| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mengjuan Wu, Guang Yu, Tonghai Yan, Dan Ke, Qun Wang, Rong Liu, Jian-Zhi Wang, Bin Zhang, Dan Chen, Xiaochuan Wan. Phosphorylation of SET mediates apoptosis via P53 hyperactivation and NM23-H1 nuclear import. Neurobiology of aging. vol 69. 2019-05-21. PMID:29852409. |
phosphorylation of set mediates apoptosis via p53 hyperactivation and nm23-h1 nuclear import. |
2019-05-21 |
2023-08-13 |
Not clear |
| Mengjuan Wu, Guang Yu, Tonghai Yan, Dan Ke, Qun Wang, Rong Liu, Jian-Zhi Wang, Bin Zhang, Dan Chen, Xiaochuan Wan. Phosphorylation of SET mediates apoptosis via P53 hyperactivation and NM23-H1 nuclear import. Neurobiology of aging. vol 69. 2019-05-21. PMID:29852409. |
to investigate its mechanism, we overexpressed set (s9e) in hek293/tau cells and observed apoptosis accompanied with a marked increase of cleaved caspase-3 and cytoplasmic set (s9e) retention with enhanced protein phosphatase-2a inhibition, which subsequently caused p53 hyperphosphorylation and activation. |
2019-05-21 |
2023-08-13 |
Not clear |
| Sarah Schoch, Vasily Sen, Sabine Gajewski, Valery Golubev, Bettina Strauch, Andrea Hartwig, Beate Köberl. Activity profile of the cisplatin analogue PN149 in different tumor cell lines. Biochemical pharmacology. vol 156. 2019-05-21. PMID:30138622. |
these findings on the transcriptional level were confirmed on the functional level revealing that pn149 treatment increased levels of p53 and resulted in cell cycle arrest and drug-induced cytotoxicity via induction of apoptosis. |
2019-05-21 |
2023-08-13 |
Not clear |
| K M Ahsanul Kabir, Ruhul Amin, Imtiaj Hasan, A K M Asaduzzaman, Hamida Khatun, Syed Rashel Kabi. Geodorum densiflorum rhizome lectin inhibits Ehrlich ascites carcinoma cell growth by inducing apoptosis through the regulation of BAX, p53 and NF-κB genes expression. International journal of biological macromolecules. vol 125. 2019-05-21. PMID:30521911. |
geodorum densiflorum rhizome lectin inhibits ehrlich ascites carcinoma cell growth by inducing apoptosis through the regulation of bax, p53 and nf-κb genes expression. |
2019-05-21 |
2023-08-13 |
mouse |
| Sudjit Luanpitpong, Paweorn Angsutararux, Parinya Samart, Nawin Chanthra, Pithi Chanvorachote, Surapol Issaragrisi. Hyper-O-GlcNAcylation induces cisplatin resistance via regulation of p53 and c-Myc in human lung carcinoma. Scientific reports. vol 7. issue 1. 2019-05-20. PMID:28878262. |
profiling of various key regulatory proteins revealed an implication of either p53 or c-myc in the apoptosis regulation by o-glcnacylation, independent of p53 status. |
2019-05-20 |
2023-08-13 |
human |
| Lvxia Dai, Qu Pan, Yanjuan Peng, Sizhou Huang, Jianmin Liu, Tian Chen, Xin Wang, Dengbang Chen, Jiandong Wang, Yanfeng Zhu, Hui Wang, Yilun Liu, Yu Ou, Xiaoping Yu, Kang Ca. p53 Plays a Key Role in the Apoptosis of Human Ovarian Cancer Cells Induced by Adenovirus-Mediated CRM197. Human gene therapy. vol 29. issue 8. 2019-05-20. PMID:29620944. |
p53 plays a key role in the apoptosis of human ovarian cancer cells induced by adenovirus-mediated crm197. |
2019-05-20 |
2023-08-13 |
mouse |
| Lvxia Dai, Qu Pan, Yanjuan Peng, Sizhou Huang, Jianmin Liu, Tian Chen, Xin Wang, Dengbang Chen, Jiandong Wang, Yanfeng Zhu, Hui Wang, Yilun Liu, Yu Ou, Xiaoping Yu, Kang Ca. p53 Plays a Key Role in the Apoptosis of Human Ovarian Cancer Cells Induced by Adenovirus-Mediated CRM197. Human gene therapy. vol 29. issue 8. 2019-05-20. PMID:29620944. |
since skov3 cells are p53 deletion cells, while a2780 cells are p53 wild-type cells, it was postulated that p53 might play a key role in adcrm197-induced apoptosis. |
2019-05-20 |
2023-08-13 |
mouse |
