| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Fan Xu, Xiao Li, Xu Xiao, Lan-Fang Liu, Li Zhang, Ping-Ping Lin, Sheng-Lin Zhang, Qing-Shan L. Effects of Ganoderma lucidum polysaccharides against doxorubicin-induced cardiotoxicity. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 95. 2018-06-19. PMID:28866417. |
furthermore, glps pretreatment was found to inhibit cul3-mediated k48-linked polyubiquitination of nrf2 through suppressing cul3 expression, thereby stabilizing nrf2 expression in h9c2 cells after dox treatment, leading to the decreased expression of p53 and p-p65 and increased levels of mdm2 and ho-1, resulted in the attenuated apoptosis, oxidative stress and inflammation induced by dox. |
2018-06-19 |
2023-08-13 |
rat |
| Matthias G J Baud, Matthias R Bauer, Lorena Verduci, Felix A Dingler, Ketan J Patel, Deeptee Horil Roy, Andreas C Joerger, Alan R Fersh. Aminobenzothiazole derivatives stabilize the thermolabile p53 cancer mutant Y220C and show anticancer activity in p53-Y220C cell lines. European journal of medicinal chemistry. vol 152. 2018-06-19. PMID:29702446. |
reduction of viability correlated with increased and selective transcription of p53 target genes such as btg2, p21, puma, fas, tnf, and tnfrsf10b, which promote apoptosis and cell cycle arrest, suggesting compound-mediated transcriptional activation of the y220c mutant. |
2018-06-19 |
2023-08-13 |
Not clear |
| Brahmanand Dube, Abhijeet Pandey, Ganesh Joshi, Krutika Sawan. Hydrophobically modified polyethylenimine-based ternary complexes for targeting brain tumor: stability, in vitro and in vivo studies. Artificial cells, nanomedicine, and biotechnology. vol 45. issue 8. 2018-06-18. PMID:28278583. |
the cell-cycle analysis of nt8e cells (p53 mutant) treated with transferrin containing nanoplexes showed increased apoptosis of cells. |
2018-06-18 |
2023-08-13 |
mouse |
| Jingwen Yan, Fengqiu Zhang, Qing Huan. FTIR Microspectroscopy Probes Particle-Radiation Effect on HCT116 cells (p53 Radiation research. vol 189. issue 2. 2018-06-18. PMID:29206599. |
ftir microspectroscopy probes particle-radiation effect on hct116 cells (p53 p53 is a crucial tumor suppressor and plays an important role in cell cycle arrest, dna damage repair, promotion of cell senescence and apoptosis, prevention of dna damage and maintaining genomic stability and integrity. |
2018-06-18 |
2023-08-13 |
Not clear |
| Mengqiu Wu, Hui Ye, Zhiyuan Tang, Chang Shao, Gaoyuan Lu, Baoqiang Chen, Yuyu Yang, Guangji Wang, Haiping Ha. p53 dynamics orchestrates with binding affinity to target genes for cell fate decision. Cell death & disease. vol 8. issue 10. 2018-06-13. PMID:29048401. |
treating cells with a genotoxic drug doxorubicin at various doses and durations, we found that a mild and prolonged challenge triggered sequential p53 pulses and ultimately resulted in a terminal pulse enacting apoptosis in a comparable rate with that induced by an acute and high-dose treatment. |
2018-06-13 |
2023-08-13 |
Not clear |
| Mengqiu Wu, Hui Ye, Zhiyuan Tang, Chang Shao, Gaoyuan Lu, Baoqiang Chen, Yuyu Yang, Guangji Wang, Haiping Ha. p53 dynamics orchestrates with binding affinity to target genes for cell fate decision. Cell death & disease. vol 8. issue 10. 2018-06-13. PMID:29048401. |
to transactivate proapoptotic genes and thereafter executing apoptosis, p53 must exceed a certain threshold and accumulate for sufficient time at levels above it. |
2018-06-13 |
2023-08-13 |
Not clear |
| Thangavelu Soundara Rajan, Sabrina Giacoppo, Francesca Diomede, Patrizia Ballerini, Michele Paolantonio, Marco Marchisio, Adriano Piattelli, Placido Bramanti, Emanuela Mazzon, Oriana Trubian. The secretome of periodontal ligament stem cells from MS patients protects against EAE. Scientific reports. vol 6. 2018-06-12. PMID:27924938. |
