| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Youhong Wang, Zhen Guo, Yu Zhao, Yi Jin, Liang An, Bin Wu, Zhaoqian Liu, Xiaoping Chen, Xiang Chen, Honghao Zhou, Hui Wang, Wei Zhan. Genetic polymorphisms of lncRNA-p53 regulatory network genes are associated with concurrent chemoradiotherapy toxicities and efficacy in nasopharyngeal carcinoma patients. Scientific reports. vol 7. issue 1. 2019-03-15. PMID:28814798. |
the relevance of the transcription factor p53 in cancer is inarguable, and numerous lncrnas are involved in the p53 regulatory network as either regulators or effectors, triggering a transcriptional response that causes either cell arrest or apoptosis following dna damage in a p53-dependent manner. |
2019-03-15 |
2023-08-13 |
Not clear |
| Y Chu, D Li, H Zhang, J Ding, P Xu, X Qiu, H Zhan. PIG3 suppresses gastric cancer proliferation by regulating p53- mediated apoptosis. Journal of biological regulators and homeostatic agents. vol 32. issue 5. 2019-03-15. PMID:30334411. |
restoration of the expression of pig3 inhibited cell proliferation, induced cell apoptosis and further activated p53 signaling in bgc823 cells. |
2019-03-15 |
2023-08-13 |
human |
| Yue Xi, Wenwen Wang, Li Wang, Ji Pan, Yisen Cheng, Feihai Shen, Zhiying Huan. Triptolide induces p53-dependent cardiotoxicity through mitochondrial membrane permeabilization in cardiomyocytes. Toxicology and applied pharmacology. vol 355. 2019-03-14. PMID:30009776. |
considering the relationship among dna damage, p53, and the role of p53 in mitochondria-dependent apoptosis, we speculate that tp-induced cardiotoxicity results from p53 activation. |
2019-03-14 |
2023-08-13 |
Not clear |
| Miles J Pfaff, Subhradip Mukhopadhyay, Mark Hoofnagle, Christine Chabasse, Rajabrata Sarka. Tumor suppressor protein p53 negatively regulates ischemia-induced angiogenesis and arteriogenesis. Journal of vascular surgery. vol 68. issue 6S. 2019-03-14. PMID:30126780. |
the tumor suppressor protein p53 regulates angiogenesis and is a key regulatory mediator of cellular apoptosis, proliferation, and growth. |
2019-03-14 |
2023-08-13 |
Not clear |
| Ken-Ichi Takayama, Takashi Suzuki, Tomoaki Tanaka, Tetsuya Fujimura, Satoru Takahashi, Tomohiko Urano, Kazuhiro Ikeda, Satoshi Inou. TRIM25 enhances cell growth and cell survival by modulating p53 signals via interaction with G3BP2 in prostate cancer. Oncogene. vol 37. issue 16. 2019-03-12. PMID:29379164. |
then, we demonstrated that trim25 knockdown resulted in p53 downstream activation for cell cycle inhibition and apoptosis induction in lncap and 22rv1 cells. |
2019-03-12 |
2023-08-13 |
mouse |
| Pingjing Wen, Xiaomin Wei, Guiqiang Liang, Yanfei Wang, Yiping Yang, Lilin Qin, Weiyi Pang, Guangqiu Qin, Hai Li, Yueming Jiang, Qijun W. Long-term exposure to low level of fluoride induces apoptosis via p53 pathway in lymphocytes of aluminum smelter workers. Environmental science and pollution research international. vol 26. issue 3. 2019-03-12. PMID:30478774. |
long-term exposure to low level of fluoride induces apoptosis via p53 pathway in lymphocytes of aluminum smelter workers. |
2019-03-12 |
2023-08-13 |
Not clear |
| Pingjing Wen, Xiaomin Wei, Guiqiang Liang, Yanfei Wang, Yiping Yang, Lilin Qin, Weiyi Pang, Guangqiu Qin, Hai Li, Yueming Jiang, Qijun W. Long-term exposure to low level of fluoride induces apoptosis via p53 pathway in lymphocytes of aluminum smelter workers. Environmental science and pollution research international. vol 26. issue 3. 2019-03-12. PMID:30478774. |
