| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Chengshan Xu, Ling Zhang, Lianning Duan, Chengrong L. MicroRNA-3196 is inhibited by H2AX phosphorylation and attenuates lung cancer cell apoptosis by downregulating PUMA. Oncotarget. vol 7. issue 47. 2018-02-22. PMID:27780918. |
microrna-3196 (mir-3196) was identified as a target of h2ax and shown to inhibit apoptosis in lung cancer cells by targeting p53 upregulated modulator of apoptosis (puma). |
2018-02-22 |
2023-08-13 |
Not clear |
| Hongbo Chen, Liqiao Han, Hsiangi Tsai, Zhiwei Wang, Yanping Wu, Yanhong Duo, Wei Cao, Lijun Chen, Zhirong Tan, Ning Xu, Xianzhang Huang, Junhua Zhuang, Laiqiang Huan. PICT-1 is a key nucleolar sensor in DNA damage response signaling that regulates apoptosis through the RPL11-MDM2-p53 pathway. Oncotarget. vol 7. issue 50. 2018-02-22. PMID:27829214. |
pict-1 is an essential ribosome biogenesis factor whose loss induces p53 accumulation and apoptosis. |
2018-02-22 |
2023-08-13 |
Not clear |
| Hongbo Chen, Liqiao Han, Hsiangi Tsai, Zhiwei Wang, Yanping Wu, Yanhong Duo, Wei Cao, Lijun Chen, Zhirong Tan, Ning Xu, Xianzhang Huang, Junhua Zhuang, Laiqiang Huan. PICT-1 is a key nucleolar sensor in DNA damage response signaling that regulates apoptosis through the RPL11-MDM2-p53 pathway. Oncotarget. vol 7. issue 50. 2018-02-22. PMID:27829214. |
furthermore, both phosphorylation and degradation of pict-1 released rpl11 from the nucleolus to the nucleoplasm, increased binding of rpl11 to mdm2, and promoted p53 accumulation and apoptosis in an atm-dependent manner after dna damage. |
2018-02-22 |
2023-08-13 |
Not clear |
| Derrick J Morton, Divya Patel, Jugal Joshi, Aisha Hunt, Ashley E Knowell, Jaideep Chaudhar. ID4 regulates transcriptional activity of wild type and mutant p53 via K373 acetylation. Oncotarget. vol 8. issue 2. 2018-02-22. PMID:27911860. |
using p53 null prostate cancer cell line we show that id4 dependent acetylation promotes mutant p53 dna-binding capabilities to its wild type consensus sequence, thus regulating p53-dependent target genes leading to subsequent cell cycle arrest and apoptosis. |
2018-02-22 |
2023-08-13 |
human |
| Joseph Mazar, Amy Rosado, John Shelley, John Marchica, Tamarah J Westmorelan. The long non-coding RNA GAS5 differentially regulates cell cycle arrest and apoptosis through activation of BRCA1 and p53 in human neuroblastoma. Oncotarget. vol 8. issue 4. 2018-02-22. PMID:28035057. |
the long non-coding rna gas5 differentially regulates cell cycle arrest and apoptosis through activation of brca1 and p53 in human neuroblastoma. |
2018-02-22 |
2023-08-13 |
human |
| Xiaolin Liao, Jiajun Huang, Wanjun Lin, Ze Long, Ying Xie, Wenzhe M. APTM, a Thiophene Heterocyclic Compound, Inhibits Human Colon Cancer HCT116 Cell Proliferation Through p53-Dependent Induction of Apoptosis. DNA and cell biology. vol 37. issue 2. 2018-02-22. PMID:29215922. |
also, the isogenic cell depletion of p53 was resistant to aptm-induced apoptosis and thus grows relatively better than the wild-type cells. |
2018-02-22 |
2023-08-13 |
human |
| Jiaxiong Lu, Shan Guan, Yanling Zhao, Yang Yu, Yongfeng Wang, Yonghua Shi, Xinfang Mao, Kristine L Yang, Wenjing Sun, Xin Xu, Joanna S Yi, Tianshu Yang, Jianhua Yang, Jed G Nuchter. Novel MDM2 inhibitor SAR405838 (MI-773) induces p53-mediated apoptosis in neuroblastoma. Oncotarget. vol 7. issue 50. 2018-02-21. PMID:27764791. |
