| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jiazhao Yan, Yuhui Qin, Jingsheng Yu, Qinghua Peng, Xiangdong Che. MiR-340/iASPP axis affects UVB-mediated retinal pigment epithelium (RPE) cell damage. Journal of photochemistry and photobiology. B, Biology. vol 186. 2018-08-22. PMID:29982095. |
in rpe cells, uvb irradiation inhibits iaspp expression through inducing mir-340 expression, thereby promoting rpe cell apoptosis and suppressing cell viability via affecting p53, p21 and caspase-3 protein expression. |
2018-08-22 |
2023-08-13 |
Not clear |
| Da Zhao, Xinyan Zhan. Selenium Antagonizes the Lead-Induced Apoptosis of Chicken Splenic Lymphocytes In Vitro by Activating the PI3K/Akt Pathway. Biological trace element research. vol 182. issue 1. 2018-08-20. PMID:28681127. |
however, se supplementation during pb exposure observably attenuated pb-induced apoptosis; increased the levels of the pi3k, akt, and bcl-2 mrnas and proteins; and decrease the levels of the p53, bax, cyt-c, caspase 3, and caspase 9 mrnas and proteins in the chicken spleen. |
2018-08-20 |
2023-08-13 |
cat |
| Yuting Chen, Shaoyun Chen, Hairong Liang, Hui Yang, Linhua Liu, Kairu Zhou, Longmei Xu, Jiaxian Liu, Lin Yun, Bei Lai, Li Song, Hao Luo, Jianming Peng, Zhidong Liu, Yongmei Xiao, Wen Chen, Huanwen Tan. Bcl-2 protects TK6 cells against hydroquinone-induced apoptosis through PARP-1 cytoplasm translocation and stabilizing mitochondrial membrane potential. Environmental and molecular mutagenesis. vol 59. issue 1. 2018-08-20. PMID:28843007. |
thus, abt-737 can influence parp-1 translocation and induce apoptosis via mitochondria-mediated apoptotic pathway, independently of p53. |
2018-08-20 |
2023-08-13 |
Not clear |
| Lei Yang, Lu Sun, Wei Wang, Hao Xu, Yi Li, Jia-Ying Zhao, Da-Zhong Liu, Fei Wang, Lin-You Zhan. Construction of a 26‑feature gene support vector machine classifier for smoking and non‑smoking lung adenocarcinoma sample classification. Molecular medicine reports. vol 17. issue 2. 2018-08-20. PMID:29257283. |
furthermore, the 26 feature genes that were significantly enriched in 9 overrepresented biological pathways, including extracellular matrix‑receptor interaction, proteoglycans in cancer, cell adhesion molecules, p53 signaling pathway, micrornas in cancer and apoptosis, were identified to be smoking‑related genes in lac. |
2018-08-20 |
2023-08-13 |
human |
| Somayeh Karimzadeh, Saman Hosseinkhani, Ali Fathi, Farangis Ataei, Hossein Baharvan. Insufficient Apaf-1 expression in early stages of neural differentiation of human embryonic stem cells might protect them from apoptosis. European journal of cell biology. vol 97. issue 2. 2018-08-17. PMID:29395479. |
our results demonstrated that ros generation, cytosolic cytochrome c release, caspases activation and rise in p53 protein level occurred upon either neural or apoptosis induction in hescs. |
2018-08-17 |
2023-08-13 |
human |
| Lufang Wang, Yanyan Zhao, Qiong Wu, Yifu Guan, Xin W. Therapeutic effects of β-elemene via attenuation of the Wnt/β-catenin signaling pathway in cervical cancer cells. Molecular medicine reports. vol 17. issue 3. 2018-08-16. PMID:29363722. |
the expression levels of cyclin‑dependent kinase inhibitor 2b (p15), cyclin d1, cellular tumor antigen p53, apoptosis regulator bcl‑2 (bcl‑2), apoptosis regulator bax (bax), 72 kda type iv collagenase (mmp‑2), matrix metalloproteinase‑9 (mmp‑9), β‑catenin, transcription factor 7 (tcf7), and myc proto‑oncogene protein (c‑myc) were analyzed via western blotting. |
2018-08-16 |
2023-08-13 |
human |
| Lufang Wang, Yanyan Zhao, Qiong Wu, Yifu Guan, Xin W. Therapeutic effects of β-elemene via attenuation of the Wnt/β-catenin signaling pathway in cervical cancer cells. Molecular medicine reports. vol 17. issue 3. 2018-08-16. PMID:29363722. |
