| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jana Cesnekova, Jana Spacilova, Hana Hansikova, Josef Houstek, Jiri Zeman, Lukas Stibure. LACE1 interacts with p53 and mediates its mitochondrial translocation and apoptosis. Oncotarget. vol 7. issue 30. 2018-03-01. PMID:27323408. |
conversely, increased expression of lace1 partitions p53 to mitochondria, causes reduction in nuclear p53 content and induces apoptosis. |
2018-03-01 |
2023-08-13 |
Not clear |
| Jana Cesnekova, Jana Spacilova, Hana Hansikova, Josef Houstek, Jiri Zeman, Lukas Stibure. LACE1 interacts with p53 and mediates its mitochondrial translocation and apoptosis. Oncotarget. vol 7. issue 30. 2018-03-01. PMID:27323408. |
thus, lace1 mediates mitochondrial translocation of p53 and its transcription-independent apoptosis. |
2018-03-01 |
2023-08-13 |
Not clear |
| Heba A Alkhatabi, Donal P McLornan, Austin G Kulasekararaj, Farooq Malik, Thomas Seidl, David Darling, Joop Gaken, Ghulam J Muft. RPL27A is a target of miR-595 and may contribute to the myelodysplastic phenotype through ribosomal dysgenesis. Oncotarget. vol 7. issue 30. 2018-03-01. PMID:27374104. |
rpl27a downregulation induced p53 activation, apoptosis and inhibited proliferation. |
2018-03-01 |
2023-08-13 |
Not clear |
| Yoshihiro Umezawa, Tetsuya Kurosu, Hiroki Akiyama, Nang Wu, Ayako Nogami, Toshikage Nagao, Osamu Miur. Down regulation of Chk1 by p53 plays a role in synergistic induction of apoptosis by chemotherapeutics and inhibitors for Jak2 or BCR/ABL in hematopoietic cells. Oncotarget. vol 7. issue 28. 2018-02-27. PMID:27286446. |
down regulation of chk1 by p53 plays a role in synergistic induction of apoptosis by chemotherapeutics and inhibitors for jak2 or bcr/abl in hematopoietic cells. |
2018-02-27 |
2023-08-13 |
Not clear |
| Yoshihiro Umezawa, Tetsuya Kurosu, Hiroki Akiyama, Nang Wu, Ayako Nogami, Toshikage Nagao, Osamu Miur. Down regulation of Chk1 by p53 plays a role in synergistic induction of apoptosis by chemotherapeutics and inhibitors for Jak2 or BCR/ABL in hematopoietic cells. Oncotarget. vol 7. issue 28. 2018-02-27. PMID:27286446. |
consistent with this, the p53 activator nutlin-3 synergistically induced apoptosis with chemotherapeutics by inhibiting chk1-mediated g2/m arrest in these cells, including cells transformed by the t315i mutant of bcr/abl resistant to various kinase inhibitors in clinical use. |
2018-02-27 |
2023-08-13 |
Not clear |
| Carlos Gorbea, Tim Mosbruger, Demián Cazall. A viral Sm-class RNA base-pairs with mRNAs and recruits microRNAs to inhibit apoptosis. Nature. vol 550. issue 7675. 2018-02-27. PMID:28976967. |
we combined in vivo psoralen-mediated rna-rna crosslinking and high-throughput sequencing to identify the mrnas targeted by hsur2, which include mrnas that encode retinoblastoma and factors involved in p53 signalling and apoptosis. |
2018-02-27 |
2023-08-13 |
squirrel_monkey |
| Sai-Qi Wang, Cong Wang, Li-Ming Chang, Kai-Rui Zhou, Jun-Wei Wang, Yu Ke, Dong-Xiao Yang, Hong-Ge Shi, Ran Wang, Xiao-Li Shi, Li-Ying Ma, Hong-Min Li. Geridonin and paclitaxel act synergistically to inhibit the proliferation of gastric cancer cells through ROS-mediated regulation of the PTEN/PI3K/Akt pathway. Oncotarget. vol 7. issue 45. 2018-02-26. PMID:27659528. |
this led to the accumulation of p53 and induced apoptosis though the mitochondrial pathway. |
2018-02-26 |
2023-08-13 |
Not clear |
| Chaojun Xue, Changyuan Wang, Yaoting Sun, Qiang Meng, Zhihao Liu, Xiaokui Huo, Pengyuan Sun, Huijun Sun, Xiaodong Ma, Xiaochi Ma, Jinyong Peng, Kexin Li. Targeting P-glycoprotein function, p53 and energy metabolism: Combination of metformin and 2-deoxyglucose reverses the multidrug resistance of MCF-7/Dox cells to doxorubicin. Oncotarget. vol 8. issue 5. 2018-02-26. PMID:28052008. |
