| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Fiona D'Souza, Shivanand M Pudakalakatti, Shubhashree Uppangala, Sachin Honguntikar, Sujith Raj Salian, Guruprasad Kalthur, Renu Pasricha, Divya Appajigowda, Hanudatta S Atreya, Satish Kumar Adig. Unraveling the association between genetic integrity and metabolic activity in pre-implantation stage embryos. Scientific reports. vol 6. 2018-05-17. PMID:27853269. |
further analysis revealed an association of apoptosis and micronuclei frequency with p53 and bax transcripts in idl embryos on the e4.5 owing to delayed induction of chromosome instability. |
2018-05-17 |
2023-08-13 |
mouse |
| S J Wallace, S R de Solla, P J Thomas, T Harner, A Eng, V S Langloi. Airborne polycyclic aromatic compounds contribute to the induction of the tumour-suppressing P53 pathway in wild double-crested cormorants. Ecotoxicology and environmental safety. vol 150. 2018-05-16. PMID:29276953. |
further hepatic and lung transcriptional analysis demonstrated that the expression of the genes involved in the dna repair and cellular apoptosis pathway were up-regulated in both tissues of dccos exposed to pacs, while genes involved in p53 regulation were down-regulated. |
2018-05-16 |
2023-08-13 |
Not clear |
| Chang-Hong Cheng, Zhi-Xun Guo, Sheng-Wei Luo, An-Li Wan. Effects of high temperature on biochemical parameters, oxidative stress, DNA damage and apoptosis of pufferfish (Takifugu obscurus). Ecotoxicology and environmental safety. vol 150. 2018-05-16. PMID:29276954. |
these results suggested that caspase-dependent and p53 signaling pathways could play important roles in thermal stress-induced apoptosis in fish. |
2018-05-16 |
2023-08-13 |
cat |
| Dávid Kovács, Nóra Igaz, Csilla Keskeny, Péter Bélteky, Tímea Tóth, Renáta Gáspár, Dániel Madarász, Zsolt Rázga, Zoltán Kónya, Imre M Boros, Mónika Kirics. Silver nanoparticles defeat p53-positive and p53-negative osteosarcoma cells by triggering mitochondrial stress and apoptosis. Scientific reports. vol 6. 2018-05-15. PMID:27291325. |
according to our findings agnps are able to kill osteosarcoma cells independently from their actual p53 status and induce p53-independent cancer cell apoptosis. |
2018-05-15 |
2023-08-13 |
human |
| Srinivas Chava, Christine Lee, Yucel Aydin, Partha K Chandra, Asha Dash, Milad Chedid, Swan N Thung, Krzysztof Moroz, Tong Wu, Nabeen C Nayak, Srikanta Das. Chaperone-mediated autophagy compensates for impaired macroautophagy in the cirrhotic liver to promote hepatocellular carcinoma. Oncotarget. vol 8. issue 25. 2018-05-15. PMID:28402954. |
interestingly, inhibition of lysosomal degradation using hydroxychloroquine (hcq) induced expression of the tumor suppressor p53, promoted apoptosis, and inhibited hcc growth, whereas activation of autophagy using an mtor inhibitor (torin1) promoted hcc growth. |
2018-05-15 |
2023-08-13 |
Not clear |
| Anna E Kowalczyk, Bartlomiej E Krazinski, Janusz Godlewski, Jolanta Kiewisz, Przemyslaw Kwiatkowski, Agnieszka Sliwinska-Jewsiewicka, Jacek Kiezun, Marian Sulik, Zbigniew Kmie. Expression of the EP300, TP53 and BAX genes in colorectal cancer: Correlations with clinicopathological parameters and survival. Oncology reports. vol 38. issue 1. 2018-05-15. PMID:28586030. |
e1a binding protein p300 (ep300), tumor protein p53 (tp53) and bcl2 associated x, apoptosis regulator (bax) genes encode proteins which cooperate to regulate important cellular processes. |
2018-05-15 |
2023-08-13 |
Not clear |
| Shohei Murakami, Takuma Suzuki, Wataru Yokoyama, Satoko Yagi, Keita Matsumura, Yuka Nakajima, Hideo Harigae, Akiyoshi Fukamizu, Hozumi Motohash. Nucleomethylin deficiency impairs embryonic erythropoiesis. Journal of biochemistry. vol 163. issue 5. 2018-05-15. PMID:29244083. |