furthermore, the present study revealed that β‑elemene induced apoptosis in siha cells by enhancing the expression of p53 and bax, and suppressing the expression of bcl‑2. |
2018-08-16 |
2023-08-13 |
human |
| Chaiyachet Nanok, Patcharee Jearanaikoon, Siriporn Proungvitaya, Temduang Limpaiboo. Aberrant methylation of HTATIP2 and UCHL1 as a predictive biomarker for cholangiocarcinoma. Molecular medicine reports. vol 17. issue 3. 2018-08-15. PMID:29359783. |
in the present study, the results obtained from our previously published methylation array were analyzed and 10 candidate genes involved in dna repair [protein phosphatase 4 catalytic subunit (ppp4c)], apoptosis [runt related transcription factor 3 (runx3), interferon regulatory factor 4 (irf4), ubiquitin c‑terminal hydrolase l1 (uchl1) and tumor protein p53 inducible protein 3 (tp53i3)], cell proliferation [cyclin d2 (ccnd2) and ras association domain family member 1 (rassf1)], drug metabolism [aldehyde dehydrogenase 1 family member a3 (aldh1a3) and solute carrier family 29 member 1 (slc29a1)] and angiogenesis [human immunodeficiency virus‑1 tat interactive protein 2 (htatip2)] were selected for quantification of their methylation levels in 54 cca and 19 adjacent normal tissues using methylation‑sensitive high‑resolution melting. |
2018-08-15 |
2023-08-13 |
human |
| Tianli He, Jiayou Guo, Hongmei Song, Hongcheng Zhu, Xiaoke Di, Hua Min, Yuandong Wang, Guangzong Chen, Wangshu Dai, Jianhua Ma, Xinchen Sun, Jianxin M. Nutlin-3, an Antagonist of MDM2, Enhances the Radiosensitivity of Esophageal Squamous Cancer with Wild-Type p53. Pathology oncology research : POR. vol 24. issue 1. 2018-08-14. PMID:28341911. |
murine double minute 2 (mdm2) negatively regulates the activity of the p53 protein and plays a vital role in cell cycle arrest, apoptosis, and senescence mediated by p53. |
2018-08-14 |
2023-08-13 |
mouse |
| Meng-Jie Yan, Zhi-Sen Tian, Zhi-Hui Zhao, Ping Yan. MiR-31a-5p protects myocardial cells against apoptosis by targeting Tp53. Molecular medicine reports. vol 17. issue 3. 2018-08-14. PMID:29286111. |
it was demonstrated that angii stimulation increased apoptosis and decreased mir‑31a‑5p expression, which coincided with increased tumor protein p53 (tp53) levels. |
2018-08-14 |
2023-08-13 |
rat |
| Hai-Bo Qiao, Jia Li, Lian-Jie Lv, Ben-Jin Nie, Peng Lu, Feng Xue, Zhi-Ming Zhan. The effects of interleukin 2 and rAd-p53 as a treatment for glioblastoma. Molecular medicine reports. vol 17. issue 3. 2018-08-14. PMID:29328445. |
the ability of il‑2 to stimulate immunoregulation and the ability of p53 to induce apoptosis for gbm was researched in the gbm tumor model. |
2018-08-14 |
2023-08-13 |
mouse |
| Feifei Wang, Jinhui Wang, Jinghong An, Guoming Yuan, Xiaolei Hao, Yi Zhan. Resveratrol ameliorates depressive disorder through the NETRIN1-mediated extracellular signal-regulated kinase/cAMP signal transduction pathway. Molecular medicine reports. vol 17. issue 3. 2018-08-14. PMID:29328454. |
in addition, the apoptosis of hippocampal neuron cells was inhibited by the upregulation of anti‑apoptotic genes, including p53, b‑cell lymphoma‑2 (bcl‑2) and bcl‑2‑associated death promoter, and the downregulation of the cleaved caspase‑3 and caspase‑9. |
2018-08-14 |
2023-08-13 |
mouse |
| Yoko Itahana, Koji Itahan. Emerging Roles of p53 Family Members in Glucose Metabolism. International journal of molecular sciences. vol 19. issue 3. 2018-08-14. PMID:29518025. |
although p53 is thought to suppress tumorigenesis primarily by inducing cell cycle arrest, apoptosis, and senescence in response to stress, the non-canonical functions of p53 in cellular energy homeostasis and metabolism are also emerging as critical factors for tumor suppression. |
2018-08-14 |
2023-08-13 |
Not clear |
| Asmaa F Khafaga, Yasser S El-Saye. All-trans-retinoic acid ameliorates doxorubicin-induced cardiotoxicity: in vivo potential involvement of oxidative stress, inflammation, and apoptosis via caspase-3 and p53 down-expression. Naunyn-Schmiedeberg's archives of pharmacology. vol 391. issue 1. 2018-08-13. PMID:29085977. |
