| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Pei Sun, Haoyang Wu, Jiali Huang, Ying Xu, Feng Yang, Qi Zhang, Xingang X. Porcine epidemic diarrhea virus through p53-dependent pathway causes cell cycle arrest in the G0/G1 phase. Virus research. vol 253. 2018-10-23. PMID:29800601. |
p53 protein exists in a wide variety of animal cells, which is involved in cell cycle regulation, apoptosis, cell differentiation and other biological functions. |
2018-10-23 |
2023-08-13 |
Not clear |
| Ramesh Elango, Jegan Athinarayanan, Vaiyapuri Periasamy Subbarayan, David K Y Lei, Ali A Alshatw. Hesperetin induces an apoptosis-triggered extrinsic pathway and a p53- independent pathway in human lung cancer H522 cells. Journal of Asian natural products research. vol 20. issue 6. 2018-10-22. PMID:28537448. |
this study shows that hesperetin induces apoptosis in h522 cells via a pathway independentof p53 and bax but triggers the death-receptor fas-initiated fadd/ caspase-8-dependent apoptotic pathway. |
2018-10-22 |
2023-08-13 |
human |
| Hirofumi Sato, Masatsugu Hiraki, Takushi Namba, Noriyuki Egawa, Koichi Baba, Tomokazu Tanaka, Hirokazu Noshir. Andrographolide induces degradation of mutant p53 via activation of Hsp70. International journal of oncology. vol 53. issue 2. 2018-10-22. PMID:29845212. |
the tumor suppressor gene p53 encodes a transcription factor that regulates various cellular functions, including dna repair, apoptosis and cell cycle progression. |
2018-10-22 |
2023-08-13 |
human |
| Tian Feng, Jiyuan Liu, Nan Zhou, Libin Wang, Xueying Liu, Shengyong Zhang, Siwang Wang, Hui Che. CLZ-8, a potent small-molecular compound, protects radiation-induced damages both in vitro and in vivo. Environmental toxicology and pharmacology. vol 61. 2018-10-22. PMID:29852368. |
puma (p53 up-regulated mediator of apoptosis) is particularly important in initiating radiation-induced damage and apoptosis. |
2018-10-22 |
2023-08-13 |
mouse |
| Xinjian Yu, Ri-Qing Yu, Duan Gui, Xiyang Zhang, Fenping Zhan, Xian Sun, Yuping W. Hexavalent chromium induces oxidative stress and mitochondria-mediated apoptosis in isolated skin fibroblasts of Indo-Pacific humpback dolphin. Aquatic toxicology (Amsterdam, Netherlands). vol 203. 2018-10-22. PMID:30153559. |
this study showed that cr(vi) markedly inhibited the viability of scsf cells via induction of apoptosis accompanied by an increase in the production of reactive oxygen species and the population of g2/m arrest or apoptotic sub-g1 phase cells, up-regulation of p53, and activation of caspase-3. |
2018-10-22 |
2023-08-13 |
Not clear |
| Jungang Deng, Ping Yu, Zhenlei Zhang, Jun Wang, Jinhua Cai, Na Wu, Hongbin Sun, Hong Liang, Feng Yan. Designing anticancer copper(II) complexes by optimizing 2-pyridine-thiosemicarbazone ligands. European journal of medicinal chemistry. vol 158. 2018-10-22. PMID:30241011. |
cu complexes exerted chemotherapeutic effects via activating p53 and inducing production of reactive oxygen species to regulate expression of the b-cell lymphoma-2 family of proteins, causing a change in the mitochondrial membrane potential and release of cytochrome c to form a dimer with apoptosis protease activating factor-1, resulting in activation of caspase-9/3 to induce apoptosis. |
2018-10-22 |
2023-08-13 |
human |
| Tian-Hua Yao, Parekejiang Pataer, Krishna Prasad Regmi, Xi-Wen Gu, Quan-Yan Li, Jing-Ting Du, Su-Meng Ge, Jun-Bo T. Propranolol induces hemangioma endothelial cell apoptosis via a p53‑BAX mediated pathway. Molecular medicine reports. vol 18. issue 1. 2018-10-19. PMID:29767244. |
the aim of the present study was to investigate the expression of proteins regulated by cellular tumor antigen p53 (p53) in associated apoptosis pathways in ih endothelial cells (hemecs) treated with propranolol. |
2018-10-19 |
2023-08-13 |
Not clear |
