| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Abhishek Jauhari, Tanisha Singh, Parul Singh, Devendra Parmar, Sanjay Yada. Regulation of miR-34 Family in Neuronal Development. Molecular neurobiology. vol 55. issue 2. 2019-01-01. PMID:28084588. |
our studies have also shown that increased expression of mir-34a controls the p53 level in differentiated pc12 cells in feedback inhibition manner, which probably prevents differentiated cells from p53 induced apoptosis. |
2019-01-01 |
2023-08-13 |
Not clear |
| Victoria J Weston, Wenbin Wei, Tatjana Stankovic, Pamela Kearn. Synergistic action of dual IGF1/R and MEK inhibition sensitizes childhood acute lymphoblastic leukemia (ALL) cells to cytotoxic agents and involves downregulation of STAT6 and PDAP1. Experimental hematology. vol 63. 2019-01-01. PMID:29656114. |
heterogeneous upregulation of multiple prosurvival pathways underlies resistance to damage-induced apoptosis in acute lymphoblastic leukemia (all) cells despite normal p53 responses. |
2019-01-01 |
2023-08-13 |
Not clear |
| Ming-Xia Ran, Yuan Li, Yan Zhang, Kai Liang, Ying-Nan Ren, Ming Zhang, Guang-Bin Zhou, Ying-Min Zhou, Kai Wu, Cheng-Dong Wang, Yan Huang, Bo Luo, Izhar Hyder Qazi, He-Min Zhang, Chang-Jun Zen. Transcriptome Sequencing Reveals the Differentially Expressed lncRNAs and mRNAs Involved in Cryoinjuries in Frozen-Thawed Giant Panda ( International journal of molecular sciences. vol 19. issue 10. 2019-01-01. PMID:30297640. |
go and kegg showed that the significantly dysregulated lncrnas and mrnas were mainly involved in regulating responses to cold stress and apoptosis, such as the integral component of membrane, calcium transport, and various signaling pathways including pi3k-akt, p53 and camp. |
2019-01-01 |
2023-08-13 |
Not clear |
| Mikhail Krasavin, Maxim A Gureyev, Dmitry Dar'in, Olga Bakulina, Maria Chizhova, Anastasia Lepikhina, Daria Novikova, Tatyana Grigoreva, Gleb Ivanov, Aisulu Zhumagalieva, Alexander V Garabadzhiu, Vyacheslav G Tribulovic. Design, in silico prioritization and biological profiling of apoptosis-inducing lactams amenable by the Castagnoli-Cushman reaction. Bioorganic & medicinal chemistry. vol 26. issue 9. 2018-12-31. PMID:29691156. |
five lactam chemotypes amenable by the castagnoli-cushman reaction of imines and cyclic anhydrides have been investigated for their ability to activate p53 tumor suppressing transcription factor thus induce apoptosis in p53 |
2018-12-31 |
2023-08-13 |
Not clear |
| Zhenqi Huang, Xinglin Liang, Wei Wu, Xiaowen Chen, Qingshu Zeng, Mingzhen Yang, Jian Ge, Ruixiang Xi. Mechanisms underlying the increased chemosensitivity of bortezomib-resistant multiple myeloma by silencing nuclear transcription factor Snail1. Oncology reports. vol 41. issue 1. 2018-12-28. PMID:30365089. |
the mechanistic studies confirmed that the enhancement of snail1 expression in bortezomib-resistant mmcs directly upregulated transcription of the intracellular mdr1 gene to immediately develop multiple drug resistance mechanisms and inhibited p53 protein expression through the snail1/hsa-mirna-22-3p/p53 pathway to inhibit tumor cell apoptosis. |
2018-12-28 |
2023-08-13 |
Not clear |
| Hussaina Banu, N Renuka, S M Faheem, Raees Ismail, Vinita Singh, Zahra Saadatmand, Saad Sultan Khan, Kavya Narayanan, Alma Raheem, Kumpati Premkumar, Geetha Vasanthakuma. Gold and Silver Nanoparticles Biomimetically Synthesized Using Date Palm Pollen Extract-Induce Apoptosis and Regulate p53 and Bcl-2 Expression in Human Breast Adenocarcinoma Cells. Biological trace element research. vol 186. issue 1. 2018-12-24. PMID:29552710. |
gold and silver nanoparticles biomimetically synthesized using date palm pollen extract-induce apoptosis and regulate p53 and bcl-2 expression in human breast adenocarcinoma cells. |