the lymphocytic apoptosis rate, dna damage, oxidative stress, and mrna levels of p53, bcl-2, and bax were assessed by annexin v/pi staining, comet assay, attenuated total reflectance fourier transform infrared spectroscopy and real-time polymerase chain reaction, respectively. |
2019-03-12 |
2023-08-13 |
Not clear |
| Wei-Wei Zhang, Longjiang Li, Dinggang Li, Jiliang Liu, Xiuqin Li, Wei Li, Xiaolong Xu, Michael J Zhang, Lois A Chandler, Hong Lin, Aiguo Hu, Wei Xu, Dominic Man-Kit La. The First Approved Gene Therapy Product for Cancer Ad-p53 (Gendicine): 12 Years in the Clinic. Human gene therapy. vol 29. issue 2. 2019-03-11. PMID:29338444. |
the wild-type (wt) p53 protein expressed by gendicine-transduced cells is a tumor suppressor that is activated by cellular stress, and mediates cell-cycle arrest and dna repair, or induces apoptosis, senescence, and/or autophagy, depending upon cellular stress conditions. |
2019-03-11 |
2023-08-13 |
human |
| Ahmad Khosravi, Iraj Sharifi, Hadi Tavakkoli, Ali Reza Keyhani, Ali Afgar, Zohreh Salari, Mehdi Bamorovat, Fatemeh Sharifi, Tabandeh Khaleghi, Rajender S Varma, Shahriar Dabiri, Seyed Noureddin Nematollahi-Mahani, Abdolreza Babaee, Mahshid Mostafavi, Maryam Hakimi Parizi, Amin Derakhshanfar, Ehsan Salarki. Toxico-pathological effects of meglumine antimoniate on human umbilical vein endothelial cells. Toxicology in vitro : an international journal published in association with BIBRA. vol 56. 2019-03-11. PMID:30599190. |
in contrast, the most leading genes involved in the phenomenon of apoptosis were p53, bax, bak, apaf-1 and caspases 3, 8 and 9, which were significantly up regulated compared to the control group (p < 0.05). |
2019-03-11 |
2023-08-13 |
human |
| Hong-Quan Chen, Dong Ga. Inhibitory effect of microRNA-154 targeting WHSC1 on cell proliferation of human skin squamous cell carcinoma through mediating the P53 signaling pathway. The international journal of biochemistry & cell biology. vol 100. 2019-03-08. PMID:29727714. |
hence, this study aims to explore the effect of microrna-154 (mir-154) targeting whsc1 on proliferation and apoptosis of scc cells via the p53 signaling pathway. |
2019-03-08 |
2023-08-13 |
human |
| Jyotsna Nambiar, Gayathri Vijayakumar, G Drishya, Sanu K Shaji, Nanjan Pandurangan, Geetha B Kumar, Bipin G Nai. (I-3,II-3)-Biacacetin-mediated cell death involves mitochondria. Molecular and cellular biochemistry. vol 451. issue 1-2. 2019-03-08. PMID:29968167. |
these results were further corroborated by studies that demonstrate biacacetin to regulate several key markers of apoptosis like caspase 3, p53, bax, and poly-adp-ribose polymerase-1. |
2019-03-08 |
2023-08-13 |
Not clear |
| Yao Zhou, Weihong Niu, Yanwei Luo, Hui Li, Yong Xie, Heran Wang, Yukun Liu, Songqing Fan, Zheng Li, Wei Xiong, Xiaoling Li, Caiping Ren, Ming Tan, Guiyuan Li, Ming Zho. p53/Lactate dehydrogenase A axis negatively regulates aerobic glycolysis and tumor progression in breast cancer expressing wild-type p53. Cancer science. vol 110. issue 3. 2019-03-08. PMID:30618169. |
tumor suppressor p53 is a master regulator of apoptosis and plays key roles in cell cycle checkpoints. |
2019-03-08 |
2023-08-13 |
Not clear |
| Joo-Young Im, Bo-Kyung Kim, Ji-Young Lee, Seung-Ho Park, Hyun Seung Ban, Kyeong Eun Jung, Misun Wo. DDIAS suppresses TRAIL-mediated apoptosis by inhibiting DISC formation and destabilizing caspase-8 in cancer cells. Oncogene. vol 37. issue 9. 2019-03-06. PMID:29242605. |
ddias depletion sensitized nsclc and hcc cells to trail-mediated apoptosis, an effect that was abrogated by pharmacological or genetic inhibition of caspase-8 and was independent of caspase-9, p53, or mitogen-activated protein kinase signaling. |
2019-03-06 |
2023-08-13 |
Not clear |
