| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Wenwen Zhang, Lulu Cao, Zijia Sun, Jing Xu, Lin Tang, Weiwei Chen, Jiayan Luo, Fang Yang, Yucai Wang, Xiaoxiang Gua. Skp2 is over-expressed in breast cancer and promotes breast cancer cell proliferation. Cell cycle (Georgetown, Tex.). vol 15. issue 10. 2018-01-17. PMID:27111245. |
skp2 suppressed p53 and inhibited pig3-induced apoptosis, while skp2b attenuated the function of pig3 by inhibiting phb. |
2018-01-17 |
2023-08-13 |
Not clear |
| Maryam Zanjirband, Richard J Edmondson, John Lune. Pre-clinical efficacy and synergistic potential of the MDM2-p53 antagonists, Nutlin-3 and RG7388, as single agents and in combined treatment with cisplatin in ovarian cancer. Oncotarget. vol 7. issue 26. 2018-01-17. PMID:27223080. |
median-drug-effect analysis showed nutlin-3 or rg7388 combination with cisplatin was additive to, or synergistic in a p53-dependent manner, resulting in increased p53 activation, cell cycle arrest and apoptosis, associated with increased p21waf1 protein and/or caspase-3/7 activity compared to cisplatin alone. |
2018-01-17 |
2023-08-13 |
human |
| Haidan Liu, Wei Li, Xinfang Yu, Feng Gao, Zhi Duan, Xiaolong Ma, Shiming Tan, Yunchang Yuan, Lijun Liu, Jian Wang, Xinmin Zhou, Yifeng Yan. EZH2-mediated Puma gene repression regulates non-small cell lung cancer cell proliferation and cisplatin-induced apoptosis. Oncotarget. vol 7. issue 35. 2018-01-16. PMID:27472460. |
unexpectedly, we discovered that, in the suppression of ezh2, p53 upregulated modulator of apoptosis (puma) expression was concomitantly induced. |
2018-01-16 |
2023-08-13 |
mouse |
| Anna Nilton, Volkan I Sayin, Zhiyuan V Zou, Sama I Sayin, Cecilia Bondjers, Nadia Gul, Pia Agren, Per Fogelstrand, Ola Nilsson, Martin O Bergo, Per Lindah. Targeting Zfp148 activates p53 and reduces tumor initiation in the gut. Oncotarget. vol 7. issue 35. 2018-01-16. PMID:27487143. |
furthermore, after activation of β-catenin-the initiating event in colorectal cancer-zfp148 deficiency activated p53 and induced apoptosis in intestinal explants of apcmin/+ mice. |
2018-01-16 |
2023-08-13 |
mouse |
| Ludger Hauck, Shanna Stanley-Hasnain, Amelia Fung, Daniela Grothe, Vivek Rao, Tak W Mak, Filio Billi. Cardiac-specific ablation of the E3 ubiquitin ligase Mdm2 leads to oxidative stress, broad mitochondrial deficiency and early death. PloS one. vol 12. issue 12. 2018-01-16. PMID:29267372. |
mdm2 is the main e3 ubiquitin ligase for p53 in mitotic cells thereby regulating cellular growth, dna repair, oxidative stress and apoptosis. |
2018-01-16 |
2023-08-13 |
mouse |
| Rouba Hage-Sleiman, Hisham Bahmad, Hadile Kobeissy, Zeinab Dakdouk, Firas Kobeissy, Ghassan Dbaib. Genomic alterations during p53-dependent apoptosis induced by γ-irradiation of Molt-4 leukemia cells. PloS one. vol 12. issue 12. 2018-01-16. PMID:29272311. |
in molt-4-lxsn cells, a significant fraction of the genes with altered expression at 3 hours were found to be involved in apoptosis signaling pathway (bcl2l11), p53 pathway (pmaip1, cdkn1a and fas) and oxidative stress response (fdxr, crot and jun). |
2018-01-16 |
2023-08-13 |
human |
| Rouba Hage-Sleiman, Hisham Bahmad, Hadile Kobeissy, Zeinab Dakdouk, Firas Kobeissy, Ghassan Dbaib. Genomic alterations during p53-dependent apoptosis induced by γ-irradiation of Molt-4 leukemia cells. PloS one. vol 12. issue 12. 2018-01-16. PMID:29272311. |
