| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yikai Zhao, Lulu Zhang, Yifan Wu, Qinsheng Dai, Yuxin Zhou, Zhiyu Li, Lin Yang, Qinglong Guo, Na L. Selective anti-tumor activity of wogonin targeting the Warburg effect through stablizing p53. Pharmacological research. vol 135. 2019-04-10. PMID:30031170. |
wogonin increases the expression of p53 and p53-inducible glycolysis and apoptosis regulator (tigar), while decreases glucose transporter 1 (glut1) and some key glycolytic enzymes. |
2019-04-10 |
2023-08-13 |
Not clear |
| Chanatip Metheetrairut, Chanticha Chotigavanich, Kanchana Amornpichetkul, Phawin Keskool, Sunun Ongard, Choakchai Metheetrairu. Expression levels of miR-34-family microRNAs are associated with TP53 mutation status in head and neck squamous cell carcinoma. European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery. vol 276. issue 2. 2019-04-10. PMID:30515607. |
p53 is a transcription factor that activates downstream genes, including the hsa-mir-34a and hsa-mir-34b/c loci, to achieve cell-cycle arrest, senescence, and/or apoptosis. |
2019-04-10 |
2023-08-13 |
Not clear |
| Shohag Bhargava, Brian Cox, Christiana Polydorou, Veronika Gresakova, Vladimir Korinek, Hynek Strnad, Radislav Sedlacek, Trevor Allan Epp, Kallayanee Chawengsaksopha. The epigenetic modifier Fam208a is required to maintain epiblast cell fitness. Scientific reports. vol 7. issue 1. 2019-04-09. PMID:28839193. |
fam208a mutants exhibited an increase in p53-driven apoptosis and complete removal of p53 could partially rescue their gastrulation block. |
2019-04-09 |
2023-08-13 |
Not clear |
| Bodo C Melni. Overexpression of p53 explains isotretinoin's teratogenicity. Experimental dermatology. vol 27. issue 1. 2019-04-08. PMID:28833556. |
this hypothesis predicts that isotretinoin (13-cis retinoic acid), the prodrug of all-trans retinoic acid (atra), exaggerates neural crest cell (ncc) apoptosis via upregulation of the pro-apoptotic transcription factor p53, the guardian of the genome. |
2019-04-08 |
2023-08-13 |
zebrafish |
| Mohmmad-Nabi Moradi, Jamshid Karimi, Iraj Khodadadi, Iraj Amiri, Manoochehr Karami, Massoud Saidijam, Akram Vatannejad, Heidar Tavilan. Evaluation of the p53 and Thioredoxin reductase in sperm from asthenozoospermic males in comparison to normozoospermic males. Free radical biology & medicine. vol 116. 2019-04-08. PMID:29305108. |
p53 is an important regulator of apoptosis and normal process of spermatogenesis. |
2019-04-08 |
2023-08-13 |
Not clear |
| Yan Du, Lan-Lan Li, Hao Chen, Cong Wang, Xue-Wen Qian, Yu-Bin Feng, Lei Zhang, Fei-Hu Che. A novel all-trans retinoic acid derivative inhibits proliferation and induces apoptosis of myelodysplastic syndromes cell line SKM-1 cells via up-regulating p53. International immunopharmacology. vol 65. 2019-04-08. PMID:30415163. |
a novel all-trans retinoic acid derivative inhibits proliferation and induces apoptosis of myelodysplastic syndromes cell line skm-1 cells via up-regulating p53. |
2019-04-08 |
2023-08-13 |
Not clear |
| Yan Du, Lan-Lan Li, Hao Chen, Cong Wang, Xue-Wen Qian, Yu-Bin Feng, Lei Zhang, Fei-Hu Che. A novel all-trans retinoic acid derivative inhibits proliferation and induces apoptosis of myelodysplastic syndromes cell line SKM-1 cells via up-regulating p53. International immunopharmacology. vol 65. 2019-04-08. PMID:30415163. |
in addition, real-time quantitative rt-pcr (qrt-pcr) and western blotting were used to analyzed the expression of p53, as well as the levels of bnip3, apoptosis proteins of caspase-3, bax and bcl-2. |
2019-04-08 |
2023-08-13 |
Not clear |