sar405838 caused significantly decreased cell viability of p53 wild-type nb cells and induced p53-mediated apoptosis, as well as augmenting the cytotoxic effects of doxorubicin (dox). |
2018-02-21 |
2023-08-13 |
mouse |
| Tao Lu, Yanmei Zou, Guogang Xu, Jane A Potter, Garry L Taylor, Qiuhong Duan, Qin Yang, Huihua Xiong, Hong Qiu, Dawei Ye, Peng Zhang, Shiying Yu, Xianglin Yuan, Feng Zhu, Yihua Wang, Hua Xion. PRIMA-1Met suppresses colorectal cancer independent of p53 by targeting MEK. Oncotarget. vol 7. issue 50. 2018-02-21. PMID:27806324. |
prima-1met is the methylated prima-1 (p53 reactivation and induction of massive apoptosis) and could restore tumor suppressor function of mutant p53 and induce p53 dependent apoptosis in cancer cells harboring mutant p53. |
2018-02-21 |
2023-08-13 |
mouse |
| Lewins Walter, Adani Pujada, Noopur Bhatnagar, Agnieszka B Bialkowska, Vincent W Yang, Hamed Laroui, Pallavi Gar. Epithelial derived-matrix metalloproteinase (MMP9) exhibits a novel defensive role of tumor suppressor in colitis associated cancer by activating MMP9-Notch1-ARF-p53 axis. Oncotarget. vol 8. issue 1. 2018-02-21. PMID:27861153. |
tgm9 mice exhibited less tumor burden, increased apoptosis, and increased expressions of active-notch1, p53, p21waf1/cip1, caspase-3 and cyclin e in cac compared to wts. |
2018-02-21 |
2023-08-13 |
mouse |
| Shanmin Zhao, Li Li, Shiyong Wang, Chenlin Yu, Bang Xiao, Lifang Lin, Wei Cong, Jishuai Cheng, Wenjing Yang, Wei Sun, Shufang Cu. H2O2 treatment or serum deprivation induces autophagy and apoptosis in naked mole-rat skin fibroblasts by inhibiting the PI3K/Akt signaling pathway. Oncotarget. vol 7. issue 51. 2018-02-21. PMID:27863375. |
furthermore, ly294002 or cq treatment decreased caspase-3, p53, and hif1-α levels, suggesting that serum starvation or h2o2 treatment increase autophagy and apoptosis in nmr skin fibroblasts by inhibiting the pi3k/akt pathway. |
2018-02-21 |
2023-08-13 |
Not clear |
| Caitlin M Roake, Steven E Artand. Control of Cellular Aging, Tissue Function, and Cancer by p53 Downstream of Telomeres. Cold Spring Harbor perspectives in medicine. vol 7. issue 5. 2018-02-21. PMID:28289249. |
telomere dysfunction in this context leads to dna-damage signaling and activation of the tumor-suppressor protein p53, which then can prompt either cellular senescence or apoptosis. |
2018-02-21 |
2023-08-13 |
human |
| Mi-Hyeon Jeong, Hyeonseok Ko, Hyelin Jeon, Gi-Jun Sung, Soo-Yeon Park, Woo Jin Jun, Yoo-Hyun Lee, Jeongmin Lee, Sang-Wook Lee, Ho-Geun Yoon, Kyung-Chul Cho. Delphinidin induces apoptosis via cleaved HDAC3-mediated p53 acetylation and oligomerization in prostate cancer cells. Oncotarget. vol 7. issue 35. 2018-02-20. PMID:27462923. |
delphinidin induces apoptosis via cleaved hdac3-mediated p53 acetylation and oligomerization in prostate cancer cells. |
2018-02-20 |
2023-08-13 |
human |
| Mi-Hyeon Jeong, Hyeonseok Ko, Hyelin Jeon, Gi-Jun Sung, Soo-Yeon Park, Woo Jin Jun, Yoo-Hyun Lee, Jeongmin Lee, Sang-Wook Lee, Ho-Geun Yoon, Kyung-Chul Cho. Delphinidin induces apoptosis via cleaved HDAC3-mediated p53 acetylation and oligomerization in prostate cancer cells. Oncotarget. vol 7. issue 35. 2018-02-20. PMID:27462923. |
moreover, the induction of apoptosis by delphinidin was dependent on caspase-mediated cleavage of hdac3, which results in the acetylation and stabilization of p53. |
2018-02-20 |
2023-08-13 |
human |
| Mi-Hyeon Jeong, Hyeonseok Ko, Hyelin Jeon, Gi-Jun Sung, Soo-Yeon Park, Woo Jin Jun, Yoo-Hyun Lee, Jeongmin Lee, Sang-Wook Lee, Ho-Geun Yoon, Kyung-Chul Cho. Delphinidin induces apoptosis via cleaved HDAC3-mediated p53 acetylation and oligomerization in prostate cancer cells. Oncotarget. vol 7. issue 35. 2018-02-20. PMID:27462923. |