combination of the two drugs resumed p53 function via inhibiting overexpression of murine doubleminute 2(mdm2) and murine doubleminute 4(mdm4) leading to g2/m arrest and apoptosis in mcf-7/dox cells. |
2018-02-26 |
2023-08-13 |
Not clear |
| J Grace Nirmala, R T Narendhirakanna. Vitis vinifera peel and seed gold nanoparticles exhibit chemopreventive potential, antioxidant activity and induce apoptosis through mutant p53, Bcl-2 and pan cytokeratin down-regulation in experimental animals. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 89. 2018-02-26. PMID:28292018. |
vitis vinifera peel and seed gold nanoparticles exhibit chemopreventive potential, antioxidant activity and induce apoptosis through mutant p53, bcl-2 and pan cytokeratin down-regulation in experimental animals. |
2018-02-26 |
2023-08-13 |
mouse |
| J Grace Nirmala, R T Narendhirakanna. Vitis vinifera peel and seed gold nanoparticles exhibit chemopreventive potential, antioxidant activity and induce apoptosis through mutant p53, Bcl-2 and pan cytokeratin down-regulation in experimental animals. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 89. 2018-02-26. PMID:28292018. |
the down-regulated expression of mutant p53, bcl-2 and the levels of pan-cytokeratins might have facilitated the process of apoptosis in the chemical carcinogenesis process. |
2018-02-26 |
2023-08-13 |
mouse |
| Yang Yu, Feng Lv, Dong Liang, Qinheng Yang, Bin Zhang, Hong Lin, Xiaofang Wang, Guo Qian, Jinzhong Xu, Wei Yo. HOTAIR may regulate proliferation, apoptosis, migration and invasion of MCF-7 cells through regulating the P53/Akt/JNK signaling pathway. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 90. 2018-02-23. PMID:28407576. |
mcf-7 cells were cultured and transfected with hotair sirna, and the proliferation rate of cells was determined using mtt and colony-forming assay; moreover, the apoptosis as well as cell cycles were determined using annexin v/propidium iodide staining methods and analyzed using flow cytometery; furthermore, cell scratch and transwell assays have been performed to examine the migration and invasion of mcf-7 cells; next, cells were collected, and rt-qpcr as well as western blotting assay were performed to examine the expression of p53, mdm2, akt, jnk, mmp-2 and mmp-9. |
2018-02-23 |
2023-08-13 |
human |
| Yang Yu, Feng Lv, Dong Liang, Qinheng Yang, Bin Zhang, Hong Lin, Xiaofang Wang, Guo Qian, Jinzhong Xu, Wei Yo. HOTAIR may regulate proliferation, apoptosis, migration and invasion of MCF-7 cells through regulating the P53/Akt/JNK signaling pathway. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 90. 2018-02-23. PMID:28407576. |
we discovered that knockdown of hotair induced significant decrease in proliferation and increase in apoptosis of mcf-7 cells, and the cell cycles of hotair sirna transfected cells have been arrested at g1 phase (p<0.01); moreover, knockdown of hotair lead to marked decrease in the migration and invasion ability of mcf-7 cells; finally, knockdown of hotair induced significant decrease in the expression of p53/akt/jnk (p<0.01), and significant increase in the expression of p53 in mcf-7 cells (p<0.01). |
2018-02-23 |
2023-08-13 |
human |
| Danuta Maślińska, Milena Laure-Kamionowska, Dariusz Szukiewicz, Sławomir Maśliński, Krystyna Księżopolska-Orłowsk. Commitment of protein p53 and amyloid-beta peptide (Aβ) in aging of human cerebellum. Folia neuropathologica. vol 55. issue 2. 2018-02-23. PMID:28677373. |
protein p53 is known to induce the cell cycle arrest and apoptosis in response to a variety of cellular distress signals and dna damage. |
2018-02-23 |
2023-08-13 |
human |