| Yan Du, Lan-Lan Li, Hao Chen, Cong Wang, Xue-Wen Qian, Yu-Bin Feng, Lei Zhang, Fei-Hu Che. A novel all-trans retinoic acid derivative inhibits proliferation and induces apoptosis of myelodysplastic syndromes cell line SKM-1 cells via up-regulating p53. International immunopharmacology. vol 65. 2019-04-08. PMID:30415163. |
consequently, these data provide the first evidence for atpr increased apoptosis in skm-1 cells by p53 that is mutually dependent on and obligatorily linked to bnip3 gene activation. |
2019-04-08 |
2023-08-13 |
Not clear |
| Haohao Liu, Shenshen Zhang, Chuanrui Liu, Jinxia Wu, Yueqin Wang, Le Yuan, Xingde Du, Rui Wang, Phelisters Wegesa Marwa, Donggang Zhuang, Xuemin Cheng, Huizhen Zhan. Resveratrol Ameliorates Microcystin-LR-Induced Testis Germ Cell Apoptosis in Rats via SIRT1 Signaling Pathway Activation. Toxins. vol 10. issue 6. 2019-04-05. PMID:29890735. |
however, res pretreatment ameliorated mc-lr-induced apoptosis and sirt1 inhibition, and downregulated the mc-lr-induced increase in p53 and ku70 acetylation, bax expression, and caspase-3 activation. |
2019-04-05 |
2023-08-13 |
rat |
| Haohao Liu, Shenshen Zhang, Chuanrui Liu, Jinxia Wu, Yueqin Wang, Le Yuan, Xingde Du, Rui Wang, Phelisters Wegesa Marwa, Donggang Zhuang, Xuemin Cheng, Huizhen Zhan. Resveratrol Ameliorates Microcystin-LR-Induced Testis Germ Cell Apoptosis in Rats via SIRT1 Signaling Pathway Activation. Toxins. vol 10. issue 6. 2019-04-05. PMID:29890735. |
the present study indicated that the administration of res could ameliorate mc-lr-induced sertoli⁻germ cell apoptosis and protect against reproductive toxicity in rats by stimulating the sirt1/p53 pathway, suppressing p53 and ku70 acetylation and enhancing the binding of ku70 to bax. |
2019-04-05 |
2023-08-13 |
rat |
| Kathryn Ondricek, Peter Thoma. Effects of hypoxia exposure on apoptosis and expression of membrane steroid receptors, ZIP9, mPRα, and GPER in Atlantic croaker ovaries. Comparative biochemistry and physiology. Part A, Molecular & integrative physiology. vol 224. 2019-04-05. PMID:30025815. |
membrane androgen receptor (zip9) enhances apoptosis of cultured atlantic croaker ovarian follicle cells via upregulation of p53 and bax, and increased caspase 3 activity through non-classical steroid signaling. |
2019-04-05 |
2023-08-13 |
Not clear |
| Kathryn Ondricek, Peter Thoma. Effects of hypoxia exposure on apoptosis and expression of membrane steroid receptors, ZIP9, mPRα, and GPER in Atlantic croaker ovaries. Comparative biochemistry and physiology. Part A, Molecular & integrative physiology. vol 224. 2019-04-05. PMID:30025815. |
the enhanced apoptosis in ovaries of hypoxia-exposed fish was associated with increased caspase-3/7 activity and elevated expression of the pro-apoptotic genes, bax and p53. |
2019-04-05 |
2023-08-13 |
Not clear |
| Jingwen Xu, Nipa H Patel, Tareq Saleh, Emmanuel K Cudjoe, Moureq Alotaibi, Yingliang Wu, Santiago Lima, Adam M Hawkridge, David A Gewirt. Differential Radiation Sensitivity in p53 Wild-Type and p53-Deficient Tumor Cells Associated with Senescence but not Apoptosis or (Nonprotective) Autophagy. Radiation research. vol 190. issue 5. 2019-04-05. PMID:30132722. |
differential radiation sensitivity in p53 wild-type and p53-deficient tumor cells associated with senescence but not apoptosis or (nonprotective) autophagy. |
2019-04-05 |
2023-08-13 |
Not clear |
| Jingwen Xu, Nipa H Patel, Tareq Saleh, Emmanuel K Cudjoe, Moureq Alotaibi, Yingliang Wu, Santiago Lima, Adam M Hawkridge, David A Gewirt. Differential Radiation Sensitivity in p53 Wild-Type and p53-Deficient Tumor Cells Associated with Senescence but not Apoptosis or (Nonprotective) Autophagy. Radiation research. vol 190. issue 5. 2019-04-05. PMID:30132722. |
moreover, functional p53 has frequently been implicated in contributing to radiation sensitivity through the facilitation of apoptosis. |
2019-04-05 |
