| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Tamilselvam Rajavel, Pandian Packiyaraj, Venkatesan Suryanarayanan, Sanjeev Kumar Singh, Kandasamy Ruckmani, Kasi Pandima Dev. β-Sitosterol targets Trx/Trx1 reductase to induce apoptosis in A549 cells via ROS mediated mitochondrial dysregulation and p53 activation. Scientific reports. vol 8. issue 1. 2018-12-11. PMID:29391428. |
indeed bs treatment increased p53 expression and its phosphorylation at ser15, while silencing the p53 expression by pifithrin-α, bs induced apoptosis was reduced in a549 cells. |
2018-12-11 |
2023-08-13 |
human |
| Tamilselvam Rajavel, Pandian Packiyaraj, Venkatesan Suryanarayanan, Sanjeev Kumar Singh, Kandasamy Ruckmani, Kasi Pandima Dev. β-Sitosterol targets Trx/Trx1 reductase to induce apoptosis in A549 cells via ROS mediated mitochondrial dysregulation and p53 activation. Scientific reports. vol 8. issue 1. 2018-12-11. PMID:29391428. |
furthermore, bs induced apoptosis was also observed in nci-h460 cells (p53 wild) but not in the nci-h23 cells (p53 mutant). |
2018-12-11 |
2023-08-13 |
human |
| DeokBeom Jung, Ashwani Khurana, Debarshi Roy, Eleftheria Kalogera, Jamie Bakkum-Gamez, Jeremy Chien, Viji Shridha. Quinacrine upregulates p21/p27 independent of p53 through autophagy-mediated downregulation of p62-Skp2 axis in ovarian cancer. Scientific reports. vol 8. issue 1. 2018-12-11. PMID:29410485. |
in the present study we extended these studies to identify the molecular pathways regulated by qc to promote apoptosis independent of p53 status in oc. |
2018-12-11 |
2023-08-13 |
Not clear |
| Qifei Wang, Guangzhen Wu, Xiangyu Che, Quanlin Li, Zhiwei Zhang, Qizhen Tan. Sorafenib induces renal cell carcinoma apoptosis Die Pharmazie. vol 73. issue 3. 2018-12-11. PMID:29544563. |
moreover, treatment with sorafenib could enhance the expression of ccaat/enhancer-binding protein-homologous protein (chop) and p53 upregulated modulator of apoptosis (puma), thereby leading to achn cell apoptosis. |
2018-12-11 |
2023-08-13 |
Not clear |
| Chun-Hua Wang, Shi-Xun Lu, Li-Li Liu, Yong Li, Xia Yang, Yang-Fan He, Shi-Lu Chen, Shao-Hang Cai, Hong Wang, Jing-Ping Yu. POH1 Knockdown Induces Cancer Cell Apoptosis via p53 and Bim. Neoplasia (New York, N.Y.). vol 20. issue 5. 2018-12-11. PMID:29573636. |
poh1 knockdown induces cancer cell apoptosis via p53 and bim. |
2018-12-11 |
2023-08-13 |
human |
| Chun-Hua Wang, Shi-Xun Lu, Li-Li Liu, Yong Li, Xia Yang, Yang-Fan He, Shi-Lu Chen, Shao-Hang Cai, Hong Wang, Jing-Ping Yu. POH1 Knockdown Induces Cancer Cell Apoptosis via p53 and Bim. Neoplasia (New York, N.Y.). vol 20. issue 5. 2018-12-11. PMID:29573636. |
furthermore, p53 or bim sirna markedly attenuated the apoptosis induced by poh1 depletion. |
2018-12-11 |
2023-08-13 |
human |
| Chun-Hua Wang, Shi-Xun Lu, Li-Li Liu, Yong Li, Xia Yang, Yang-Fan He, Shi-Lu Chen, Shao-Hang Cai, Hong Wang, Jing-Ping Yu. POH1 Knockdown Induces Cancer Cell Apoptosis via p53 and Bim. Neoplasia (New York, N.Y.). vol 20. issue 5. 2018-12-11. PMID:29573636. |
poh1 depletion resulted in cell apoptosis by increasing the stability of p53 and bim and inhibiting their ubiquitination. |
2018-12-11 |
2023-08-13 |
human |
| Chun-Hua Wang, Shi-Xun Lu, Li-Li Liu, Yong Li, Xia Yang, Yang-Fan He, Shi-Lu Chen, Shao-Hang Cai, Hong Wang, Jing-Ping Yu. POH1 Knockdown Induces Cancer Cell Apoptosis via p53 and Bim. Neoplasia (New York, N.Y.). vol 20. issue 5. 2018-12-11. PMID:29573636. |
overall, poh1 knockdown induced cell apoptosis through increased expression of p53 and bim via enhanced protein stability and attenuated degradation. |
2018-12-11 |
2023-08-13 |
human |
| Christina McKee, Naimisha Beeravolu, Shreeya Bakshi, Bryan Thibodeau, George Wilson, Mick Perez-Cruet, G Rasul Chaudhr. Cytotoxicity of radiocontrast dyes in human umbilical cord mesenchymal stem cells. Toxicology and applied pharmacology. vol 349. 2018-12-11. PMID:29705293. |
based on these results a molecular mechanism of radiocontast dye induced cell death via intrinsic apoptosis pathway mediated by p53 was proposed. |
2018-12-11 |
2023-08-13 |
human |
| Jingchao Wang, Danrui Cui, Shanshan Gu, Xiaoyu Chen, Yanli Bi, Xiufang Xiong, Yongchao Zha. Autophagy regulates apoptosis by targeting NOXA for degradation. Biochimica et biophysica acta. Molecular cell research. vol 1865. issue 8. 2018-12-11. PMID:29758299. |
noxa accumulation effectively suppresses tumor cell growth by inducing apoptosis, which is further enhanced when p53 is present. |
2018-12-11 |
2023-08-13 |
Not clear |
| Tao Liu, Xiaorong Ma, Tianxiang Ouyang, Huiping Chen, Jun Lin, Jun Liu, Yan Xiao, Jie Yu, Yingying Huan. SIRT1 reverses senescence via enhancing autophagy and attenuates oxidative stress-induced apoptosis through promoting p53 degradation. International journal of biological macromolecules. vol 117. 2018-12-11. PMID:29803744. |
