| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Cédric Castrogiovanni, Béranger Waterschoot, Olivier De Backer, Patrick Dumon. Serine 392 phosphorylation modulates p53 mitochondrial translocation and transcription-independent apoptosis. Cell death and differentiation. vol 25. issue 1. 2018-07-16. PMID:28937686. |
the tumor suppressor p53 is a key regulator of apoptosis induced by various cellular stresses. |
2018-07-16 |
2023-08-13 |
Not clear |
| Cédric Castrogiovanni, Béranger Waterschoot, Olivier De Backer, Patrick Dumon. Serine 392 phosphorylation modulates p53 mitochondrial translocation and transcription-independent apoptosis. Cell death and differentiation. vol 25. issue 1. 2018-07-16. PMID:28937686. |
p53 can induce apoptosis by two mechanisms. |
2018-07-16 |
2023-08-13 |
Not clear |
| Noa Furth, Yael Aylon, Moshe Ore. p53 shades of Hippo. Cell death and differentiation. vol 25. issue 1. 2018-07-16. PMID:28984872. |
here, we review interactions between the p53 and hippo pathways within a subset of physiological contexts, focusing on normal stem cells and development, as well as regulation of apoptosis, senescence and metabolism in transformed cells. |
2018-07-16 |
2023-08-13 |
Not clear |
| Alyssa M Kaiser, Laura D Attard. Deconstructing networks of p53-mediated tumor suppression in vivo. Cell death and differentiation. vol 25. issue 1. 2018-07-16. PMID:29099489. |
although early studies of p53 suggested that its ability to induce cell cycle arrest, senescence and apoptosis programs accounted for its tumor-suppressor activity, more recent studies have challenged this notion. |
2018-07-16 |
2023-08-13 |
mouse |
| Brandon J Aubrey, Gemma L Kelly, Ana Janic, Marco J Herold, Andreas Strasse. How does p53 induce apoptosis and how does this relate to p53-mediated tumour suppression? Cell death and differentiation. vol 25. issue 1. 2018-07-16. PMID:29149101. |
how does p53 induce apoptosis and how does this relate to p53-mediated tumour suppression? |
2018-07-16 |
2023-08-13 |
mouse |
| Pei Zhou, Liqing Tu, Xi Lin, Xiangqi Hao, Qingxu Zheng, Weijie Zeng, Xin Zhang, Yun Zheng, Lifang Wang, Shoujun L. cfa-miR-143 Promotes Apoptosis via the p53 Pathway in Canine Influenza Virus H3N2-Infected Cells. Viruses. vol 9. issue 12. 2018-07-16. PMID:29186842. |
cfa-mir-143 promotes apoptosis via the p53 pathway in canine influenza virus h3n2-infected cells. |
2018-07-16 |
2023-08-13 |
Not clear |
| Pei Zhou, Liqing Tu, Xi Lin, Xiangqi Hao, Qingxu Zheng, Weijie Zeng, Xin Zhang, Yun Zheng, Lifang Wang, Shoujun L. cfa-miR-143 Promotes Apoptosis via the p53 Pathway in Canine Influenza Virus H3N2-Infected Cells. Viruses. vol 9. issue 12. 2018-07-16. PMID:29186842. |
this study demonstrated that cfa-mir-143 stimulated p53 and caspase3 activation and induced apoptosis via the p53 pathway in civ h3n2-infected cells. |
2018-07-16 |
2023-08-13 |
Not clear |
| Zhi Ye, Qing Li, Qulian Guo, Yunchuan Xiong, Dong Guo, Hong Yang, Yan Sh. Ketamine induces hippocampal apoptosis through a mechanism associated with the caspase-1 dependent pyroptosis. Neuropharmacology. vol 128. 2018-07-13. PMID:28963039. |
active caspase-3 and -9 proteins, which are responsible for the release of cytochrome c, and the mitochondrial translocation of p53, which is associated with mitochondrial apoptosis, were found to be significantly up-regulated in the ketamine-induced hippocampal neurotoxicity. |
