| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Qiuguo Han, Xin Xu, Jing Li, Jinggang Wang, Li Bai, Aihong Wang, Wei Wang, Bo Zhan. GATA4 is highly expressed in childhood acute lymphoblastic leukemia, promotes cell proliferation and inhibits apoptosis by activating BCL2 and MDM2. Molecular medicine reports. vol 16. issue 5. 2018-06-08. PMID:28849107. |
in addition, gata4 was revealed to regulate p53 through the transcriptional activation of mdm2, subsequently influencing cell cycle and apoptosis. |
2018-06-08 |
2023-08-13 |
mouse |
| Guo-Dong Yao, Jing Yang, Xiu-Xiu Li, Xiao-Yu Song, Toshihiko Hayashi, Shin-Ichi Tashiro, Satoshi Onodera, Shao-Jiang Song, Takashi Ikejim. Blocking the utilization of glucose induces the switch from senescence to apoptosis in pseudolaric acid B-treated human lung cancer cells in vitro. Acta pharmacologica Sinica. vol 38. issue 10. 2018-06-07. PMID:28649131. |
our previous study showed that pab mainly induced senescence via p53-p21 activation rather than apoptosis in suppression of the growth of human lung cancer a549 cells (p53 wild-type). |
2018-06-07 |
2023-08-13 |
human |
| Guo-Dong Yao, Jing Yang, Xiu-Xiu Li, Xiao-Yu Song, Toshihiko Hayashi, Shin-Ichi Tashiro, Satoshi Onodera, Shao-Jiang Song, Takashi Ikejim. Blocking the utilization of glucose induces the switch from senescence to apoptosis in pseudolaric acid B-treated human lung cancer cells in vitro. Acta pharmacologica Sinica. vol 38. issue 10. 2018-06-07. PMID:28649131. |
in p53 wild-type a549 cells, pab (20 μmol/l) caused senescence, and time-dependently increased glucose utilization; knockdown of p53 or p21 significantly decreased the uptake and metabolism of glucose but elevated pab-induced apoptosis. |
2018-06-07 |
2023-08-13 |
human |
| Guo-Dong Yao, Jing Yang, Xiu-Xiu Li, Xiao-Yu Song, Toshihiko Hayashi, Shin-Ichi Tashiro, Satoshi Onodera, Shao-Jiang Song, Takashi Ikejim. Blocking the utilization of glucose induces the switch from senescence to apoptosis in pseudolaric acid B-treated human lung cancer cells in vitro. Acta pharmacologica Sinica. vol 38. issue 10. 2018-06-07. PMID:28649131. |
thus, blocking glucose utilization contributes to the switch from senescence to apoptosis, and p53 plays an important role in this process. |
2018-06-07 |
2023-08-13 |
human |
| Carolina Sánchez-Rodríguez, Keyliz Peraza Cruces, Juan Riestra Ayora, Eduardo Martín-Sanz, Ricardo Sanz-Fernánde. BCG immune activation reduces growth and angiogenesis in an in vitro model of head and neck squamous cell carcinoma. Vaccine. vol 35. issue 47. 2018-06-06. PMID:29029943. |
in addition, coculture with bcg-activated pbmcs reduced fadu proliferation and increased cytotoxicity and apoptosis in parallel with an increase in caspase-3 activity and p53 expression. |
2018-06-06 |
2023-08-13 |
human |
| Riajul Wahab, Vinod Gopalan, Farhadul Islam, Robert A Smith, Bin Qiao, Alfred K La. Cellular expression, in-vitro and in-vivo confirmation of GAEC1 oncogenic properties in colon cancer. European journal of cell biology. vol 96. issue 6. 2018-06-05. PMID:28764863. |
the transient knockdown of gaec1 using sirna induced apoptosis in sw480 and sw48 cells, which was associated with g2/m phase arrest and decreased expression of bcl-2 and k-ras proteins and increased expression of p53. |
2018-06-05 |
2023-08-13 |
mouse |
| Ting Ma, Bo-Yi Fan, Chao Zhang, Hui-Jun Zhao, Chao Han, Cai-Yun Gao, Jian-Guang Luo, Ling-Yi Kon. Metabonomics applied in exploring the antitumour mechanism of physapubenolide on hepatocellular carcinoma cells by targeting glycolysis through the Akt-p53 pathway. Scientific reports. vol 6. 2018-06-04. PMID:27416811. |
