| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ruhao Yang, Xuan Xu, Huiling Li, Jinwen Chen, Xudong Xiang, Zheng Dong, Dongshan Zhan. p53 induces miR199a-3p to suppress SOCS7 for STAT3 activation and renal fibrosis in UUO. Scientific reports. vol 7. 2018-11-01. PMID:28240316. |
here, we show that pharmacological and genetic blockade of p53 attenuated renal interstitial fibrosis, apoptosis, and inflammation in mice with unilateral urethral obstruction (uuo). |
2018-11-01 |
2023-08-13 |
mouse |
| Jiajia Shen, Pengyu Li, Xuejing Shao, Yang Yang, Xiujun Liu, Min Feng, Qiang Yu, Ronggui Hu, Zhen Wan. The E3 Ligase RING1 Targets p53 for Degradation and Promotes Cancer Cell Proliferation and Survival. Cancer research. vol 78. issue 2. 2018-11-01. PMID:29187402. |
ring1 depletion inhibited the proliferation and survival of the p53 wild-type cancer cells by inducing cell-cycle arrest, apoptosis, and senescence, with only modest effects on p53-deficient cells. |
2018-11-01 |
2023-08-13 |
human |
| Aram Ko, Su Yeon Han, Jaewhan Son. Regulatory Network of ARF in Cancer Development. Molecules and cells. vol 41. issue 5. 2018-10-30. PMID:29665672. |
thus, many cancer cells either lack a functional arf or p53, which enables them to evade cell oncogenic stress-mediated cycle arrest, senescence, or apoptosis. |
2018-10-30 |
2023-08-13 |
Not clear |
| Zhangxiao Peng, Yan Wang, Jianhui Fan, Xuejing Lin, Chunying Liu, Yang Xu, Weidan Ji, Chao Yan, Changqing S. Costunolide and dehydrocostuslactone combination treatment inhibit breast cancer by inducing cell cycle arrest and apoptosis through c-Myc/p53 and AKT/14-3-3 pathway. Scientific reports. vol 7. 2018-10-29. PMID:28117370. |
cell cycle arrest and apoptosis were induced in a dose-dependent manner, and the expressions of p53 and p-14-3-3 were significantly up-regulated, whereas the expressions of c-myc, p-akt, p-bid were significantly down-regulated, furthermore, the ratio of bax/bcl-2 were significantly increased in breast cancer cells after cd and vosl treatment. |
2018-10-29 |
2023-08-13 |
Not clear |
| Duksun Han, Jin Hyoung Cho, Ra Ham Lee, Woong Bang, Kyungho Park, Minseok S Kim, Jung-Hyun Shim, Jung-Il Chae, Se Youn Moo. Antitumorigenic effect of atmospheric-pressure dielectric barrier discharge on human colorectal cancer cells via regulation of Sp1 transcription factor. Scientific reports. vol 7. 2018-10-29. PMID:28225083. |
also, expression of negative regulators related to the cell cycle (such as p53, p21, and p27) was increased and of the positive regulator cyclin d1 was decreased, indicating that the plasma treatment led to apoptosis and cell-cycle arrest. |
2018-10-29 |
2023-08-13 |
human |
| J-R Tenório, T Santana, S-I-M-L Queiroz, D-H-I-P de Oliveira, L-M-G Queiro. Apoptosis and cell cycle aberrations in epithelial odontogenic lesions: An evidence by the expression of p53, Bcl-2 and Bax. Medicina oral, patologia oral y cirugia bucal. vol 23. issue 2. 2018-10-29. PMID:29476674. |
apoptosis and cell cycle aberrations in epithelial odontogenic lesions: an evidence by the expression of p53, bcl-2 and bax. |
2018-10-29 |
2023-08-13 |
Not clear |
| J-R Tenório, T Santana, S-I-M-L Queiroz, D-H-I-P de Oliveira, L-M-G Queiro. Apoptosis and cell cycle aberrations in epithelial odontogenic lesions: An evidence by the expression of p53, Bcl-2 and Bax. Medicina oral, patologia oral y cirugia bucal. vol 23. issue 2. 2018-10-29. PMID:29476674. |
defects in regulation of apoptosis and cell cycle may be involved in the development and progression of those lesions, therefore we aimed to investigate the expression of bcl-2, bax and p53 to better understand the possible role of these proteins in ambs, okcs and aots. |
