| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xing Chen, Jianfeng Zhou, Xianyang Yue, Shaobo Wang, Baokang Yu, Yi Luo, Xin Huan. Selective bio-labeling and induced apoptosis of hematopoietic cancer cells using dual-functional polyethylenimine-caged platinum nanoclusters. Biochemical and biophysical research communications. vol 503. issue 3. 2019-02-11. PMID:30029883. |
these zerovalent pt ncs are capable to selectively enter into blood cancer cells (k562, bv173 cell lines) when compared to the peripheral blood mononucleated cells (pbmcs) from healthy donors, in addition, it can specifically induce pro-apoptotic protein expression (p53, puma, cleaved caspase) in hematopoietic cancer cells and promote cell apoptosis. |
2019-02-11 |
2023-08-13 |
Not clear |
| J F A Valente, A Sousa, J A Queiroz, F Sous. DoE to improve supercoiled p53-pDNA purification by O-phospho-l-tyrosine chromatography. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. vol 1105. 2019-02-11. PMID:30597418. |
p53 is implicated in various cellular functions and several studies have shown that transfection of cancer cells with wild-type p53-expressing plasmids could directly drive cells into growth arrest and/or apoptosis. |
2019-02-11 |
2023-08-13 |
Not clear |
| R S Redman, E Paal, S Chauhan, R Avers, N Bayle. Botryoid odontogenic cyst. Exploration of proliferative activity, apoptosis and expression of TP53 and BCL2 compared to the histologically identical lateral periodontal and gingival cysts. Biotechnic & histochemistry : official publication of the Biological Stain Commission. vol 92. issue 8. 2019-02-08. PMID:28910164. |
sections of neutral buffered formalin fixed, paraffin-embedded tissues from the boc and archival specimens of four gcs, four lpcs and three odontogenic keratocysts (okcs) were stained using immunohistochemistry for ki-67, a marker of proliferating cells, caspase-3, a marker of cells undergoing apoptosis, tumor suppressor p53, and the apoptosis inhibitor bcl2. |
2019-02-08 |
2023-08-13 |
Not clear |
| Bente Benedict, Tanja van Harn, Marleen Dekker, Simone Hermsen, Asli Kucukosmanoglu, Wietske Pieters, Elly Delzenne-Goette, Josephine C Dorsman, Eva Petermann, Floris Foijer, Hein Te Riel. Loss of p53 suppresses replication-stress-induced DNA breakage in G1/S checkpoint deficient cells. eLife. vol 7. 2019-02-08. PMID:30322449. |
in cancer cells, loss of g1/s control is often accompanied by p53 pathway inactivation, the latter usually rationalized as a necessity for suppressing cell cycle arrest and apoptosis. |
2019-02-08 |
2023-08-13 |
mouse |
| Bente Benedict, Tanja van Harn, Marleen Dekker, Simone Hermsen, Asli Kucukosmanoglu, Wietske Pieters, Elly Delzenne-Goette, Josephine C Dorsman, Eva Petermann, Floris Foijer, Hein Te Riel. Loss of p53 suppresses replication-stress-induced DNA breakage in G1/S checkpoint deficient cells. eLife. vol 7. 2019-02-08. PMID:30322449. |
in this system, loss of p53 allowed mitogen-independent proliferation, not by suppressing apoptosis, but rather by restoring origin firing and reducing dna breakage. |
2019-02-08 |
2023-08-13 |
mouse |
| Yan-Qiang Chen, Tong-Qun Yang, Bin Zhou, Ming-Xuan Yang, Hai-Jun Feng, Yu-Liang Wan. HOXA5 overexpression promotes osteosarcoma cell apoptosis through the p53 and p38α MAPK pathway. Gene. vol 689. 2019-02-07. PMID:30521886. |
hoxa5 overexpression promotes osteosarcoma cell apoptosis through the p53 and p38α mapk pathway. |
2019-02-07 |
2023-08-13 |
human |
| Yan-Qiang Chen, Tong-Qun Yang, Bin Zhou, Ming-Xuan Yang, Hai-Jun Feng, Yu-Liang Wan. HOXA5 overexpression promotes osteosarcoma cell apoptosis through the p53 and p38α MAPK pathway. Gene. vol 689. 2019-02-07. PMID:30521886. |
treating u2os and mg63 cells with the p53 inhibitor α-pifithrin or the p38α mapk inhibitor sb203580 led to higher cell survival and proliferation and lower cell apoptosis, compared with the pcdna3.1-hoxa5 group. |