2023-08-13 |
Not clear |
| Jingwen Xu, Nipa H Patel, Tareq Saleh, Emmanuel K Cudjoe, Moureq Alotaibi, Yingliang Wu, Santiago Lima, Adam M Hawkridge, David A Gewirt. Differential Radiation Sensitivity in p53 Wild-Type and p53-Deficient Tumor Cells Associated with Senescence but not Apoptosis or (Nonprotective) Autophagy. Radiation research. vol 190. issue 5. 2019-04-05. PMID:30132722. |
to address the involvement of apoptosis, autophagy, senescence and p53 status in the response to radiation, the current studies utilized isogenic h460 non-small cell lung cancer cells that were either p53-wild type (h460wt) or null (h460crp53). |
2019-04-05 |
2023-08-13 |
Not clear |
| Chengjun Wu, Kersti Nilsson, Yunji Zheng, Camilla Ekenstierna, Natsuki Sugiyama, Ola Forslund, Naoko Kajitani, Haoran Yu, Johan Wennerberg, Lars Ekblad, Stefan Schwart. Short half-life of HPV16 E6 and E7 mRNAs sensitizes HPV16-positive tonsillar cancer cell line HN26 to DNA-damaging drugs. International journal of cancer. vol 144. issue 2. 2019-04-05. PMID:30303514. |
here we show that treatment of the hpv16-positive tonsillar cancer cell line hn26 with dna alkylating cancer drug melphalan-induced p53 and activated apoptosis. |
2019-04-05 |
2023-08-13 |
mouse |
| Chengjun Wu, Kersti Nilsson, Yunji Zheng, Camilla Ekenstierna, Natsuki Sugiyama, Ola Forslund, Naoko Kajitani, Haoran Yu, Johan Wennerberg, Lars Ekblad, Stefan Schwart. Short half-life of HPV16 E6 and E7 mRNAs sensitizes HPV16-positive tonsillar cancer cell line HN26 to DNA-damaging drugs. International journal of cancer. vol 144. issue 2. 2019-04-05. PMID:30303514. |
as a consequence of hpv16 e6 and e7 down-regulation, the dna damage inflicted on the cells by melphalan caused induction of p53 and activation of apoptosis in the hn26 cells. |
2019-04-05 |
2023-08-13 |
mouse |
| Jing Zhou, Wen-Li Li, Zi-Xuan Wang, Nai-Yuan Chen, Yue Tang, Xiao-Xiao Hu, Jing-Huan Deng, Yixin Lu, Guo-Dong L. Varacin-1, a novel analog of varacin C, induces p53-independent apoptosis in cancer cells through ROS-mediated reduction of XIAP. Acta pharmacologica Sinica. vol 40. issue 2. 2019-04-03. PMID:29773887. |
note that this action is independent of p53 status, because vca-1 induced similar levels of apoptosis in two different panels of cell lines (hct116 p53- wild-type vs. hct116 p53-knockout colon cancer cells, and p53-expressing u2os vs. p53-deficient saos2 osteosarcoma cancer cells). |
2019-04-03 |
2023-08-13 |
human |
| Haicong Chen, Chaojun Wang, Xin Wang, Zhen Guo, Zhujin Xu, Yi Zhao, Jiashang Cai, Jun Li. A polysaccharide from Enterobacter cloacae induces apoptosis of human osteosarcoma cells through the activation of p53 and mitochondrial intrinsic pathway. International journal of biological macromolecules. vol 122. 2019-04-03. PMID:30336239. |
a polysaccharide from enterobacter cloacae induces apoptosis of human osteosarcoma cells through the activation of p53 and mitochondrial intrinsic pathway. |
2019-04-03 |
2023-08-13 |
human |
| Haicong Chen, Chaojun Wang, Xin Wang, Zhen Guo, Zhujin Xu, Yi Zhao, Jiashang Cai, Jun Li. A polysaccharide from Enterobacter cloacae induces apoptosis of human osteosarcoma cells through the activation of p53 and mitochondrial intrinsic pathway. International journal of biological macromolecules. vol 122. 2019-04-03. PMID:30336239. |
ecp-induced apoptotic cell death was associated with collapse of mitochondrial membrane, cytochrome c release into the cytosol, activation of caspase-9 and-3, degradation of poly (adp-ribose) polymerase (parp), elevated the ratio of bax/bcl-2 protein and overexpression of p53, suggesting the involvement of the activation of p53 and mitochondrial intrinsic pathway in ecp-induced apoptosis. |
2019-04-03 |
2023-08-13 |
human |