| Tian-Hua Yao, Parekejiang Pataer, Krishna Prasad Regmi, Xi-Wen Gu, Quan-Yan Li, Jing-Ting Du, Su-Meng Ge, Jun-Bo T. Propranolol induces hemangioma endothelial cell apoptosis via a p53‑BAX mediated pathway. Molecular medicine reports. vol 18. issue 1. 2018-10-19. PMID:29767244. |
the expression levels of downstream proteins regulated by p53 [tumour necrosis factor receptor superfamily member 6 (fas), p53‑induced death domain‑containing protein (pidd), death receptor 5 (dr5), bh3‑interacting domain death agonist (bid), apoptosis regulator bax (bax), p53 unregulated modulator of apoptosis (puma), phosphatidylinositol‑glycan biosynthesis class s protein (pigs), and insulin‑like growth factor‑binding protein 3 (igf‑bp3)] were revealed in the experimental and control groups via western blotting. |
2018-10-19 |
2023-08-13 |
Not clear |
| Tian-Hua Yao, Parekejiang Pataer, Krishna Prasad Regmi, Xi-Wen Gu, Quan-Yan Li, Jing-Ting Du, Su-Meng Ge, Jun-Bo T. Propranolol induces hemangioma endothelial cell apoptosis via a p53‑BAX mediated pathway. Molecular medicine reports. vol 18. issue 1. 2018-10-19. PMID:29767244. |
this result suggested that there is an association between p53 expression and the rate of apoptosis of propranolol‑treated hemecs. |
2018-10-19 |
2023-08-13 |
Not clear |
| Tian-Hua Yao, Parekejiang Pataer, Krishna Prasad Regmi, Xi-Wen Gu, Quan-Yan Li, Jing-Ting Du, Su-Meng Ge, Jun-Bo T. Propranolol induces hemangioma endothelial cell apoptosis via a p53‑BAX mediated pathway. Molecular medicine reports. vol 18. issue 1. 2018-10-19. PMID:29767244. |
this result suggests that p53 has an important role in hemec apoptosis. |
2018-10-19 |
2023-08-13 |
Not clear |
| Lin Zheng, Yum-Shing Wong, Mumin Shao, Shiying Huang, Fochang Wang, Jianping Che. Apoptosis induced by 9,11‑dehydroergosterol peroxide from Ganoderma Lucidum mycelium in human malignant melanoma cells is Mcl‑1 dependent. Molecular medicine reports. vol 18. issue 1. 2018-10-19. PMID:29845223. |
the steroid did not cause significant changes in the expression levels of b‑cell lymphoma 2 (bcl‑2) family proteins, bcl‑2‑like protein 11, p53 upregulated modulator of apoptosis, bcl‑2‑associated x protein, bh3 interacting‑domain death agonist, bcl‑2‑associated death promoter and bcl‑2, but it significantly downregulated induced myeloid leukemia cell differentiation protein mcl‑1 (mcl‑1) in melanoma cells, suggesting the key role of mcl‑1 in regulating apoptosis of melanoma cells induced by the steroid. |
2018-10-19 |
2023-08-13 |
human |
| Zhe Wang, Yudi Han, Zhaoqing Zhang, Cunfeng Jia, Qiang Zhao, Wei Song, Tao Chen, Yifan Zhang, Xiuhui Wan. Identification of genes and signaling pathways associated with the pathogenesis of juvenile spondyloarthritis. Molecular medicine reports. vol 18. issue 2. 2018-10-19. PMID:29901120. |
degs, including c‑x‑c motif chemokine ligand 5 (cxcl5), bcl2 interacting protein 3 like (bnip3l), dual specificity phosphatase 5 (dusp5) and tumor protein p53 (tp53) were enriched in functions associated with apoptosis, the cell cycle and immune responses. |
2018-10-19 |
2023-08-13 |
human |
| Eun Ji Ryu, Dae Won Kim, Min Jea Shin, Hyo Sang Jo, Jung Hwan Park, Su Bin Cho, Chi Hern Lee, Hyeon Ji Yeo, Eun Ji Yeo, Yeon Joo Choi, Duk-Soo Kim, Sung-Woo Cho, Yong-Jun Cho, Eun Jeong Sohn, Ora Son, Keun Wook Lee, Kyu Hyung Han, Jinseu Park, Won Sik Eum, Soo Young Cho. PEP‑1‑glutaredoxin 1 protects against hippocampal neuronal cell damage from oxidative stress via regulation of MAPK and apoptotic signaling pathways. Molecular medicine reports. vol 18. issue 2. 2018-10-19. PMID:29916538. |
in addition, pep‑1‑glrx1 protein regulated rac‑a serine/threonine‑protein kinase and mitogen‑activated protein kinase signaling, in addition to apoptotic signaling including b cell lymphoma (bcl)‑2, bcl‑2 associated x, apoptosis regulator, pro‑caspase‑9 and p53 expression levels. |
2018-10-19 |
2023-08-13 |
Not clear |
