| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yasamin Dabiri, Sara Kalman, Clara-Marie Gürth, Jee Young Kim, Viola Mayer, Xinlai Chen. The essential role of TAp73 in bortezomib-induced apoptosis in p53-deficient colorectal cancer cells. Scientific reports. vol 7. issue 1. 2019-01-28. PMID:28710427. |
thus, our results clearly demonstrated that tap73 served as a substitute for p53 in bortezomib-induced apoptosis in p53-deficient or mutated cells, implicating that tap73 could be a potential therapeutic target for treatment of crcs, in particular those lacking functional p53. |
2019-01-28 |
2023-08-13 |
human |
| Ying Jin, Wenquan Hu, Tong Liu, Ujala Rana, Irene Aguilera-Barrantes, Amanda Kong, Suresh N Kumar, Bei Wang, Pin Gao, Xiang Wang, Yajun Duan, Aiping Shi, Dong Song, Ming Yang, Sijie Li, Bing Han, Gang Zhao, Zhimin Fan, Qing Robert Mia. Nogo-B receptor increases the resistance of estrogen receptor positive breast cancer to paclitaxel. Cancer letters. vol 419. 2019-01-28. PMID:29373839. |
ngbr knockdown enhanced paclitaxel-induced cell apoptosis by modulating expression of p53 and survivin in erα positive breast cancer cells via ngbr-mediated pi3k/akt and mapk/erk signaling pathways. |
2019-01-28 |
2023-08-13 |
Not clear |
| R Kumar, L Coronel, B Somalanka, A Raju, O A Aning, O An, Y S Ho, S Chen, S Y Mak, P Y Hor, H Yang, M Lakshmanan, H Itoh, S Y Tan, Y K Lim, A P C Wong, S H Chew, T H Huynh, B C Goh, C Y Lim, V Tergaonkar, C F Cheo. Mitochondrial uncoupling reveals a novel therapeutic opportunity for p53-defective cancers. Nature communications. vol 9. issue 1. 2019-01-28. PMID:30258081. |
metabolome profiling reveals that niclosamide induces mitochondrial uncoupling, which renders mutant p53 cells susceptible to mitochondrial-dependent apoptosis through preferential accumulation of arachidonic acid (aa), and represents a first-in-class inhibitor of p53 mutant tumors. |
2019-01-28 |
2023-08-13 |
Not clear |
| Yanzhou Chang, Lizhen He, Zhibin Li, Lilan Zeng, Zhenhuan Song, Penghui Li, Leung Chan, Yuanyuan You, Xue-Feng Yu, Paul K Chu, Tianfeng Che. Designing Core-Shell Gold and Selenium Nanocomposites for Cancer Radiochemotherapy. ACS nano. vol 11. issue 5. 2019-01-25. PMID:28460158. |
in vitro studies show that the combined treatment of a375 melanoma cells in culture with ncs and x-ray induces cell apoptosis through alteration in expression of p53 and dna-damaging genes and triggers intracellular ros overproduction, leading to greatly enhanced anticancer efficacy. |
2019-01-25 |
2023-08-13 |
Not clear |
| Xi Wang, Hui Chen, Yiping Wen, Xiaoxin Yang, Qing Han, Ping Jiang, Zaiju Huang, Jing Cai, Zehua Wan. Dicer affects cisplatin‑mediated apoptosis in epithelial ovarian cancer cells. Molecular medicine reports. vol 18. issue 5. 2019-01-25. PMID:30221734. |
furthermore, downregulating dicer significantly inhibited cisplatin‑induced apoptosis in ovarian cancer cells, and decreased the levels of proteins involved in apoptosis signaling pathways, including p73, p63, p53, caspase‑9 and caspase‑3. |
2019-01-25 |
2023-08-13 |
Not clear |
| Józefa Węsierska-Gąde. Targeting p53 as a promising therapeutic option for cancer by re-activating the wt or mutant p53's tumor suppression. Future medicinal chemistry. vol 10. issue 7. 2019-01-24. PMID:29569948. |
p53 protein, a product of the tp53 tumor suppressor gene, controls the cellular genome's integrity and is an important regulator of cell cycling, proliferation, apoptosis and metabolism. |
2019-01-24 |
2023-08-13 |
Not clear |