2018-12-24 |
2023-08-13 |
human |
| Kaitlin R Carroll, Eileen E Elfers, Joseph J Stevens, Jonathan P McNally, David A Hildeman, Michael B Jordan, Jonathan D Kat. Extending Remission and Reversing New-Onset Type 1 Diabetes by Targeted Ablation of Autoreactive T Cells. Diabetes. vol 67. issue 11. 2018-12-24. PMID:30104248. |
effector t (teff) cells, such as diabetogenic t cells, are naturally poised on the edge of apoptosis because of activation-induced dna damage that stresses the p53 regulation of the cell cycle. |
2018-12-24 |
2023-08-13 |
Not clear |
| Kaitlin R Carroll, Eileen E Elfers, Joseph J Stevens, Jonathan P McNally, David A Hildeman, Michael B Jordan, Jonathan D Kat. Extending Remission and Reversing New-Onset Type 1 Diabetes by Targeted Ablation of Autoreactive T Cells. Diabetes. vol 67. issue 11. 2018-12-24. PMID:30104248. |
we have found that using small molecular inhibitors that further potentiate p53 while inhibiting the g2/m cell cycle checkpoint control drives apoptosis of activated t cells in vivo. |
2018-12-24 |
2023-08-13 |
Not clear |
| Pouria Samadi, Sahar Saki, Fatemeh Karimi Dermani, Mona Pourjafar, Massoud Saidija. Emerging ways to treat breast cancer: will promises be met? Cellular oncology (Dordrecht). vol 41. issue 6. 2018-12-24. PMID:30259416. |
these components include erbb family members (her1, her2, her3 and her4), ras/mapk pathway components (ras, raf, mek and erk), vegf family members (vegfa, vegfb, vegfc, vegf and pgf), apoptosis and cell cycle regulators (bak, bax, bcl-2, bcl-x, mcl-1 and bcl-w, p53 and pi3k/akt/mtor pathway components) and dna repair pathway components such as brca1. |
2018-12-24 |
2023-08-13 |
Not clear |
| Fei Ye, Jizhong Song, Yetao Wang, Xuemei Xu, Kaiguang Zhan. Proliferation Potential-Related Protein Promotes the Esophageal Cancer Cell Proliferation, Migration and Suppresses Apoptosis by Mediating the Expression of p53 and Interleukin-17. Pathobiology : journal of immunopathology, molecular and cellular biology. vol 85. issue 5-6. 2018-12-20. PMID:30223275. |
proliferation potential-related protein promotes the esophageal cancer cell proliferation, migration and suppresses apoptosis by mediating the expression of p53 and interleukin-17. |
2018-12-20 |
2023-08-13 |
Not clear |
| Z F Yuan, Y M Tang, X J Xu, S S Li, J Y Zhan. 10-Hydroxycamptothecin induces apoptosis in human neuroblastoma SMS-KCNR cells through p53, cytochrome c and caspase 3 pathways. Neoplasma. vol 63. issue 1. 2018-12-19. PMID:26639236. |
10-hydroxycamptothecin induces apoptosis in human neuroblastoma sms-kcnr cells through p53, cytochrome c and caspase 3 pathways. |
2018-12-19 |
2023-08-13 |
human |
| Sumit Siddharth, Anmada Nayak, Deepika Nayak, Birendra Kumar Bindhani, Chanakya Nath Kund. Chitosan-Dextran sulfate coated doxorubicin loaded PLGA-PVA-nanoparticles caused apoptosis in doxorubicin resistance breast cancer cells through induction of DNA damage. Scientific reports. vol 7. issue 1. 2018-12-18. PMID:28526868. |
these np enhances the uptake of dox in mcf-7-dox-r cells and caused apoptosis by increasing apoptotic nuclei, bax/bcl-xl ratio, cleaved product parp-1, tumor suppressor gene p21, p53, topoisomerase inhibition activity, dna damage and decreasing the migratory potential of cells. |
2018-12-18 |
2023-08-13 |
Not clear |
| Qiyu Wang, Jiujiu Yu, Tatenda Kadungure, Joseph Beyene, Hong Zhang, Quan L. ARMMs as a versatile platform for intracellular delivery of macromolecules. Nature communications. vol 9. issue 1. 2018-12-12. PMID:29511190. |
p53 delivered via armms induces dna damage-dependent apoptosis in multiple tissues in mice. |
2018-12-12 |
2023-08-13 |
mouse |
