| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ruo-Jing Wei, Xin-Shi Zhang, Da-Lin H. Andrographolide sensitizes prostate cancer cells to TRAIL-induced apoptosis. Asian journal of andrology. vol 20. issue 2. 2019-05-14. PMID:28869219. |
further research revealed that the dr4 inhibition, p53 expression, and ros generation can significantly reduce the apoptosis induced by the combination of trail and andro in pca cells. |
2019-05-14 |
2023-08-13 |
mouse |
| Ruo-Jing Wei, Xin-Shi Zhang, Da-Lin H. Andrographolide sensitizes prostate cancer cells to TRAIL-induced apoptosis. Asian journal of andrology. vol 20. issue 2. 2019-05-14. PMID:28869219. |
in conclusion, andro increases the sensitivity of pca cells to trail-induced apoptosis through the generation of ros and up-regulation of p53 and then promotes pca cell apoptosis associated with the activation of dr4. |
2019-05-14 |
2023-08-13 |
mouse |
| Irina I Suvorova, Aleksandra R Knyazeva, Valery A Pospelo. Resveratrol-induced p53 activation is associated with autophagy in mouse embryonic stem cells. Biochemical and biophysical research communications. vol 503. issue 3. 2019-05-13. PMID:30098786. |
resveratrol-induced p53 activation may trigger differentiation and apoptosis in embryonic stem cells (escs). |
2019-05-13 |
2023-08-13 |
mouse |
| Irina I Suvorova, Aleksandra R Knyazeva, Valery A Pospelo. Resveratrol-induced p53 activation is associated with autophagy in mouse embryonic stem cells. Biochemical and biophysical research communications. vol 503. issue 3. 2019-05-13. PMID:30098786. |
surprisingly, the resveratrol-activated p53 is not associated with either g1/s cell cycle checkpoint or apoptosis in mescs. |
2019-05-13 |
2023-08-13 |
mouse |
| T P Klushnik, I N Otman, A S Chukanova, G G Nadareishvili, M S Guliyeva, E I Guse. [The dynamics of markers of apoptosis in the acute period of ischemic stroke]. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova. vol 118. issue 9. Vyp. 2. 2019-05-13. PMID:30499556. |
to study the dynamics of markers of apoptosis (bcl-2, p53) in serum in the acute period of ischemic stroke (is) in comparison to the severity of the neurological condition and the volume of infarct. |
2019-05-13 |
2023-08-13 |
Not clear |
| Ana Janic, Liz J Valente, Matthew J Wakefield, Leon Di Stefano, Liz Milla, Stephen Wilcox, Haoyu Yang, Lin Tai, Cassandra J Vandenberg, Andrew J Kueh, Shinsuke Mizutani, Margs S Brennan, Robyn L Schenk, Lisa M Lindqvist, Anthony T Papenfuss, Liam O'Connor, Andreas Strasser, Marco J Herol. DNA repair processes are critical mediators of p53-dependent tumor suppression. Nature medicine. vol 24. issue 7. 2019-05-10. PMID:29892060. |
it has long been assumed that p53 suppresses tumor development through induction of apoptosis, possibly with contributions by cell cycle arrest and cell senescence |
2019-05-10 |
2023-08-13 |
Not clear |
| Giovanni Blandino, Silvia Di Agostin. New therapeutic strategies to treat human cancers expressing mutant p53 proteins. Journal of experimental & clinical cancer research : CR. vol 37. issue 1. 2019-05-09. PMID:29448954. |
the tumor suppressor p53 plays a critical role to preserve dna fidelity from diverse insults through the regulation of cell-cycle checkpoints, dna repair, senescence and apoptosis. |
2019-05-09 |
2023-08-13 |
mouse |
