| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shan Liao, Songshu Xiao, Hongxiang Chen, Manying Zhang, Zhifang Chen, Yuehua Long, Lu Gao, Junyu He, Yanshan Ge, Wei Yi, Minghua Wu, Guiyuan Li, Yanhong Zho. The receptor for activated protein kinase C promotes cell growth, invasion and migration in cervical cancer. International journal of oncology. vol 51. issue 5. 2018-07-23. PMID:29048616. |
these results suggest that rack1 promotes cell growth and invasion and inhibits the senescence and apoptosis in cervical cancer cells probably by affecting the p53 pathway. |
2018-07-23 |
2023-08-13 |
Not clear |
| Tien-Huang Chen, Yi-Jun Wu, Jiun-Nan Hou, Cheng-Hsun Chiu, Wei-June Che. The p53 gene with emphasis on its paralogues in mosquitoes. Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi. vol 50. issue 6. 2018-07-20. PMID:28690024. |
the p53 gene is highly important in human cancer because it usually transcribes genes that function by causing apoptosis in mammalian cells. |
2018-07-20 |
2023-08-13 |
human |
| Sung-Min Ju, Yong-Seok Jo, Yoo-Min Jeon, Hyun-Ock Pae, Dae-Gill Kang, Ho-Sub Lee, Jun-Sang Bae, Byung-Hun Jeo. Phosphorylation of eIF2α suppresses cisplatin-induced p53 activation and apoptosis by attenuating oxidative stress via ATF4-mediated HO-1 expression in human renal proximal tubular cells. International journal of molecular medicine. vol 40. issue 6. 2018-07-20. PMID:29039478. |
phosphorylation of eif2α suppresses cisplatin-induced p53 activation and apoptosis by attenuating oxidative stress via atf4-mediated ho-1 expression in human renal proximal tubular cells. |
2018-07-20 |
2023-08-13 |
human |
| Sung-Min Ju, Yong-Seok Jo, Yoo-Min Jeon, Hyun-Ock Pae, Dae-Gill Kang, Ho-Sub Lee, Jun-Sang Bae, Byung-Hun Jeo. Phosphorylation of eIF2α suppresses cisplatin-induced p53 activation and apoptosis by attenuating oxidative stress via ATF4-mediated HO-1 expression in human renal proximal tubular cells. International journal of molecular medicine. vol 40. issue 6. 2018-07-20. PMID:29039478. |
it has been demonstrated that the eukaryotic translation initiation factor 2α (eif2α) may protect hk-2 human renal proximal tubular cells against cisplatin-induced apoptosis through inhibition of reactive oxygen species (ros)‑mediated p53 activation. |
2018-07-20 |
2023-08-13 |
human |
| Sung-Min Ju, Yong-Seok Jo, Yoo-Min Jeon, Hyun-Ock Pae, Dae-Gill Kang, Ho-Sub Lee, Jun-Sang Bae, Byung-Hun Jeo. Phosphorylation of eIF2α suppresses cisplatin-induced p53 activation and apoptosis by attenuating oxidative stress via ATF4-mediated HO-1 expression in human renal proximal tubular cells. International journal of molecular medicine. vol 40. issue 6. 2018-07-20. PMID:29039478. |
in particular, inhibition of p53 by pifithrin‑α, and upregulation of eif2α phosphorylation by sal003, reduced cisplatin-induced apoptosis. |
2018-07-20 |
2023-08-13 |
human |
| Sung-Min Ju, Yong-Seok Jo, Yoo-Min Jeon, Hyun-Ock Pae, Dae-Gill Kang, Ho-Sub Lee, Jun-Sang Bae, Byung-Hun Jeo. Phosphorylation of eIF2α suppresses cisplatin-induced p53 activation and apoptosis by attenuating oxidative stress via ATF4-mediated HO-1 expression in human renal proximal tubular cells. International journal of molecular medicine. vol 40. issue 6. 2018-07-20. PMID:29039478. |
furthermore, reduction of eif2α phosphorylation by perk knockdown enhanced cisplatin-induced p53 activation and apoptosis. |
2018-07-20 |
2023-08-13 |
human |
| Sung-Min Ju, Yong-Seok Jo, Yoo-Min Jeon, Hyun-Ock Pae, Dae-Gill Kang, Ho-Sub Lee, Jun-Sang Bae, Byung-Hun Jeo. Phosphorylation of eIF2α suppresses cisplatin-induced p53 activation and apoptosis by attenuating oxidative stress via ATF4-mediated HO-1 expression in human renal proximal tubular cells. International journal of molecular medicine. vol 40. issue 6. 2018-07-20. PMID:29039478. |