in addition, apoptosis related stat1, p53, caspase 3, and bax expressions were attenuated. |
2018-06-12 |
2023-08-13 |
mouse |
| Xue Zhu, Ke Wang, Yong Yao, Kai Zhang, Fanfan Zhou, Ling Zh. Triggering p53 activation is essential in ziyuglycoside I-induced human retinoblastoma WERI-Rb-1 cell apoptosis. Journal of biochemical and molecular toxicology. vol 32. issue 1. 2018-06-12. PMID:28960612. |
triggering p53 activation is essential in ziyuglycoside i-induced human retinoblastoma weri-rb-1 cell apoptosis. |
2018-06-12 |
2023-08-13 |
human |
| T M Boychuk, O M Nika, S S Tkachu. THE RATIO OF P53-PROAPOPTOTIC AND BCL-2 ANTIAPOPTOTIC ACTIVITY IN THE HIPPOCAMPUS OF RATS WITH BRAIN ISCHEMIA-REPERFUSION AND EXPERIMENTAL DIABETES. Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994). vol 62. issue 6. 2018-06-12. PMID:29762968. |
on the 12th day of post-ischemic period, activation of apoptosis in field cal occurs in the background of inert antiapoptotic processes, in animals without diabetes, as well as in diabetic rats, but the indicators characterizing of apoptotic activity in rats with diabetes were higher (specific contents of p53 protein and area ofp53 -irm increases on 38 and 43 %). |
2018-06-12 |
2023-08-13 |
rat |
| Er Jin, Wenzhe Wang, Mengdie Fang, Limin Wang, Kan Wu, Yemei Zhang, Shirong Zhang, Shenglin M. Lung cancer suppressor gene GPRC5A mediates p53 activity in non‑small cell lung cancer cells in vitro. Molecular medicine reports. vol 16. issue 5. 2018-06-11. PMID:28849235. |
cellular tumor antigen p53 (p53) functions to maintain genomic stability and regulate cell apoptosis, while g protein‑coupled receptor class c group 5 member a (gpcr5a) is a lung cancer suppressor gene whose expression is induced by retinoids. |
2018-06-11 |
2023-08-13 |
human |
| Er Jin, Wenzhe Wang, Mengdie Fang, Limin Wang, Kan Wu, Yemei Zhang, Shirong Zhang, Shenglin M. Lung cancer suppressor gene GPRC5A mediates p53 activity in non‑small cell lung cancer cells in vitro. Molecular medicine reports. vol 16. issue 5. 2018-06-11. PMID:28849235. |
the results of the present study demonstrated that knockdown of gprc5a expression markedly upregulated tumor cell viability and reduced tumor cell apoptosis, while p53 overexpression in h1299 cells significantly increased the expression level of gprc5a. |
2018-06-11 |
2023-08-13 |
human |
| Er Jin, Wenzhe Wang, Mengdie Fang, Limin Wang, Kan Wu, Yemei Zhang, Shirong Zhang, Shenglin M. Lung cancer suppressor gene GPRC5A mediates p53 activity in non‑small cell lung cancer cells in vitro. Molecular medicine reports. vol 16. issue 5. 2018-06-11. PMID:28849235. |
p53 overexpression and gprc5a induction markedly inhibited tumor cell viability and induced apoptosis, while knockdown of p53 resulted in a decrease in gprc5a expression, inhibited tumor cell apoptosis and increased tumor cell viability. |
2018-06-11 |
2023-08-13 |
human |
| Yali Zhang, Huanhuan Dong, Jingfang Zhang, Liyu Zhan. Inhibitory effect of hyperoside isolated from Zanthoxylum bungeanum leaves on SW620 human colorectal cancer cells via induction of the p53 signaling pathway and apoptosis. Molecular medicine reports. vol 16. issue 2. 2018-06-11. PMID:29067453. |
inhibitory effect of hyperoside isolated from zanthoxylum bungeanum leaves on sw620 human colorectal cancer cells via induction of the p53 signaling pathway and apoptosis. |
2018-06-11 |
2023-08-13 |
human |
| Yali Zhang, Huanhuan Dong, Jingfang Zhang, Liyu Zhan. Inhibitory effect of hyperoside isolated from Zanthoxylum bungeanum leaves on SW620 human colorectal cancer cells via induction of the p53 signaling pathway and apoptosis. Molecular medicine reports. vol 16. issue 2. 2018-06-11. PMID:29067453. |