furthermore, the increased level of p53 and decreased expression of p-akt were observed, and the attenuated glycolysis and enhanced apoptosis were reversed in the presence of akt cdna or p53 sirna. |
2018-06-04 |
2023-08-13 |
Not clear |
| Pallab Ray, Deblina Guha, Juni Chakraborty, Shuvomoy Banerjee, Arghya Adhikary, Samik Chakraborty, Tanya Das, Gaurisankar S. Crocetin exploits p53-induced death domain (PIDD) and FAS-associated death domain (FADD) proteins to induce apoptosis in colorectal cancer. Scientific reports. vol 6. 2018-06-04. PMID:27622714. |
here we have shown the effectiveness of crocetin, a dietary component, in inducing apoptosis of colon cancer cells with varying p53 status. |
2018-06-04 |
2023-08-13 |
Not clear |
| Zhiying Liu, Yunjin Zang, Luxin Qiao, Kai Liu, Yabo Ouyang, Yulin Zhang, Dexi Che. ASPP2 involvement in p53-mediated HIV-1 envelope glycoprotein gp120 neurotoxicity in mice cerebrocortical neurons. Scientific reports. vol 6. 2018-06-04. PMID:27625111. |
apoptosis-stimulating protein 2 of p53 (aspp2) is a damage-inducible p53-binding protein that stimulates p53-mediated apoptosis and transactivates proapoptotic and cell cycle regulatory genes. |
2018-06-04 |
2023-08-13 |
mouse |
| Tian Feng, Libin Wang, Nan Zhou, Chang Liu, Jiahui Cui, Rangxin Wu, Juan Jing, Shengyong Zhang, Hui Chen, Siwang Wan. Salidroside, a scavenger of ROS, enhances the radioprotective effect of Ex-RAD® via a p53-dependent apoptotic pathway. Oncology reports. vol 38. issue 5. 2018-06-04. PMID:28901519. |
sal downregulated the expression of bax and p53 and increased the ratio of bcl-2/bax, which indicated that sal inhibited the radiation-induced apoptosis through p53-dependent pathways. |
2018-06-04 |
2023-08-13 |
mouse |
| Juan Wang, Huiling Li, Shuangfa Qiu, Zheng Dong, Xudong Xiang, Dongshan Zhan. MBD2 upregulates miR-301a-5p to induce kidney cell apoptosis during vancomycin-induced AKI. Cell death & disease. vol 8. issue 10. 2018-06-04. PMID:29022913. |
furthermore, anti-mir-301a-5p significantly blocked van-induced apoptosis and caspase activity in hk-2 cells, which was accompanied by downregulation of p53, and upregulation of mitf, hdgf and mdm-4 together. |
2018-06-04 |
2023-08-13 |
mouse |
| Tulika Kakati, Hirak Kashyap, Dhruba K Bhattacharyy. THD-Module Extractor: An Application for CEN Module Extraction and Interesting Gene Identification for Alzheimer's Disease. Scientific reports. vol 6. 2018-05-30. PMID:27901073. |
the biological pathways associated with alzheimer's disease, such as, wnt signaling, apoptosis, p53 signaling, and notch signaling, incorporate these interesting genes. |
2018-05-30 |
2023-08-13 |
Not clear |
| Derek A Franklin, Yizhou He, Patrick L Leslie, Andrey P Tikunov, Nick Fenger, Jeffrey M Macdonald, Yanping Zhan. p53 coordinates DNA repair with nucleotide synthesis by suppressing PFKFB3 expression and promoting the pentose phosphate pathway. Scientific reports. vol 6. 2018-05-30. PMID:27901115. |
although previous studies have emphasized the importance of p53-dependent cell cycle arrest and apoptosis for tumor suppression, recent studies have suggested that other areas of p53 regulation, such as metabolism and dna damage repair (ddr), are also essential for p53-dependent tumor suppression. |
2018-05-30 |
2023-08-13 |
Not clear |
| Annapina Russo, Assunta Saide, Roberta Cagliani, Monica Cantile, Gerardo Botti, Giulia Russ. rpL3 promotes the apoptosis of p53 mutated lung cancer cells by down-regulating CBS and NFκB upon 5-FU treatment. Scientific reports. vol 6. 2018-05-30. PMID:27924828. |
rpl3 promotes the apoptosis of p53 mutated lung cancer cells by down-regulating cbs and nfκb upon 5-fu treatment. |
2018-05-30 |
2023-08-13 |
human |
