| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hongyan Yang, Yan Xie, Dongyu Yang, Decheng Re. Oxidative stress-induced apoptosis in granulosa cells involves JNK, p53 and Puma. Oncotarget. vol 8. issue 15. 2018-04-10. PMID:28445976. |
oxidative stress-induced apoptosis in granulosa cells involves jnk, p53 and puma. |
2018-04-10 |
2023-08-13 |
human |
| Haibo Chen, Dingyuan Luo, Lin Zhang, Xiaofeng Lin, Qiuyun Luo, Hanjie Yi, Jing Wang, Xianglei Yan, Baoxia Li, Yuelei Chen, Xingguang Liu, Hong Zhang, Sheng Liu, Miaozhen Qiu, Dajun Yang, Ningyi Jian. Restoration of p53 using the novel MDM2-p53 antagonist APG115 suppresses dedifferentiated papillary thyroid cancer cells. Oncotarget. vol 8. issue 26. 2018-04-06. PMID:28498808. |
inhibition of the mdm2-p53 interaction restores p53 activity and leads to cell cycle arrest and apoptosis. |
2018-04-06 |
2023-08-13 |
mouse |
| Haibo Chen, Dingyuan Luo, Lin Zhang, Xiaofeng Lin, Qiuyun Luo, Hanjie Yi, Jing Wang, Xianglei Yan, Baoxia Li, Yuelei Chen, Xingguang Liu, Hong Zhang, Sheng Liu, Miaozhen Qiu, Dajun Yang, Ningyi Jian. Restoration of p53 using the novel MDM2-p53 antagonist APG115 suppresses dedifferentiated papillary thyroid cancer cells. Oncotarget. vol 8. issue 26. 2018-04-06. PMID:28498808. |
apg115 diminished the viability of p53 wild-type deptc cells and induced cell cycle arrest and apoptosis. |
2018-04-06 |
2023-08-13 |
mouse |
| Mireia Borràs-Fresneda, Joan-Francesc Barquinero, Maria Gomolka, Sabine Hornhardt, Ute Rössler, Gemma Armengol, Leonardo Barrio. Differences in DNA Repair Capacity, Cell Death and Transcriptional Response after Irradiation between a Radiosensitive and a Radioresistant Cell Line. Scientific reports. vol 6. 2018-04-05. PMID:27245205. |
functional analysis showed that 24 h after irradiation genes involved in "dna damage response", "direct p53 effectors" and apoptosis were still differentially up-regulated in the rs cell line but not in the rr cell line. |
2018-04-05 |
2023-08-13 |
Not clear |
| Jana Zemanova, Ondrej Hylse, Jana Collakova, Pavel Vesely, Alexandra Oltova, Marek Borsky, Kristina Zaprazna, Marie Kasparkova, Pavlina Janovska, Jan Verner, Jiri Kohoutek, Marta Dzimkova, Vitezslav Bryja, Zuzana Jaskova, Yvona Brychtova, Kamil Paruch, Martin Trbuse. Chk1 inhibition significantly potentiates activity of nucleoside analogs in TP53-mutated B-lymphoid cells. Oncotarget. vol 7. issue 38. 2018-04-04. PMID:27556692. |
in p53-proficient nalm-6 cells, sch900776 added to nas enhanced signaling towards chk1 (pser317/pser345), effectively blocked chk1 activation (ser296 autophosphorylation), increased replication stress (p53 and γ-h2ax accumulation) and temporarily potentiated apoptosis. |
2018-04-04 |
2023-08-13 |
mouse |
| Zeinab Akbarnejad, Hossein Eskandary, Luciana Dini, Cristian Vergallo, Seyed Noureddin Nematollahi-Mahani, Alireza Farsinejad, Maryam Fekri Soofi Abadi, Meysam Ahmad. Cytotoxicity of temozolomide on human glioblastoma cells is enhanced by the concomitant exposure to an extremely low-frequency electromagnetic field (100Hz, 100G). Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 92. 2018-04-03. PMID:28551545. |
co-treatment synergistically enhanced apoptosis in u87 and t98g cells, by increasing the expression of p53, bax, and caspase-3 and decreasing that of bcl-2 and cyclin-d1. |
2018-04-03 |
2023-08-13 |
human |
| Yue Pan, Dan Shao, Yawei Zhao, Fan Zhang, Xiao Zheng, Yongfei Tan, Kan He, Jing Li, Li Che. Berberine Reverses Hypoxia-induced Chemoresistance in Breast Cancer through the Inhibition of AMPK- HIF-1α. International journal of biological sciences. vol 13. issue 6. 2018-04-03. PMID:28656004. |