| Benjamin Bourgeois, Tobias Mad. Regulation of cellular senescence via the FOXO4-p53 axis. FEBS letters. vol 592. issue 12. 2019-05-07. PMID:29683489. |
forkhead box o (foxo) and p53 proteins are transcription factors that regulate diverse signalling pathways to control cell cycle, apoptosis and metabolism. |
2019-05-07 |
2023-08-13 |
Not clear |
| Uddin Md Nazim, Sang-Youel Par. Attenuation of autophagy flux by 6-shogaol sensitizes human liver cancer cells to TRAIL-induced apoptosis via p53 and ROS. International journal of molecular medicine. vol 43. issue 2. 2019-05-03. PMID:30483736. |
attenuation of autophagy flux by 6-shogaol sensitizes human liver cancer cells to trail-induced apoptosis via p53 and ros. |
2019-05-03 |
2023-08-13 |
human |
| Uddin Md Nazim, Sang-Youel Par. Attenuation of autophagy flux by 6-shogaol sensitizes human liver cancer cells to TRAIL-induced apoptosis via p53 and ROS. International journal of molecular medicine. vol 43. issue 2. 2019-05-03. PMID:30483736. |
in conclusion, attenuation of 6‑sho‑induced autophagy flux sensitized cells to trail‑induced apoptosis via p53 and ros, suggesting that the administration of trail in combination with 6‑sho may be a suitable therapeutic method for the treatment of trail‑resistant huh7 liver cells. |
2019-05-03 |
2023-08-13 |
human |
| Yangxi Xiang, Peng Jia, Wei Liu, Meisheng Yi, Kuntong Ji. Comparative transcriptome analysis reveals the role of p53 signalling pathway during red-spotted grouper nervous necrosis virus infection in Lateolabrax japonicus brain cells. Journal of fish diseases. vol 42. issue 4. 2019-05-02. PMID:30659619. |
overexpression of l. japonicus p53 (ljp53) significantly inhibited rgnnv replication and up-regulated the expression of apoptosis-related genes, whereas the down-regulation caused by pifithrin-α led to the opposite effect, suggesting ljp53 might promote cell apoptosis to repress virus replication. |
2019-05-02 |
2023-08-13 |
zebrafish |
| Ayushi Agarwal, Akiladdevi Kasinathan, Ramamoorthi Ganesan, Akhila Balasubramanian, Jahnavi Bhaskaran, Samyuktha Suresh, Revanth Srinivasan, K B Aravind, Nageswaran Sivalinga. Curcumin induces apoptosis and cell cycle arrest via the activation of reactive oxygen species-independent mitochondrial apoptotic pathway in Smad4 and p53 mutated colon adenocarcinoma HT29 cells. Nutrition research (New York, N.Y.). vol 51. 2019-05-01. PMID:29673545. |
curcumin induces apoptosis and cell cycle arrest via the activation of reactive oxygen species-independent mitochondrial apoptotic pathway in smad4 and p53 mutated colon adenocarcinoma ht29 cells. |
2019-05-01 |
2023-08-13 |
Not clear |
| Ayushi Agarwal, Akiladdevi Kasinathan, Ramamoorthi Ganesan, Akhila Balasubramanian, Jahnavi Bhaskaran, Samyuktha Suresh, Revanth Srinivasan, K B Aravind, Nageswaran Sivalinga. Curcumin induces apoptosis and cell cycle arrest via the activation of reactive oxygen species-independent mitochondrial apoptotic pathway in Smad4 and p53 mutated colon adenocarcinoma HT29 cells. Nutrition research (New York, N.Y.). vol 51. 2019-05-01. PMID:29673545. |
in conclusion, our data provide the first evidence that curcumin induces ros independent apoptosis and cell cycle arrest in colon cancer cells that carry mutation on smad4 and p53. |
2019-05-01 |
2023-08-13 |
Not clear |
