| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Satomi Yogosawa, Kiyotsugu Yoshid. Tumor suppressive role for kinases phosphorylating p53 in DNA damage-induced apoptosis. Cancer science. vol 109. issue 11. 2018-11-19. PMID:30191640. |
the molecular basis by which p53 and its kinases induce apoptosis for cancer prevention has been extensively studied. |
2018-11-19 |
2023-08-13 |
Not clear |
| Satomi Yogosawa, Kiyotsugu Yoshid. Tumor suppressive role for kinases phosphorylating p53 in DNA damage-induced apoptosis. Cancer science. vol 109. issue 11. 2018-11-19. PMID:30191640. |
in this review, we discuss various roles for p53 phosphorylation and its responsible kinases to induce apoptosis and a new therapeutic approach in a broad range of cancers. |
2018-11-19 |
2023-08-13 |
Not clear |
| Khaled Alsayegh, Katsuhisa Matsuura, Hidekazu Sekine, Tatsuya Shimiz. Dinaciclib potently suppresses MCL-1 and selectively induces the cell death in human iPS cells without affecting the viability of cardiac tissue. Scientific reports. vol 7. 2018-11-14. PMID:28361959. |
gene knockdown experiments revealed that p53 downregulation only increased the threshold of dinaciclib induced apoptosis in ips cells. |
2018-11-14 |
2023-08-13 |
human |
| Zhaoyang Yan, Xiaoyong Huang, Yangzhouyun Xie, Meirong Song, Kui Zhu, Shuangyang Din. Macrolides induce severe cardiotoxicity and developmental toxicity in zebrafish embryos. The Science of the total environment. vol 649. 2018-11-14. PMID:30308910. |
lastly, apoptosis was observed in zebrafish embryos under tms treatment, with up-regulation of apoptosis associated genes such as p53, bcl 2, bax, caspase 3 and caspase 9, confirmed by increased protein expression based on western blot analysis. |
2018-11-14 |
2023-08-13 |
human |
| Mohammad Bagher Mahmoudi, Majid Abed Khojasteh, Fereshteh Alsahebfosoul, Farhad Gharibdoost, Shayan Mostafaei, Mazdak Ganjalikhani-Hakemi, Mahdi Mahmoud. Expressions of p53 and PUMA in fibroblasts of systemic sclerosis patients are normal at transcription level. Journal of cosmetic dermatology. vol 17. issue 3. 2018-11-13. PMID:28905491. |
impaired function of p53 upregulated modulator of apoptosis (puma) has been related to deficits in p53-dependant apoptosis pathway. |
2018-11-13 |
2023-08-13 |
Not clear |
| Won Hye Ka, Seok Keun Cho, Byung Nyun Chun, Sang Yo Byun, Jong Cheol Ah. The ubiquitin ligase COP1 regulates cell cycle and apoptosis by affecting p53 function in human breast cancer cell lines. Breast cancer (Tokyo, Japan). vol 25. issue 5. 2018-11-13. PMID:29516369. |
the ubiquitin ligase cop1 regulates cell cycle and apoptosis by affecting p53 function in human breast cancer cell lines. |
2018-11-13 |
2023-08-13 |
human |
| Jianli Liu, Meijia Liu, Shuai Wang, Yin He, Yapeng Huo, Zhijun Yang, Xiangyu Ca. Alantolactone induces apoptosis and suppresses migration in MCF‑7 human breast cancer cells via the p38 MAPK, NF‑κB and Nrf2 signaling pathways. International journal of molecular medicine. vol 42. issue 4. 2018-11-08. PMID:30015828. |
alantolactone induced apoptosis of mcf‑7 cells by regulating the protein expression levels of b‑cell lymphoma 2 (bcl‑2), bcl‑2‑associated x protein, p53, caspase‑3 and caspase‑12, which are associated with the apoptotic pathway, and suppressed colony formation and migration by regulating the protein expression of matrix metalloproteinase (mmp)‑2, mmp‑7 and mmp‑9. |
2018-11-08 |
2023-08-13 |
human |