hzl had a marked anti‑proliferative effect on the sw620 human colorectal cancer cells by inducing cell cycle g2/m phase arrest and apoptosis, which was associated with an increase in the expression of p53 and p21. |
2018-06-11 |
2023-08-13 |
human |
| Yali Zhang, Huanhuan Dong, Jingfang Zhang, Liyu Zhan. Inhibitory effect of hyperoside isolated from Zanthoxylum bungeanum leaves on SW620 human colorectal cancer cells via induction of the p53 signaling pathway and apoptosis. Molecular medicine reports. vol 16. issue 2. 2018-06-11. PMID:29067453. |
these data indicated that hzl may be involved in the pro‑apoptotic signaling of sw620 human colorectal cancer cells via induction of the caspase‑dependent apoptosis and p53 signaling pathways. |
2018-06-11 |
2023-08-13 |
human |
| Xiao-Jing Li, Zhi-Feng Li, Jiu-Jiang Wang, Zhao Han, Zhao Liu, Bao-Guo Li. Effects of microRNA-374 on proliferation, migration, invasion, and apoptosis of human SCC cells by targeting Gadd45a through P53 signaling pathway. Bioscience reports. vol 37. issue 4. 2018-06-08. PMID:28679648. |
effects of microrna-374 on proliferation, migration, invasion, and apoptosis of human scc cells by targeting gadd45a through p53 signaling pathway. |
2018-06-08 |
2023-08-13 |
human |
| Xiao-Jing Li, Zhi-Feng Li, Jiu-Jiang Wang, Zhao Han, Zhao Liu, Bao-Guo Li. Effects of microRNA-374 on proliferation, migration, invasion, and apoptosis of human SCC cells by targeting Gadd45a through P53 signaling pathway. Bioscience reports. vol 37. issue 4. 2018-06-08. PMID:28679648. |
the present study investigated the effects of microrna-374 (mir-374) on human squamous cell carcinoma (scc) cell proliferation, migration, invasion, and apoptosis through p53 signaling pathway by targeting growth arrest and dna-damage-inducible protein 45 α (gadd45a). |
2018-06-08 |
2023-08-13 |
human |
| Xiao-Jing Li, Zhi-Feng Li, Jiu-Jiang Wang, Zhao Han, Zhao Liu, Bao-Guo Li. Effects of microRNA-374 on proliferation, migration, invasion, and apoptosis of human SCC cells by targeting Gadd45a through P53 signaling pathway. Bioscience reports. vol 37. issue 4. 2018-06-08. PMID:28679648. |
the mir-374 inhibitors group exhibited decreased expression of mir-374, p73, p16, bax caspase-3 and caspase-9, and increased expression of gadd45a, p53, c-myc, and bcl-2, enhanced cell proliferation, migration, and invasion, and reduced apoptosis compared with the blank and nc groups; the mir-374 mimics group followed opposite trends. |
2018-06-08 |
2023-08-13 |
human |
| Xiao-Jing Li, Zhi-Feng Li, Jiu-Jiang Wang, Zhao Han, Zhao Liu, Bao-Guo Li. Effects of microRNA-374 on proliferation, migration, invasion, and apoptosis of human SCC cells by targeting Gadd45a through P53 signaling pathway. Bioscience reports. vol 37. issue 4. 2018-06-08. PMID:28679648. |
compared with the blank and nc groups, the mir-374 inhibitors + sirna-gadd45a group showed decreased mir-374 level; the sirna-gadd45a group showed elevated levels of p73, p16, bax, caspase-3 and caspase-9, decreased levels of gadd45a, p53, c-myc, and bcl-2, reduced cell proliferation, migration, and invasion, and accelerated apoptosis. |
2018-06-08 |
2023-08-13 |
human |
| Xiao-Jing Li, Zhi-Feng Li, Jiu-Jiang Wang, Zhao Han, Zhao Liu, Bao-Guo Li. Effects of microRNA-374 on proliferation, migration, invasion, and apoptosis of human SCC cells by targeting Gadd45a through P53 signaling pathway. Bioscience reports. vol 37. issue 4. 2018-06-08. PMID:28679648. |
mir-374 induces apoptosis and inhibits proliferation, migration, and invasion of scc cells through p53 signaling pathway by down-regulating gadd45a. |
2018-06-08 |
2023-08-13 |
human |