dong, Erqun Song, Yang Son. Polychlorinated biphenyl quinone-induced signaling transition from autophagy to apoptosis is regulated by HMGB1 and p53 in human hepatoma HepG2 cells. Toxicology letters. vol 306. 2019-03-18. PMID:30742880. |
together, hmgb1 and p53 provided a subtle balance between autophagy and apoptosis, thus determining the fate of pcb29-pq-treated cells. |
2019-03-18 |
2023-08-13 |
human |
| Yunyun Quan, Lihong Gong, Junlin He, Yimeng Zhou, Meichen Liu, Zhixing Cao, Yunxia Li, Cheng Pen. Aloe emodin induces hepatotoxicity by activating NF-κB inflammatory pathway and P53 apoptosis pathway in zebrafish. Toxicology letters. vol 306. 2019-03-18. PMID:30771440. |
aloe emodin induces hepatotoxicity by activating nf-κb inflammatory pathway and p53 apoptosis pathway in zebrafish. |
2019-03-18 |
2023-08-13 |
zebrafish |
| Yunyun Quan, Lihong Gong, Junlin He, Yimeng Zhou, Meichen Liu, Zhixing Cao, Yunxia Li, Cheng Pen. Aloe emodin induces hepatotoxicity by activating NF-κB inflammatory pathway and P53 apoptosis pathway in zebrafish. Toxicology letters. vol 306. 2019-03-18. PMID:30771440. |
ae was docked with the targets of nf-κb inflammatory pathway and p53 apoptosis pathway respectively by using molecular docking technique. |
2019-03-18 |
2023-08-13 |
zebrafish |
| Yunyun Quan, Lihong Gong, Junlin He, Yimeng Zhou, Meichen Liu, Zhixing Cao, Yunxia Li, Cheng Pen. Aloe emodin induces hepatotoxicity by activating NF-κB inflammatory pathway and P53 apoptosis pathway in zebrafish. Toxicology letters. vol 306. 2019-03-18. PMID:30771440. |
ae could activate the nf-κb inflammatory pathway and the p53 apoptosis pathway, and its hepatotoxic mechanism was related to activation of nf-κb-p53 inflammation-apoptosis pathways. |
2019-03-18 |
2023-08-13 |
zebrafish |