| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yao Wang, Han Li, Shu-Ping Son. β-Arrestin 1/2 Aggravates Podocyte Apoptosis of Diabetic Nephropathy via Wnt/β-Catenin Pathway. Medical science monitor : international medical journal of experimental and clinical research. vol 24. 2018-09-05. PMID:29572435. |
up-regulated β-arrestin 1/2 promoted podocyte apoptosis and p53 pathway by increasing bax, cleaved caspase-3, and p-p53 levels in high-glucose-induced podocytes. |
2018-09-05 |
2023-08-13 |
Not clear |
| Atul Ranjan, Tomoo Iwakum. Emerging Non-Canonical Functions and Regulation of p53. International journal of molecular sciences. vol 19. issue 4. 2018-09-05. PMID:29597309. |
the tumor suppressor p53 induces cell cycle arrest and/or apoptosis by transactivating numerous downstream target genes and also translocating to the mitochondrial outer membrane. |
2018-09-05 |
2023-08-13 |
Not clear |
| Tengfei Chao, Xiang Zhou, Bo Cao, Peng Liao, Hongbing Liu, Yun Chen, Hee-Won Park, Shelya X Zeng, Hua L. Pleckstrin homology domain-containing protein PHLDB3 supports cancer growth via a negative feedback loop involving p53. Nature communications. vol 7. 2018-09-04. PMID:28008906. |
phldb3 overexpression increases proliferation and restrains apoptosis of wild-type p53-harboring cancer cells by reducing p53 protein levels. |
2018-09-04 |
2023-08-13 |
mouse |
| Neeraj Kumar, Heerak Chugh, Ravi Tomar, Vartika Tomar, Vimal Kishor Singh, Ramesh Chandr. Exploring the interplay between autoimmunity and cancer to find the target therapeutic hotspots. Artificial cells, nanomedicine, and biotechnology. vol 46. issue 4. 2018-09-04. PMID:28687059. |
impaired repairment of immune system and apoptosis regulation can be seen as major landmarks in autoimmune disorders such as the mutation of p53 gene which results in rheumatoid arthritis, bowel disease which consequently lead to tissue destruction, inflammation and dysfunctioning of body organs. |
2018-09-04 |
2023-08-13 |
human |
| Tomasz Lech, Józefa Styrna, Katarzyna Kotarsk. The contribution of p53 and Y chromosome long arm genes to regulation of apoptosis in mouse testis. Reproduction, fertility, and development. vol 30. issue 3. 2018-09-04. PMID:28763629. |
the contribution of p53 and y chromosome long arm genes to regulation of apoptosis in mouse testis. |
2018-09-04 |
2023-08-13 |
mouse |
| Tomasz Lech, Józefa Styrna, Katarzyna Kotarsk. The contribution of p53 and Y chromosome long arm genes to regulation of apoptosis in mouse testis. Reproduction, fertility, and development. vol 30. issue 3. 2018-09-04. PMID:28763629. |
the aim of this study was to evaluate the combined influence of the p53 and y chromosome long arm genes on male germ cell apoptosis. |
2018-09-04 |
2023-08-13 |
mouse |
| Tomasz Lech, Józefa Styrna, Katarzyna Kotarsk. The contribution of p53 and Y chromosome long arm genes to regulation of apoptosis in mouse testis. Reproduction, fertility, and development. vol 30. issue 3. 2018-09-04. PMID:28763629. |
the study revealed that although p53 is involved in germ cell apoptosis in peripubertal testes, this process can also be mediated by p53-independent mechanisms. |
2018-09-04 |
2023-08-13 |
mouse |
| Tomasz Lech, Józefa Styrna, Katarzyna Kotarsk. The contribution of p53 and Y chromosome long arm genes to regulation of apoptosis in mouse testis. Reproduction, fertility, and development. vol 30. issue 3. 2018-09-04. PMID:28763629. |
the study confirmed, instead, that p53 does participate in spontaneous apoptosis in mature testes. |
2018-09-04 |
2023-08-13 |
mouse |
| Wanhong Chen, Qingbai Liu, Bin Fu, Kai Liu, Wenchao Jian. Overexpression of GRIM-19 accelerates radiation-induced osteosarcoma cells apoptosis by p53 stabilization. Life sciences. vol 208. 2018-09-04. PMID:30005830. |
overexpression of grim-19 accelerates radiation-induced osteosarcoma cells apoptosis by p53 stabilization. |
2018-09-04 |
2023-08-13 |
Not clear |
| Muralidhar Allam, A K D Bhavani, Anwita Mudiraj, Nikhil Ranjan, Mallikarjuna Thippana, Phanithi Prakash Bab. Synthesis of pyrazolo[3,4-d]pyrimidin-4(5H)-ones tethered to 1,2,3-triazoles and their evaluation as potential anticancer agents. European journal of medicinal chemistry. vol 156. 2018-09-04. PMID:30006173. |
further, apoptosis was evidenced by the cleavage of caspase-3, parp and up regulation of p53. |
2018-09-04 |
2023-08-13 |
human |
| Yanhong Zhang, Yingjuan Qian, Jin Zhang, Wensheng Yan, Yong-Sam Jung, Mingyi Chen, Eric Huang, Kent Lloyd, Yuyou Duan, Jian Wang, Gang Liu, Xinbin Che. Ferredoxin reductase is critical for p53-dependent tumor suppression via iron regulatory protein 2. Genes & development. vol 31. issue 12. 2018-08-31. PMID:28747430. |
ferredoxin reductase (fdxr), a target of p53, modulates p53-dependent apoptosis and is necessary for steroidogenesis and biogenesis of iron-sulfur clusters. |