but the downstream of hif-1α occurred the bifurcation dependent on the dosage of berberine: ampk-hif-1α-p-gp inactivation played a crucial role on the dox chemosensitivity of low-dose berberine, while ampk-hif-1α downregulaton inducing p53 activation led to apoptosis in high-dose berberine. |
2018-04-03 |
2023-08-13 |
mouse |
| Hongjing Zhao, Ying He, Siwen Li, Xiao Sun, Yu Wang, Yizhi Shao, Zhijun Hou, Mingwei Xin. Subchronic arsenism-induced oxidative stress and inflammation contribute to apoptosis through mitochondrial and death receptor dependent pathways in chicken immune organs. Oncotarget. vol 8. issue 25. 2018-04-02. PMID:28454103. |
(4) as2o3-induced apoptosis of immune organs involved in mitochondrial pathway (decrease of b-cell lymphoma-2 (bcl-2) and increase of protein 53 (p53), bcl-2 associated x protein (bax), caspase-9, caspase-3) and death receptor pathway (increase of factor associated suicide (fas) and caspase-8). |
2018-04-02 |
2023-08-13 |
chicken |
| Kyoung-Jin Min, Ju-Ock Nam, Taeg Kyu Kwo. Fisetin Induces Apoptosis Through p53-Mediated Up-Regulation of DR5 Expression in Human Renal Carcinoma Caki Cells. Molecules (Basel, Switzerland). vol 22. issue 8. 2018-04-02. PMID:28767099. |
taken together, our study demonstrates that fisetin induced apoptosis through p53 mediated up-regulation of dr5 expression at the transcriptional level. |
2018-04-02 |
2023-08-13 |
human |
| Izumi Horikawa, Kye-Yoon Park, Kazunobu Isogaya, Yukiharu Hiyoshi, Han Li, Katsuhiro Anami, Ana I Robles, Abdul M Mondal, Kaori Fujita, Manuel Serrano, Curtis C Harri. Δ133p53 represses p53-inducible senescence genes and enhances the generation of human induced pluripotent stem cells. Cell death and differentiation. vol 24. issue 6. 2018-03-29. PMID:28362428. |
however, p53 also has essential roles in these cells through dna damage repair for maintaining genomic integrity and high sensitivity to apoptosis for eliminating severely damaged cells. |
2018-03-29 |
2023-08-13 |
human |
| Izumi Horikawa, Kye-Yoon Park, Kazunobu Isogaya, Yukiharu Hiyoshi, Han Li, Katsuhiro Anami, Ana I Robles, Abdul M Mondal, Kaori Fujita, Manuel Serrano, Curtis C Harri. Δ133p53 represses p53-inducible senescence genes and enhances the generation of human induced pluripotent stem cells. Cell death and differentiation. vol 24. issue 6. 2018-03-29. PMID:28362428. |
we hypothesized that Δ133p53, a physiological inhibitory p53 isoform, is involved in the balanced regulation of self-renewing capacity, dna damage repair and apoptosis. |
2018-03-29 |
2023-08-13 |
human |
| Anna Skwarska, Shaliny Ramachandran, Grzegorz Dobrynin, Katarzyna B Leszczynska, Ester M Hammon. The imidazoacridinone C-1311 induces p53-dependent senescence or p53-independent apoptosis and sensitizes cancer cells to radiation. Oncotarget. vol 8. issue 19. 2018-03-26. PMID:28415717. |
in contrast, cells lines without functional p53 underwent mitotic catastrophe and apoptosis. |
2018-03-26 |
2023-08-13 |
Not clear |
| Hui Zhai, Xiao-Mei Li, Fen Liu, Bang-Dang Chen, Hong Zheng, Xue-Mei Wang, Wu Liao, Qing-Jie Chen, Yi-Tong Ma, Yi-Ning Yan. Expression pattern of genome-scale long noncoding RNA following acute myocardial infarction in Chinese Uyghur patients. Oncotarget. vol 8. issue 19. 2018-03-26. PMID:28418905. |
the annotation result of their co-expressed mrnas showed that the most significantly related category of go analysis was regulation of biological processes, and the most significantly related pathway was apoptosis and its corresponding p53. |
2018-03-26 |
2023-08-13 |
human |
