| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Bin Ma, Lizhen He, Yuanyuan You, Jianbin Mo, Tianfeng Che. Controlled synthesis and size effects of multifunctional mesoporous silica nanosystem for precise cancer therapy. Drug delivery. vol 25. issue 1. 2018-08-06. PMID:29334793. |
moreover, ru@msns induced ros overproduction in cancer cells, leading to dna damage and p53 phosphorylation, consequently promoting cancer cells apoptosis. |
2018-08-06 |
2023-08-13 |
mouse |
| Vinay Kumar Tripathi, Allur Subramaniyan Sivakumar, Anupam Dhasmana, Inho Hwan. Crosstalk Between Co-Cultured 3T3-L1 and C2C12 Cells After the Exposure of Nano-Titanium Dioxide. Journal of nanoscience and nanotechnology. vol 18. issue 6. 2018-08-06. PMID:29442721. |
additionally, real-time pcr data analysis shown an increased in the expression of p53, bax, caspase-9, caspase-3 and decreased the level of bcl-2, by this means specifying that apoptosis induced by tio2 nps occurs via the caspase-dependent pathway. |
2018-08-06 |
2023-08-13 |
Not clear |
| Hedyieh Karbasforooshan, Gholamreza Karim. The role of SIRT1 in diabetic retinopathy. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 97. 2018-08-03. PMID:29091865. |
oxidative stress- induced apoptosis is due to activation of some transcriptional factors such as p53 and protein arginine methyl transferase 1 (prmit1) which are inhibited by sirt1. |
2018-08-03 |
2023-08-13 |
Not clear |
| Sumit Mukherjee, Juliet N E Baidoo, Samay Sampat, Andrew Mancuso, Lovena David, Leah S Cohen, Shuiqin Zhou, Probal Banerje. Liposomal TriCurin, A Synergistic Combination of Curcumin, Epicatechin Gallate and Resveratrol, Repolarizes Tumor-Associated Microglia/Macrophages, and Eliminates Glioblastoma (GBM) and GBM Stem Cells. Molecules (Basel, Switzerland). vol 23. issue 1. 2018-08-03. PMID:29346317. |
we have now prepared liposomal tricurin (trlp) and demonstrated that trlp boosts activated p53 in cultured gl261 mouse gbm cells to trigger apoptosis of gbm and gbm stem cells in vitro. |
2018-08-03 |
2023-08-13 |
mouse |
| Bartosz Wawrzynow, Alicja Zylicz, Maciej Zylic. Chaperoning the guardian of the genome. The two-faced role of molecular chaperones in p53 tumor suppressor action. Biochimica et biophysica acta. Reviews on cancer. vol 1869. issue 2. 2018-07-30. PMID:29355591. |
on the molecular level, heat shock proteins by unwinding the mutant p53 protein expose aggregation-prone sites leading to the sequestration of other tumor suppressor proteins causing inhibition of apoptosis and chemoresistance. |
2018-07-30 |
2023-08-13 |
Not clear |
| Yu-Ling Ni, Chang-Heng Hsieh, Jing-Ping Wang, Kang Fan. Teroxirone motivates apoptotic death in tumorspheres of human lung cancer cells. Chemico-biological interactions. vol 291. 2018-07-27. PMID:29908167. |
the current study further affirmed that teroxirone inhibited the propagation of cscs as enriched from nsclc cells by inducing p53 that lead to ultimate apoptosis. |
2018-07-27 |
2023-08-13 |
human |
| Xiaoxu Li, Ruiyu Ding, Zewen Han, Zeyun Ma, Yixiang Wan. Targeting of cell cycle and let-7a/STAT3 pathway by niclosamide inhibits proliferation, migration and invasion in oral squamous cell carcinoma cells. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 96. 2018-07-26. PMID:29031202. |
we showed that niclosamide could inhibit oscc cells proliferation through causing cell cycle arrest in g1 phase and promoting apoptosis, while the cell cycle-related proteins mcm2, mcm7, cdk2 and cdk4 were downregulated and the apoptosis-related proteins p53 and cleaved caspase-3 were upregulated. |