all-trans-retinoic acid ameliorates doxorubicin-induced cardiotoxicity: in vivo potential involvement of oxidative stress, inflammation, and apoptosis via caspase-3 and p53 down-expression. |
2018-08-13 |
2023-08-13 |
rat |
| Hong Pan, Li-Yuan Lu, Xue-Qian Wang, Bin-Xue Li, Kathleen Kelly, Hong-Sheng Li. Gambogic Acid Induces Cell Apoptosis and Inhibits MAPK Pathway in PTEN Chinese journal of integrative medicine. vol 24. issue 2. 2018-08-10. PMID:28578487. |
gambogic acid induces cell apoptosis and inhibits mapk pathway in pten to investigate the effect of gambogic acid (ga) on the growth and cell death of castrate resistant prostate cancer (pc) with phosphate and tension homology (pten) and p53 genes deleted in vitro and ex vivo, and elucidate the underlying possible molecular mechanisms. |
2018-08-10 |
2023-08-13 |
Not clear |
| Xiaohui Chen, Kai Hao, Xiaobo Yu, Aiguo Huang, Bin Zhu, Gao-Xue Wang, Fei Lin. Magnolol protects Ctenopharyngodon idella kidney cells from apoptosis induced by grass carp reovirus. Fish & shellfish immunology. vol 74. 2018-08-10. PMID:29277695. |
moreover, interactions between magnolol and proteins were predicted by using the stitch program, which revealed that ten proteins including caspase 3, were involved in the apoptosis pathway, p53 signaling pathway, mitogen-activated protein kinase (mapk) signaling pathway and toll-like receptor signaling pathway. |
2018-08-10 |
2023-08-13 |
Not clear |
| Linh N K Tran, Ganessan Kichenadasse, Lisa M Butler, Margaret M Centenera, Katherine L Morel, Rebecca J Ormsby, Michael Z Michael, Karen M Lower, Pamela J Syke. The Combination of Metformin and Valproic Acid Induces Synergistic Apoptosis in the Presence of p53 and Androgen Signaling in Prostate Cancer. Molecular cancer therapeutics. vol 16. issue 12. 2018-08-07. PMID:28802253. |
the combination of metformin and valproic acid induces synergistic apoptosis in the presence of p53 and androgen signaling in prostate cancer. |
2018-08-07 |
2023-08-13 |
Not clear |
| R Schipp, J Varga, J Bátor, M Vecsernyés, Z Árvai, M Pap, József Szeberény. Partial p53-dependence of anisomycin-induced apoptosis in PC12 cells. Molecular and cellular biochemistry. vol 434. issue 1-2. 2018-08-06. PMID:28432551. |
in the presence of the dominant inhibitory p53 protein, p53- dependent genes involved in the regulation of apoptosis may be less transcribed and this can lead to the decrease of apoptotic processes in p143p53pc12 cells. |
2018-08-06 |
2023-08-13 |
Not clear |
| Peethambaran Divya, Bijesh Puthusseri, Denny Joseph Kollareth Manual, Mohammed Azharuddin Savanu. Epigallocatechin gallate protects BEAS-2B cells from lipopolysaccharide-induced apoptosis through upregulation of gastrin-releasing peptide. Molecular and cellular biochemistry. vol 434. issue 1-2. 2018-08-06. PMID:28432554. |
the present study shows that human bronchial epithelial beas-2b cells challenged with lipopolysaccharide (lps), an endotoxin from gram-negative bacteria, downregulated grp expression and induced apoptosis via upregulation of p53 and active caspase-3, signifying the importance of grp in lung epithelial cell survival. |
2018-08-06 |
2023-08-13 |
human |
| Yuting Wu, Zhiqiang Qian, Shu Fu, Yun Yue, Yeli Li, Ruimin Sun, Bo Huang, Danli Yan. IcarisideII improves left ventricular remodeling in spontaneously hypertensive rats by inhibiting the ASK1-JNK/p38 signaling pathway. European journal of pharmacology. vol 819. 2018-08-06. PMID:29175071. |
icarisideii down-regulated the activation of the oxidative stress associated proteins ask1, p38 and jnk; inhibited the expression of p53, bax and cleaved-caspase3 in the mitochondrial apoptosis pathway; and up-regulated the expression of bcl-2. |
2018-08-06 |
2023-08-13 |
rat |