| Bin Jiang, Wentao Zhao, Minggang Shi, Jia Zhang, Ai Chen, Huanhuan Ma, Muhammad Suleman, Furong Lin, Lin Zhou, Jinyang Wang, Yan Zhang, Mengjue Liu, Shixiong Wen, Cong Ouyang, Huihui Wang, Xiumin Huang, Huamin Zhou, Qinxi L. IDH1 Arg-132 mutant promotes tumor formation through down-regulating p53. The Journal of biological chemistry. vol 293. issue 25. 2019-01-22. PMID:29743236. |
p53 is crucial for apoptosis triggered by a broad range of stresses and a well-known gatekeeper for neoplastic transformation. |
2019-01-22 |
2023-08-13 |
mouse |
| Bin Jiang, Wentao Zhao, Minggang Shi, Jia Zhang, Ai Chen, Huanhuan Ma, Muhammad Suleman, Furong Lin, Lin Zhou, Jinyang Wang, Yan Zhang, Mengjue Liu, Shixiong Wen, Cong Ouyang, Huihui Wang, Xiumin Huang, Huamin Zhou, Qinxi L. IDH1 Arg-132 mutant promotes tumor formation through down-regulating p53. The Journal of biological chemistry. vol 293. issue 25. 2019-01-22. PMID:29743236. |
rescue expression of p53 can inhibit the proliferation rate and impair the resistance of apoptosis induced by doxorubicin in idh1 r132q mouse embryonic fibroblast cells. |
2019-01-22 |
2023-08-13 |
mouse |
| Bin Jiang, Wentao Zhao, Minggang Shi, Jia Zhang, Ai Chen, Huanhuan Ma, Muhammad Suleman, Furong Lin, Lin Zhou, Jinyang Wang, Yan Zhang, Mengjue Liu, Shixiong Wen, Cong Ouyang, Huihui Wang, Xiumin Huang, Huamin Zhou, Qinxi L. IDH1 Arg-132 mutant promotes tumor formation through down-regulating p53. The Journal of biological chemistry. vol 293. issue 25. 2019-01-22. PMID:29743236. |
our results thus shed a new light on how p53 is down-regulated by 2-hg and suggests that impairment of p53-mediated apoptosis contributes to the tumorigenesis driven by idh1 mutants. |
2019-01-22 |
2023-08-13 |
mouse |
| Wamidh H Talib, Lina T Al Kur. Parthenolide inhibits tumor-promoting effects of nicotine in lung cancer by inducing P53 - dependent apoptosis and inhibiting VEGF expression. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 107. 2019-01-22. PMID:30257366. |
parthenolide inhibits tumor-promoting effects of nicotine in lung cancer by inducing p53 - dependent apoptosis and inhibiting vegf expression. |
2019-01-22 |
2023-08-13 |
Not clear |
| Wamidh H Talib, Lina T Al Kur. Parthenolide inhibits tumor-promoting effects of nicotine in lung cancer by inducing P53 - dependent apoptosis and inhibiting VEGF expression. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 107. 2019-01-22. PMID:30257366. |
real time pcr assay was used to detect the change in expression of several genes associated with cell proliferation and apoptosis (casp3, casp7, casp8, casp9, p53, gadd45, bax, bim, bcl-2, topo i, and topo ii). |
2019-01-22 |
2023-08-13 |
Not clear |
| Wamidh H Talib, Lina T Al Kur. Parthenolide inhibits tumor-promoting effects of nicotine in lung cancer by inducing P53 - dependent apoptosis and inhibiting VEGF expression. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 107. 2019-01-22. PMID:30257366. |
the real time pcr assay demonstrated that parthenolide down-regulated the expression of bcl-2 and up-regulated the expression of e2f1, p53, gadd45, bax, bim, and casp 3,7,8,9, which indicates an activation of p53- dependent apoptosis pathway in response to parthenolide. |
2019-01-22 |
2023-08-13 |
Not clear |
| Qingyan Zhang, Danhui Huang, Zhenfei Zhang, Yuzhen Feng, Meiting Fu, Min Wei, Jueyu Zhou, Yuanjin Huang, Shuguang Liu, Rong Sh. High expression of TMEM40 contributes to progressive features of tongue squamous cell carcinoma. Oncology reports. vol 41. issue 1. 2019-01-22. PMID:30320346. |
furthermore, experiments revealed that tmem40 knockdown resulted in increased levels of p53 and bax, and decreased levels of mmp‑9, which indicated that tmem40 regulated cell apoptosis and migration via involvement of p53, bax and mmp‑9 in tscc cells. |
2019-01-22 |