2018-07-26 |
2023-08-13 |
Not clear |
| Batzaya Davaadelger, Ricardo E Perez, Yalu Zhou, Lei Duan, Steven Gitelis, Carl G Mak. The IGF-1R/AKT pathway has opposing effects on Nutlin-3a-induced apoptosis. Cancer biology & therapy. vol 18. issue 11. 2018-07-25. PMID:28696156. |
however, igf-1r and akt inhibitors also reduced p53 accumulation in nutlin-3a treated cells and increased autophagy flux, which we showed can promote apoptosis resistance. |
2018-07-25 |
2023-08-13 |
Not clear |
| Batzaya Davaadelger, Ricardo E Perez, Yalu Zhou, Lei Duan, Steven Gitelis, Carl G Mak. The IGF-1R/AKT pathway has opposing effects on Nutlin-3a-induced apoptosis. Cancer biology & therapy. vol 18. issue 11. 2018-07-25. PMID:28696156. |
second, it can enhance nutlin-3a induced apoptosis through a combination of maintaining p53 levels and inhibiting pro-survival autophagy. |
2018-07-25 |
2023-08-13 |
Not clear |
| Yating Zhang, Guoliang Li, Yizhou Zhong, Manqi Huang, Jiejiao Wu, Jiewei Zheng, Weifeng Rong, Lihai Zeng, Xiao Yin, Fengrong Lu, Zhiwei Xie, Dandan Xu, Qiming Fan, Xiaohui Jia, Ting Wang, Qiansheng Hu, Wen Chen, Qing Wang, Zhenlie Huan. 1,2-Dichloroethane Induces Reproductive Toxicity Mediated by the CREM/CREB Signaling Pathway in Male NIH Swiss Mice. Toxicological sciences : an official journal of the Society of Toxicology. vol 160. issue 2. 2018-07-25. PMID:28973639. |
moreover, the activation of p53 and bax with the inhibition of bcl-2 might be the reason for the upregulation of caspase-3 in the apoptosis, as detected by tdt-mediated dutp nick-end labeling assay in the testes induced by 1,2-dce. |
2018-07-25 |
2023-08-13 |
mouse |
| Yating Zhang, Guoliang Li, Yizhou Zhong, Manqi Huang, Jiejiao Wu, Jiewei Zheng, Weifeng Rong, Lihai Zeng, Xiao Yin, Fengrong Lu, Zhiwei Xie, Dandan Xu, Qiming Fan, Xiaohui Jia, Ting Wang, Qiansheng Hu, Wen Chen, Qing Wang, Zhenlie Huan. 1,2-Dichloroethane Induces Reproductive Toxicity Mediated by the CREM/CREB Signaling Pathway in Male NIH Swiss Mice. Toxicological sciences : an official journal of the Society of Toxicology. vol 160. issue 2. 2018-07-25. PMID:28973639. |
these findings suggest that 1,2-dce inhibits crem/creb signaling cascade and subsequently induces apoptosis associated with p53 activation and mitochondrial dysfunction. |
2018-07-25 |
2023-08-13 |
mouse |
| Bassem Y Sheikh, Md Moklesur Rahman Sarker, Muhamad Noor Alfarizal Kamarudin, Gokula Moha. Antiproliferative and apoptosis inducing effects of citral via p53 and ROS-induced mitochondrial-mediated apoptosis in human colorectal HCT116 and HT29 cell lines. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 96. 2018-07-25. PMID:29078261. |
antiproliferative and apoptosis inducing effects of citral via p53 and ros-induced mitochondrial-mediated apoptosis in human colorectal hct116 and ht29 cell lines. |
2018-07-25 |
2023-08-13 |
human |
| Bassem Y Sheikh, Md Moklesur Rahman Sarker, Muhamad Noor Alfarizal Kamarudin, Gokula Moha. Antiproliferative and apoptosis inducing effects of citral via p53 and ROS-induced mitochondrial-mediated apoptosis in human colorectal HCT116 and HT29 cell lines. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 96. 2018-07-25. PMID:29078261. |
collectively, our data suggest that citral induced p53 and ros-mediated mitochondrial-mediated apoptosis in human colorectal cancer hct116 and ht29 cells. |
2018-07-25 |
2023-08-13 |
human |
