| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Junli Shao, Chaoxi Wang, Linqiu Li, Hairong Liang, Juanxiu Dai, Xiaoxuan Ling, Huanwen Tan. Luteoloside Inhibits Proliferation and Promotes Intrinsic and Extrinsic Pathway-Mediated Apoptosis Involving MAPK and mTOR Signaling Pathways in Human Cervical Cancer Cells. International journal of molecular sciences. vol 19. issue 6. 2018-10-15. PMID:29874795. |
the study demonstrated that luteoloside could inhibit proliferation remarkably; promote apoptosis and cytochrome c release; decrease the mitochondrial membrane potential and reactive oxygen species level; upregulate the expression of fas, bax, p53, phospho-p38, phospho-jnk, and cleaved parp; downregulate the expression of bcl-2 and phospho-mtor; activate caspase-3 and caspase-8; change the nuclear morphology, and fragmentate dna in hela cells. |
2018-10-15 |
2023-08-13 |
human |
| Junli Shao, Chaoxi Wang, Linqiu Li, Hairong Liang, Juanxiu Dai, Xiaoxuan Ling, Huanwen Tan. Luteoloside Inhibits Proliferation and Promotes Intrinsic and Extrinsic Pathway-Mediated Apoptosis Involving MAPK and mTOR Signaling Pathways in Human Cervical Cancer Cells. International journal of molecular sciences. vol 19. issue 6. 2018-10-15. PMID:29874795. |
furthermore, the luteoloside-induced apoptosis in hela cells is mediated by both intrinsic and extrinsic pathways and the effects of luteoloside may be regulated by the mitogen-activated protein kinases and mtor signaling pathways via p53. |
2018-10-15 |
2023-08-13 |
human |
| Hiroaki Iwasa, Aradhan Sarkar, Takanobu Shimizu, Takeru Sawada, Shakhawoat Hossain, Xiaoyin Xu, Junichi Maruyama, Kyoko Arimoto-Matsuzaki, Kanchanamala Withanage, Kentaro Nakagawa, Hidetake Kurihara, Hidehito Kuroyanagi, Yutaka Hat. UNC119 is a binding partner of tumor suppressor Ras-association domain family 6 and induces apoptosis and cell cycle arrest by MDM2 and p53. Cancer science. vol 109. issue 9. 2018-10-15. PMID:29931788. |
unc119 is a binding partner of tumor suppressor ras-association domain family 6 and induces apoptosis and cell cycle arrest by mdm2 and p53. |
2018-10-15 |
2023-08-13 |
caenorhabditis_elegans |
| Hiroaki Iwasa, Aradhan Sarkar, Takanobu Shimizu, Takeru Sawada, Shakhawoat Hossain, Xiaoyin Xu, Junichi Maruyama, Kyoko Arimoto-Matsuzaki, Kanchanamala Withanage, Kentaro Nakagawa, Hidetake Kurihara, Hidehito Kuroyanagi, Yutaka Hat. UNC119 is a binding partner of tumor suppressor Ras-association domain family 6 and induces apoptosis and cell cycle arrest by MDM2 and p53. Cancer science. vol 109. issue 9. 2018-10-15. PMID:29931788. |
thus, unc119 induces apoptosis by rassf6 and p53. |
2018-10-15 |
2023-08-13 |
caenorhabditis_elegans |
| Jhin-Baek Choi, Ju-Ha Kim, Hyemin Lee, Ji-Na Pak, Bum Sang Shim, Sung-Hoon Ki. Reactive Oxygen Species and p53 Mediated Activation of p38 and Caspases is Critically Involved in Kaempferol Induced Apoptosis in Colorectal Cancer Cells. Journal of agricultural and food chemistry. vol 66. issue 38. 2018-10-15. PMID:30211553. |
reactive oxygen species and p53 mediated activation of p38 and caspases is critically involved in kaempferol induced apoptosis in colorectal cancer cells. |
2018-10-15 |
2023-08-13 |
Not clear |
| Jhin-Baek Choi, Ju-Ha Kim, Hyemin Lee, Ji-Na Pak, Bum Sang Shim, Sung-Hoon Ki. Reactive Oxygen Species and p53 Mediated Activation of p38 and Caspases is Critically Involved in Kaempferol Induced Apoptosis in Colorectal Cancer Cells. Journal of agricultural and food chemistry. vol 66. issue 38. 2018-10-15. PMID:30211553. |
therefore, these findings provide novel insight that ros and p53 signalings mediate p38 phosphorylation and caspase activation in kaempferol stimulated apoptosis in crcs. |
2018-10-15 |
2023-08-13 |