2018-07-13 |
2023-08-13 |
mouse |
| Qi Han, Rui Chen, Fangjie Wang, Sha Chen, Xiongshan Sun, Xiao Guan, Yao Yang, Bingjie Peng, Xiaodong Pan, Jinfang Li, Weijing Yi, Peng Li, Hongwei Zhang, Dongfang Feng, An Chen, Xiaohui Li, Shuhui Li, Zuoming Yi. Pre-exposure to 50 Hz-electromagnetic fields enhanced the antiproliferative efficacy of 5-fluorouracil in breast cancer MCF-7 cells. PloS one. vol 13. issue 4. 2018-07-13. PMID:29617363. |
exposure to 50 hz-emfs had no effect on apoptosis and p53 expression of mcf-7 and mcf10a cells, whereas it promoted dna synthesis, induced entry of mcf-7 cells into the s phase of cell cycle, and upregulated the expression levels of cell cycle-related proteins cyclin d1 and cyclin e. considering the pharmacological mechanisms of 5-fu in specifically disrupting dna synthesis, this enhanced inhibitory effect might have resulted from the specific sensitivity of mcf7 cells in active s phase to 5-fu. |
2018-07-13 |
2023-08-13 |
human |
| Hailian Wang, Wei Ge, Wen Jiang, Dong Li, Xiuli J. SRPK1‑siRNA suppresses K562 cell growth and induces apoptosis via the PARP‑caspase3 pathway. Molecular medicine reports. vol 17. issue 1. 2018-07-12. PMID:29138847. |
the roles of caspase‑3, poly (adp‑ribose) polymerase (parp), p53 and b-cell lymphoma (bcl)‑2/bcl‑2 associated x, apoptosis regulator (bax) proteins in the apoptosis of human k562 cells were further examined through western blot analysis. |
2018-07-12 |
2023-08-13 |
human |
| Jinwen Chen, Juan Wang, Huiling Li, Shixuan Wang, Xudong Xiang, Dongshan Zhan. p53 activates miR-192-5p to mediate vancomycin induced AKI. Scientific reports. vol 6. 2018-07-10. PMID:27941921. |
mice with p53 knock out (p53-ko) were resistant to van induced aki, indicated by the analysis of renal function, histology, and apoptosis. |
2018-07-10 |
2023-08-13 |
mouse |
| Amelia H Baker, Ting Hua Wu, Alicia M Bolt, Louis C Gerstenfeld, Koren K Mann, Jennifer J Schlezinge. From the Cover: Tributyltin Alters the Bone Marrow Microenvironment and Suppresses B Cell Development. Toxicological sciences : an official journal of the Society of Toxicology. vol 158. issue 1. 2018-07-10. PMID:28398592. |
tbt activated apoptosis in developing b cells at environmentally relevant concentrations (as low as 80 nm) in vitro, via a mechanism that is distinct from that induced by high dose (μm) tbt and that requires p53. |
2018-07-10 |
2023-08-13 |
human |
| Hongjing Zhao, Jian Ma, Yu Wang, Juanjuan Liu, Yizhi Shao, Jinglun Li, Guangshun Jiang, Mingwei Xin. Molecular cloning and functional characterization of eleven subtypes of interferon-α in Amur tigers (Panthera tigris altaica). Developmental and comparative immunology. vol 77. 2018-07-10. PMID:28751224. |
additionally, ptifn-α and ptifn-α9 can up-regulate the transcription and expression of p53, a tumor suppressor factor, which could promote apoptosis of virus-infected cells. |
2018-07-10 |
2023-08-13 |
cat |
| Yanhong Cheng, Yingchan Hao, Aimei Zhang, Chaojie Hu, Xiaoxiao Jiang, Quan Wu, Xiucai X. Persistent STAT5-mediated ROS production and involvement of aberrant p53 apoptotic signaling in the resistance of chronic myeloid leukemia to imatinib. International journal of molecular medicine. vol 41. issue 1. 2018-07-09. PMID:29115375. |