2023-08-13 |
Not clear |
| Moo Rim Kang, Ki Hwan Park, Chang Woo Lee, Myeong Youl Lee, Sang-Bae Han, Long-Cheng Li, Jong Soon Kan. Small activating RNA induced expression of VHL gene in renal cell carcinoma. The international journal of biochemistry & cell biology. vol 97. 2019-01-17. PMID:29425832. |
functional analysis showed that dsvhl-821 induced apoptosis by increasing p53, decreasing bcl-xl, activating caspase 3/7 and poly-adp-ribose polymerase in a dose-dependent manner. |
2019-01-17 |
2023-08-13 |
Not clear |
| Ali H El-Far, Soad K Al Jaouni, Weikun Li, Shaker A Mous. Protective Roles of Thymoquinone Nanoformulations: Potential Nanonutraceuticals in Human Diseases. Nutrients. vol 10. issue 10. 2019-01-17. PMID:30257423. |
nano-tq effectively augments the anticancer roles of doxorubicin by upregulation of p53 and downregulation of bcl2 and potentiates paclitaxel's apoptosis in mcf-7 breast cancer cells. |
2019-01-17 |
2023-08-13 |
human |
| Vinoth Prasanna Gunasekaran, Kumari Nishi, Dakshinamurthy Sivakumar, Thirunavukkarasu Sivaraman, Ganeshan Matha. Identification of 2,4-dihydroxy-5-pyrimidinyl imidothiocarbomate as a novel inhibitor to Y box binding protein-1 (YB-1) and its therapeutic actions against breast cancer. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. vol 116. 2019-01-15. PMID:28916481. |
moreover, dpi modulated yb-1 downstream targets such as p53, caspase-3, cdk-1 which are involved in cell cycle progression and apoptosis. |
2019-01-15 |
2023-08-13 |
chicken |
| Zainab Fatima, Pu Guo, Deyu Huang, Qirong Lu, Qinghua Wu, Menghong Dai, Guyue Cheng, Dapeng Peng, Yanfei Tao, Muhammad Ayub, Muhammad Tahir Ul Qamar, Muhammad Waqar Ali, Xu Wang, Zonghui Yua. The critical role of p16/Rb pathway in the inhibition of GH3 cell cycle induced by T-2 toxin. Toxicology. vol 400-401. 2019-01-15. PMID:29567467. |
these findings for the first time demonstrate that t-2 toxin induces g1 phase cell cycle arrest by the involvement of p16/rb pathway, along with ros mediated oxidative stress and dna damage with p53 and caspase cascade interaction, resulting in apoptosis in gh3 cells. |
2019-01-15 |
2023-08-13 |
rat |
| Wen-Kai Yang, Li-Fen Chiang, Shi-Wei Tan, Pei-Jen Che. Environmentally relevant concentrations of di(2-ethylhexyl)phthalate exposure alter larval growth and locomotion in medaka fish via multiple pathways. The Science of the total environment. vol 640-641. 2019-01-15. PMID:29864665. |
as well, dehp altered the mrna expression of p53-regulated apoptosis pathways, such as upregulated p53, p21 and bcl-2 and downregulated caspase-3 expression, with increased enzymatic activity of caspase-3 in larvae. |
2019-01-15 |
2023-08-13 |
human |
| R Sindhu, H K Manonman. l-asparaginase induces intrinsic mitochondrial-mediated apoptosis in human gastric adenocarcinoma cells and impedes tumor progression. Biochemical and biophysical research communications. vol 503. issue 4. 2019-01-15. PMID:29966654. |
additionally, higher protein expressions of p53, caspase-3 and tem analysis showing modulations in mitochondria confirmed intrinsic apoptosis pathway. |
2019-01-15 |
2023-08-13 |
human |
| Jorge Hernandez-Valencia, Enrique Garcia-Villa, Aquetzalli Arenas-Hernandez, Jaime Garcia-Mena, Jose Diaz-Chavez, Patricio Garigli. Induction of p53 Phosphorylation at Serine 20 by Resveratrol Is Required to Activate p53 Target Genes, Restoring Apoptosis in MCF-7 Cells Resistant to Cisplatin. Nutrients. vol 10. issue 9. 2019-01-15. PMID:30142917. |
induction of p53 phosphorylation at serine 20 by resveratrol is required to activate p53 target genes, restoring apoptosis in mcf-7 cells resistant to cisplatin. |
2019-01-15 |
2023-08-13 |
human |