because the previous study demonstrated p53-dependent apoptosis of nml-knockdown cells, and because we observed upregulation of p21, one of the p53 target genes, in nml-/- fl cells, we tested whether p53 disruption cancelled the nml-deficient phenotypes. |
2018-05-15 |
2023-08-13 |
mouse |
| Xinyu Tian, Bo Huang, Xiao-Peng Zhang, Mingyang Lu, Feng Liu, José N Onuchic, Wei Wan. Modeling the response of a tumor-suppressive network to mitogenic and oncogenic signals. Proceedings of the National Academy of Sciences of the United States of America. vol 114. issue 21. 2018-05-14. PMID:28484034. |
here, we built a tumor-suppressive network model composed of three modules responsible for the regulation of cell proliferation, activation of p53, and induction of apoptosis. |
2018-05-14 |
2023-08-13 |
human |
| Xinyu Tian, Bo Huang, Xiao-Peng Zhang, Mingyang Lu, Feng Liu, José N Onuchic, Wei Wan. Modeling the response of a tumor-suppressive network to mitogenic and oncogenic signals. Proceedings of the National Academy of Sciences of the United States of America. vol 114. issue 21. 2018-05-14. PMID:28484034. |
p53 and e2f1 cooperate to induce apoptosis, whereas akt phosphorylates p21 to repress caspase activation. |
2018-05-14 |
2023-08-13 |
human |
| Fangfang Huang, Yinwen Jing, Guofang Ding, Zuisu Yan. Isolation and purification of novel peptides derived from Sepia ink: Effects on apoptosis of prostate cancer cell PC‑3. Molecular medicine reports. vol 16. issue 4. 2018-05-14. PMID:28731187. |
shp‑induced apoptosis was accompanied by the activation of cellular tumor antigen p53 and caspase‑3, the upregulation of apoptosis regulator bax, and the downregulation of apoptosis regulator bcl‑2. |
2018-05-14 |
2023-08-13 |
Not clear |
| Xiao Ling Li, Murugan Subramanian, Matthew F Jones, Ritu Chaudhary, Deepak K Singh, Xinying Zong, Berkley Gryder, Sivasish Sindri, Min Mo, Aaron Schetter, Xinyu Wen, Swetha Parvathaneni, Dickran Kazandjian, Lisa M Jenkins, Wei Tang, Fathi Elloumi, Jennifer L Martindale, Maite Huarte, Yuelin Zhu, Ana I Robles, Susan M Frier, Frank Rigo, Maggie Cam, Stefan Ambs, Sudha Sharma, Curtis C Harris, Mary Dasso, Kannanganattu V Prasanth, Ashish La. Long Noncoding RNA PURPL Suppresses Basal p53 Levels and Promotes Tumorigenicity in Colorectal Cancer. Cell reports. vol 20. issue 10. 2018-05-14. PMID:28877474. |
disrupting this regulation results in elevated p53 levels to induce cell cycle arrest, apoptosis, and tumor suppression. |
2018-05-14 |
2023-08-13 |
mouse |
| Si-Jie Li, Chun-Shui Liu, Hai-Jun Li, Yan Li, Lei Zhou, Jin-Cheng Li, Yi-Chang Chen, Tian-Qi Su, De-Hai Y. A novel engineered interferon-α hybrid molecule increases anticancer efficacy of doxorubicin in breast cancer chemotherapy. International journal of oncology. vol 51. issue 3. 2018-05-10. PMID:28677808. |
additionally, imbp potentiated the therapeutic efficacy of doxorubicin-based breast cancer chemotherapy via the activation of cell cycle arrest and cell apoptosis pathway genes including p53, p21, cdk2, cyclin a, caspase 9, bcl-2 and bax. |
2018-05-10 |
2023-08-13 |
Not clear |
| Sun-Young Park, Hyung-Hoon Oh, Young-Lan Park, Hyung-Min Yu, Dae-Seong Myung, Sung-Bum Cho, Wan-Sik Lee, Daeho Park, Young-Eun Jo. Malformin A1 treatment alters invasive and oncogenic phenotypes of human colorectal cancer cells through stimulation of the p38 signaling pathway. International journal of oncology. vol 51. issue 3. 2018-05-10. PMID:28713983. |
ma1 treatment led to the increase in p53 upregulated modulator of apoptosis (puma) and the decrease in x-linked inhibitor of apoptosis protein (xiap) and survivin. |
2018-05-10 |
2023-08-13 |
human |
