| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hongmei Zhang, Xiaorong Yang, Huajun Zhang, Xin Li, Zhihong Zhang, Lifang Hou, Zemin Wang, Qiao Niu, Tong Wan. Neurotrophins and cholinergic enzyme regulated by calpain-2: New insights into neuronal apoptosis induced by polybrominated diphenyl ether-153. Toxicology letters. vol 291. 2018-05-23. PMID:29621559. |
results showed that the neuronal apoptosis induced by bde-153 was dependent on p53, and dependent on more calpain-2 than caspase-3 in the cerebral cortex of rats. |
2018-05-23 |
2023-08-13 |
rat |
| Durgesh Nandini Das, Prashanta Kumar Panda, Niharika Sinha, Subhadip Mukhopadhyay, Prajna Parimita Naik, Sujit K Bhuti. DNA damage by 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced p53-mediated apoptosis through activation of cytochrome P450/aryl hydrocarbon receptor. Environmental toxicology and pharmacology. vol 55. 2018-05-22. PMID:28886471. |
moreover, tcdd increased expression of p53 and puma and our data showed that tcdd induced dna damage followed by p53-mediated apoptosis. |
2018-05-22 |
2023-08-13 |
Not clear |
| Hanna Piotrowska-Kempisty, Marcin Ruciński, Sylwia Borys, Małgorzata Kucińska, Mariusz Kaczmarek, Piotr Zawierucha, Marcin Wierzchowski, Dawid Łażewski, Marek Murias, Jadwiga Jodynis-Lieber. 3'-hydroxy-3,4,5,4'-tetramethoxystilbene, the metabolite of resveratrol analogue DMU-212, inhibits ovarian cancer cell growth in vitro and in a mice xenograft model. Scientific reports. vol 6. 2018-05-21. PMID:27585955. |
we found that in skov-3 cells lacking p53, dmu-214 induced receptor-mediated apoptosis. |
2018-05-21 |
2023-08-13 |
mouse |
| Hanna Piotrowska-Kempisty, Marcin Ruciński, Sylwia Borys, Małgorzata Kucińska, Mariusz Kaczmarek, Piotr Zawierucha, Marcin Wierzchowski, Dawid Łażewski, Marek Murias, Jadwiga Jodynis-Lieber. 3'-hydroxy-3,4,5,4'-tetramethoxystilbene, the metabolite of resveratrol analogue DMU-212, inhibits ovarian cancer cell growth in vitro and in a mice xenograft model. Scientific reports. vol 6. 2018-05-21. PMID:27585955. |
in a-2780 cell line with expression of wild-type p53, dmu-214 modulated the expression pattern of p53-target genes driving intrinsic and extrinsic apoptosis pathways, as well as dna repair and damage prevention. |
2018-05-21 |
2023-08-13 |
mouse |
| Zhenghu Chen, Long Wang, Dayong Yao, Tianshu Yang, Wen-Ming Cao, Jun Dou, Jonathan C Pang, Shan Guan, Huiyuan Zhang, Yang Yu, Yanling Zhao, Yongfeng Wang, Xin Xu, Yan Shi, Roma Patel, Hong Zhang, Sanjeev A Vasudevan, Shangfeng Liu, Jianhua Yang, Jed G Nuchter. Wip1 inhibitor GSK2830371 inhibits neuroblastoma growth by inducing Chk2/p53-mediated apoptosis. Scientific reports. vol 6. 2018-05-21. PMID:27991505. |
taken together, this study suggests that gsk2830371 induces chk2/p53-mediated apoptosis both in vitro and in vivo in a p53 dependent manner. |
2018-05-21 |
2023-08-13 |
mouse |
| Xiaohong Yang, Rui Yang, Xianli Li, Xiaohui Zhen. Danshensu attenuates aldosterone-induced cardiomyocytes injury through interfering p53 pathway. Molecular medicine reports. vol 16. issue 4. 2018-05-21. PMID:28765913. |
further research indicated that dss‑ and cellular tumor antigen p53 (p53)‑alone or combination treatment was able to decrease the expression levels of apoptosis regulator bax and caspase‑3, and increase the expression of apoptosis regulator b‑cell lymphoma (bcl)‑2 in ald‑stimulated cardiomyocytes. |
2018-05-21 |
2023-08-13 |
Not clear |
| Qianqian Wang, Fei Lu, Rongfeng La. RNA-sequencing dissects the transcriptome of polyploid cancer cells that are resistant to combined treatments of cisplatin with paclitaxel and docetaxel. Molecular bioSystems. vol 13. issue 10. 2018-05-21. PMID:28825433. |
