| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yingqi Xu, Shengpeng Wang, Hon Fai Chan, Huaiwu Lu, Zhongqiu Lin, Chengwei He, Meiwan Che. Dihydromyricetin Induces Apoptosis and Reverses Drug Resistance in Ovarian Cancer Cells by p53-mediated Downregulation of Survivin. Scientific reports. vol 7. 2018-11-27. PMID:28436480. |
survivin, an inhibitor of apoptosis (iaps) family member, exhibited a decreased expression level after dhm treatment, which may be attributed to the activation of p53. |
2018-11-27 |
2023-08-13 |
Not clear |
| Xiaorong Liu, Zhiguang Jia, Jianhan Che. Enhanced Sampling of Intrinsic Structural Heterogeneity of the BH3-Only Protein Binding Interface of Bcl-xL. The journal of physical chemistry. B. vol 121. issue 39. 2018-11-27. PMID:28903561. |
partial unfolding of bcl-xl has been observed at the interface upon specific binding to the pro-apoptotic bh3-only protein puma, which in turn disrupts the interaction of bcl-xl with tumor suppressor p53 and promotes apoptosis. |
2018-11-27 |
2023-08-13 |
Not clear |
| Zahra Shajani-Yi, Francine B de Abreu, Jason D Peterson, Gregory J Tsongali. Frequency of Somatic TP53 Mutations in Combination with Known Pathogenic Mutations in Colon Adenocarcinoma, Non-Small Cell Lung Carcinoma, and Gliomas as Identified by Next-Generation Sequencing. Neoplasia (New York, N.Y.). vol 20. issue 3. 2018-11-26. PMID:29454261. |
it encodes p53, a dna-binding transcription factor that regulates multiple genes involved in dna repair, metabolism, cell cycle arrest, apoptosis, and senescence. |
2018-11-26 |
2023-08-13 |
human |
| Teresa Cunha-Oliveira, Luciana L Ferreira, Ana Raquel Coelho, Cláudia M Deus, Paulo J Oliveir. Doxorubicin triggers bioenergetic failure and p53 activation in mouse stem cell-derived cardiomyocytes. Toxicology and applied pharmacology. vol 348. 2018-11-26. PMID:29653124. |
at the lowest concentration, dox increased the expression of p53 target transcripts associated with mitochondria-dependent apoptosis and decreased transcripts related with dna-damage response and glycolysis. |
2018-11-26 |
2023-08-13 |
mouse |
| Di Li, Haibo Ni, Qin Rui, Rong Gao, Gang Che. Mst1: Function and Mechanism in Brain and Myocardial Ischemia Reperfusion Injury. Current neuropharmacology. vol 16. issue 9. 2018-11-26. PMID:29766810. |
previous studies have shown that mst1 is not only a target for some apoptosis- related molecules such as caspase 3 and p53, but also act as an activator of these proteinases to magnify apoptosis signal pathways. |
2018-11-26 |
2023-08-13 |
Not clear |
| Martina Magni, Giacomo Buscemi, Laura Zannin. Cell cycle and apoptosis regulator 2 at the interface between DNA damage response and cell physiology. Mutation research. Reviews in mutation research. vol 776. 2018-11-26. PMID:29807573. |
this event promotes the acetylation and activation of p53, a sirt1 target, and the subsequent induction of p53 dependent apoptosis. |
2018-11-26 |
2023-08-13 |
human |
| Chun-Hao Huang, Yen-Ting Chen, Jing-Heng Lin, Hsiang-Tsui Wan. Acrolein induces ribotoxic stress in human cancer cells regardless of p53 status. Toxicology in vitro : an international journal published in association with BIBRA. vol 52. 2018-11-26. PMID:29964147. |
acr induced apoptosis in cells with wild type p53, while it induced g2/m cell cycle arrest in cancer cells with deficient p53. |
2018-11-26 |
2023-08-13 |
human |
| Yang Bai, Guanghong Han, Kaimin Guo, Lili Yu, Xiadong Du, Ying X. Effect of lentiviral vector-mediated KSR1 gene silencing on the proliferation of renal tubular epithelial cells and expression of inflammatory factors in a rat model of ischemia/reperfusion injury. Acta biochimica et biophysica Sinica. vol 50. issue 8. 2018-11-26. PMID:30020400. |
as compared with the blank and nc groups, the siksr1, u0126, and siksr1 + u0126 groups showed decreased levels of tnf-α, il-6, il-1β, hsp47, n-ras, raf-1, c-fos, tnf-α, il-6, p38 mapk, cleaved caspase-3, cleaved caspase-9, p53, and cell apoptosis, accompanied by an increased mrna and protein level of bcl-2. |
2018-11-26 |
2023-08-13 |
human |
| Xiao-Qian Li, Qian Yu, Feng-Shou Chen, Wen-Fei Tan, Zai-Li Zhang, Hong M. Inhibiting aberrant p53-PUMA feedback loop activation attenuates ischaemia reperfusion-induced neuroapoptosis and neuroinflammation in rats by downregulating caspase 3 and the NF-κB cytokine pathway. Journal of neuroinflammation. vol 15. issue 1. 2018-11-26. PMID:30172256. |
in addition to its classical role in regulating tumourigenesis, the feedback loop formed by p53 and its driven target p53-upregulated modulator of apoptosis (puma) was recently demonstrated to be the common node tightly controlling various cellular responses during myocardial ir. |
2018-11-26 |
2023-08-13 |
rat |