taken together, these results show that delphinidin induces p53-mediated apoptosis by suppressing hdac activity and activating p53 acetylation in human prostate cancer lncap cells. |
2018-02-20 |
2023-08-13 |
human |
| Gabriele Catyana Krause, Kelly Goulart Lima, Gabriela Viegas Haute, Aline Daniele Schuster, Henrique Bregolin Dias, Fernanda Cristina Mesquita, Leonardo Pedrazza, Elisa Simon Marczak, Bruno Souza Basso, Anderson Catarina Velasque, Bianca Andrade Martha, Fernanda Bordignon Nunes, Márcio Vinícius Donadio, Jarbas Rodrigues de Oliveir. Fructose-1,6-bisphosphate decreases IL-8 levels and increases the activity of pro-apoptotic proteins in HepG2 cells. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 89. 2018-02-20. PMID:28242545. |
then, we found, by rt-pcr, a high expression level of pro-apoptotic protein, such as bax and p53, and decreased the expression levels of anti-apoptotic proteins, like bcl-2 suggesting apoptosis. |
2018-02-20 |
2023-08-13 |
Not clear |
| Marta Kinga Lemieszek, Miguel Ribeiro, Helena Guichard Alves, Guilhermina Marques, Fernando Milheiro Nunes, Wojciech Rzesk. Boletus edulis ribonucleic acid - a potent apoptosis inducer in human colon adenocarcinoma cells. Food & function. vol 7. issue 7. 2018-02-15. PMID:27302173. |
the revealed mechanism of apoptosis triggering was dependent on the presence of functional p53 and consequently was a little different in investigated cell lines. |
2018-02-15 |
2023-08-13 |
human |
| Fathia Zaki El Sharkawi, Shaimaa Mohammed Ewais, Rania Hassan Fahmy, Laila Ahmed Rashe. PTEN and TRAIL genes loaded zein nanoparticles as potential therapy for hepatocellular carcinoma. Journal of drug targeting. vol 25. issue 6. 2018-02-15. PMID:28140697. |
also, mrna expression of p53, vgef and mmp-2 were carried out as markers of apoptosis, angiogenesis and metastasis in animal liver tissues. |
2018-02-15 |
2023-08-13 |
rat |
| Dahlia M Nuñez-Hernandez, Monserrath Felix-Portillo, Alma B Peregrino-Uriarte, Gloria Yepiz-Plascenci. Cell cycle regulation and apoptosis mediated by p53 in response to hypoxia in hepatopancreas of the white shrimp Litopenaeus vannamei. Chemosphere. vol 190. 2018-02-15. PMID:28992477. |
cell cycle regulation and apoptosis mediated by p53 in response to hypoxia in hepatopancreas of the white shrimp litopenaeus vannamei. |
2018-02-15 |
2023-08-13 |
Not clear |
| Dahlia M Nuñez-Hernandez, Monserrath Felix-Portillo, Alma B Peregrino-Uriarte, Gloria Yepiz-Plascenci. Cell cycle regulation and apoptosis mediated by p53 in response to hypoxia in hepatopancreas of the white shrimp Litopenaeus vannamei. Chemosphere. vol 190. 2018-02-15. PMID:28992477. |
p53 is a key transcription factor that determines cells fate towards cell cycle arrest or induction of apoptosis in humans. |
2018-02-15 |
2023-08-13 |
Not clear |
| Dahlia M Nuñez-Hernandez, Monserrath Felix-Portillo, Alma B Peregrino-Uriarte, Gloria Yepiz-Plascenci. Cell cycle regulation and apoptosis mediated by p53 in response to hypoxia in hepatopancreas of the white shrimp Litopenaeus vannamei. Chemosphere. vol 190. 2018-02-15. PMID:28992477. |
the aim of this work was to study the role of p53 in cell cycle regulation and apoptosis in response to hypoxia in hepatopancreas of the white shrimp litopenaeus vannamei. |
2018-02-15 |
2023-08-13 |
Not clear |