| Mingming Fan, Jun Shen, Hu Liu, Zhijian Wen, Jue Yang, Pinghua Yang, Kai Liu, Yanxin Chang, Jicheng Duan, Kai L. Downregulation of PRRX1 via the p53-dependent signaling pathway predicts poor prognosis in hepatocellular carcinoma. Oncology reports. vol 38. issue 2. 2018-07-23. PMID:28677793. |
furthermore, the loss of prrx1 inhibits hepatocellular carcinoma (hcc) cell apoptosis, an anti-apoptotic expression profile was upregulated accompanied by downregulated expression of p53. |
2018-07-23 |
2023-08-13 |
Not clear |
| Li Wan, Lin Zhang, Kai Fan, Jianjun Wan. Aloin promotes A549 cell apoptosis via the reactive oxygen species‑mitogen activated protein kinase signaling pathway and p53 phosphorylation. Molecular medicine reports. vol 16. issue 5. 2018-07-23. PMID:28901386. |
aloin promotes a549 cell apoptosis via the reactive oxygen species‑mitogen activated protein kinase signaling pathway and p53 phosphorylation. |
2018-07-23 |
2023-08-13 |
mouse |
| Li Wan, Lin Zhang, Kai Fan, Jianjun Wan. Aloin promotes A549 cell apoptosis via the reactive oxygen species‑mitogen activated protein kinase signaling pathway and p53 phosphorylation. Molecular medicine reports. vol 16. issue 5. 2018-07-23. PMID:28901386. |
the results demonstrated that 200, 300 and 400 µm aloin induced intrinsic cell apoptosis, which was further confirmed by disruption of the mitochondrial membrane potential, elevation of cytosolic ca2+ levels, and activation of b‑cell lymphoma 2 (bcl‑2) homologous antagonist killer, bcl‑2 x‑associated protein, p53 upregulated modulator of apoptosis and phorbol‑12‑myristate‑13‑acetate‑induced protein 1. |
2018-07-23 |
2023-08-13 |
mouse |
| Li Wan, Lin Zhang, Kai Fan, Jianjun Wan. Aloin promotes A549 cell apoptosis via the reactive oxygen species‑mitogen activated protein kinase signaling pathway and p53 phosphorylation. Molecular medicine reports. vol 16. issue 5. 2018-07-23. PMID:28901386. |
aloin‑induced apoptosis was also accompanied by the induction of p53 phosphorylation on serine (ser)15, threonine 18, ser20 and ser392; however, there were no significant differences in the expression of p53 and mouse double minute 2 homolog. |
2018-07-23 |
2023-08-13 |
mouse |
| Li Wan, Lin Zhang, Kai Fan, Jianjun Wan. Aloin promotes A549 cell apoptosis via the reactive oxygen species‑mitogen activated protein kinase signaling pathway and p53 phosphorylation. Molecular medicine reports. vol 16. issue 5. 2018-07-23. PMID:28901386. |
in conclusion, these results suggested that aloin may induce apoptosis in a549 cells via the ros‑mitogen activated protein kinase signaling pathway, with p53 phosphorylation. |
2018-07-23 |
2023-08-13 |
mouse |
| Tingting Wang, Youxun Liu, Yun Fu, Tengfei Huang, Yun Yang, Shaoshan Li, Changzheng L. Antiproliferative activity of di-2-pyridylhydrazone dithiocarbamate acetate partly involved in p53 mediated apoptosis and autophagy. International journal of oncology. vol 51. issue 6. 2018-07-23. PMID:29039462. |
antiproliferative activity of di-2-pyridylhydrazone dithiocarbamate acetate partly involved in p53 mediated apoptosis and autophagy. |
2018-07-23 |
2023-08-13 |
Not clear |
| Tingting Wang, Youxun Liu, Yun Fu, Tengfei Huang, Yun Yang, Shaoshan Li, Changzheng L. Antiproliferative activity of di-2-pyridylhydrazone dithiocarbamate acetate partly involved in p53 mediated apoptosis and autophagy. International journal of oncology. vol 51. issue 6. 2018-07-23. PMID:29039462. |
western blotting demonstrated that dpdtaa could upregulate p53 via down-regulating the mdm2, accordingly leading to changes of bcl family proteins, indicating that a p53-dependent intrinsic apoptosis was partly involved. |
2018-07-23 |
2023-08-13 |
Not clear |