| Xin Zhao, Shicai Sun, Jianting Xu, Yang Luo, Ying Xin, Yanbing Wan. MicroRNA-152 inhibits cell proliferation of osteosarcoma by directly targeting Wnt/β-catenin signaling pathway in a DKK1-dependent manner. Oncology reports. vol 40. issue 2. 2018-10-17. PMID:29845282. |
the downregulation of microrna‑152 promotes cell proliferation, decreases apoptosis, and suppresses ldh activity, caspase-3/9 activities and bax/bcl-2 and p53 protein expression levels of osteosarcoma through activation of the wnt/β-catenin signaling pathway by targeting dkk1. |
2018-10-17 |
2023-08-13 |
Not clear |
| Xin Zhao, Shicai Sun, Jianting Xu, Yang Luo, Ying Xin, Yanbing Wan. MicroRNA-152 inhibits cell proliferation of osteosarcoma by directly targeting Wnt/β-catenin signaling pathway in a DKK1-dependent manner. Oncology reports. vol 40. issue 2. 2018-10-17. PMID:29845282. |
whereas, overexpression of microrna‑152 targets dkk1 to inhibit cell proliferation, induce apoptosis, and promote ldh activity, caspase-3/9 activities and bax/bcl-2 and p53 protein expression levels of osteosarcoma through inactivation of the wnt/β-catenin signaling pathway. |
2018-10-17 |
2023-08-13 |
Not clear |
| Santi Phosri, Nisachon Jangpromma, Leng Chee Chang, Ghee T Tan, Supakit Wongwiwatthananukit, Surachai Maijaroen, Preeyanan Anwised, Wisarut Payoungkiattikun, Sompong Klaynongsruan. Siamese Crocodile White Blood Cell Extract Inhibits Cell Proliferation and Promotes Autophagy in Multiple Cancer Cell Lines. Journal of microbiology and biotechnology. vol 28. issue 6. 2018-10-16. PMID:29847866. |
the molecular mechanisms of cwbc in apoptosis induction were to decrease bcl-2 and xiap expression levels and increase the expression levels of caspase-3, caspase-8, and p53. |
2018-10-16 |
2023-08-13 |
human |
| Felipe Teixeira Lima, Viviane Seba, Gabriel Silva, Guilherme Silva Torrezan, Carlos Roberto Polaquini, Vitor Caressato Pinhanelli, Seung J Baek, Ana Lúcia Fachin, Luis Octavio Regasini, Mozart Marin. The Curcumin Analog CH-5 Exerts Anticancer Effects in Human Osteosarcoma Cells via Modulation of Transcription Factors p53/Sp1. International journal of molecular sciences. vol 19. issue 7. 2018-10-16. PMID:29966255. |
the cellular levels of the transcription factors p53 and sp1 affect the expression of cellular pathways that lead to apoptosis. |
2018-10-16 |
2023-08-13 |
human |
| Maliheh Moradzadeh, Alijan Tabarraei, Hamid Reza Sadeghnia, Ahmad Ghorbani, Ashraf Mohamadkhani, Saiedeh Erfanian, Amirhossein Sahebka. Kaempferol increases apoptosis in human acute promyelocytic leukemia cells and inhibits multidrug resistance genes. Journal of cellular biochemistry. vol 119. issue 2. 2018-10-15. PMID:28865123. |
furthermore, the expression levels of genes involved in apoptosis (pi3 k, akt, bcl2, bax, p53, p21, pten, casp3, casp8, and casp9), differentiation (pml-rar and hdac1), and multi-drug resistance (abcb1 and abcc1) were determined using quantitative real-time pcr. |
2018-10-15 |
2023-08-13 |
human |
| Deepmala Shrestha, Namil Kim, Kiwon Son. Stathmin/Op18 depletion induces genomic instability and leads to premature senescence in human normal fibroblasts. Journal of cellular biochemistry. vol 119. issue 2. 2018-10-15. PMID:28885720. |
double knock-down of both stathmin and p53 also did not induce cell death in imr-90 cells, while the stathmin knock-down triggered apoptosis in p53-proficient human lung adenocarcinoma cells. |
2018-10-15 |
2023-08-13 |
human |
| L Xia, X Xiao, W L Liu, Y Song, T J J Liu, Y J Li, E Zacksenhaus, X J Hao, Y Ben-Davi. Coactosin-like protein CLP/Cotl1 suppresses breast cancer growth through activation of IL-24/PERP and inhibition of non-canonical TGFβ signaling. Oncogene. vol 37. issue 3. 2018-10-15. PMID:28925397. |
first, clp/cotl1 re-expression in fe1.2 and in human mcf7 breast cancer cells induced expression of the growth-suppressor gene interleukin-24 (il-24), which independently of p53 upregulates the tumor-suppressor genes p53 apoptosis effector related to pmp-22 (perp) and p21 |
2018-10-15 |
2023-08-13 |
mouse |