| Jing Xiong, Tiefen Su, Zhiling Qu, Qin Yang, Yu Wang, Jiansha Li, Sheng Zho. Triptolide has anticancer and chemosensitization effects by down-regulating Akt activation through the MDM2/REST pathway in human breast cancer. Oncotarget. vol 7. issue 17. 2018-02-23. PMID:27004407. |
we further showed that, regardless of p53 status, triptolide inhibited proliferation, induced apoptosis, and caused g1 phase cell cycle arrest. |
2018-02-23 |
2023-08-13 |
mouse |
| Emma A Heart, Shpetim Karandrea, Xiaomei Liang, Maren E Balke, Patrick A Beringer, Elyse M Bobczynski, Delaine Zayas-Bazán Burgos, Tiffany Richardson, Joshua P Gra. Mechanisms of Doxorubicin Toxicity in Pancreatic β-Cells. Toxicological sciences : an official journal of the Society of Toxicology. vol 152. issue 2. 2018-02-23. PMID:27255381. |
doxorubicin induced the expression of mrna for mdm2, cyclin g1, and fas whereas downregulating p53, and increased the melting temperature of genomic dna, consistent with dna damage and induction of apoptosis. |
2018-02-23 |
2023-08-13 |
mouse |
| Valentina Pagliara, Assunta Saide, Emma Mitidieri, Roberta d'Emmanuele di Villa Bianca, Raffaella Sorrentino, Giulia Russo, Annapina Russ. 5-FU targets rpL3 to induce mitochondrial apoptosis via cystathionine-β-synthase in colon cancer cells lacking p53. Oncotarget. vol 7. issue 31. 2018-02-22. PMID:27385096. |
5-fu targets rpl3 to induce mitochondrial apoptosis via cystathionine-β-synthase in colon cancer cells lacking p53. |
2018-02-22 |
2023-08-13 |
Not clear |
| Valentina Pagliara, Assunta Saide, Emma Mitidieri, Roberta d'Emmanuele di Villa Bianca, Raffaella Sorrentino, Giulia Russo, Annapina Russ. 5-FU targets rpL3 to induce mitochondrial apoptosis via cystathionine-β-synthase in colon cancer cells lacking p53. Oncotarget. vol 7. issue 31. 2018-02-22. PMID:27385096. |
recent findings revealed in cancer cells novel stress response pathways, which in response to many chemotherapeutic drugs causing nucleolar stress, will function independently from tumor protein p53 (p53) and still lead to cell cycle arrest and/or apoptosis. |
2018-02-22 |
2023-08-13 |
Not clear |
| Valentina Pagliara, Assunta Saide, Emma Mitidieri, Roberta d'Emmanuele di Villa Bianca, Raffaella Sorrentino, Giulia Russo, Annapina Russ. 5-FU targets rpL3 to induce mitochondrial apoptosis via cystathionine-β-synthase in colon cancer cells lacking p53. Oncotarget. vol 7. issue 31. 2018-02-22. PMID:27385096. |
these data reveal a novel mechanism to accomplish p53-independent apoptosis and suggest a potential therapeutic approach aimed at upregulating rpl3 for treating cancers lacking p53. |
2018-02-22 |
2023-08-13 |
Not clear |
| Lei Zhan, Haiyan Cao, Gang Wang, Yinghua Lyu, Xiacheng Sun, Jiaze An, Zhenbiao Wu, Qichao Huang, Bingrong Liu, Jinliang Xin. Drp1-mediated mitochondrial fission promotes cell proliferation through crosstalk of p53 and NF-κB pathways in hepatocellular carcinoma. Oncotarget. vol 7. issue 40. 2018-02-22. PMID:27542250. |
recently, we have reported that increased mitochondrial fission promotes autophagy and apoptosis resistance in hepatocellular carcinoma (hcc) cell through ros-mediated coordinated regulation of nf-κb and p53 pathways. |
2018-02-22 |
2023-08-13 |
Not clear |
| Hsiang-Tsui Wang, Tzu-Ying Chen, Ching-Wen Weng, Chun-Hsiang Yang, Moon-Shong Tan. Acrolein preferentially damages nucleolus eliciting ribosomal stress and apoptosis in human cancer cells. Oncotarget. vol 7. issue 49. 2018-02-22. PMID:27741518. |
we propose that acr induces ribosomal stress which leads to activation of mdm2 and rpl11-mdm2 binding, consequently, activates p53 and enhances e2f-1 degradation, and that taken together these two processes induce apoptosis and cell death. |
2018-02-22 |
2023-08-13 |
human |