2018-10-29 |
2023-08-13 |
Not clear |
| Wei Tu, Qian Zhang, Yin Liu, Lianyong Han, Qin Wang, Panpan Chen, Shun Zhang, Aiguo Wang, Xue Zho. Fluoride induces apoptosis via inhibiting SIRT1 activity to activate mitochondrial p53 pathway in human neuroblastoma SH-SY5Y cells. Toxicology and applied pharmacology. vol 347. 2018-10-29. PMID:29609003. |
fluoride induces apoptosis via inhibiting sirt1 activity to activate mitochondrial p53 pathway in human neuroblastoma sh-sy5y cells. |
2018-10-29 |
2023-08-13 |
human |
| Wei Tu, Qian Zhang, Yin Liu, Lianyong Han, Qin Wang, Panpan Chen, Shun Zhang, Aiguo Wang, Xue Zho. Fluoride induces apoptosis via inhibiting SIRT1 activity to activate mitochondrial p53 pathway in human neuroblastoma SH-SY5Y cells. Toxicology and applied pharmacology. vol 347. 2018-10-29. PMID:29609003. |
apoptosis and upregulation of cleaved caspase-3, cleaved parp and p53 (acetyl k382) induced by fluoride could be ameliorated by sirt1 overexpression or its activator resveratrol in sh-sy5y cells. |
2018-10-29 |
2023-08-13 |
human |
| Wei Tu, Qian Zhang, Yin Liu, Lianyong Han, Qin Wang, Panpan Chen, Shun Zhang, Aiguo Wang, Xue Zho. Fluoride induces apoptosis via inhibiting SIRT1 activity to activate mitochondrial p53 pathway in human neuroblastoma SH-SY5Y cells. Toxicology and applied pharmacology. vol 347. 2018-10-29. PMID:29609003. |
taken together, our study demonstrates that fluoride induces apoptosis by inhibiting the deacetylase activity of sirt1 to activate mitochondrial p53 pathway in sh-sy5y cells, which depends on p53 transcriptional activity. |
2018-10-29 |
2023-08-13 |
human |
| Wei Duan, Yan Chen, Xiao-Rong Wan. MicroRNA‑155 contributes to the occurrence of epilepsy through the PI3K/Akt/mTOR signaling pathway. International journal of molecular medicine. vol 42. issue 3. 2018-10-29. PMID:29901097. |
overexpression of mirna‑155 resulted in decreased brain‑derived neurotrophic factor (bdnf) and tropomyosin receptor kinase b (trkb) protein expression, increased caspase‑3 activity, tumor protein p53 (p53) and apoptosis regulator bax (bax) protein expression, and inhibited phosphoinositide 3‑kinase (pi3k), phosphorylated (p‑)protein kinase b (akt) and p‑mechanistic target of rapamycin (mtor) protein expression in epilepsy cells. |
2018-10-29 |
2023-08-13 |
human |
| Shiqing Li, Cui Wan. Study on the potential way of hepatic cytotoxicity of N,N-dimethylformamide. Journal of biochemical and molecular toxicology. vol 32. issue 9. 2018-10-29. PMID:29984871. |
we observed that dmf induced cell apoptosis through mitochondrial-dependent and p53 pathway. |
2018-10-29 |
2023-08-13 |
Not clear |
| Ye Ji Jeong, Yeonghoon Son, Na-Kyung Han, Hyung-Do Choi, Jeong-Ki Pack, Nam Kim, Yun-Sil Lee, Hae-June Le. Impact of Long-Term RF-EMF on Oxidative Stress and Neuroinflammation in Aging Brains of C57BL/6 Mice. International journal of molecular sciences. vol 19. issue 7. 2018-10-29. PMID:30029554. |
in addition, levels of markers for dna damage (8-hydroxy-2'-deoxyguanosine, p53, p21, γh2ax, and bax), apoptosis (cleaved caspase-3 and cleaved poly(adp-ribose) polymerase 1 (parp-1)), astrocyte (gfap), and microglia (iba-1) were significantly elevated in the brains of aged mice. |
2018-10-29 |
2023-08-13 |
mouse |
| Gaofei Wei, Jiahong Sun, Zhuang Hou, Weijing Luan, Shuai Wang, Shanshan Cui, Maosheng Cheng, Yang Li. Novel antitumor compound optimized from natural saponin Albiziabioside A induced caspase-dependent apoptosis and ferroptosis as a p53 activator through the mitochondrial pathway. European journal of medicinal chemistry. vol 157. 2018-10-29. PMID:30142612. |