| Alessia Garufi, Giuseppa Pistritto, Silvia Baldari, Gabriele Toietta, Mara Cirone, Gabriella D'Oraz. p53-Dependent PUMA to DRAM antagonistic interplay as a key molecular switch in cell-fate decision in normal/high glucose conditions. Journal of experimental & clinical cancer research : CR. vol 36. issue 1. 2018-05-10. PMID:28893313. |
as an important cellular stress sensor phosphoprotein p53 can trigger cell cycle arrest and apoptosis and regulate autophagy. |
2018-05-10 |
2023-08-13 |
Not clear |
| Xianmin Wu, Xiaofei Li, Yongdong Song, He Li, Xiaohui Bai, Wenwen Liu, Yuechen Han, Lei Xu, Jianfeng Li, Daogong Zhang, Haibo Wang, Zhaomin Fa. Allicin protects auditory hair cells and spiral ganglion neurons from cisplatin - Induced apoptosis. Neuropharmacology. vol 116. 2018-05-09. PMID:28062185. |
all data suggested that allicin could prevent hearing loss induced by cisplatin effectively, of which allicin protected sgns from apoptosis via mitochondrial pathway while protected ohcs and supporting cells (scs) from apoptosis through p53 pathway. |
2018-05-09 |
2023-08-13 |
mouse |
| Yichao Fan, Jiao Yue, Mengtao Xiao, Han Han-Zhang, Yao Vickie Wang, Chun Ma, Zhilin Deng, Yingxiang Li, Yanyan Yu, Xinghao Wang, Shen Niu, Youjia Hua, Zhiping Weng, Peter Atadja, En Li, Bin Xian. FXR1 regulates transcription and is required for growth of human cancer cells with eLife. vol 6. 2018-05-09. PMID:28767039. |
fxr1 regulates transcription and is required for growth of human cancer cells with tumor suppressor p53 prevents cell transformation by inducing apoptosis and other responses. |
2018-05-09 |
2023-08-13 |
human |
| Vaikundamoorthy Ramalingam, Krishnamoorthy Varunkumar, Vilwanathan Ravikumar, Rajendran Rajara. p53 mediated transcriptional regulation of long non-coding RNA by 1-hydroxy-1-norresistomycin triggers intrinsic apoptosis in adenocarcinoma lung cancer. Chemico-biological interactions. vol 287. 2018-05-09. PMID:29596799. |
p53 mediated transcriptional regulation of long non-coding rna by 1-hydroxy-1-norresistomycin triggers intrinsic apoptosis in adenocarcinoma lung cancer. |
2018-05-09 |
2023-08-13 |
Not clear |
| Vaikundamoorthy Ramalingam, Krishnamoorthy Varunkumar, Vilwanathan Ravikumar, Rajendran Rajara. p53 mediated transcriptional regulation of long non-coding RNA by 1-hydroxy-1-norresistomycin triggers intrinsic apoptosis in adenocarcinoma lung cancer. Chemico-biological interactions. vol 287. 2018-05-09. PMID:29596799. |
in the present study, marine actinomycetes derived 1-hydroxy-1-norresistomycin (hnm) was used to enhance the expression of lncrnas through p53 transcriptional regulation and induced intrinsic apoptosis in non-small cell lung cancer cells. |
2018-05-09 |
2023-08-13 |
Not clear |
| Vaikundamoorthy Ramalingam, Krishnamoorthy Varunkumar, Vilwanathan Ravikumar, Rajendran Rajara. p53 mediated transcriptional regulation of long non-coding RNA by 1-hydroxy-1-norresistomycin triggers intrinsic apoptosis in adenocarcinoma lung cancer. Chemico-biological interactions. vol 287. 2018-05-09. PMID:29596799. |
moreover, chip assay results showed that hnm upregulates the p53 mediated transcriptional regulation of lncrnas lead to apoptosis of cancer cells through cell cycle arrest and inhibition of proliferation. |
2018-05-09 |
2023-08-13 |
Not clear |
| Lumei Wang, Nanzhe Zhong, Shujuan Liu, Xiaoyan Zhu, Yujian Li. High glucose stimulates proliferation and inhibits apoptosis of non-small-cell lung cancer cells by JNK-mediated downregulation of p53 pathway. Acta biochimica et biophysica Sinica. vol 49. issue 3. 2018-05-08. PMID:28104581. |
high glucose stimulates proliferation and inhibits apoptosis of non-small-cell lung cancer cells by jnk-mediated downregulation of p53 pathway. |
2018-05-08 |
2023-08-13 |
Not clear |