similarly, at 8 hours the genes with altered expression were involved in the apoptosis signaling pathway (bax, bik and jun), p53 pathway (bax, cdkn1a and fas), oxidative stress response (fdxr and crot) and p53 pathway feedback loops 2 (mdm2 and cdkn1a). |
2018-01-16 |
2023-08-13 |
human |
| Gurugirijha Rathnasamy, Madhuvika Murugan, Eng-Ang Ling, Charanjit Kau. Hypoxia-Induced Iron Accumulation in Oligodendrocytes Mediates Apoptosis by Eliciting Endoplasmic Reticulum Stress. Molecular neurobiology. vol 53. issue 7. 2018-01-16. PMID:26319559. |
associated with these subcellular changes, the apoptosis of hypoxic oligodendrocytes was evident with an increase in p53 and caspase-3 expression, which was attenuated when these cells were treated with deferoxamine. |
2018-01-16 |
2023-08-13 |
Not clear |
| A A Guirguis, C I Slape, L M Failla, J Saw, C S Tremblay, D R Powell, F Rossello, A Wei, A Strasser, D J Curti. PUMA promotes apoptosis of hematopoietic progenitors driving leukemic progression in a mouse model of myelodysplasia. Cell death and differentiation. vol 23. issue 6. 2018-01-16. PMID:26742432. |
the absence of p53 or puma but not noxa reduced apoptosis and expanded the numbers of mds-repopulating cells. |
2018-01-16 |
2023-08-13 |
mouse |
| A A Guirguis, C I Slape, L M Failla, J Saw, C S Tremblay, D R Powell, F Rossello, A Wei, A Strasser, D J Curti. PUMA promotes apoptosis of hematopoietic progenitors driving leukemic progression in a mouse model of myelodysplasia. Cell death and differentiation. vol 23. issue 6. 2018-01-16. PMID:26742432. |
despite a similar effect on apoptosis and cell numbers, the absence of p53 and puma had diametrically opposed effects on progression to aml: absence of p53 accelerated leukemic progression, while absence of puma significantly delayed progression. |
2018-01-16 |
2023-08-13 |
mouse |
| Jerome Thiery, Thouraya Ben Safta, Linda Ziani, Salem Chouai. Mechanisms of Cytotoxic Lymphocyte-Mediated Apoptosis and Relationship with the Tumor Suppressor p53. Critical reviews in immunology. vol 35. issue 6. 2018-01-15. PMID:27279042. |
mechanisms of cytotoxic lymphocyte-mediated apoptosis and relationship with the tumor suppressor p53. |
2018-01-15 |
2023-08-13 |
Not clear |
| Jerome Thiery, Thouraya Ben Safta, Linda Ziani, Salem Chouai. Mechanisms of Cytotoxic Lymphocyte-Mediated Apoptosis and Relationship with the Tumor Suppressor p53. Critical reviews in immunology. vol 35. issue 6. 2018-01-15. PMID:27279042. |
we also discuss the role of an important player in the field of apoptosis, the well-known p53 tumor suppressor, in the modulation of cytotoxic lymphocyte-mediated cell death. |
2018-01-15 |
2023-08-13 |
Not clear |
| Tiziana de Cristofaro, Tina Di Palma, Amata Amy Soriano, Antonella Monticelli, Ornella Affinito, Sergio Cocozza, Mariastella Zannin. Candidate genes and pathways downstream of PAX8 involved in ovarian high-grade serous carcinoma. Oncotarget. vol 7. issue 27. 2018-01-15. PMID:27259239. |
interestingly, we highlighted the involvement of pathways like wnt signaling, epithelial-mesenchymal transition, p53 and apoptosis. |
2018-01-15 |
2023-08-13 |
Not clear |
