| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jorge Hernandez-Valencia, Enrique Garcia-Villa, Aquetzalli Arenas-Hernandez, Jaime Garcia-Mena, Jose Diaz-Chavez, Patricio Garigli. Induction of p53 Phosphorylation at Serine 20 by Resveratrol Is Required to Activate p53 Target Genes, Restoring Apoptosis in MCF-7 Cells Resistant to Cisplatin. Nutrients. vol 10. issue 9. 2019-01-15. PMID:30142917. |
the tumor suppressor protein p53 is a key factor in the induction of cell cycle arrest, dna repair, and apoptosis in response to cellular stimuli. |
2019-01-15 |
2023-08-13 |
human |
| Chun-Hua Shan, Jianjun Guo, Xinsheng Sun, Nan Li, Xinyu Yang, Yuhong Gao, Dianrui Qiu, Xuemei Li, Yanan Wang, Man Feng, Chao Wang, Juan Juan Zha. Effects of fermented Chinese herbal medicines on milk performance and immune function in late-lactation cows under heat stress conditions. Journal of animal science. vol 96. issue 10. 2019-01-14. PMID:30032262. |
the immunity-related biochemistry and genes transcript responses involving cytokines (il-1, il-2, il-6, and il-12), apoptosis (bak, mcl-1, bax, bcl-2, bcl-xl, and p53), and immunoglobulins (iga, igg, and igm) were investigated. |
2019-01-14 |
2023-08-13 |
Not clear |
| Yan Yan, Yulan Qing, John J Pink, Stanton L Gerso. Loss of Uracil DNA Glycosylase Selectively Resensitizes p53-Mutant and -Deficient Cells to 5-FdU. Molecular cancer research : MCR. vol 16. issue 2. 2019-01-11. PMID:29117941. |
importantly, in p53 wt cells, the apoptosis pathway induced by 5-fdu is activated independent of udg status. |
2019-01-11 |
2023-08-13 |
human |
| Yan Yan, Yulan Qing, John J Pink, Stanton L Gerso. Loss of Uracil DNA Glycosylase Selectively Resensitizes p53-Mutant and -Deficient Cells to 5-FdU. Molecular cancer research : MCR. vol 16. issue 2. 2019-01-11. PMID:29117941. |
however, in p53 ko cells, apoptosis is compromised in udg-expressing cells, but dramatically elevated in udg-depleted cells. |
2019-01-11 |
2023-08-13 |
human |
| Julia B Krajewska, Jakub Fichna, Paula Mosińsk. One step ahead: miRNA-34 in colon cancer-future diagnostic and therapeutic tool? Critical reviews in oncology/hematology. vol 132. 2019-01-11. PMID:30447913. |
this mirna is involved in the regulation of cell cycle and apoptosis through multiple signaling pathways such as p53, ra and wnt signaling. |
2019-01-11 |
2023-08-13 |
Not clear |
| Caixia Xia, Liyan Shui, Guohua Lou, Bingjue Ye, Wei Zhu, Jing Wang, Shanshan Wu, Xiao Xu, Long Mao, Wanhong Xu, Zhi Chen, Yanning Liu, Min Zhen. 0404 inhibits hepatocellular carcinoma through a p53/miR-34a/SIRT1 positive feedback loop. Scientific reports. vol 7. issue 1. 2019-01-10. PMID:28667294. |
our findings show that 0404 is probably an attractive agent for treating hcc, especially in hcc with wide type (wt) p53, through forming a p53/mir-34a/sirt1 signal feedback loop to promote cell apoptosis. |
2019-01-10 |
2023-08-13 |
mouse |
| Eman M Mantawy, Ahmed Esmat, Wesam M El-Bakly, Rania A Salah ElDin, Ebtehal El-Demerdas. Mechanistic clues to the protective effect of chrysin against doxorubicin-induced cardiomyopathy: Plausible roles of p53, MAPK and AKT pathways. Scientific reports. vol 7. issue 1. 2019-01-09. PMID:28684738. |
moreover, chrysin attenuated dox-induced apoptosis via decreasing expression of p53, bax, puma, noxa, cytochrome c and caspase-3 while increasing expression of bcl-2. |