genes involved in the pathways of p53 signaling, lysosomes and apoptosis were up-regulated, and in contrast, genes in the cell cycle, dna replication, and mismatch repair pathways were down-regulated. |
2018-05-21 |
2023-08-13 |
Not clear |
| Bodo C Melni. p53: key conductor of all anti-acne therapies. Journal of translational medicine. vol 15. issue 1. 2018-05-21. PMID:28927457. |
p53 inhibits the expression of androgen receptor and igf-1 receptor, and induces the expression of igf binding protein 3. p53 induces foxo1, foxo3, p21 and sestrin 1, sestrin 2, and tumour necrosis factor-related apoptosis-inducing ligand (trail), the key inducer of isotretinoin-mediated sebocyte apoptosis explaining isotretinoin's sebum-suppressive effect. |
2018-05-21 |
2023-08-13 |
Not clear |
| Rabia Johnson, Samukelisiwe Shabalala, Johan Louw, Abidemi Paul Kappo, Christo John Frederick Mulle. Aspalathin Reverts Doxorubicin-Induced Cardiotoxicity through Increased Autophagy and Decreased Expression of p53/mTOR/p62 Signaling. Molecules (Basel, Switzerland). vol 22. issue 10. 2018-05-21. PMID:28937626. |
increasing evidence indicates that tumour protein p53 (p53), adenosine monophosphate-activated protein kinase (ampk), nucleoporin p62 (p62), and the mammalian target of rapamycin (mtor) are critical mediators of dox-induced apoptosis, and subsequent dysregulation of autophagy. |
2018-05-21 |
2023-08-13 |
Not clear |
| Michaela Angelika Ihle, Sebastian Huss, Wiebke Jeske, Wolfgang Hartmann, Sabine Merkelbach-Bruse, Hans-Ulrich Schildhaus, Reinhard Büttner, Harri Sihto, Kirsten Sundby Hall, Mikael Eriksson, Peter Reichardt, Heikki Joensuu, Eva Wardelman. Expression of cell cycle regulators and frequency of TP53 mutations in high risk gastrointestinal stromal tumors prior to adjuvant imatinib treatment. PloS one. vol 13. issue 2. 2018-05-21. PMID:29451912. |
320 primary tumor samples with available tumor tissue were immunohistochemically analyzed prior to treatment for the expression of cell cycle regulators and apoptosis modulators cyclin d1, p21, p16, cdk4, e2f1, mdm2, p53 and p-rb1. |
2018-05-21 |
2023-08-13 |
Not clear |
| Delphine Duteil, Yves Tourrette, Adrien Eberlin, Dominica Willmann, Dharmeshkumar Patel, Nicolaus Friedrichs, Judith M Müller, Roland Schül. The histone acetyltransferase inhibitor Nir regulates epidermis development. Development (Cambridge, England). vol 145. issue 6. 2018-05-21. PMID:29490983. |
cell proliferation is inhibited, whereas apoptosis and p53 acetylation are increased, indicating that nir is controlling cell proliferation by limiting p53 acetylation. |
2018-05-21 |
2023-08-13 |
Not clear |
| Lvfen Gao, Ming Chen, Yuan Ouyang, Ruobin Li, Xian Zhang, Xuesong Gao, Shaoqiang Lin, Xiaoyu Wan. Icaritin induces ovarian cancer cell apoptosis through activation of p53 and inhibition of Akt/mTOR pathway. Life sciences. vol 202. 2018-05-21. PMID:29625193. |
icaritin induces ovarian cancer cell apoptosis through activation of p53 and inhibition of akt/mtor pathway. |
2018-05-21 |
2023-08-13 |
Not clear |
| Ngoc Hoan Nguyen, Hyung Jun Park, Sang Sik Yang, Kyeong Sook Choi, Jong-Soo Le. Anti-cancer efficacy of nonthermal plasma dissolved in a liquid, liquid plasma in heterogeneous cancer cells. Scientific reports. vol 6. 2018-05-18. PMID:27364630. |
here, we show that treatment with nonthermal atmospheric-pressure plasma dissolved in a liquid (liquid plasma) induces oxidative stress in heterogeneous populations of cancer cells and ultimately kills these cells via apoptosis, regardless of genetic status, e.g., mutations in p53 and other dna-damage-response genes. |
2018-05-18 |
2023-08-13 |
Not clear |
