| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Myung-Shik Le. Role of mitochondrial function in cell death and body metabolism. Frontiers in bioscience (Landmark edition). vol 21. 2018-01-05. PMID:27100503. |
mitochondrial dna (mtdna)-depleted r0 cells were resistant to diverse apoptosis inducers such as tnf-alpha, tnfsf10, staurosporine and p53. |
2018-01-05 |
2023-08-13 |
Not clear |
| He Yong-Ming, Ji Ai-Jun, Xu Xiao-Yue, Lu Jian-Wei, Yu Chen, Chen Y. miR-449a: a potential therapeutic agent for cancer. Anti-cancer drugs. vol 28. issue 10. 2018-01-03. PMID:29023247. |
among mirnas, one that may be of particular interest in cancer biology is mir-449a, which has been reported to inhibit tumor growth, invasion, and metastasis, and to promote apoptosis and differentiation through the transforming growth factor-β activated kinase 1, notch, nuclear factor-κb/p65/vascular endothelial growth factor, retinoblastoma-e2f, mitogen-activated protein kinase signaling pathways, wnt-β-catenin signaling, tumor protein p53, and androgen receptor signaling pathways. |
2018-01-03 |
2023-08-13 |
Not clear |
| Toshiyuki Matsunaga, Kyoko Kamase, Hiroaki Takasawa, Yukiko Yamaji, Satoshi Endo, Ossama El-Kabbani, Akira Ikar. Facilitation of 9,10-phenanthrenequinone-elicited neuroblastoma cell apoptosis by NAD(P)H:quinone oxidoreductase 1. Chemico-biological interactions. vol 279. 2018-01-03. PMID:29108775. |
the treatment also promoted formation of 8-hydroxy-deoxyguanosine, p53 activation, elevation of bax/bcl-2 ratio, lowering of mitochondrial membrane potential, and resultant activation of caspase-9 and caspase-3, inferring that ros production, dna damage and mitochondrial dysfunction are crucial processes of the pq-triggered sk-n-sh cell apoptosis. |
2018-01-03 |
2023-08-13 |
human |
| Ruchi Ghildiyal, Ellora Se. CK2 induced RIG-I drives metabolic adaptations in IFNγ-treated glioma cells. Cytokine. vol 89. 2018-01-03. PMID:26631910. |
while rig-i had no effect on glioma cell survival, it increased expression of p53 and its downstream target tp53 induced glycolysis and apoptosis regulator (tigar). |
2018-01-03 |
2023-08-13 |
Not clear |
| Maria Vincenza Chiantore, Giorgio Mangino, Marco Iuliano, Maria Simona Zangrillo, Ilaria De Lillis, Gabriele Vaccari, Rosita Accardi, Massimo Tommasino, Gianna Fiorucci, Giovanna Rome. IFN-β antiproliferative effect and miRNA regulation in Human Papilloma Virus E6- and E7-transformed keratinocytes. Cytokine. vol 89. 2018-01-03. PMID:26748726. |
in view of our previous data showing senescence induction by the cytokine in k38 cells, we observe that ifn-β treatment leads to p53-indipendent apoptosis in k16 cells whereas induces senescence in k16 cells if e6 is silenced and p53 expression is restored. |
2018-01-03 |
2023-08-13 |
human |
| Jing-Hua Wu, Jia-Pei Guo, Jun Shi, Hui Wang, Lei-Lei Li, Bin Guo, Dian-Xing Liu, Qing Cao, Zhi-Yong Yua. CMA down-regulates p53 expression through degradation of HMGB1 protein to inhibit irradiation-triggered apoptosis in hepatocellular carcinoma. World journal of gastroenterology. vol 23. issue 13. 2018-01-02. PMID:28428710. |
cma down-regulates p53 expression through degradation of hmgb1 protein to inhibit irradiation-triggered apoptosis in hepatocellular carcinoma. |
2018-01-02 |
2023-08-13 |
Not clear |
| Jing-Hua Wu, Jia-Pei Guo, Jun Shi, Hui Wang, Lei-Lei Li, Bin Guo, Dian-Xing Liu, Qing Cao, Zhi-Yong Yua. CMA down-regulates p53 expression through degradation of HMGB1 protein to inhibit irradiation-triggered apoptosis in hepatocellular carcinoma. World journal of gastroenterology. vol 23. issue 13. 2018-01-02. PMID:28428710. |
to investigate the mechanism of chaperone-mediated autophagy (cma)-induced resistance to irradiation-triggered apoptosis through regulation of the p53 protein in hepatocellular carcinoma (hcc). |
2018-01-02 |
2023-08-13 |
Not clear |
| Jianrui Lv, Junbin Tian, Guoxi Zheng, Jing Zha. Sirtuin7 is involved in protecting neurons against oxygen-glucose deprivation and reoxygenation-induced injury through regulation of the p53 signaling pathway. Journal of biochemical and molecular toxicology. vol 31. issue 10. 2018-01-02. PMID:28675767. |
moreover, knockdown of sirt7 markedly increased the transcriptional activity of p53 toward apoptosis and activated the p53-mediated proapoptotic signaling pathway. |