novel antitumor compound optimized from natural saponin albiziabioside a induced caspase-dependent apoptosis and ferroptosis as a p53 activator through the mitochondrial pathway. |
2018-10-29 |
2023-08-13 |
Not clear |
| A Sudha, P Srinivasan, V Kanimozhi, K Palanivel, B Kadalman. Antiproliferative and apoptosis-induction studies of 5-hydroxy 3',4',7-trimethoxyflavone in human breast cancer cells MCF-7: an in vitro and in silico approach. Journal of receptor and signal transduction research. vol 38. issue 3. 2018-10-26. PMID:29734849. |
the treatment of mcf-7 cells with htmf encouraged apoptosis through the modulation of apoptotic markers, such as p53, bcl-2, bax, and cleaved parp. |
2018-10-26 |
2023-08-13 |
human |
| A Sudha, P Srinivasan, V Kanimozhi, K Palanivel, B Kadalman. Antiproliferative and apoptosis-induction studies of 5-hydroxy 3',4',7-trimethoxyflavone in human breast cancer cells MCF-7: an in vitro and in silico approach. Journal of receptor and signal transduction research. vol 38. issue 3. 2018-10-26. PMID:29734849. |
in silico molecular docking and dynamics studies with mdm2-p53 protein revealed that htmf was more potent compound that could inhibit the binding of mdm2 with p53 and, therefore, could trigger apoptosis in cancer cell. |
2018-10-26 |
2023-08-13 |
human |
| Younju An, Khong Trong Quan, Jungsug Gwak, Bong Gun Ju, MinKyun Na, Sangtaek O. Activation of the p53 pathway with digiferrol isolated from Rubia philippinensis induces cell cycle arrest, apoptosis, and autophagy in colon cancer cells. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 118. 2018-10-25. PMID:29842910. |
activation of the p53 pathway with digiferrol isolated from rubia philippinensis induces cell cycle arrest, apoptosis, and autophagy in colon cancer cells. |
2018-10-25 |
2023-08-13 |
Not clear |
| Himakshi Sidhar, Ranjit K Gir. Induction of Bex genes by curcumin is associated with apoptosis and activation of p53 in N2a neuroblastoma cells. Scientific reports. vol 7. 2018-10-24. PMID:28145533. |
induction of bex genes by curcumin is associated with apoptosis and activation of p53 in n2a neuroblastoma cells. |
2018-10-24 |
2023-08-13 |
Not clear |
| Himakshi Sidhar, Ranjit K Gir. Induction of Bex genes by curcumin is associated with apoptosis and activation of p53 in N2a neuroblastoma cells. Scientific reports. vol 7. 2018-10-24. PMID:28145533. |
inhibition of curcumin-mediated induction of bex genes by pifithrin-α also inhibited n2a cells apoptosis suggesting, a direct role of bex genes in n2a cells apoptosis and involvement of p53 in bex genes induction. |
2018-10-24 |
2023-08-13 |
Not clear |
| Kariyappa Vijay, Poorigali Raghavendra-Rao Sowmya, Bangalore Prabhashankar Arathi, Shivaprasad Shilpa, Hulikere Jagdish Shwetha, Marisiddaiah Raju, Vallikannan Baskaran, Rangaswamy Lakshminarayan. Low-dose doxorubicin with carotenoids selectively alters redox status and upregulates oxidative stress-mediated apoptosis in breast cancer cells. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 118. 2018-10-24. PMID:29920287. |
furthermore, mitochondrial dysfunction, cell growth arrest at g0/g1 phase and caspase cascades as well as up- and down-regulated expression levels of related proteins (p21, p27, bax, p53, bcl-2, and cyclin d1) revealed the synergistic effect of carotenoid and dox treatment on ros-mediated apoptosis. |
2018-10-24 |
2023-08-13 |
Not clear |