| Fernanda DA Silva Machado, Fernanda Mosena Munari, Fernando Joel Scariot, Sergio Echeverrigaray, Cesar Aguzzoli, Claus Tröger Pich, Massuo Jorge Kato, Lydia Yamaguchi, Sidnei Moura, João Antonio Pêgas Henriques, Mariana Roesch-El. Piperlongumine Induces Apoptosis in Colorectal Cancer HCT 116 Cells Independent of Bax, p21 and p53 Status. Anticancer research. vol 38. issue 11. 2018-11-08. PMID:30396942. |
piperlongumine induces apoptosis in colorectal cancer hct 116 cells independent of bax, p21 and p53 status. |
2018-11-08 |
2023-08-13 |
Not clear |
| Chieh Kao, Ritu Chandna, Abhijeet Ghode, Charlotte Dsouza, Mo Chen, Andreas Larsson, Siau Hoi Lim, Minjun Wang, Zhonglian Cao, Yizhun Zhu, Ganesh S Anand, Ruowen G. Proapoptotic Cyclic Peptide BC71 Targets Cell-Surface GRP78 and Functions as an Anticancer Therapeutic in Mice. EBioMedicine. vol 33. 2018-11-07. PMID:29907328. |
we show that bc71 triggers apoptosis via cell-surface grp78 and activates caspase-8 and p53 signaling pathways in huvecs. |
2018-11-07 |
2023-08-13 |
mouse |
| Yitao Wang, Chunxue Zhang, Yuelei Jin, Wang, Qing He, Zhu Liu, Qing Ai, Yunlong Lei, Yi Li, Fangzhou Song, Youquan B. Alkaline ceramidase 2 is a novel direct target of p53 and induces autophagy and apoptosis through ROS generation. Scientific reports. vol 7. 2018-11-06. PMID:28294157. |
alkaline ceramidase 2 is a novel direct target of p53 and induces autophagy and apoptosis through ros generation. |
2018-11-06 |
2023-08-13 |
human |
| Yitao Wang, Chunxue Zhang, Yuelei Jin, Wang, Qing He, Zhu Liu, Qing Ai, Yunlong Lei, Yi Li, Fangzhou Song, Youquan B. Alkaline ceramidase 2 is a novel direct target of p53 and induces autophagy and apoptosis through ROS generation. Scientific reports. vol 7. 2018-11-06. PMID:28294157. |
in this study, we have for the first time identified the human acer2 gene promoter, and found that human acer2 transcription is directly regulated by p53 and acer2 is implicated in the induction of autophagy as well as apoptosis. |
2018-11-06 |
2023-08-13 |
human |
| Xin-Bin Guo, Xin Deng, Ying We. Hematopoietic Substrate-1-Associated Protein X-1 Regulates the Proliferation and Apoptosis of Endothelial Progenitor Cells Through Akt Pathway Modulation. Stem cells (Dayton, Ohio). vol 36. issue 3. 2018-11-05. PMID:29139175. |
in conclusion, this novel study suggests that hax-1 could facilitate the akt1 pathway through hsp90, which led to a decline in the levels of p53, and finally promoted the proliferation and inhibited the apoptosis of epcs. |
2018-11-05 |
2023-08-13 |
Not clear |
| Shizuka Makino, Rina Hamajima, Aya Saito, Moe Tomizaki, Asako Iwamoto, Michihiro Kobayashi, Hayato Yamada, Motoko Iked. Bombyx mori homolog of tumor suppressor p53 is involved in apoptosis-mediated antiviral immunity of B. mori cells infected with nucleopolyhedrovirus. Developmental and comparative immunology. vol 84. 2018-11-05. PMID:29448034. |
here, we showed that bombyx mori cells transiently expressing b. mori homolog of the tumor suppressor p53 (bm-p53) protein underwent apoptosis accompanied by elevated caspase-3-like protease activity and processing of b. mori dronc (bm-dronc). |
2018-11-05 |
2023-08-13 |
Not clear |
| Zhen-Dong Zhu, Ji-Yun Ye, Hua Niu, Yu-Mei Ma, Xue-Mei Fu, Zhong-Hua Xia, Xuan Zhan. Effects of microRNA-292-5p on myocardial ischemia-reperfusion injury through the peroxisome proliferator-activated receptor-α/-γ signaling pathway. Gene therapy. vol 25. issue 3. 2018-11-05. PMID:29670247. |
compared with the model group and the t0070907 + mir-292-5p inhibitor, the mir-292-5p inhibitor group exhibited decreased incidence and duration time of ventricular tachycardia and ventricular fibrillation, serum myocardial enzymes, tnf-α, il-6, il-1β, mda, cardiomyocyte apoptosis, expressions of bax and p53 in addition to increased sod and gsh-px activity, and increased expressions of bcl-2, pparα, pparγ, plin5, aqp7, and pck1. |