| Lvxia Dai, Qu Pan, Yanjuan Peng, Sizhou Huang, Jianmin Liu, Tian Chen, Xin Wang, Dengbang Chen, Jiandong Wang, Yanfeng Zhu, Hui Wang, Yilun Liu, Yu Ou, Xiaoping Yu, Kang Ca. p53 Plays a Key Role in the Apoptosis of Human Ovarian Cancer Cells Induced by Adenovirus-Mediated CRM197. Human gene therapy. vol 29. issue 8. 2019-05-20. PMID:29620944. |
taking these results together, it is concluded that adcrm197 induces apoptosis of human ovarian cancer cells via the p53 pathway. |
2019-05-20 |
2023-08-13 |
mouse |
| Francesco Merlino, Simona Daniele, Valeria La Pietra, Salvatore Di Maro, Francesco Saverio Di Leva, Diego Brancaccio, Stefano Tomassi, Stefano Giuntini, Linda Cerofolini, Marco Fragai, Claudio Luchinat, Florian Reichart, Chiara Cavallini, Barbara Costa, Rebecca Piccarducci, Sabrina Taliani, Federico Da Settimo, Claudia Martini, Horst Kessler, Ettore Novellino, Luciana Marinell. Simultaneous Targeting of RGD-Integrins and Dual Murine Double Minute Proteins in Glioblastoma Multiforme. Journal of medicinal chemistry. vol 61. issue 11. 2019-05-20. PMID:29775303. |
in the fight against glioblastoma multiforme, recent literature data have highlighted that integrin α5β1 and p53 are part of convergent pathways in the control of glioma apoptosis. |
2019-05-20 |
2023-08-13 |
Not clear |
| Xuan Kang, Yun Feng, Zhixue Gan, Shiyang Zeng, Xiaobo Guo, Xirui Chen, Ye Zhang, Chen Wang, Kuinan Liu, Xuelin Chen, Xiaoxue Jiang, Shuting Song, Yabin Li, Su Chen, Feng Sun, Zhiyong Mao, Xiaomei Yang, Jianfeng Chan. NASP antagonize chromatin accessibility through maintaining histone H3K9me1 in hepatocellular carcinoma. Biochimica et biophysica acta. Molecular basis of disease. vol 1864. issue 10. 2019-05-20. PMID:30076957. |
this also resulted in a synergistic effect on enhanced apoptosis with myc and p53 decreases. |
2019-05-20 |
2023-08-13 |
Not clear |
| Luciana P Rangel, Giulia D S Ferretti, Caroline L Costa, Sarah M M V Andrade, Renato S Carvalho, Danielly C F Costa, Jerson L Silv. p53 reactivation with induction of massive apoptosis-1 (PRIMA-1) inhibits amyloid aggregation of mutant p53 in cancer cells. The Journal of biological chemistry. vol 294. issue 10. 2019-05-20. PMID:30602570. |
p53 reactivation with induction of massive apoptosis-1 (prima-1) and its primary active metabolite, 2-methylene-3-quinuclidinone (mq), can restore unfolded p53 mutants to a native conformation that induces apoptosis and activates several p53 target genes. |
2019-05-20 |
2023-08-13 |
Not clear |
| Ling Liu, Li Yang, Hui Chang, Yan-Nan Chen, Feng Zhang, Shuo Feng, Juan Peng, Chen-Chen Ren, Xiao-An Zhan. CP‑31398 attenuates endometrial cancer cell invasion, metastasis and resistance to apoptosis by downregulating MDM2 expression. International journal of oncology. vol 54. issue 3. 2019-05-20. PMID:30628640. |
the expression of p53, p21, bad, bax, b‑cell lymphoma‑2 (bcl‑2), cytochrome c (cyt‑c), caspase‑3, cox‑2, matrix metalloproteinase (mmp)‑2 and mmp‑9 was measured to further confirm the effects of cp‑31398 on cell migration, invasion and apoptosis. |
2019-05-20 |
2023-08-13 |
Not clear |
| Ling Liu, Li Yang, Hui Chang, Yan-Nan Chen, Feng Zhang, Shuo Feng, Juan Peng, Chen-Chen Ren, Xiao-An Zhan. CP‑31398 attenuates endometrial cancer cell invasion, metastasis and resistance to apoptosis by downregulating MDM2 expression. International journal of oncology. vol 54. issue 3. 2019-05-20. PMID:30628640. |
the ec cells treated with cp‑31398 or sirna against mdm2 exhibited an increased apoptosis and a suppressed migration and invasion, corresponding to an increased expression of p53, p21, bad, bax, cyt‑c and caspase‑3, as well as to a decreased expression of bcl‑2, cox‑2, mmp‑2 and mmp‑9. |
2019-05-20 |
2023-08-13 |
Not clear |