| Lu Gong, Xiao Pan, Haide Chen, Lingjun Rao, Yelin Zeng, Honghui Hang, Jinrong Peng, Lei Xiao, Jun Che. p53 isoform Δ133p53 promotes efficiency of induced pluripotent stem cells and ensures genomic integrity during reprogramming. Scientific reports. vol 6. 2018-05-18. PMID:27874035. |
dna damage response can trigger tumor suppressor p53 activation, which ensures genome integrity of reprogramming cells by inducing apoptosis and senescence. |
2018-05-18 |
2023-08-13 |
human |
| Lu Gong, Xiao Pan, Haide Chen, Lingjun Rao, Yelin Zeng, Honghui Hang, Jinrong Peng, Lei Xiao, Jun Che. p53 isoform Δ133p53 promotes efficiency of induced pluripotent stem cells and ensures genomic integrity during reprogramming. Scientific reports. vol 6. 2018-05-18. PMID:27874035. |
p53 isoform Δ133p53 is a p53 target gene and functions to not only antagonize p53 mediated apoptosis, but also promote dna double-strand break (dsb) repair. |
2018-05-18 |
2023-08-13 |
human |
| Homa Mollaei, Reza Safaralizadeh, Esmaeil Babaei, Mohamad Reza Abedini, Reyhane Hoshya. The anti-proliferative and apoptotic effects of crocin on chemosensitive and chemoresistant cervical cancer cells. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 94. 2018-05-18. PMID:28763753. |
moreover, the genetic mechanism of crocin-induced apoptosis was accomplished by studying the relative expressions of p53, bax, bcl2 and mir-365, an upstream regulator of the last two ones. |
2018-05-18 |
2023-08-13 |
human |
| Kai Liu, Xinke Zhao, Jing Gu, Jianjun Wu, Hong Zhang, Yingdong L. Effects of 12C6+ heavy ion beam irradiation on the p53 signaling pathway in HepG2 liver cancer cells. Acta biochimica et biophysica Sinica. vol 49. issue 11. 2018-05-18. PMID:29036263. |
the p53 tumor suppressor gene senses dna damage and transducts intracellular apoptosis signals. |
2018-05-18 |
2023-08-13 |
human |
| Kai Liu, Xinke Zhao, Jing Gu, Jianjun Wu, Hong Zhang, Yingdong L. Effects of 12C6+ heavy ion beam irradiation on the p53 signaling pathway in HepG2 liver cancer cells. Acta biochimica et biophysica Sinica. vol 49. issue 11. 2018-05-18. PMID:29036263. |
in order to explore whether the intrinsic or extrinsic pathway participates this process, hepg2 cells were treated with 12c6+ hib irradiation at doses of 0 (control), 1, 2, 4, and 6 gy with various methods employed to understand relevant mechanisms, such as detection of apoptosis, cell cycle, and fas expression by flow cytometry, analysis of apoptotic morphology by electron microscopy and laser scanning confocal microscopy, and screening differentially expressed genes relating to p53 signaling pathway by pcr-array assay following with any genes confirmed by western blot analysis. |
2018-05-18 |
2023-08-13 |
human |
| Kai Liu, Xinke Zhao, Jing Gu, Jianjun Wu, Hong Zhang, Yingdong L. Effects of 12C6+ heavy ion beam irradiation on the p53 signaling pathway in HepG2 liver cancer cells. Acta biochimica et biophysica Sinica. vol 49. issue 11. 2018-05-18. PMID:29036263. |
differentially expressed genes in the p53 signaling pathway related to dna damage repair, apoptosis, cycle regulation, metastasis, deterioration and radioresistance were also discovered. |
2018-05-18 |
2023-08-13 |
human |
| Kai Liu, Xinke Zhao, Jing Gu, Jianjun Wu, Hong Zhang, Yingdong L. Effects of 12C6+ heavy ion beam irradiation on the p53 signaling pathway in HepG2 liver cancer cells. Acta biochimica et biophysica Sinica. vol 49. issue 11. 2018-05-18. PMID:29036263. |
in conclusion, this study demonstrated the mechanisms of inhibition and apoptosis induced by 12c6+ heavy ion beam irradiation on hepg2 cancer cells is mediated by initiation of the biological function of p53 signaling pathway including extrinsic and intrinsic apoptosis pathway. |
2018-05-18 |
2023-08-13 |
human |