| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Richard Ballweg, Andrew L Paek, Tongli Zhan. A dynamical framework for complex fractional killing. Scientific reports. vol 7. issue 1. 2019-02-28. PMID:28808338. |
consequently, cells in which p53 is activated early undergo apoptosis while cells in which p53 is activated late survive. |
2019-02-28 |
2023-08-13 |
Not clear |
| Yan Wang, Xiaomin Liu, Gang Liu, Xiaojuan Wang, Rong Hu, Xiaoqiu Lian. PIG11 over-expression predicts good prognosis and induces HepG2 cell apoptosis via reactive oxygen species-dependent mitochondrial pathway. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 108. 2019-02-28. PMID:30241046. |
p53-induced protein 11 (pig11), one of the primeval transcriptional targets of p53, is up-regulated in apoptosis induced by multiple chemopreventive agents and is involved in tumorigenesis or tumor development. |
2019-02-28 |
2023-08-13 |
Not clear |
| Min Zhang, Yinghui Song, Furui Zha. ARFHPV E7 oncogene, lncRNA HOTAIR, miR-331-3p and its target, NRP2, form a negative feedback loop to regulate the apoptosis in the tumorigenesis in HPV positive cervical cancer. Journal of cellular biochemistry. vol 119. issue 6. 2019-02-27. PMID:29130509. |
cell transfected with hpv16 e7 displayed lower levels of hotair, nrp2 and p53, a higher level of mir-331-3p, over-expression of e7 further repressed cell apoptosis, while improved cell proliferation compared with control. |
2019-02-27 |
2023-08-13 |
Not clear |
| Guan Sun, Yingyi Wang, Junxia Zhang, Ning Lin, Yongping Yo. MiR-15b/HOTAIR/p53 form a regulatory loop that affects the growth of glioma cells. Journal of cellular biochemistry. vol 119. issue 6. 2019-02-27. PMID:29323737. |
furthermore, the examination of cell proliferation, apoptosis, and invasion revealed that both mir-15b and p53 inhibited the proliferation and invasion, but promoted the apoptosis, of glioma cells. |
2019-02-27 |
2023-08-13 |
human |
| Guan Sun, Yingyi Wang, Junxia Zhang, Ning Lin, Yongping Yo. MiR-15b/HOTAIR/p53 form a regulatory loop that affects the growth of glioma cells. Journal of cellular biochemistry. vol 119. issue 6. 2019-02-27. PMID:29323737. |
the upregulation of hotair suppressed the inhibitory effects of mir-15b and p53 on cell proliferation and invasion as well as the promoting effect of mir-15b and p53 on apoptosis. |
2019-02-27 |
2023-08-13 |
human |
| Shenglong Guo, Ruili Chen, Xiaoli Chen, Zhen Xie, Fangfang Huo, Zhongliang W. Che-1 inhibits oxygen-glucose deprivation/reoxygenation-induced neuronal apoptosis associated with inhibition of the p53-mediated proapoptotic signaling pathway. Neuroreport. vol 29. issue 14. 2019-02-27. PMID:30001227. |
in addition, we showed that che-1 impeded the transcript activity of p53 toward apoptosis. |
2019-02-27 |
2023-08-13 |
Not clear |
| Huynh Nhu Mai, Garima Sharma, Naveen Sharma, Eun-Joo Shin, Dae-Joong Kim, Duc Toan Pham, Quynh Dieu Trinh, Choon-Gon Jang, Seung Yeol Nah, Ji Hoon Jeong, Hyoung-Chun Ki. Genetic depletion of p53 attenuates cocaine-induced hepatotoxicity in mice. Biochimie. vol 158. 2019-02-27. PMID:30576773. |
since p53, a tumor suppressor gene, plays a major role in inducing oxidative stress and apoptosis, we examined the role of p53 inhibition against cocaine-induced hepatotoxicity. |
2019-02-27 |
2023-08-13 |
mouse |