| Do-Hee Kim, Ji Eun Park, In Gyeong Chae, Geumi Park, Sooyeun Lee, Kyung-Soo Chu. Isoliquiritigenin inhibits the proliferation of human renal carcinoma Caki cells through the ROS-mediated regulation of the Jak2/STAT3 pathway. Oncology reports. vol 38. issue 1. 2018-03-26. PMID:28560439. |
taken together, the present study provides the first report that isl induces apoptosis in caki cells via generation of ros, which causes induction of p53 and inhibition of the stat3 signaling pathway. |
2018-03-26 |
2023-08-13 |
human |
| D Q Xin, Z M Hu, H J Huo, X J Yang, D Han, W H Xing, Y Zhao, Q H Qi. Schisandrin B attenuates the inflammatory response, oxidative stress and apoptosis induced by traumatic spinal cord injury via inhibition of p53 signaling in adult rats. Molecular medicine reports. vol 16. issue 1. 2018-03-26. PMID:28560444. |
schisandrin b attenuates the inflammatory response, oxidative stress and apoptosis induced by traumatic spinal cord injury via inhibition of p53 signaling in adult rats. |
2018-03-26 |
2023-08-13 |
rat |
| D Q Xin, Z M Hu, H J Huo, X J Yang, D Han, W H Xing, Y Zhao, Q H Qi. Schisandrin B attenuates the inflammatory response, oxidative stress and apoptosis induced by traumatic spinal cord injury via inhibition of p53 signaling in adult rats. Molecular medicine reports. vol 16. issue 1. 2018-03-26. PMID:28560444. |
the present study investigated the potential protective effects of schisandrin b on the p53 signaling pathway in attenuating the inflammatory response, oxidative stress and apoptosis induced by traumatic spinal cord injury (tsci) in adult rats. |
2018-03-26 |
2023-08-13 |
rat |
| D Q Xin, Z M Hu, H J Huo, X J Yang, D Han, W H Xing, Y Zhao, Q H Qi. Schisandrin B attenuates the inflammatory response, oxidative stress and apoptosis induced by traumatic spinal cord injury via inhibition of p53 signaling in adult rats. Molecular medicine reports. vol 16. issue 1. 2018-03-26. PMID:28560444. |
these results indicated that schisandrin b may attenuate the inflammatory response, oxidative stress and apoptosis in tsci rats by inhibiting the p53 signaling pathway in adult rats. |
2018-03-26 |
2023-08-13 |
rat |
| Eun Sun Jung, Hyunjung Choi, Hyundong Song, Yu Jin Hwang, Ahbin Kim, Hoon Ryu, Inhee Mook-Jun. p53-dependent SIRT6 expression protects Aβ42-induced DNA damage. Scientific reports. vol 6. 2018-03-26. PMID:27156849. |
also, there is a strong negative correlation between aβ42-induced dna damage and p53 levels, a protein involved in dna repair and apoptosis. |
2018-03-26 |
2023-08-13 |
mouse |
| Alexander S Tikhomirov, Chia-Yang Lin, Yulia L Volodina, Lyubov G Dezhenkova, Victor V Tatarskiy, Dominique Schols, Alexander A Shtil, Punit Kaur, Pin Ju Chueh, Andrey E Shchekotikhi. New antitumor anthra[2,3-b]furan-3-carboxamides: Synthesis and structure-activity relationship. European journal of medicinal chemistry. vol 148. 2018-03-23. PMID:29459273. |
finally, we demonstrated that 6 and 9 at 1 μm induced intracellular oxidative stress, accumulation in g2/m phase of the cell cycle, and apoptosis in gastric carcinoma cell lines regardless of their p53 status. |
2018-03-23 |
2023-08-13 |
Not clear |
| Yang Ou, Shang-Jui Wang, Dawei Li, Bo Chu, Wei G. Activation of SAT1 engages polyamine metabolism with p53-mediated ferroptotic responses. Proceedings of the National Academy of Sciences of the United States of America. vol 113. issue 44. 2018-03-22. PMID:27698118. |
although p53-mediated cell-cycle arrest, senescence, and apoptosis remain critical barriers to cancer development, the emerging role of p53 in cell metabolism, oxidative responses, and ferroptotic cell death has been a topic of great interest. |
2018-03-22 |
2023-08-13 |
Not clear |