| Aline B de P Abrantes, Gustavo C Dias, Nadja C Souza-Pinto, Mauricio S Baptist. p53-Dependent and p53-Independent Responses of Cells Challenged by Photosensitization. Photochemistry and photobiology. vol 95. issue 1. 2019-05-01. PMID:30240018. |
cells lacking p53 activity were slightly more resistant to photoactivated dmmb, which was correlated with a smaller sub-g1 population, indicative of a lower level of apoptosis. |
2019-05-01 |
2023-08-13 |
Not clear |
| Daofeng Qu, Mengxue Jiang, Dongping Huang, Hui Zhang, Lifang Feng, Yuewen Chen, Xuan Zhu, Suhua Wang, Jianzhong Ha. Synergistic Effects of The Enhancements to Mitochondrial ROS, p53 Activation and Apoptosis Generated by Aspartame and Potassium Sorbate in HepG2 Cells. Molecules (Basel, Switzerland). vol 24. issue 3. 2019-05-01. PMID:30696035. |
synergistic effects of the enhancements to mitochondrial ros, p53 activation and apoptosis generated by aspartame and potassium sorbate in hepg2 cells. |
2019-05-01 |
2023-08-13 |
Not clear |
| Olga Fedorova, Alexey Petukhov, Alexandra Daks, Oleg Shuvalov, Tatyana Leonova, Elena Vasileva, Nikolai Aksenov, Gerry Melino, Nikolai A Barle. Orphan receptor NR4A3 is a novel target of p53 that contributes to apoptosis. Oncogene. vol 38. issue 12. 2019-04-30. PMID:30455429. |
orphan receptor nr4a3 is a novel target of p53 that contributes to apoptosis. |
2019-04-30 |
2023-08-13 |
Not clear |
| Olga Fedorova, Alexey Petukhov, Alexandra Daks, Oleg Shuvalov, Tatyana Leonova, Elena Vasileva, Nikolai Aksenov, Gerry Melino, Nikolai A Barle. Orphan receptor NR4A3 is a novel target of p53 that contributes to apoptosis. Oncogene. vol 38. issue 12. 2019-04-30. PMID:30455429. |
major tumor suppressor and transcription factor p53 coordinates expression of many genes hence affecting critical cellular functions including cell cycle, senescence, and apoptosis. |
2019-04-30 |
2023-08-13 |
Not clear |
| Olga Fedorova, Alexey Petukhov, Alexandra Daks, Oleg Shuvalov, Tatyana Leonova, Elena Vasileva, Nikolai Aksenov, Gerry Melino, Nikolai A Barle. Orphan receptor NR4A3 is a novel target of p53 that contributes to apoptosis. Oncogene. vol 38. issue 12. 2019-04-30. PMID:30455429. |
collectively, our studies revealed a novel transcriptional target of p53, nr4a3, which triggers apoptosis and thus likely has a tumor suppressive role in breast and lung cancers. |
2019-04-30 |
2023-08-13 |
Not clear |
| Habib Yaribeygi, Mohammad T Mohammadi, Ramin Rezaee, Amirhossein Sahebka. Crocin improves renal function by declining Nox-4, IL-18, and p53 expression levels in an experimental model of diabetic nephropathy. Journal of cellular biochemistry. vol 119. issue 7. 2019-04-29. PMID:29575259. |
moreover, expressions of il-18 (as a marker of inflammation) and p53 (as a marker of apoptosis) were increased. |
2019-04-29 |
2023-08-13 |
rat |
| Li Chen, Ya-Ping Li, Xin-Xin Li, Zhi-Hao Lu, Qiu-Hong Zheng, Qin-Ying Li. Isolation of 4,4'-bond secalonic acid D from the marine-derived fungus Penicillium oxalicum with inhibitory property against hepatocellular carcinoma. The Journal of antibiotics. vol 72. issue 1. 2019-04-29. PMID:30258223. |
herein, we performed an in vitro biology test and found that 4,4'-sad stimulated the apoptosis of tumor cells in the human hepatocellular carcinoma cell lines plc/prf/5 and huh-7 by activating caspase-3, caspase-8, caspase-9, parp, p53, and cyclin b1, as well as by regulating the bax/bcl-2 ratio. |
2019-04-29 |
2023-08-13 |
human |