| Yongliang Hu, Rui Jin, Ming Gao, Huan Xu, Shuxian Zou, Xiaoguang Li, Chen Xing, Qiyu Wang, Hongli Wang, Jiannan Feng, Meiru Hu, Lun Son. Transcriptional repression of IKKβ by p53 in arsenite-induced GADD45α accumulation and apoptosis. Oncogene. vol 38. issue 5. 2019-02-26. PMID:30177839. |
transcriptional repression of ikkβ by p53 in arsenite-induced gadd45α accumulation and apoptosis. |
2019-02-26 |
2023-08-13 |
Not clear |
| Nazem El Husseini, Barbara F Hale. The Roles of P53 and Its Family Proteins, P63 and P73, in the DNA Damage Stress Response in Organogenesis-Stage Mouse Embryos. Toxicological sciences : an official journal of the Society of Toxicology. vol 162. issue 2. 2019-02-25. PMID:29228353. |
members of the p53 transcription factor family, p53, p63, and p73, play important roles in normal development and in regulating the expression of genes that control apoptosis and cell cycle progression in response to genotoxic stress. |
2019-02-25 |
2023-08-13 |
mouse |
| Souvik Roy, Rituparna Das, Balaram Ghosh, Tania Chakrabort. Deciphering the biochemical and molecular mechanism underlying the in vitro and in vivo chemotherapeutic efficacy of ruthenium quercetin complex in colon cancer. Molecular carcinogenesis. vol 57. issue 6. 2019-02-25. PMID:29442390. |
in vitro study confirmed that the complex increased p53 expression, reduced vegf and mtor expression, apoptosis induction, and dna fragmentation in the ht-29 cells. |
2019-02-25 |
2023-08-13 |
human |
| Jin Woo Park, Yun-Cheol Chae, Ji-Young Kim, Hyein Oh, Sang-Beom Se. Methylation of Aurora kinase A by MMSET reduces p53 stability and regulates cell proliferation and apoptosis. Oncogene. vol 37. issue 48. 2019-02-22. PMID:30013191. |
methylation of aurora kinase a by mmset reduces p53 stability and regulates cell proliferation and apoptosis. |
2019-02-22 |
2023-08-13 |
Not clear |
| Akinori Morita, Ippei Takahashi, Megumi Sasatani, Shin Aoki, Bing Wang, Shinya Ariyasu, Kaoru Tanaka, Tetsuji Yamaguchi, Akiko Sawa, Yurie Nishi, Tatsuro Teraoka, Shohei Ujita, Yosuke Kawate, Chihiro Yanagawa, Keiji Tanimoto, Atsushi Enomoto, Mitsuru Nenoi, Kenji Kamiya, Yasushi Nagata, Yoshio Hosoi, Toshiya Inab. A Chemical Modulator of p53 Transactivation that Acts as a Radioprotective Agonist. Molecular cancer therapeutics. vol 17. issue 2. 2019-02-20. PMID:28939557. |
inhibiting p53-dependent apoptosis by inhibitors of p53 is an effective strategy for preventing radiation-induced damage in hematopoietic lineages, while p53 and p21 also play radioprotective roles in the gastrointestinal epithelium. |
2019-02-20 |
2023-08-13 |
mouse |
| Akinori Morita, Ippei Takahashi, Megumi Sasatani, Shin Aoki, Bing Wang, Shinya Ariyasu, Kaoru Tanaka, Tetsuji Yamaguchi, Akiko Sawa, Yurie Nishi, Tatsuro Teraoka, Shohei Ujita, Yosuke Kawate, Chihiro Yanagawa, Keiji Tanimoto, Atsushi Enomoto, Mitsuru Nenoi, Kenji Kamiya, Yasushi Nagata, Yoshio Hosoi, Toshiya Inab. A Chemical Modulator of p53 Transactivation that Acts as a Radioprotective Agonist. Molecular cancer therapeutics. vol 17. issue 2. 2019-02-20. PMID:28939557. |
we previously identified some zinc(ii) chelators, including 8-quinolinol derivatives, that suppress apoptosis in attempts to discover compounds that target the zinc-binding site in p53. |
2019-02-20 |
2023-08-13 |
mouse |