| Xiaoqi Zhang, Hao Feng, Juan Du, Jing Sun, Dongfang Li, Tomoka Hasegawa, Norio Amizuka, Minqi L. Aspirin promotes apoptosis and inhibits proliferation by blocking G0/G1 into S phase in rheumatoid arthritis fibroblast-like synoviocytes via downregulation of JAK/STAT3 and NF-κB signaling pathway. International journal of molecular medicine. vol 42. issue 6. 2019-03-06. PMID:30221683. |
bioinformatics prediction revealed that aspirin was closely associated with cell proliferation and apoptosis, including the p53 and nf‑κb signaling pathways. |
2019-03-06 |
2023-08-13 |
Not clear |
| Stephanie A Luff, Chen-Yuan Kao, Eleftherios T Papoutsaki. Role of p53 and transcription-independent p53-induced apoptosis in shear-stimulated megakaryocytic maturation, particle generation, and platelet biogenesis. PloS one. vol 13. issue 9. 2019-03-06. PMID:30231080. |
role of p53 and transcription-independent p53-induced apoptosis in shear-stimulated megakaryocytic maturation, particle generation, and platelet biogenesis. |
2019-03-06 |
2023-08-13 |
Not clear |
| Liu-Zhong Jin, Ji-Shou Lu, Jian-Wen Ga. Silencing SUMO2 promotes protection against degradation and apoptosis of nucleus pulposus cells through p53 signaling pathway in intervertebral disc degeneration. Bioscience reports. vol 38. issue 3. 2019-03-05. PMID:29700214. |
silencing sumo2 promotes protection against degradation and apoptosis of nucleus pulposus cells through p53 signaling pathway in intervertebral disc degeneration. |
2019-03-05 |
2023-08-13 |
rat |
| Henrique Barbosa Hooper, Priscila Dos Santos Silva, Sandra Aparecida de Oliveira, Giovana Krempel Fonseca Merighe, João Alberto Negrã. Acute heat stress induces changes in physiological and cellular responses in Saanen goats. International journal of biometeorology. vol 62. issue 12. 2019-03-05. PMID:30368674. |
in this context, this study evaluated the physiological responses and gene expression of heat shock proteins (hsp60, 70, and 90) and genes related to apoptosis (bax, bcl-2, and p53) of saanen goats subjected to acute heat stress. |
2019-03-05 |
2023-08-13 |
Not clear |
| Dan Li, Gangcheng Wang, Guoguo Jin, Ke Yao, Zhenjiang Zhao, Liangyu Bie, Yongjun Guo, Ning Li, Wenying Deng, Xiaobin Chen, Beibei Chen, Yuanyuan Liu, Suxia Luo, Zhiping Gu. Resveratrol suppresses colon cancer growth by targeting the AKT/STAT3 signaling pathway. International journal of molecular medicine. vol 43. issue 1. 2019-03-05. PMID:30387805. |
additionally, resveratrol treatment decreased the protein expression levels of cyclin d1, cyclin e2 and bcl2 apoptosis regulator, while it increased bcl2 associated x and tumor protein p53, all of which are involved in the regulation of cell cycle and apoptosis. |
2019-03-05 |
2023-08-13 |
Not clear |
| Yin-Gi Jang, Kyung-A Hwang, Kyung-Chul Cho. Rosmarinic Acid, a Component of Rosemary Tea, Induced the Cell Cycle Arrest and Apoptosis through Modulation of HDAC2 Expression in Prostate Cancer Cell Lines. Nutrients. vol 10. issue 11. 2019-03-05. PMID:30453545. |
especially, hdac2, which belongs to hdac class i composed of hdac 1, 2, 3 and 8, has been reported to be highly expressed in prostate cancer (pca) where it downregulates the expression of p53, resulting in an inhibition of apoptosis. |
2019-03-05 |
2023-08-13 |
human |
| Richard Ballweg, Andrew L Paek, Tongli Zhan. A dynamical framework for complex fractional killing. Scientific reports. vol 7. issue 1. 2019-02-28. PMID:28808338. |
through an incoherent feedforward loop, chemotherapy drugs not only activate p53 to induce cell death, but also promote the expression of apoptosis inhibitors which inhibit cell death. |
2019-02-28 |
2023-08-13 |
Not clear |