2019-01-09 |
2023-08-13 |
human |
| Wenhu Zhang, Shaozhuang Liu, Hanxiang Zhan, Zhibo Yan, Guangyong Zhan. Transcriptome sequencing identifies key pathways and genes involved in gastric adenocarcinoma. Molecular medicine reports. vol 18. issue 4. 2019-01-09. PMID:30106143. |
genes in cluster 1 were significantly involved in metabolism of xenobiotics by cytochrome p450, genes in cluster 2 were majorly involved in apoptosis, tight junction formation, and platelet activation, genes in cluster 3 were primarily enriched in the p53 signaling pathway and genes in cluster 4 were significantly enriched in the insulin resistance pathway. |
2019-01-09 |
2023-08-13 |
Not clear |
| Ha Na Gil, Euitaek Jung, Dongsoo Koh, Yoongho Lim, Young Han Lee, Soon Young Shi. A synthetic chalcone derivative, 2-hydroxy-3',5,5'-trimethoxychalcone (DK-139), triggers reactive oxygen species-induced apoptosis independently of p53 in A549 lung cancer cells. Chemico-biological interactions. vol 298. 2019-01-09. PMID:30408460. |
a synthetic chalcone derivative, 2-hydroxy-3',5,5'-trimethoxychalcone (dk-139), triggers reactive oxygen species-induced apoptosis independently of p53 in a549 lung cancer cells. |
2019-01-09 |
2023-08-13 |
human |
| Ha Na Gil, Euitaek Jung, Dongsoo Koh, Yoongho Lim, Young Han Lee, Soon Young Shi. A synthetic chalcone derivative, 2-hydroxy-3',5,5'-trimethoxychalcone (DK-139), triggers reactive oxygen species-induced apoptosis independently of p53 in A549 lung cancer cells. Chemico-biological interactions. vol 298. 2019-01-09. PMID:30408460. |
interestingly, using p53-null hct116 cells revealed that p53 was not involved in dk-139-induced apoptosis. |
2019-01-09 |
2023-08-13 |
human |
| Q Li, X Li, C Wan. Uc.206 regulates cell proliferation and apoptosis by targeting P53 in cervical cancer cells. Neoplasma. vol 63. issue 3. 2019-01-09. PMID:26925787. |
uc.206 regulates cell proliferation and apoptosis by targeting p53 in cervical cancer cells. |
2019-01-09 |
2023-08-13 |
Not clear |
| Q Li, X Li, C Wan. Uc.206 regulates cell proliferation and apoptosis by targeting P53 in cervical cancer cells. Neoplasma. vol 63. issue 3. 2019-01-09. PMID:26925787. |
inhibition of uc.206 effectively delays cervical cells proliferation and promotes apoptosis, accompanied by increased expression of p53 protein. |
2019-01-09 |
2023-08-13 |
Not clear |
| Li Gao, Yue Ji, Yan Lu, Ming Qiu, Yejiao Shen, Yaqing Wang, Xiangqing Kong, Yongfeng Shao, Yanhui Sheng, Wei Su. Low-level overexpression of p53 promotes warfarin-induced calcification of porcine aortic valve interstitial cells by activating The Journal of biological chemistry. vol 293. issue 10. 2019-01-07. PMID:29358327. |
low-level overexpression of p53 in pavics via an adenovirus vector did not affect pavic apoptosis but promoted warfarin-induced calcium deposition and expression of osteogenic markers. |
2019-01-07 |
2023-08-13 |
mouse |
| E Eluka-Okoludoh, A J Ewunkem, S Thorpe, A Blanchard, P Mugand. Diepoxybutane-induced apoptosis is mediated through the ERK1/2 pathway. Human & experimental toxicology. vol 37. issue 10. 2019-01-07. PMID:29405768. |
the mek inhibitor pd98059 and erk1/2 sirna significantly inhibited apoptosis, erk1/2 activation, as well as p53 and phospho-p53 (serine-15) levels in human lymphoblasts undergoing deb-induced apoptosis. |
2019-01-07 |
