| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Saman Khan, Atif Zafar, Imrana Nasee. Copper-redox cycling by coumarin-di(2-picolyl)amine hybrid molecule leads to ROS-mediated DNA damage and apoptosis: A mechanism for cancer chemoprevention. Chemico-biological interactions. vol 290. 2018-07-05. PMID:29803612. |
results showed that ligand-l-cu(ii) interaction leads to ros generation, lipid peroxidation/protein carbonylation (oxidative stress parameters), dna damage, up-regulation of p53 and mitochondrial-mediated apoptosis in treated lymphocytes. |
2018-07-05 |
2023-08-13 |
Not clear |
| Shaowei Qiu, Shuang Liu, Tengteng Yu, Jing Yu, Min Wang, Qing Rao, Haiyan Xing, Kejing Tang, Yinchang Mi, Jianxiang Wan. Sertad1 antagonizes iASPP function by hindering its entrance into nuclei to interact with P53 in leukemic cells. BMC cancer. vol 17. issue 1. 2018-07-03. PMID:29179704. |
as the important suppressor of p53, iaspp is found to be overexpressed in leukemia, and functions as oncogene that inhibited apoptosis of leukemia cells. |
2018-07-03 |
2023-08-13 |
Not clear |
| Dengqiang Lin, Li Meng, Feifei Xu, Jianpo Lian, Yunze Xu, Xin Xie, Xiaojing Wang, Hongchao He, Chenghe Wang, Yu Zh. Enhanced wild-type p53 expression by small activating RNA dsP53-285 induces cell cycle arrest and apoptosis in pheochromocytoma cell line PC12. Oncology reports. vol 38. issue 5. 2018-07-02. PMID:29048679. |
enhanced wild-type p53 expression by small activating rna dsp53-285 induces cell cycle arrest and apoptosis in pheochromocytoma cell line pc12. |
2018-07-02 |
2023-08-13 |
Not clear |
| Dengqiang Lin, Li Meng, Feifei Xu, Jianpo Lian, Yunze Xu, Xin Xie, Xiaojing Wang, Hongchao He, Chenghe Wang, Yu Zh. Enhanced wild-type p53 expression by small activating RNA dsP53-285 induces cell cycle arrest and apoptosis in pheochromocytoma cell line PC12. Oncology reports. vol 38. issue 5. 2018-07-02. PMID:29048679. |
we found that the upregulation of wild-type p53 blocked the transition of pc12 cells from the g0/g1 to the s phase, with induction of apoptosis. |
2018-07-02 |
2023-08-13 |
Not clear |
| Kuan Hu, Feng Yin, Mengyin Yu, Chengjie Sun, Jingxu Li, Yujie Liang, Wenjun Li, Mingsheng Xie, Yuanzhi Lao, Wei Liang, Zi-Gang L. In-Tether Chiral Center Induced Helical Peptide Modulators Target p53-MDM2/MDMX and Inhibit Tumor Growth in Stem-Like Cancer Cell. Theranostics. vol 7. issue 18. 2018-07-02. PMID:29158845. |
the activation of p53 inhibits cell proliferation and induces apoptosis in both the mcf-7 normal tumor cell line and the pa-1 pluripotent cancer cell line with only minimal cellular toxicity towards normal cells or cancer cell lines with p53 mutations. |
2018-07-02 |
2023-08-13 |
Not clear |
| Matthew S Dai, Susan J Hall, Marguerite M Vantangoli Policelli, Kim Boekelheide, Daniel J Spad. Spontaneous testicular atrophy occurs despite normal spermatogonial proliferation in a Tp53 knockout rat. Andrology. vol 5. issue 6. 2018-06-29. PMID:28834365. |
the tumor suppressor protein p53 (tp53) has many functions in cell cycle regulation, apoptosis, and dna damage repair and is also involved in spermatogenesis in the mouse. |
2018-06-29 |
2023-08-13 |
mouse |
| Weitao Tang, Kuiran Dong, Kai Li, Rui Dong, Shan Zhen. MEG3, HCN3 and linc01105 influence the proliferation and apoptosis of neuroblastoma cells via the HIF-1α and p53 pathways. Scientific reports. vol 6. 2018-06-28. PMID:27824082. |