2019-02-07 |
2023-08-13 |
human |
| Yan-Qiang Chen, Tong-Qun Yang, Bin Zhou, Ming-Xuan Yang, Hai-Jun Feng, Yu-Liang Wan. HOXA5 overexpression promotes osteosarcoma cell apoptosis through the p53 and p38α MAPK pathway. Gene. vol 689. 2019-02-07. PMID:30521886. |
in conclusion, our study showed that the p53 and p38α mapk signal axis facilitated hoxa5's role in inhibiting growth and stimulating apoptosis of osteosarcoma cells. |
2019-02-07 |
2023-08-13 |
human |
| Xing-He Wang, Wei Li, Xing-Hui Wang, Mei-Yu Han, Ishfaq Muhammad, Xiu-Ying Zhang, Xiao-Qi Sun, Xiao-Xu Cu. Water-soluble substances of wheat: a potential preventer of aflatoxin B1-induced liver damage in broilers. Poultry science. vol 98. issue 1. 2019-02-06. PMID:30107611. |
the results showed that (i) wsw restored afb1-induced changes in serum biochemical parameters, and ameliorated histomorphological changes in hepatocytes, (ii) wsw reduced the content of afb1 in chicken liver, (iii) wsw alleviated afb1-induced autophagy inhibition by up-regulating hepatic lc3, beclin-1, and down-regulating hepatic mtor and cytoplasmic p53 expressions, (iv) wsw alleviated afb1-induced hepatocellular apoptosis via inhibiting pro-apoptotic gene expression (nuclear p53, caspase3, bax), and promoting anti-apoptotic gene expression (bcl-2), (v) wsw feeding ameliorated afb1-induced liver inflammation via impeding tlr4/nf-${{f \kappa }}$b and il-1/nf-${{f \kappa }}$b signaling pathways, down-regulating pro-inflammatory cytokines (il-1${{f eta }}$, il-6, and il-8), and markedly up-regulating anti-inflammatory genes (il-10 and ho-1). |
2019-02-06 |
2023-08-13 |
chicken |
| Nasim Rahmani Kukia, Yousef Rasmi, Ardeshir Abbasi, Nana Koshoridze, Alireza Shirpoor, George Burjanadze, Ehsan Saboor. Bio-Effects of TiO2 Nanoparticles on Human Colorectal Cancer and Umbilical Vein Endothelial Cell Lines Asian Pacific journal of cancer prevention : APJCP. vol 19. issue 10. 2019-02-06. PMID:30361551. |
results: exposure to increasing concentrations of tio2 nps enhanced overall cell survivalof hct116 cells and reduced the bcl-2 and caspase 3 expression while the ratio of bax/bcl-2 was down-regulated.tio2 nps at 400 and 50 μg/ml concentrations suppressed cell proliferation and induced apoptosis of ht29 cells andalso up-regulated p53 and bax at the mrna level, enhanced the bax/bcl-2 ratio and eventually up-regulated caspase3 mrna. |
2019-02-06 |
2023-08-13 |
human |
| ShengLei Li, Ming Gao, ZongMing Li, LiJie Song, XianZheng Gao, Jing Han, Feng Wang, YongFang Chen, WenCai Li, JianPing Yan. p53 and P-glycoprotein influence chemoresistance in hepatocellular carcinoma. Frontiers in bioscience (Elite edition). vol 10. 2019-02-04. PMID:29772519. |
p53 plays a role in cell growth; therefore, resistance mechanisms involve chemotherapy-induced apoptosis and p53 mutation and inactivation. |
2019-02-04 |
2023-08-13 |
Not clear |
| K C Rashmi, M Harsha Raj, Manoj Paul, Kesturu S Girish, Bharathi P Salimath, H S Aparn. A new pyrrole based small molecule from Tinospora cordifolia induces apoptosis in MDA-MB-231 breast cancer cells via ROS mediated mitochondrial damage and restoration of p53 activity. Chemico-biological interactions. vol 299. 2019-02-04. PMID:30543781. |
a new pyrrole based small molecule from tinospora cordifolia induces apoptosis in mda-mb-231 breast cancer cells via ros mediated mitochondrial damage and restoration of p53 activity. |
2019-02-04 |
2023-08-13 |
Not clear |
| Regina Hertfelder Reynolds, Maria Hvidberg Petersen, Cecilie Wennemoes Willert, Marie Heinrich, Nynne Nymann, Morten Dall, Jonas T Treebak, Maria Björkqvist, Asli Silahtaroglu, Lis Hasholt, Anne Nørremøll. Perturbations in the p53/miR-34a/SIRT1 pathway in the R6/2 Huntington's disease model. Molecular and cellular neurosciences. vol 88. 2019-01-31. PMID:29289683. |