2023-08-13 |
human |
| Huihui Huang, Chunhua Xu, Yang Wang, Chenling Meng, Wenjing Liu, Yueshui Zhao, Xiao-Ru Huang, Wenxing You, Bo Feng, Zhi-Hua Zheng, Yu Huang, Hui-Yao Lan, Jinzhong Qin, Yin Xi. Lethal (3) malignant brain tumor-like 2 (L3MBTL2) protein protects against kidney injury by inhibiting the DNA damage-p53-apoptosis pathway in renal tubular cells. Kidney international. vol 93. issue 4. 2019-01-02. PMID:29276099. |
ablation of l3mbtl2 in renal tubular cells resulted in increases in nuclear dna damage, p53 activation, apoptosis, tubular injury and kidney dysfunction after cisplatin treatment or unilateral ureteral obstruction. |
2019-01-02 |
2023-08-13 |
mouse |
| Huihui Huang, Chunhua Xu, Yang Wang, Chenling Meng, Wenjing Liu, Yueshui Zhao, Xiao-Ru Huang, Wenxing You, Bo Feng, Zhi-Hua Zheng, Yu Huang, Hui-Yao Lan, Jinzhong Qin, Yin Xi. Lethal (3) malignant brain tumor-like 2 (L3MBTL2) protein protects against kidney injury by inhibiting the DNA damage-p53-apoptosis pathway in renal tubular cells. Kidney international. vol 93. issue 4. 2019-01-02. PMID:29276099. |
in vitro, inhibition of l3mbtl2 sequentially promoted histone γh2ax expression, p53 activation and apoptosis in cisplatin-treated mouse proximal tubular tkpts cells. |
2019-01-02 |
2023-08-13 |
mouse |
| Huihui Huang, Chunhua Xu, Yang Wang, Chenling Meng, Wenjing Liu, Yueshui Zhao, Xiao-Ru Huang, Wenxing You, Bo Feng, Zhi-Hua Zheng, Yu Huang, Hui-Yao Lan, Jinzhong Qin, Yin Xi. Lethal (3) malignant brain tumor-like 2 (L3MBTL2) protein protects against kidney injury by inhibiting the DNA damage-p53-apoptosis pathway in renal tubular cells. Kidney international. vol 93. issue 4. 2019-01-02. PMID:29276099. |
inhibition of p53 activity attenuated the apoptosis induced by l3mbtl2 deficiency after cisplatin treatment both in vivo and in vitro. |
2019-01-02 |
2023-08-13 |
mouse |
| Xiaoyan Wang, Ting Yuan, Nannan Yin, Xiaofei Ma, Zhenbiao Zhang, Zhe Zhu, Aftab Shaukat, Ganzhen Den. Luteoloside Protects the Uterus from Staphylococcus aureus-Induced Inflammation, Apoptosis, and Injury. Inflammation. vol 41. issue 5. 2019-01-02. PMID:29987481. |
moreover, luteoloside inhibited the apoptosis of endometrial epithelial cells (eecs), suppressed the phosphorylation of p53, and decreased the expression of caspase-3 induced by s. aureus. |
2019-01-02 |
2023-08-13 |
Not clear |
| Umasankar De, Ji Yeon Son, Richa Sachan, Yu Jin Park, Dongwan Kang, Kyungsil Yoon, Byung Mu Lee, In Su Kim, Hyung Ryong Moon, Hyung Sik Ki. A New Synthetic Histone Deacetylase Inhibitor, MHY2256, Induces Apoptosis and Autophagy Cell Death in Endometrial Cancer Cells via p53 Acetylation. International journal of molecular sciences. vol 19. issue 9. 2019-01-02. PMID:30217020. |
a new synthetic histone deacetylase inhibitor, mhy2256, induces apoptosis and autophagy cell death in endometrial cancer cells via p53 acetylation. |
2019-01-02 |
2023-08-13 |
human |
| Lianqin Liu, Yuxin Sun, Yunxia Zhao, Qian Wang, Hua Guo, Rui Guo, Yanan Liu, Shuang Fu, Ling Zhang, Yang Li, Yan Men. Urea transport B gene induces melanoma B16 cell death via activation of p53 and mitochondrial apoptosis. Cancer science. vol 109. issue 12. 2019-01-02. PMID:30290033. |
urea transport b gene induces melanoma b16 cell death via activation of p53 and mitochondrial apoptosis. |
2019-01-02 |
2023-08-13 |
human |