| Nian Wang, Fen Zhang, Liu Yang, Jiang Zou, Hao Wang, Ke Liu, Meidong Liu, Huali Zhang, Xianzhong Xiao, Kangkai Wan. Resveratrol protects against L-arginine-induced acute necrotizing pancreatitis in mice by enhancing SIRT1-mediated deacetylation of p53 and heat shock factor 1. International journal of molecular medicine. vol 40. issue 2. 2018-05-30. PMID:28586010. |
mice with anp showed increased apoptosis of pancreatic acinar cells, pancreatic myeloperoxidase activity, serum lactate dehydrogenase activity, amylase, tumor necrosis factor-α (tnf-α), interleukin-6 (il-6) levels as well as decreased serum il-10 level, pancreatic expression of heat shock factor 1 (hsf1), sirtuin 1 (sirt1) and p53, but the ratio of acetylated hsf1 and p53 was markedly increased. |
2018-05-30 |
2023-08-13 |
mouse |
| Colby Richardson, Shengliang Zhang, Liz J Hernandez Borrero, Wafik S El-Deir. Small-molecule CB002 restores p53 pathway signaling and represses colorectal cancer cell growth. Cell cycle (Georgetown, Tex.). vol 16. issue 18. 2018-05-30. PMID:28749206. |
a decrease of mutant p53 protein expression, restoration of inactivated p53, or some activation of p73 are candidate mechanisms this agent could cause tumor cell apoptosis and growth arrest. |
2018-05-30 |
2023-08-13 |
human |
| Csaba Tóth, Farkas Sükösd, Erzsébet Valicsek, Esther Herpel, Peter Schirmacher, Marcus Renner, Christoph Mader, László Tiszlavicz, Jörg Kriegsman. Expression of ERCC1, RRM1, TUBB3 in correlation with apoptosis repressor ARC, DNA mismatch repair proteins and p53 in liver metastasis of colorectal cancer. International journal of molecular medicine. vol 40. issue 5. 2018-05-30. PMID:28949378. |
expression of ercc1, rrm1, tubb3 in correlation with apoptosis repressor arc, dna mismatch repair proteins and p53 in liver metastasis of colorectal cancer. |
2018-05-30 |
2023-08-13 |
Not clear |
| Csaba Tóth, Farkas Sükösd, Erzsébet Valicsek, Esther Herpel, Peter Schirmacher, Marcus Renner, Christoph Mader, László Tiszlavicz, Jörg Kriegsman. Expression of ERCC1, RRM1, TUBB3 in correlation with apoptosis repressor ARC, DNA mismatch repair proteins and p53 in liver metastasis of colorectal cancer. International journal of molecular medicine. vol 40. issue 5. 2018-05-30. PMID:28949378. |
in statistical analysis, we compared the expression of ercc1, rrm1 and tubb3 to mismatch proteins (mlh1, msh2, msh6 and pms2), p53 and to apoptosis repressor protein (arc). |
2018-05-30 |
2023-08-13 |
Not clear |
| Leslie Calapre, Elin S Gray, Sandrine Kurdykowski, Anthony David, Pascal Descargues, Mel Zima. SIRT1 activation mediates heat-induced survival of UVB damaged Keratinocytes. BMC dermatology. vol 17. issue 1. 2018-05-23. PMID:28601088. |
this heat-mediated evasion of apoptosis appears to be mediated by activation of sirt1 and inactivation of p53 signalling. |
2018-05-23 |
2023-08-13 |
human |
| b' Jarmila Her\\xc5\\xafdkov\\xc3\\xa1, Kamil Paruch, Prashant Khirsariya, Karel Sou\\xc4\\x8dek, Martin Krko\\xc5\\xa1ka, Olga Vond\\xc3\\xa1lov\\xc3\\xa1 Blan\\xc3\\xa1\\xc5\\x99ov\\xc3\\xa1, Petr Sova, Alois Kozub\\xc3\\xadk, Alena Hyr\\xc5\\xa1lov\\xc3\\xa1 Vaculov\\xc3\\xa. Chk1 Inhibitor SCH900776 Effectively Potentiates the Cytotoxic Effects of Platinum-Based Chemotherapeutic Drugs in Human Colon Cancer Cells. Neoplasia (New York, N.Y.). vol 19. issue 10. 2018-05-23. PMID:28888100.' |
while the cell death induced by sch900776 and cisplatin or la-12 is significantly delayed in the absence of p53, the anticancer action of the drug combinations is significantly accelerated in p21-deficient cells, which is associated with stimulation of apoptosis beyond g2/m cell cycle phase. |
2018-05-23 |
2023-08-13 |
human |