| Fan Niu, Jin Yan, Bohan Ma, Shichao Li, Yongping Shao, Pengcheng He, Wanggang Zhang, Wangxiao He, Peter X Ma, Wuyuan L. Lanthanide-doped nanoparticles conjugated with an anti-CD33 antibody and a p53-activating peptide for acute myeloid leukemia therapy. Biomaterials. vol 167. 2019-05-17. PMID:29571049. |
the resultant nanoparticle anticd33-lonp-pmi, while nontoxic to normal cells, induced apoptosis of aml cell lines and primary leukemic cells isolated from aml patients by antagonizing mdm2 and/or mdmx to activate the p53 pathway. |
2019-05-17 |
2023-08-13 |
human |
| Miaomiao Chen, Hongqin Zhang, Guihong Zhang, Ailing Zhong, Qian Ma, Jinyan Kai, Yin Tong, Suhong Xie, Yanchun Wang, Hui Zheng, Lin Guo, Renquan L. Targeting TPX2 suppresses proliferation and promotes apoptosis via repression of the PI3k/AKT/P21 signaling pathway and activation of p53 pathway in breast cancer. Biochemical and biophysical research communications. vol 507. issue 1-4. 2019-05-17. PMID:30454896. |
targeting tpx2 suppresses proliferation and promotes apoptosis via repression of the pi3k/akt/p21 signaling pathway and activation of p53 pathway in breast cancer. |
2019-05-17 |
2023-08-13 |
human |
| Miaomiao Chen, Hongqin Zhang, Guihong Zhang, Ailing Zhong, Qian Ma, Jinyan Kai, Yin Tong, Suhong Xie, Yanchun Wang, Hui Zheng, Lin Guo, Renquan L. Targeting TPX2 suppresses proliferation and promotes apoptosis via repression of the PI3k/AKT/P21 signaling pathway and activation of p53 pathway in breast cancer. Biochemical and biophysical research communications. vol 507. issue 1-4. 2019-05-17. PMID:30454896. |
taken together, our findings indicate that tpx2 silencing negatively regulates the pi3k/akt and activates p53 signaling pathway by which breast cancer cells proliferation were inhibited whereas cellulars apoptosis were accelerated, suggesting that tpx2 may be a potential target for anticancer therapy in breast cancer. |
2019-05-17 |
2023-08-13 |
human |
| Yuan Gao, Xiaochun Wu, Shuqin Zhao, Yujun Zhang, Hailong Ma, Zhen Yang, Wanghao Yang, Chen Zhao, Li Wang, Quanwei Zhan. Melatonin receptor depletion suppressed hCG-induced testosterone expression in mouse Leydig cells. Cellular & molecular biology letters. vol 24. 2019-05-17. PMID:30915128. |
in addition, our further data showed that knockdown of mtnr1a and mtnr1b promoted hcg-induced expression of apoptosis markers, including p53, caspase-3 and bcl-2. |
2019-05-17 |
2023-08-13 |
mouse |
| María Clara Ingaramo, Juan A Sánchez, Andrés Dekant. Regulation and function of p53: A perspective from Drosophila studies. Mechanisms of development. vol 154. 2019-05-16. PMID:29800619. |
additionally to its classical functions in regulating cell cycle arrest, apoptosis and senescence, newly described non-canonical functions of p53 are increasingly coming under the spotlight as important functions not only for its role as a tumour suppressor but also for its non-cancer associated activities. |
2019-05-16 |
2023-08-13 |
human |
| Bhavana Tiwari, Amanda E Jones, John M Abram. Transposons, p53 and Genome Security. Trends in genetics : TIG. vol 34. issue 11. 2019-05-16. PMID:30195581. |
p53, the most commonly mutated tumor suppressor, is a transcription factor known to regulate proliferation, senescence, and apoptosis. |
2019-05-16 |
2023-08-13 |
human |
| Pankaj Gupta, Adeel H Zaidi, Sunil K Mann. Suppression of IKK, but not activation of p53 is responsible for cell death mediated by naturally occurring oxidized tetranortriterpenoid. Journal of cellular biochemistry. vol 119. issue 8. 2019-05-15. PMID:29738082. |
further, azadirachtin is unable to potentiate apoptosis in nf-κb-downregulated (iκb-dn) cells, whereas ectopic expression of p65 rescues azadirachtin-mediated apoptosis, regardless of their p53 status. |
2019-05-15 |
2023-08-13 |
Not clear |