2018-08-31 |
2023-08-13 |
Not clear |
| Petar Ozretic, Ilija Alvir, Bozena Sarcevic, Zeljko Vujaskovic, Zrinka Rendic-Miocevic, Ana Roguljic, Lidija Beketic-Oreskovi. Apoptosis regulator Bcl-2 is an independent prognostic marker for worse overall survival in triple-negative breast cancer patients. The International journal of biological markers. vol 33. issue 1. 2018-08-31. PMID:28777433. |
the objective of this study was to examine the prognostic significance of carbonic anhydrase ix (caix), an endogenous marker for tumor hypoxia; the cellular tumor antigen p53; and the apoptosis regulator bcl-2, in triple-negative breast cancer (tnbc) patients. |
2018-08-31 |
2023-08-13 |
Not clear |
| Qing-An Zhang, Xu-Hai Yang, Dong Chen, Xiang Yan, Fu-Chun Jing, Hong-Qian Liu, Ronghua Zhan. miR-34 increases in vitro PANC-1 cell sensitivity to gemcitabine via targeting Slug/PUMA. Cancer biomarkers : section A of Disease markers. vol 21. issue 4. 2018-08-31. PMID:29355113. |
mir-34 induced down-regulation of slug expression and upregulation of p53 up-regulated modulator of apoptosis (puma) expression. |
2018-08-31 |
2023-08-13 |
human |
| Tomoya Takeda, Masanobu Tsubaki, Yoshika Tomonari, Keishi Kawashima, Tatsuki Itoh, Motohiro Imano, Takao Satou, Shozo Nishid. Bavachin induces the apoptosis of multiple myeloma cell lines by inhibiting the activation of nuclear factor kappa B and signal transducer and activator of transcription 3. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 100. 2018-08-31. PMID:29477912. |
furthermore, bavachin increased the expression of p53 and noxa, and decreased the expression of x-linked inhibitor of apoptosis protein (xiap), survivin, b cell lymphoma-extra large (bcl-xl), and bcl-2. |
2018-08-31 |
2023-08-13 |
Not clear |
| Liugen Gu, Juan Zhao, Shiqing Zhang, Weisong Xu, Runzhou Ni, Xiaojuan Li. Runt-related transcription factor 2 (RUNX2) inhibits apoptosis of intestinal epithelial cells in Crohn's disease. Pathology, research and practice. vol 214. issue 2. 2018-08-30. PMID:29129496. |
runt-related transcription factor 2 (runx2) inhibits apoptosis in osteosarcoma-derived u2os cells via down-regulating the transcriptional activity of p53. |
2018-08-30 |
2023-08-13 |
mouse |
| Wenjun Zeng, Chunyun Zhang, Hongwei Cheng, Yun-Long Wu, Jie Liu, Zekun Chen, Jian-Gang Huang, Russell Erick Ericksen, Liqun Chen, Haiping Zhang, Alice Sze Tsai Wong, Xiao-Kun Zhang, Weiping Han, Jin-Zhang Zen. Targeting to the non-genomic activity of retinoic acid receptor-gamma by acacetin in hepatocellular carcinoma. Scientific reports. vol 7. issue 1. 2018-08-29. PMID:28336971. |
acacetin induces cancer cell apoptosis through antagonizing the non-genomic effect of rarγ on akt and p53. |
2018-08-29 |
2023-08-13 |
Not clear |
| Qiang Liu, Jinxin Song, Hong Li, Lei Dong, Shejiao Da. Schizandrin B inhibits the cis‑DDP‑induced apoptosis of HK‑2 cells by activating ERK/NF‑κB signaling to regulate the expression of survivin. International journal of molecular medicine. vol 41. issue 4. 2018-08-29. PMID:29393335. |
additionally, the mechanism underlying the cis‑ddp‑induced apoptosis was indicated to involve the activation of p53, c‑jun‑n‑terminal kinase (jnk) and p38 signaling. |
2018-08-29 |
2023-08-13 |
Not clear |
| Sharad S Singhal, Lokesh Nagaprashantha, Preeti Singhal, Sulabh Singhal, Jyotsana Singhal, Sanjay Awasthi, David Horn. RLIP76 Inhibition: A Promising Developmental Therapy for Neuroblastoma. Pharmaceutical research. vol 34. issue 8. 2018-08-23. PMID:28386633. |
in addition, recent studies indicate that the interactions between p53, mycn, and wnt regulate apoptosis resistance and protein ubiquitination. |
2018-08-23 |
2023-08-13 |
Not clear |
| Sharad S Singhal, Lokesh Nagaprashantha, Preeti Singhal, Sulabh Singhal, Jyotsana Singhal, Sanjay Awasthi, David Horn. RLIP76 Inhibition: A Promising Developmental Therapy for Neuroblastoma. Pharmaceutical research. vol 34. issue 8. 2018-08-23. PMID:28386633. |
targeted depletion/inhibition of rlip76 causes apoptosis and tumor regression in nb irrespective of p53 status. |
2018-08-23 |
2023-08-13 |
Not clear |
| Yushi Ochiai, Emiko Sano, Yutaka Okamoto, Sodai Yoshimura, Kotaro Makita, Shun Yamamuro, Takashi Ohta, Akiyoshi Ogino, Hisashi Tadakuma, Takuya Ueda, Tomohiro Nakayama, Hiroyuki Hara, Atsuo Yoshino, Yoichi Katayam. Efficacy of ribavirin against malignant glioma cell lines: Follow-up study. Oncology reports. vol 39. issue 2. 2018-08-23. PMID:29251333. |
additionally, analysis by facs indicated that apoptosis was induced following ribavirin treatment and caspase cascade, downstream of the p53 pathway, which indicated the activation of both exogenous and endogenous apoptosis in both malignant glioma cell lines. |
2018-08-23 |
2023-08-13 |
Not clear |