| Carmela Mazzoccoli, Vitalba Ruggieri, Tiziana Tataranni, Francesca Agriesti, Ilaria Laurenzana, Angelo Fratello, Nazzareno Capitanio, Claudia Piccol. N-acetylaspartate (NAA) induces neuronal differentiation of SH-SY5Y neuroblastoma cell line and sensitizes it to chemotherapeutic agents. Oncotarget. vol 7. issue 18. 2018-01-12. PMID:27036033. |
this effect is partly due to enhanced apoptosis, shown by decrease of the anti-apoptotic factors survivin and bcl-xl, and partly to arrest of the cell-cycle progression, linked to enhanced expression of the cyclin-inhibitors p53, p21cip1/waf1 and p27kip1. |
2018-01-12 |
2023-08-13 |
Not clear |
| Kamil Andrzej Lipinski, Christian Britschgi, Karen Schrader, Yann Christinat, Lukas Frischknecht, Wilhelm Kre. Colorectal cancer cells display chaperone dependency for the unconventional prefoldin URI1. Oncotarget. vol 7. issue 20. 2018-01-12. PMID:27105489. |
interestingly, in uri1-dependent crc cells, uri1 deficiency is associated with non-genotoxic p53 activation and p53-dependent apoptosis. |
2018-01-12 |
2023-08-13 |
human |
| Shen-Nien Wang, Li-Ting Wang, Ding-Ping Sun, Chee-Yin Chai, Edward Hsi, Hsing-Tao Kuo, Kazunari K Yokoyama, Shih-Hsien Hs. Intestine-specific homeobox (ISX) upregulates E2F1 expression and related oncogenic activities in HCC. Oncotarget. vol 7. issue 24. 2018-01-12. PMID:27175585. |
coexpression of isx and e2f1 significantly promoted p53 and rb-mediated cell proliferation and anti-apoptosis, and repressed apoptosis and autophagy. |
2018-01-12 |
2023-08-13 |
human |
| Min Yan, Yuan-Min Qian, Cai-Feng Yue, Zi-Feng Wang, Bi-Cheng Wang, Wei Zhang, Fei-Meng Zheng, Quentin Li. Inhibition of histone deacetylases induces formation of multipolar spindles and subsequent p53-dependent apoptosis in nasopharyngeal carcinoma cells. Oncotarget. vol 7. issue 28. 2018-01-09. PMID:27283770. |
moreover, mgcd-induced apoptosis was decreased by inhibition of p53 using short interfering rna (sirna), suggesting that p53 was required for mgcd-induced cell apoptosis. |
2018-01-09 |
2023-08-13 |
Not clear |
| Pei-Hua Lu, Min-Bin Chen, Chao Ji, Wen-Ting Li, Mu-Xin Wei, Mian-Hua W. Aqueous Oldenlandia diffusa extracts inhibits colorectal cancer cells via activating AMP-activated protein kinase signalings. Oncotarget. vol 7. issue 29. 2018-01-08. PMID:27322552. |
this might be important for p53 activation and subsequent cancer cell apoptosis. |
2018-01-08 |
2023-08-13 |
mouse |
| Paolo Benatti, Valentina Basile, Diletta Dolfini, Silvia Belluti, Margherita Tomei, Carol Imbrian. NF-Y loss triggers p53 stabilization and apoptosis in HPV18-positive cells by affecting E6 transcription. Oncotarget. vol 7. issue 29. 2018-01-08. PMID:27323853. |
nf-y loss triggers p53 stabilization and apoptosis in hpv18-positive cells by affecting e6 transcription. |
2018-01-08 |
2023-08-13 |
Not clear |
| Kun Wang, Xiao-Yan Fu, Xiao-Ting Fu, Ya-Jun Hou, Jie Fang, Shuai Zhang, Ming-Feng Yang, Da-Wei Li, Lei-Lei Mao, Jing-Yi Sun, Hui Yuan, Xiao-Yi Yang, Cun-Dong Fan, Zong-Yong Zhang, Bao-Liang Su. DSePA Antagonizes High Glucose-Induced Neurotoxicity: Evidences for DNA Damage-Mediated p53 Phosphorylation and MAPKs and AKT Pathways. Molecular neurobiology. vol 53. issue 7. 2018-01-08. PMID:26232068. |
p53 rna interference partially suppressed high glucose-induced cytotoxicity and apoptosis, indicating the role of p53 in high glucose-induced signal. |
2018-01-08 |
2023-08-13 |
Not clear |