| Lukasz P Slomnicki, Justin Hallgren, Aruna Vashishta, Scott C Smith, Steven R Ellis, Michal Hetma. Proapoptotic Requirement of Ribosomal Protein L11 in Ribosomal Stress-Challenged Cortical Neurons. Molecular neurobiology. vol 55. issue 1. 2018-12-11. PMID:27975169. |
in addition, inhibition of p53, or l11 knockdown, blocked apoptosis in response to the rna analog 5-fluorouridine which perturbed nucleolar structure, inhibited ribosomal synthesis, and activated p53. |
2018-12-11 |
2023-08-13 |
rat |
| Qingchang Chen, Meng Xu, Wenjing Zheng, Taoyuan Xu, Hong Deng, Jie Li. Se/Ru-Decorated Porous Metal-Organic Framework Nanoparticles for The Delivery of Pooled siRNAs to Reversing Multidrug Resistance in Taxol-Resistant Breast Cancer Cells. ACS applied materials & interfaces. vol 9. issue 8. 2018-12-11. PMID:28191840. |
se@mil-101 and ru@mil-101 loaded with mdr gene-silencing sirnas via surface coordination can significantly enhance protection of sirnas against nuclease degradation, increase sirna cellular uptake, and promote sirna escape from endosomes/lysosome to silence mdr genes in mcf-7/t cell, resulting in enhanced cytotoxicity through the induction of apoptosis with the signaling pathways of phosphorylation of p53, mapk, and pi3k/akt and the dynamic instability of mts and disrupting normal mitotic spindle formation. |
2018-12-11 |
2023-08-13 |
mouse |
| Nada K Sedky, Zaynab H El Gammal, Amir E Wahba, Eman Mosad, Zahraa Y Waly, Amira Ali El-Fallal, Reem K Arafa, Nagwa El-Badr. The molecular basis of cytotoxicity of α-spinasterol from Ganoderma resinaceum: Induction of apoptosis and overexpression of p53 in breast and ovarian cancer cell lines. Journal of cellular biochemistry. vol 119. issue 5. 2018-12-11. PMID:29143969. |
the molecular basis of cytotoxicity of α-spinasterol from ganoderma resinaceum: induction of apoptosis and overexpression of p53 in breast and ovarian cancer cell lines. |
2018-12-11 |
2023-08-13 |
human |
| H Xue, M X L. MicroRNA-150 protects against cigarette smoke-induced lung inflammation and airway epithelial cell apoptosis through repressing p53: MicroRNA-150 in CS-induced lung inflammation. Human & experimental toxicology. vol 37. issue 9. 2018-12-11. PMID:29205062. |
microrna-150 protects against cigarette smoke-induced lung inflammation and airway epithelial cell apoptosis through repressing p53: microrna-150 in cs-induced lung inflammation. |
2018-12-11 |
2023-08-13 |
mouse |
| H Xue, M X L. MicroRNA-150 protects against cigarette smoke-induced lung inflammation and airway epithelial cell apoptosis through repressing p53: MicroRNA-150 in CS-induced lung inflammation. Human & experimental toxicology. vol 37. issue 9. 2018-12-11. PMID:29205062. |
additionally, mir-150 protected beas-2b cells from cse-induced apoptosis, which was associated with reduced p53 expression. |
2018-12-11 |
2023-08-13 |
mouse |
| H Xue, M X L. MicroRNA-150 protects against cigarette smoke-induced lung inflammation and airway epithelial cell apoptosis through repressing p53: MicroRNA-150 in CS-induced lung inflammation. Human & experimental toxicology. vol 37. issue 9. 2018-12-11. PMID:29205062. |
collectively, mir-150 suppresses cs-induced lung inflammation and airway epithelial cell apoptosis, which is causally linked to repression of p53 expression and nf-κb activity. |
2018-12-11 |
2023-08-13 |
mouse |
| Tamilselvam Rajavel, Pandian Packiyaraj, Venkatesan Suryanarayanan, Sanjeev Kumar Singh, Kandasamy Ruckmani, Kasi Pandima Dev. β-Sitosterol targets Trx/Trx1 reductase to induce apoptosis in A549 cells via ROS mediated mitochondrial dysregulation and p53 activation. Scientific reports. vol 8. issue 1. 2018-12-11. PMID:29391428. |
β-sitosterol targets trx/trx1 reductase to induce apoptosis in a549 cells via ros mediated mitochondrial dysregulation and p53 activation. |
2018-12-11 |
2023-08-13 |
human |