meg3, hcn3 and linc01105 influence the proliferation and apoptosis of neuroblastoma cells via the hif-1α and p53 pathways. |
2018-06-28 |
2023-08-13 |
Not clear |
| LiLi Wang, Rodney F Minchin, Neville J Butche. Arylamine N-acetyltransferase 1 protects against reactive oxygen species during glucose starvation: Role in the regulation of p53 stability. PloS one. vol 13. issue 3. 2018-06-28. PMID:29518119. |
when p53 expression was inhibited with sirna in parental ht-29 cells, ros production and apoptosis increased to levels seen in the nat1 knockout cells. |
2018-06-28 |
2023-08-13 |
human |
| B O Yilmaz, N Yildizbayrak, Y Aydin, M Erka. Evidence of acrylamide- and glycidamide-induced oxidative stress and apoptosis in Leydig and Sertoli cells. Human & experimental toxicology. vol 36. issue 12. 2018-06-27. PMID:28067054. |
the present experiment was conducted to investigate the effect of oxidative stress on the apoptosis of mouse leydig (tm3) and sertoli (tm4) cells induced by aa and its metabolite ga. tm3 and tm4 cells were exposed to aa (10 µm and 1 mm) and ga (1 µm and 0.5 mm) for 24 h. following the exposure time, the leydig and sertoli cells were evaluated for measurement of cell viability, lactate dehydrogenase activity, lipid peroxidation and hydrogen peroxide levels, apoptosis/necrosis rate, and mrna expression levels of apoptotic genes (caspase3, bcl-2, bax, and p53). |
2018-06-27 |
2023-08-13 |
mouse |
| Kohei Kitami, Megumi Kitami, Masaru Kaku, Bin Wang, Yoshihiro Komats. BRCA1 and BRCA2 tumor suppressors in neural crest cells are essential for craniofacial bone development. PLoS genetics. vol 14. issue 5. 2018-06-26. PMID:29718910. |
importantly, the craniofacial skeletal defects were sufficiently rescued by superimposing p53 null alleles in a neural crest-specific manner in vivo, indicating that brca1 deficiency induced dna damage, cell apoptosis, and that the pathogenesis of craniofacial bone defects can be compensated by inactivation of p53. |
2018-06-26 |
2023-08-13 |
mouse |
| Linlin Wang, Shanshan Lin, Deqing Yi, Yun Huang, Caiyun Wang, Lei Jin, Jufen Liu, Yali Zhang, Aiguo Re. Apoptosis, Expression of PAX3 and P53, and Caspase Signal in Fetuses with Neural Tube Defects. Birth defects research. vol 109. issue 19. 2018-06-25. PMID:28786179. |
apoptosis, expression of pax3 and p53, and caspase signal in fetuses with neural tube defects. |
2018-06-25 |
2023-08-13 |
human |
| Cong Qian, Jianxiang Jin, Jingyin Chen, Jianru Li, Xiaobo Yu, Hangbo Mo, Gao Che. SIRT1 activation by resveratrol reduces brain edema and neuronal apoptosis in an experimental rat subarachnoid hemorrhage model. Molecular medicine reports. vol 16. issue 6. 2018-06-22. PMID:29039533. |
sirtuin 1 (sirt1) was reported to be involved in apoptosis in cerebral ischemia and brain tumor formation through p53 deacetylation. |
2018-06-22 |
2023-08-13 |
rat |
| Cong Qian, Jianxiang Jin, Jingyin Chen, Jianru Li, Xiaobo Yu, Hangbo Mo, Gao Che. SIRT1 activation by resveratrol reduces brain edema and neuronal apoptosis in an experimental rat subarachnoid hemorrhage model. Molecular medicine reports. vol 16. issue 6. 2018-06-22. PMID:29039533. |
proteins associated with the blood brain barrier (bbb), apoptosis and sirt1 in the cortex, such as zona occludens 1 (zo‑1), occludin, claudin‑5, sirt1, p53 and cleaved caspase3 were investigated. |
2018-06-22 |
2023-08-13 |
rat |