| Junsheng Fu, Dominique N Soroka, Yingdong Zhu, Shengmin San. Induction of Apoptosis and Cell-Cycle Arrest in Human Colon-Cancer Cells by Whole-Grain Alkylresorcinols via Activation of the p53 Pathway. Journal of agricultural and food chemistry. vol 66. issue 45. 2018-11-26. PMID:30354111. |
induction of apoptosis and cell-cycle arrest in human colon-cancer cells by whole-grain alkylresorcinols via activation of the p53 pathway. |
2018-11-26 |
2023-08-13 |
human |
| Junsheng Fu, Dominique N Soroka, Yingdong Zhu, Shengmin San. Induction of Apoptosis and Cell-Cycle Arrest in Human Colon-Cancer Cells by Whole-Grain Alkylresorcinols via Activation of the p53 Pathway. Journal of agricultural and food chemistry. vol 66. issue 45. 2018-11-26. PMID:30354111. |
the results of treatment with p53 inhibitor further confirmed that the p53 pathway might play a very important role in ar-induced apoptosis in colon-cancer cells. |
2018-11-26 |
2023-08-13 |
human |
| Junsheng Fu, Dominique N Soroka, Yingdong Zhu, Shengmin San. Induction of Apoptosis and Cell-Cycle Arrest in Human Colon-Cancer Cells by Whole-Grain Alkylresorcinols via Activation of the p53 Pathway. Journal of agricultural and food chemistry. vol 66. issue 45. 2018-11-26. PMID:30354111. |
altogether these results show that ar c15 and ar c17 can specifically activate the mitochondrial pathway of apoptosis and cause cell-cycle arrest and that inhibition of p53 greatly reduces the activation of this pathway. |
2018-11-26 |
2023-08-13 |
human |
| Ashish Kumar, Sudhir Chandn. Evidence for a radiation-responsive 'p53 gateway' contributing significantly to the radioresistance of lepidopteran insect cells. Scientific reports. vol 8. issue 1. 2018-11-21. PMID:29311662. |
while ectopic overexpression of a well-conserved sfp53 caused typical apoptosis, radiation-induced p53 accumulation observed selectively at sub-lethal doses failed to induce cell death. |
2018-11-21 |
2023-08-13 |
human |
| Ming Ma, Junyu Yang, Bolun Wang, Zhihua Zhao, Jianzhong Jeff X. High-Throughput Identification of miR-596 Inducing p53-Mediated Apoptosis in HeLa and HCT116 Cells Using Cell Microarray. SLAS technology. vol 22. issue 6. 2018-11-20. PMID:28732184. |
to further explain the roles of these mrnas in apoptosis, a second round of screening was conducted between p53 +/+ and -/- cells. |
2018-11-20 |
2023-08-13 |
Not clear |
| Ming Ma, Junyu Yang, Bolun Wang, Zhihua Zhao, Jianzhong Jeff X. High-Throughput Identification of miR-596 Inducing p53-Mediated Apoptosis in HeLa and HCT116 Cells Using Cell Microarray. SLAS technology. vol 22. issue 6. 2018-11-20. PMID:28732184. |
the overexpression of mir-596 significantly increased p53 at the protein level, thereby inducing apoptosis. |
2018-11-20 |
2023-08-13 |
Not clear |
| Dongmei Su, Lina Guan, Qianqian Gao, Qian Li, Cuige Shi, Yi Liu, Lei Sun, Cailing Lu, Xu Ma, Jing Zha. ROCK1/p53/NOXA signaling mediates cardiomyocyte apoptosis in response to high glucose in vitro and vivo. Biochimica et biophysica acta. Molecular basis of disease. vol 1863. issue 4. 2018-11-19. PMID:28131915. |
further investigation showed that p53 and noxa protein levels increased during rock1-meidated apoptosis in response to hg. |
2018-11-19 |
2023-08-13 |
Not clear |
| Dongmei Su, Lina Guan, Qianqian Gao, Qian Li, Cuige Shi, Yi Liu, Lei Sun, Cailing Lu, Xu Ma, Jing Zha. ROCK1/p53/NOXA signaling mediates cardiomyocyte apoptosis in response to high glucose in vitro and vivo. Biochimica et biophysica acta. Molecular basis of disease. vol 1863. issue 4. 2018-11-19. PMID:28131915. |
furthermore, we found that p53 mediated the expression of noxa during hg-induced apoptosis, and histone acetyltransferase p300 participated in this process. |
2018-11-19 |
2023-08-13 |
Not clear |
| Satomi Yogosawa, Kiyotsugu Yoshid. Tumor suppressive role for kinases phosphorylating p53 in DNA damage-induced apoptosis. Cancer science. vol 109. issue 11. 2018-11-19. PMID:30191640. |
tumor suppressive role for kinases phosphorylating p53 in dna damage-induced apoptosis. |
2018-11-19 |
2023-08-13 |
Not clear |
| Satomi Yogosawa, Kiyotsugu Yoshid. Tumor suppressive role for kinases phosphorylating p53 in DNA damage-induced apoptosis. Cancer science. vol 109. issue 11. 2018-11-19. PMID:30191640. |
however, in response to various cellular stresses, p53 is stabilized and activated, which, in turn, initiates dna repair, cell-cycle arrest, senescence and apoptosis. |
2018-11-19 |
2023-08-13 |
Not clear |
| Satomi Yogosawa, Kiyotsugu Yoshid. Tumor suppressive role for kinases phosphorylating p53 in DNA damage-induced apoptosis. Cancer science. vol 109. issue 11. 2018-11-19. PMID:30191640. |
particularly, phosphorylation of p53 plays a critical role in modulating its activation to induce apoptosis in cancer cells. |
2018-11-19 |
2023-08-13 |
Not clear |