| Lubing Gu, Hailong Zhang, Tao Liu, Alexander Draganov, Sha Yi, Binghe Wang, Muxiang Zho. Inhibition of MDM2 by a Rhein-Derived Compound AQ-101 Suppresses Cancer Development in SCID Mice. Molecular cancer therapeutics. vol 17. issue 2. 2019-02-20. PMID:29282301. |
this aq-101-induced mdm2 downregulation led to activation of p53, which contributed to apoptosis of acute lymphoblastic leukemia (all), especially those with a wild-type p53 phenotype and mdm2 expression |
2019-02-20 |
2023-08-13 |
mouse |
| Behnaz Ghaemi, Elnaz Shaabani, Roqya Najafi-Taher, Saeedeh Jafari Nodooshan, Amin Sadeghpour, Sharmin Kharrazi, Amir Aman. Intracellular ROS Induction by Ag@ZnO Core-Shell Nanoparticles: Frontiers of Permanent Optically Active Holes in Breast Cancer Theranostic. ACS applied materials & interfaces. vol 10. issue 29. 2019-02-20. PMID:29932633. |
in this context, upregulation of apoptotic cascade proteins (i.e., bax/bcl2 association, p53, cytochrome c, and caspase-3) along with activation of oxidative stress proteins suggested the occurrence of apoptosis by ag@zno nps in cancer cells through the mitochondrial pathway. |
2019-02-20 |
2023-08-13 |
human |
| Hae Ryung Chang, Anudari Munkhjargal, Myung-Jin Kim, Seon Young Park, Eunyoung Jung, Jae-Ha Ryu, Young Yang, Jong-Seok Lim, Yonghwan Ki. The functional roles of PML nuclear bodies in genome maintenance. Mutation research. vol 809. 2019-02-19. PMID:28521962. |
their interaction with proteins such as p53 indicates that pml-nbs may play a significant role in apoptosis and cancer. |
2019-02-19 |
2023-08-13 |
Not clear |
| Huinan Zhang, Jun Wang, Jing Huang, Tingyu Shi, Xue Ma, Xiaoxing Luo, Xia Li, Mingkai L. Inhibiting Jumoji domain containing protein 3 (JMJD3) prevent neuronal apoptosis from stroke. Experimental neurology. vol 308. 2019-02-19. PMID:30028997. |
control of p53 by histone methylation is closely related in the neuronal apoptosis following ischemic stroke. |
2019-02-19 |
2023-08-13 |
Not clear |
| Shing-Jyh Chang, En-Chi Liao, Hsin-Yueh Yeo, Wen-Hung Kuo, Hsin-Yi Chen, Yi-Ting Tsai, Yu-Shan Wei, Ying-Jen Chen, Yi-Shiuan Wang, Ji-Min Li, Chuan-Chi Shih, Chia-Hao Chan, Zih-Yin Lai, Hsiu-Chuan Chou, Yung-Jen Chuang, Hong-Lin Cha. Proteomic investigating the cooperative lethal effect of EGFR and MDM2 inhibitors on ovarian carcinoma. Archives of biochemistry and biophysics. vol 647. 2019-02-18. PMID:29655550. |
in contrast, cellular stress such as dna damage will activate p53 to carry out dna repair, cell cycle arrest, and apoptosis. |
2019-02-18 |
2023-08-13 |
human |
| Konstantinos Voskaride. Combination of 247 Genome-Wide Association Studies Reveals High Cancer Risk as a Result of Evolutionary Adaptation. Molecular biology and evolution. vol 35. issue 2. 2019-02-15. PMID:29220501. |
these results can be viewed along with those of previous functional studies that showed that reduced apoptosis potential due to specific p53 variants (the most important tumor suppressor gene) is beneficial in high-altitude and cold environments. |
2019-02-15 |
2023-08-13 |
Not clear |
| Franck Pellestor, Vincent Gatinoi. Potential Role of Chromothripsis in the Genesis of Complex Chromosomal Rearrangements in Human Gametes and Preimplantation Embryo. Methods in molecular biology (Clifton, N.J.). vol 1769. 2019-02-11. PMID:29564816. |
several mechanisms, involving abortive apoptosis, telomere erosion, mitotic errors, micronuclei formation, and p53 inactivation, might cause chromothripsis. |
2019-02-11 |
2023-08-13 |
human |