the p53 protein network regulates important mechanisms in dna damage repair, cell cycle regulation/checkpoints, and cell senescence and apoptosis, as demonstrated by its ability to positively regulate the expression of various pro-apoptotic genes, including b-cell lymphoma-2 (bcl-2) and bcl-2-associated x protein (bax). |
2018-07-09 |
2023-08-13 |
mouse |
| In-Hye Kim, Mi-Jin Kwon, Jae-Hun Jung, Taek-Jeong Na. Protein extracted from Porphyra yezoensis prevents cisplatin-induced nephrotoxicity by downregulating the MAPK and NF-κB pathways. International journal of molecular medicine. vol 41. issue 1. 2018-07-09. PMID:29115386. |
cisplatin exerts a cytotoxic effect on renal cells by inducing apoptosis through activating the tumor suppressor p53, nuclear factor‑κb (nf‑κb) and mitogen‑activated protein kinase (mapk)/p38 pathways. |
2018-07-09 |
2023-08-13 |
mouse |
| Lei Liu, Lei Zhang, Jianping Wang, Xuerong Zhao, Qian Xu, Yanjie Lu, Yanzhen Zuo, Long Chen, Jia Du, Yali Lian, Qin Zhan. Downregulation of TRIM28 inhibits growth and increases apoptosis of nude mice with non‑small cell lung cancer xenografts. Molecular medicine reports. vol 17. issue 1. 2018-07-09. PMID:29115614. |
furthermore, trim28 knockdown decreased the expression of b cell lymphoma (bcl)‑2 and increased the expression of bcl‑2 associated x, apoptosis regulator and p53 at the gene and protein levels. |
2018-07-09 |
2023-08-13 |
mouse |
| Prashanta Kumar Panda, Prajna Paramita Naik, Biswa Ranjan Meher, Durgesh Nandini Das, Subhadip Mukhopadhyay, Prakash Priyadarshi Praharaj, Tapas K Maiti, Sujit K Bhuti. PUMA dependent mitophagy by Abrus agglutinin contributes to apoptosis through ceramide generation. Biochimica et biophysica acta. Molecular cell research. vol 1865. issue 3. 2018-07-09. PMID:29229477. |
interestingly, the induction of puma by p53 plays a critical role in dna damage-induced apoptosis. |
2018-07-09 |
2023-08-13 |
Not clear |
| Jia Yao, Feng Xu, Danhua Zhang, Wenjun Yi, Xianyu Chen, Gannong Chen, Enxiang Zho. TP73-AS1 promotes breast cancer cell proliferation through miR-200a-mediated TFAM inhibition. Journal of cellular biochemistry. vol 119. issue 1. 2018-07-06. PMID:28639399. |
p73 antisense rna 1t (tp73-as1 or pdam) is a long non-coding rna, which can regulate apoptosis through regulation of p53 signaling-related anti-apoptotic genes. |
2018-07-06 |
2023-08-13 |
human |
| Daiha Shin, Eun Hye Kim, Jaewang Lee, Jong-Lyel Ro. RITA plus 3-MA overcomes chemoresistance of head and neck cancer cells via dual inhibition of autophagy and antioxidant systems. Redox biology. vol 13. 2018-07-05. PMID:28582730. |
reactivation of p53 and induction of tumor cell apoptosis (rita) is a small molecule that blocks p53-mdm2 interaction, thereby reactivating p53 in tumors. |
2018-07-05 |
2023-08-13 |
mouse |
| Daiha Shin, Eun Hye Kim, Jaewang Lee, Jong-Lyel Ro. RITA plus 3-MA overcomes chemoresistance of head and neck cancer cells via dual inhibition of autophagy and antioxidant systems. Redox biology. vol 13. 2018-07-05. PMID:28582730. |
rita can induce exclusive apoptosis in cancer cells independently of the p53 pathway; however, the resistance of cancer cells remains a major drawback. |
2018-07-05 |
2023-08-13 |
mouse |