Not clear |
| Yingzhuan Zhan, Han Zhang, Bingling Dai, Yanmin Zhang, Jie Zhang, Langchong H. A novel biphenyl urea compound, TPD7, stimulates apoptosis through modulating Fas signaling and Bcl-2 family proteins in cervical cancer. Oncology reports. vol 40. issue 2. 2018-10-12. PMID:29901176. |
mechanistically, tpd7 altered the extrinsic apoptosis pathway by upregulating fas expression, and the intrinsic pathway by modulating bcl-2 family proteins, p53, and nf-κb p65, leading to enhanced apoptosis. |
2018-10-12 |
2023-08-13 |
mouse |
| Mohammed A El-Missiry, Magda A ElKomy, Azza I Othman, Ali M AbouEl-Ez. Punicalagin ameliorates the elevation of plasma homocysteine, amyloid-β, TNF-α and apoptosis by advocating antioxidants and modulating apoptotic mediator proteins in brain. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 102. 2018-10-11. PMID:29579708. |
compared with methionine-treated animals, mice that treated with methionine and punicalagin remarkably displayed less apoptosis, indicated by the lower level of proapoptotic protein (bax, caspases- 3, 9 and p53) and higher levels of antiapoptotic bcl-2 protein than those in hyperhomocysteinemic mice. |
2018-10-11 |
2023-08-13 |
mouse |
| Khaled Habas, Martin H Brinkworth, Diana Anderso. Silver nanoparticle-mediated cellular responses in isolated primary Sertoli cells in vitro. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 116. issue Pt B. 2018-10-11. PMID:29665414. |
the mrna expression of p53 and bcl-2 genes and their proteins involved in apoptosis was also investigated. |
2018-10-11 |
2023-08-13 |
mouse |
| Weilan Kong, Kai Kang, Yang Gao, Haitao Liu, Xianglin Meng, Yanhui Cao, Songliu Yang, Wen Liu, Jiannan Zhang, Kaijiang Yu, Mingyan Zha. GTS-21 Protected Against LPS-Induced Sepsis Myocardial Injury in Mice Through α7nAChR. Inflammation. vol 41. issue 3. 2018-10-10. PMID:29680908. |
the pathological results of myocardial tissue were detected by the he method; the apoptosis rate was detected by the tunel method; the relative expressions of nf-κb p65, caspase-3, caspase-8, bcl-2, bax, p53, and a7nachr were detected by real-time quantitative pcr (rt-pcr); and the protein expressions of il-6, il-1 β, tnf-α, and pstat3 were detected by western blot. |
2018-10-10 |
2023-08-13 |
mouse |
| Tianqi Wu, Hongming Song, Dan Xie, Bingkun Zhao, Hui Xu, Chenyang Wu, Kaiyao Hua, Yijun Deng, Changle Ji, Jiashu Hu, Lin Fan. Silencing of ASPP2 promotes the proliferation, migration and invasion of triple-negative breast cancer cells via the PI3K/AKT pathway. International journal of oncology. vol 52. issue 6. 2018-10-09. PMID:29568874. |
apoptosis-stimulating p53 protein 2 (aspp2) is an apoptosis inducer that acts via binding with p53 and then enhancing the transcriptional activities toward pro‑apoptosis genes. |
2018-10-09 |
2023-08-13 |
Not clear |
| Xingkang Wu, Yuemao She. PMN inhibits colorectal cancer cells through inducing mitotic arrest and p53-dependent apoptosis via the inhibition of tubulin polymerization. Biochemical and biophysical research communications. vol 499. issue 4. 2018-10-09. PMID:29626471. |
pmn-induced mitotic arrest resulted in apoptosis and p53 upregulation. |
2018-10-09 |
2023-08-13 |
Not clear |
| Xingkang Wu, Yuemao She. PMN inhibits colorectal cancer cells through inducing mitotic arrest and p53-dependent apoptosis via the inhibition of tubulin polymerization. Biochemical and biophysical research communications. vol 499. issue 4. 2018-10-09. PMID:29626471. |
furthermore, p53 upregulation sensitized pmn-induced mitotic cells to apoptosis. |
2018-10-09 |
2023-08-13 |
Not clear |