in addition, the ros scavenger n-acetyl-l-cysteine inhibited eif2α phosphorylation as well as p53 activation in hk-2 cells treated with cisplatin, suggesting that oxidative stress induced by cisplatin may lead to apoptosis through p53 activation; furthermore, this stress may confer resistance to apoptosis via eif2α phosphorylation, which was further supported by the finding that cisplatin‑induced ros generation was attenuated by sal003, whereas it was enhanced by perk knockdown. |
2018-07-20 |
2023-08-13 |
human |
| Sung-Min Ju, Yong-Seok Jo, Yoo-Min Jeon, Hyun-Ock Pae, Dae-Gill Kang, Ho-Sub Lee, Jun-Sang Bae, Byung-Hun Jeo. Phosphorylation of eIF2α suppresses cisplatin-induced p53 activation and apoptosis by attenuating oxidative stress via ATF4-mediated HO-1 expression in human renal proximal tubular cells. International journal of molecular medicine. vol 40. issue 6. 2018-07-20. PMID:29039478. |
taken together, these results suggest that phosphorylation of eif2α suppresses cisplatin‑induced p53 activation and apoptosis by attenuating oxidative stress via atf4-mediated ho-1 expression in hk-2 cells, as atf4 expression is usually dependent on the phosphorylation of eif2α and may also transcriptionally induce the expression of ho-1 in response to oxidative stress. |
2018-07-20 |
2023-08-13 |
human |
| Guodong Lian, Leping Li, Fei Ye, Daguang Wang, Jinglei Liu, Yulong Shi, Changqing Jing, Jian Suo, David Y Zhang, Man Che. The screening and analysis of protein signatures and signaling associated with chemoresistance based on Protein Pathway Array technology in gastric cancer. Oncology reports. vol 39. issue 1. 2018-07-20. PMID:29115543. |
in addition, the present study revealed that differentially expressed proteins were closely related to cellular activity, dna methylation and dna damage and repair, and also involved in the erk/mapk, wnt/β-catenin, pi3k/akt, apoptosis and p53 signaling pathways. |
2018-07-20 |
2023-08-13 |
Not clear |
| Arkornnut Rattanawong, Vilawan Payon, Wacharee Limpanasittikul, Chatikorn Boonkrai, Apiwat Mutirangura, Piyanuch Wongana. Cepharanthine exhibits a potent anticancer activity in p53-mutated colorectal cancer cells through upregulation of p21Waf1/Cip1. Oncology reports. vol 39. issue 1. 2018-07-20. PMID:29138869. |
many studies reported that mutation of p53 induced chemoresistance through several mechanisms, including induction of drug efflux, disruption of cell cycle regulation, evasion of apoptosis and upregulation of dna repair. |
2018-07-20 |
2023-08-13 |
Not clear |
| Zhili Ni, Jingmei Y. Oxymatrine induces nasopharyngeal cancer cell death through inhibition of PI3K/AKT and NF‑κB pathways. Molecular medicine reports. vol 16. issue 6. 2018-07-20. PMID:29152662. |
oxymatrine treatment also induced apoptosis, induced the activities of caspase‑3 and caspase‑9, promoted p53 and bax protein expression, and suppressed cyclin d protein expression in these cells. |
2018-07-20 |
2023-08-13 |
Not clear |
| D A Gritsenko, O A Orlova, N S Linkova, V Kh Khavinso. [Transcription factor p53 and skin aging]. Advances in gerontology = Uspekhi gerontologii. vol 30. issue 1. 2018-07-19. PMID:28557384. |
on the one hand, suppression of p53 expression decreases apoptosis in skin cells that slows down the process of aging. |
2018-07-19 |
2023-08-13 |
Not clear |
| Dah-Ching Ding, Yao-Tseng Wen, Rong-Kung Tsa. Pigment epithelium-derived factor from ARPE19 promotes proliferation and inhibits apoptosis of human umbilical mesenchymal stem cells in serum-free medium. Experimental & molecular medicine. vol 49. issue 12. 2018-07-18. PMID:29244789. |