the three factors, p53, the microrna-34 family and sirtuin 1 (sirt1), interact in a positive feedback loop involved in cell cycle progression, cellular senescence and apoptosis. |
2019-01-31 |
2023-08-13 |
mouse |
| Li Ding, Jiawei Li, Weihao Li, Zhenhua Fang, Na Li, Qiqi Guo, Haoyue Qu, Dan Feng, Jiangyue Li, Meiling Hon. p53 mediated IFN-β signaling to affect viral replication upon TGEV infection. Veterinary microbiology. vol 227. 2019-01-31. PMID:30473353. |
our previous studies showed that tgev infection activated p53 signaling to induce host cell apoptosis, which might influence virus replication. |
2019-01-31 |
2023-08-13 |
Not clear |
| Stephano S Mello, Laura D Attard. Deciphering p53 signaling in tumor suppression. Current opinion in cell biology. vol 51. 2019-01-30. PMID:29195118. |
studies in mouse models have revealed that p53 cell cycle arrest and apoptosis responses to acute dna damage signals are dispensable for tumor suppression, prompting a search for new mechanisms underlying p53-mediated cancer suppression. |
2019-01-30 |
2023-08-13 |
mouse |
| Donglin He, Zhihai Yu, Sheng Liu, Hong Dai, Qing Xu, Feng L. Methylenetetrahydrofolate Dehydrogenase 1 (MTHFD1) is Underexpressed in Clear Cell Renal Cell Carcinoma Tissue and Transfection and Overexpression in Caki-1 Cells Inhibits Cell Proliferation and Increases Apoptosis. Medical science monitor : international medical journal of experimental and clinical research. vol 24. 2019-01-30. PMID:30459299. |
mthfd1 transfection of human ccrcc caki-1 cells in vitro inhibited cell proliferation and promoted apoptosis, associated with reduced expression of cyclin d1, reduced akt phosphorylation, and increased expression of bax/bcl-2 and p53. |
2019-01-30 |
2023-08-13 |
human |
| Fengge Wang, Shuxiong Chen, Yanwen Jiang, Yun Zhao, Liting Sun, Biaobiao Zheng, Lu Chen, Zhuo Liu, Xue Zheng, Kangle Yi, Chunjin Li, Xu Zho. Effects of ammonia on apoptosis and oxidative stress in bovine mammary epithelial cells. Mutagenesis. vol 33. issue 4. 2019-01-29. PMID:30184101. |
these data suggest that ammonia exposure induces apoptosis in bovine mammary epithelial cells via activation of the p53 pathway and the mitochondrial apoptotic pathway, and that these effects involved the na+ k+ 2cl--cotransporter. |
2019-01-29 |
2023-08-13 |
cattle |
| Xian Wu, Wei Zhou, Qingshuang Wei, Peng Chen, Yan L. Cytoprotective effects of the medicinal herb Astragalus membranaceus on lipopolysaccharide‑exposed cells. Molecular medicine reports. vol 18. issue 5. 2019-01-29. PMID:30221731. |
across all cell lines, lps significantly elevated apoptosis rates, shifted cells to s/g2 phase, increased ros production, reduced Δψmit, upregulated cleaved caspase‑3, upregulated p53, and downregulated bcl‑2 relative to controls (all p<0.05). |
2019-01-29 |
2023-08-13 |
human |
| Xian Wu, Wei Zhou, Qingshuang Wei, Peng Chen, Yan L. Cytoprotective effects of the medicinal herb Astragalus membranaceus on lipopolysaccharide‑exposed cells. Molecular medicine reports. vol 18. issue 5. 2019-01-29. PMID:30221731. |
as a general trend, increasing am concentrations produced progressively greater reductions in the apoptosis rate, greater reductions in s/g2 phase %, greater reductions in ros production, greater increases in Δψmit, greater reductions in cleaved caspase‑3 and p53 expression, and greater increases in bcl‑2 expression. |
2019-01-29 |
2023-08-13 |
human |
| Qinghua Wu, Zhongxu Cao, Weiwei Xiao, Li Zhu, Qian Xie, Ling Li, Bao Zhang, Wei Zha. Study on Therapeutic Action and Mechanism of TMZ Combined with RITA Against Glioblastoma. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. vol 51. issue 6. 2019-01-29. PMID:30562758. |
reactivating p53 and inducing tumor apoptosis (rita) is a novel potential anti-cancer small molecular drug. |
2019-01-29 |
2023-08-13 |
Not clear |