| Weimin Dong, Yan Lin, Yang Cao, Yue Liu, Xiaobao Xie, Weiying G. Luteolin induces myelodysplastic syndrome‑derived cell apoptosis via the p53‑dependent mitochondrial signaling pathway mediated by reactive oxygen species. International journal of molecular medicine. vol 42. issue 2. 2018-10-09. PMID:29786746. |
the increased intracellular level of ros appeared to induce the activation of p53 and elevate the b‑cell lymphoma 2 (bcl‑2)‑associated x protein/bcl‑2 ratio, which modulates ΔΨm and triggers the release of cytochrome c, and may increase the activities of apoptotic protease activating factor 1, caspase‑3, ‑8 and ‑9 to further trigger the destruction of structural and specific proteins and thereby cell apoptosis. |
2018-10-09 |
2023-08-13 |
Not clear |
| Xiao Fang, Guojun Lu, Kyungsoo Ha, Han Lin, Ye Du, Qiuhong Zuo, Yi Fu, Chaoxia Zou, Pumin Zhan. Acetylation of TIP60 at K104 is essential for metabolic stress-induced apoptosis in cells of hepatocellular cancer. Experimental cell research. vol 362. issue 2. 2018-10-05. PMID:29174981. |
here we found that suppressing tip60 inhibited p53 k120 acetylation and thus rescued apoptosis induced by glucose deprivation in hepatocellular cancer cells. |
2018-10-05 |
2023-08-13 |
human |
| Ajda Coker Gurkan, Elif Damla Arisan, Pinar Obakan Yerlikaya, Halime Ilhan, Narcin Palavan Unsa. Inhibition of autophagy enhances DENSpm-induced apoptosis in human colon cancer cells in a p53 independent manner. Cellular oncology (Dordrecht). vol 41. issue 3. 2018-10-03. PMID:29492901. |
inhibition of autophagy enhances denspm-induced apoptosis in human colon cancer cells in a p53 independent manner. |
2018-10-03 |
2023-08-13 |
human |
| Zhenbiao Zhang, Dandan Luo, Jianhui Xie, Guosheng Lin, Jiangtao Zhou, Weihai Liu, Huilin Li, Tiegang Yi, Ziren Su, Jianping Che. Octahydrocurcumin, a final hydrogenated metabolite of curcumin, possesses superior anti-tumor activity through induction of cellular apoptosis. Food & function. vol 9. issue 4. 2018-10-03. PMID:29616245. |
ohc significantly induced h22 cell apoptosis by upregulating the p53 expression and downregulating the mdm2 expression. |
2018-10-03 |
2023-08-13 |
mouse |
| Sadia Afrin, Francesca Giampieri, Massimiliano Gasparrini, Tamara Y Forbes-Hernández, Danila Cianciosi, Patricia Reboredo-Rodriguez, Adolfo Amici, Josè L Quiles, Maurizio Battin. The inhibitory effect of Manuka honey on human colon cancer HCT-116 and LoVo cell growth. Part 1: the suppression of cell proliferation, promotion of apoptosis and arrest of the cell cycle. Food & function. vol 9. issue 4. 2018-10-03. PMID:29645049. |
the apoptosis event was associated with the increasing expression of p53, cleaved-parp and caspase-3 and with the activation of both intrinsic (caspase-9) and extrinsic (caspase-8) apoptotic pathways. |
2018-10-03 |
2023-08-13 |
human |
| Hany H Arab, Samir A Salama, Ibrahim A Maghrab. Camel milk attenuates methotrexate-induced kidney injury via activation of PI3K/Akt/eNOS signaling and intervention with oxidative aberrations. Food & function. vol 9. issue 5. 2018-10-03. PMID:29667662. |
with respect to apoptosis, cm curbed the cleavage of parp and caspase-3, downregulated p53, bax and cyt c proapoptotic signals and enhanced bcl-2 and pcna levels. |
2018-10-03 |
2023-08-13 |
rat |
| Hui Shi, Yinting Mao, Qianqian Ju, Yingcheng Wu, Wen Bai, Peiwen Wang, Yudong Zhang, Maorong Jian. C-terminal binding protein‑2 mediates cisplatin chemoresistance in esophageal cancer cells via the inhibition of apoptosis. International journal of oncology. vol 53. issue 1. 2018-10-02. PMID:29658564. |
furthermore, the western blotting results indicated that ctbp2 overexpression inhibited the ddp-induced apoptosis of eca109 cells via the reduction of p53, activated caspase-3 and bax expression, and promotion of bcl‑2 expression. |
2018-10-02 |
2023-08-13 |
human |