in conclusion, this study is the first to demonstrate that pedf promotes hucmsc proliferation and protects them from apoptosis by reducing p53 expression in the serum-free medium. |
2018-07-18 |
2023-08-13 |
mouse |
| Sherly M Caroline Diana, M R Rekh. Efficacy of vinyl imidazole grafted cationized pullulan and dextran as gene delivery vectors: A comparative study. International journal of biological macromolecules. vol 105. issue Pt 1. 2018-07-17. PMID:28743575. |
similarly transfection studies carried out with p53 plasmid also revealed that ppi derivatives promote more apoptosis in both c6 and hela cell lines as compared to that of dpi derivatives. |
2018-07-17 |
2023-08-13 |
Not clear |
| Eun Gyeong Lim, Guen Tae Kim, Bo Min Kim, Eun Ji Kim, Sang-Yong Kim, Young Min Ki. Ethanol extract from Cnidium monnieri (L.) Cusson induces cell cycle arrest and apoptosis via regulation of the p53‑independent pathway in HepG2 and Hep3B hepatocellular carcinoma cells. Molecular medicine reports. vol 17. issue 2. 2018-07-17. PMID:29207130. |
in conclusion, cme induces g1 arrest and apoptosis via the akt/gsk‑3β signaling pathway which is regulated by mdm2‑induced degradation of p21, rather than p53. |
2018-07-17 |
2023-08-13 |
Not clear |
| Hao Song, Mei Wei, Wenfen Liu, Shulin Shen, Jiaqun Li, Liming Wan. Cisplatin induced apoptosis of ovarian cancer A2780s cells by activation of ERK/p53/PUMA signals. Histology and histopathology. vol 33. issue 1. 2018-07-16. PMID:28287251. |
using sirna targeting p53 and puma, and a selective mek inhibitor, pd98059 to examine the relation between erk1/2 activation, p53 and puma expression after exposure to cddp, and the effect on cddp-induced apoptosis. |
2018-07-16 |
2023-08-13 |
Not clear |
| Hao Song, Mei Wei, Wenfen Liu, Shulin Shen, Jiaqun Li, Liming Wan. Cisplatin induced apoptosis of ovarian cancer A2780s cells by activation of ERK/p53/PUMA signals. Histology and histopathology. vol 33. issue 1. 2018-07-16. PMID:28287251. |
the results shown that treatment of a2780s cells with cddp (3 μg/ml) for 6-24h induced apoptosis, resulting in the activation of extracellular signal-regulated kinase 1/2 (erk1/2) and accumulation of p53 and puma (p53 upregulated modulator of apoptosis) protein. |
2018-07-16 |
2023-08-13 |
Not clear |
| Hao Song, Mei Wei, Wenfen Liu, Shulin Shen, Jiaqun Li, Liming Wan. Cisplatin induced apoptosis of ovarian cancer A2780s cells by activation of ERK/p53/PUMA signals. Histology and histopathology. vol 33. issue 1. 2018-07-16. PMID:28287251. |
knockdown of p53 or puma by sirna transfection blocked cddp-induced apoptosis. |
2018-07-16 |
2023-08-13 |
Not clear |
| Kumari Nishi, Vinoth Prasanna Gunasekaran, Jaganath Arunachalam, Mathan Ganesha. Doxorubicin-induced female reproductive toxicity: an assessment of ovarian follicular apoptosis, cyclicity and reproductive tissue histology in Wistar rats. Drug and chemical toxicology. vol 41. issue 1. 2018-07-16. PMID:28441888. |
the immunohistochemical analysis of ovarian tissues showed an increased p53 and caspase 3 expression and apoptosis in primordial follicles of treated rats. |
2018-07-16 |
2023-08-13 |
rat |
| Cédric Castrogiovanni, Béranger Waterschoot, Olivier De Backer, Patrick Dumon. Serine 392 phosphorylation modulates p53 mitochondrial translocation and transcription-independent apoptosis. Cell death and differentiation. vol 25. issue 1. 2018-07-16. PMID:28937686. |
serine 392 phosphorylation modulates p53 mitochondrial translocation and transcription-independent apoptosis. |
2018-07-16 |
2023-08-13 |
Not clear |