| Cong Qian, Jianxiang Jin, Jingyin Chen, Jianru Li, Xiaobo Yu, Hangbo Mo, Gao Che. SIRT1 activation by resveratrol reduces brain edema and neuronal apoptosis in an experimental rat subarachnoid hemorrhage model. Molecular medicine reports. vol 16. issue 6. 2018-06-22. PMID:29039533. |
mrna expression of the p53 downstream molecules including bcl‑associated x protein, p53 upregulated modulator of apoptosis, noxa and bh3 interacting‑domain death agonist were also investigated. |
2018-06-22 |
2023-08-13 |
rat |
| Cong Qian, Jianxiang Jin, Jingyin Chen, Jianru Li, Xiaobo Yu, Hangbo Mo, Gao Che. SIRT1 activation by resveratrol reduces brain edema and neuronal apoptosis in an experimental rat subarachnoid hemorrhage model. Molecular medicine reports. vol 16. issue 6. 2018-06-22. PMID:29039533. |
sirt1 may also affect apoptosis post‑sah through p53 deacetylation, and the analysis of p53 related downstream pro‑apoptotic molecules supported this hypothesis. |
2018-06-22 |
2023-08-13 |
rat |
| Ting Zhao, Jun Bai, Qingyun Zou, Feng Chen, Yan Xi. Insulin in combination with cisplatin induces the apoptosis of ovarian cancer cells via p53 and JNK activation. Molecular medicine reports. vol 16. issue 6. 2018-06-22. PMID:29039558. |
insulin in combination with cisplatin induces the apoptosis of ovarian cancer cells via p53 and jnk activation. |
2018-06-22 |
2023-08-13 |
Not clear |
| Ting Zhao, Jun Bai, Qingyun Zou, Feng Chen, Yan Xi. Insulin in combination with cisplatin induces the apoptosis of ovarian cancer cells via p53 and JNK activation. Molecular medicine reports. vol 16. issue 6. 2018-06-22. PMID:29039558. |
in conclusion, the combination of ins and ddp facilitated the apoptosis of a2780 cells, which may be associated with the activation of the jnk signaling pathway and consequently the involvement of p53 at both mrna and protein expression levels. |
2018-06-22 |
2023-08-13 |
Not clear |
| Narges Baghi, Babak Bakhshinejad, Reihaneh Keshavarz, Sadegh Babashah, Majid Sadeghizade. Dendrosomal nanocurcumin and exogenous p53 can act synergistically to elicit anticancer effects on breast cancer cells. Gene. vol 670. 2018-06-22. PMID:29753810. |
annexin-v/pi staining followed by flow cytometry and wound healing assay were used to evaluate the effects of dnc and exogenous p53, alone and in combination, on apoptosis induction and migratory capacity of mda-mb-231 cells, respectively. |
2018-06-22 |
2023-08-13 |
Not clear |
| Narges Baghi, Babak Bakhshinejad, Reihaneh Keshavarz, Sadegh Babashah, Majid Sadeghizade. Dendrosomal nanocurcumin and exogenous p53 can act synergistically to elicit anticancer effects on breast cancer cells. Gene. vol 670. 2018-06-22. PMID:29753810. |
apoptosis and wound healing assays indicated that combination treatment with dnc and exogenous p53 leads to significantly increased apoptosis and decreased migration of breast cancer cells, compared with single treatment. |
2018-06-22 |
2023-08-13 |
Not clear |
| Zi-Gang Zhen, Shao-Hua Ren, Hong-Ming Ji, Jiu-Hong Ma, Xin-Min Ding, Fu-Qiang Feng, Shing-Li Chen, Peng Zou, Jin-Rui Ren, Lu Ji. Linarin suppresses glioma through inhibition of NF-κB/p65 and up-regulating p53 expression in vitro and in vivo. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 95. 2018-06-19. PMID:28858735. |
linarin significantly triggered apoptosis as well as the tumor growth in animals, accompanied with p53 increase and p65 decrease. |
2018-06-19 |
2023-08-13 |
human |