sirt1 reverses senescence via enhancing autophagy and attenuates oxidative stress-induced apoptosis through promoting p53 degradation. |
2018-12-11 |
2023-08-13 |
human |
| Jiangli Zheng, Xue Dai, Hailin Chen, Chunli Fang, Jian Chen, Lizhou Su. Down-regulation of LHPP in cervical cancer influences cell proliferation, metastasis and apoptosis by modulating AKT. Biochemical and biophysical research communications. vol 503. issue 2. 2018-12-11. PMID:29944886. |
moreover, suppressing p53 expression with its inhibitor of pftα abrogated the activity of lhpp to impede cell proliferation and metastasis, and to trigger apoptosis. |
2018-12-11 |
2023-08-13 |
human |
| Saba Shahin, Surya Pal Singh, Chandra Mohini Chaturved. 2.45 GHz microwave radiation induced oxidative and nitrosative stress mediated testicular apoptosis: Involvement of a p53 dependent bax-caspase-3 mediated pathway. Environmental toxicology. vol 33. issue 9. 2018-12-11. PMID:29968967. |
2.45 ghz microwave radiation induced oxidative and nitrosative stress mediated testicular apoptosis: involvement of a p53 dependent bax-caspase-3 mediated pathway. |
2018-12-11 |
2023-08-13 |
mouse |
| Patrick P Carriere, Neeraj Kapur, Hina Mir, Ashley B Ward, Shailesh Sing. Cinnamtannin B-1 inhibits cell survival molecules and induces apoptosis in colon cancer. International journal of oncology. vol 53. issue 4. 2018-12-11. PMID:30066888. |
of note, ctb-1 modulated the expression of several cell survival molecules, which tend to be deregulated in colon cancer, including p53, a key transcription factor involved in apoptosis. |
2018-12-11 |
2023-08-13 |
Not clear |
| Weiguo Liao, Jie Liu, Bin Liu, Xiaojie Huang, Yongxin Yin, De Cai, Mingyi Li, Runzhi Zh. JIB‑04 induces cell apoptosis via activation of the p53/Bcl‑2/caspase pathway in MHCC97H and HepG2 cells. Oncology reports. vol 40. issue 6. 2018-12-11. PMID:30272369. |
annexin v/pi staining, a cck‑8 assay and western blot analysis demonstrated that jib‑04 induced apoptosis in mhcc97h and hepg2 cells, which was evidenced by the expression of proapoptotic and apoptotic proteins including p53, bak, bax, caspase‑3 and caspase‑9. |
2018-12-11 |
2023-08-13 |
human |
| Hui Zhang, Cheng-Feng Xu, Chao Ren, Tian-Tian Wu, Ning Dong, Yong-Ming Ya. Novel Role of p53 in Septic Immunosuppression: Involvement in Loss and Dysfunction of CD4+ T Lymphocytes. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. vol 51. issue 1. 2018-12-11. PMID:30453300. |
p53 acts as a pivotal transcription factor in regulating cell proliferation and apoptosis, which control tumorigenesis. |
2018-12-11 |
2023-08-13 |
Not clear |
| Enxu Bi, Dengqiang Liu, Youxi Li, Xuying Mao, Aihua Wang, Jingtao Wan. Oridonin induces growth inhibition and apoptosis in human gastric carcinoma cells by enhancement of p53 expression and function. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. vol 51. issue 12. 2018-12-11. PMID:30462771. |
oridonin induces growth inhibition and apoptosis in human gastric carcinoma cells by enhancement of p53 expression and function. |
2018-12-11 |
2023-08-13 |
human |
| Enxu Bi, Dengqiang Liu, Youxi Li, Xuying Mao, Aihua Wang, Jingtao Wan. Oridonin induces growth inhibition and apoptosis in human gastric carcinoma cells by enhancement of p53 expression and function. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. vol 51. issue 12. 2018-12-11. PMID:30462771. |
western blot was used to evaluate the protein expression of apoptosis, dna damage and p53 function related factors. |
2018-12-11 |
2023-08-13 |
human |
| Zhibin Yan, Xiaokang Miao, Bangzhi Zhang, Junqiu Xi. p53 as a double-edged sword in the progression of non-alcoholic fatty liver disease. Life sciences. vol 215. 2018-12-11. PMID:30473026. |
tumor-suppressor factor p53 has a crucial role in many signaling pathways that induce apoptosis and has become an emerging focus for liver disease research. |
2018-12-11 |
2023-08-13 |
Not clear |
| S Ehtesham, R Sariri, A Eidi, S Hosseinkhan. Effect of Disulfide Bond Incorporation on the Structure and Activity of Endostatin Peptide. Biochemistry. Biokhimiia. vol 83. issue 11. 2018-12-11. PMID:30482150. |
in contrast, treatment of metastatic 4t1 breast tumors in mice with es-zn and es-sszn (5 mg/kg body weight daily) for 14 days resulted in similar regression of tumor size, comparable downregulation of angiogenesis (cd31 and cd34) and cell proliferation (ki67), and therefore, the same extent of apoptosis induction (tunel, p53, and bcl-2) for both peptides (as compared to the untreated controls). |
2018-12-11 |
2023-08-13 |
mouse |