2018-11-05 |
2023-08-13 |
mouse |
| Jiming Li, Jingjing Zeng, Lianpin Wu, Luyuan Tao, Zhiyong Liao, Maoping Chu, Lei L. Loss of P53 regresses cardiac remodeling induced by pressure overload partially through inhibiting HIF1α signaling in mice. Biochemical and biophysical research communications. vol 501. issue 2. 2018-11-05. PMID:29729274. |
global knockout of p53 in the mice reduced the hypertrophic response and markedly reduced cardiac apoptosis, and fibrosis. |
2018-11-05 |
2023-08-13 |
mouse |
| Jiming Li, Jingjing Zeng, Lianpin Wu, Luyuan Tao, Zhiyong Liao, Maoping Chu, Lei L. Loss of P53 regresses cardiac remodeling induced by pressure overload partially through inhibiting HIF1α signaling in mice. Biochemical and biophysical research communications. vol 501. issue 2. 2018-11-05. PMID:29729274. |
the study indicated p53 deteriorated cardiac functions and cardiac hypertrophy, apoptosis, and fibrosis by partially inhibition of hif1α and vegf. |
2018-11-05 |
2023-08-13 |
mouse |
| Faiha A Suliman, Dina M Khodeer, Afaf Ibrahiem, Eman T Mehanna, Mohamed K El-Kherbetawy, Hala M F Mohammad, Sawsan A Zaitone, Yasser M Moustaf. Renoprotective effect of the isoflavonoid biochanin A against cisplatin induced acute kidney injury in mice: Effect on inflammatory burden and p53 apoptosis. International immunopharmacology. vol 61. 2018-11-05. PMID:29793166. |
renoprotective effect of the isoflavonoid biochanin a against cisplatin induced acute kidney injury in mice: effect on inflammatory burden and p53 apoptosis. |
2018-11-05 |
2023-08-13 |
mouse |
| Faiha A Suliman, Dina M Khodeer, Afaf Ibrahiem, Eman T Mehanna, Mohamed K El-Kherbetawy, Hala M F Mohammad, Sawsan A Zaitone, Yasser M Moustaf. Renoprotective effect of the isoflavonoid biochanin A against cisplatin induced acute kidney injury in mice: Effect on inflammatory burden and p53 apoptosis. International immunopharmacology. vol 61. 2018-11-05. PMID:29793166. |
further, renal homogenates showed increased level of inflammatory cytokines and upregulation of the expression of p53 up-regulated modulator of apoptosis (puma), p53 and caspase 3 but downregulation in nrf2 expression. |
2018-11-05 |
2023-08-13 |
mouse |
| Zhi-Lei Zhang, Guang-Chao Liu, Li Peng, Chong Zhang, Yu-Ming Jia, Wu-Han Yang, Lei Ma. Effect of PAK1 gene silencing on proliferation and apoptosis in hepatocellular carcinoma cell lines MHCC97-H and HepG2 and cells in xenograft tumor. Gene therapy. vol 25. issue 4. 2018-11-05. PMID:29802374. |
cell proliferation, the cells at s phase, the mrna and protein expressions of pak1, pcna, ki67, cyclin e, cdk2 and bcl-2 of mhcc97-h and hepg2 cells and cells in xenograft tumor were decreased, while the cells at g1 phase, apoptosis rate, the mrna and protein expressions of p21, p53 and bax of mhcc97-h and hepg2 cells and cells in xenograft tumor were increased in the pak1 shrna group. |
2018-11-05 |
2023-08-13 |
mouse |
| Aifen Yan, Chunhua Ren, Ting Chen, Da Huo, Xiao Jiang, Hongyan Sun, Chaoqun H. A novel caspase-6 from sea cucumber Holothuria leucospilota: Molecular characterization, expression analysis and apoptosis detection. Fish & shellfish immunology. vol 80. 2018-11-05. PMID:29890217. |
moreover, we further confirmed that overexpression of hlcaspase-6 could induce apoptosis and activate the p53 signal pathway. |
2018-11-05 |
2023-08-13 |
Not clear |