2018-01-02 |
2023-08-13 |
Not clear |
| Cristina Corno, Simone Stucchi, Michelandrea De Cesare, Nives Carenini, Serena Stamatakos, Emilio Ciusani, Lucia Minoli, Eugenio Scanziani, Christian Argueta, Yosef Landesman, Nadia Zaffaroni, Laura Gatti, Paola Pereg. FoxO-1 contributes to the efficacy of the combination of the XPO1 inhibitor selinexor and cisplatin in ovarian carcinoma preclinical models. Biochemical pharmacology. vol 147. 2018-01-01. PMID:29155058. |
a modulation of proteins involved in apoptosis (p53, bax) and in cell cycle progression (p21 |
2018-01-01 |
2023-08-13 |
Not clear |
| Ke-Jia Wu, Hai-Jing Zhong, Guodong Li, Chenfu Liu, Hui-Min David Wang, Dik-Lung Ma, Chung-Hang Leun. Structure-based identification of a NEDD8-activating enzyme inhibitor via drug repurposing. European journal of medicinal chemistry. vol 143. 2018-01-01. PMID:29232579. |
furthermore, compound 1 induced apoptosis of colorectal adenocarcinoma cancer cells through inhibiting the degradation of the neddylation substrate p53. |
2018-01-01 |
2023-08-13 |
Not clear |
| Peng Duan, Chunhui Hu, Holly J Butler, Chao Quan, Wei Chen, Wenting Huang, Sha Tang, Wei Zhou, Meng Yuan, Yuqin Shi, Francis L Martin, Kedi Yan. Effects of 4-nonylphenol on spermatogenesis and induction of testicular apoptosis through oxidative stress-related pathways. Reproductive toxicology (Elmsford, N.Y.). vol 62. 2018-01-01. PMID:27109770. |
moreover, 60mg/kg np resulted in a significant reduction in fructose, fsh and lh; induced apoptosis related to oxidative stress; inhibited mrna and protein levels of bcl-2 and pcna; as well as the additional up-regulation of p53, bax, apaf-1, cytochrome c, cleaved-caspase-3, fas and fasl expression. |
2018-01-01 |
2023-08-13 |
rat |
| Dan Song, Jiabao Zhao, Chen Su, Ying Jiang, Jingjing Ho. Etoposide induced NMI promotes cell apoptosis by activating the ARF-p53 signaling pathway in lung carcinoma. Biochemical and biophysical research communications. vol 495. issue 1. 2017-12-29. PMID:29030066. |
by contrast, when silencing nmi, the proliferation suppression and cell apoptosis caused by etoposide were repressed and the p53 signaling pathway activation was also suppressed. |
2017-12-29 |
2023-08-13 |
Not clear |
| Mohd Isa Farhanah, Abd Rahaman Yasmin, Nurulfiza Mat Isa, Mohd Hair-Bejo, Aini Ideris, Claire Powers, Omobolanle Oladapo, Venugopal Nair, Jia-Shiun Khoo, Ahmad-Kamal Ghazali, Wai-Yan Yee, Abdul Rahman Oma. Bursal transcriptome profiling of different inbred chicken lines reveals key differentially expressed genes at 3 days post-infection with very virulent infectious bursal disease virus. The Journal of general virology. vol 99. issue 1. 2017-12-29. PMID:29058656. |
various genes that are associated with b-cell functions and genes related to apoptosis were downregulated, together with the genes involved in p53 signalling. |
2017-12-29 |
2023-08-13 |
chicken |
| Maya Saison-Ridinger, Kathleen E DelGiorno, Tejia Zhang, Annabelle Kraus, Randall French, Dawn Jaquish, Crystal Tsui, Galina Erikson, Benjamin T Spike, Maxim N Shokhirev, Christopher Liddle, Ruth T Yu, Michael Downes, Ronald M Evans, Alan Saghatelian, Andrew M Lowy, Geoffrey M Wah. Reprogramming pancreatic stellate cells via p53 activation: A putative target for pancreatic cancer therapy. PloS one. vol 12. issue 12. 2017-12-29. PMID:29211796. |
the p53 tumor suppressor is known to restrict tumor initiation and progression through cell autonomous mechanisms including apoptosis, cell cycle arrest, and senescence. |
2017-12-29 |
2023-08-13 |
mouse |
| Aline Monezi Montel, Raquel Gouvêa Dos Santos, Pryscila Rodrigues da Costa, Elisângela de Paula Silveira-Lacerda, Alzir Azevedo Batista, Wagner Gouvêa Dos Santo. Neutron activation increases activity of ruthenium-based complexes and induces cell death in glioma cells independent of p53 tumor suppressor gene. Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine. vol 30. issue 2. 2017-12-28. PMID:28258507. |
the phosphine ruthenium ii complexes tested were highly active against glioblastoma cell lines inducing cell death both through apoptosis and autophagy in a p53 independent fashion. |
2017-12-28 |
2023-08-13 |
human |
| Mouna Tabebi, Bodour Khabou, Hanen Boukadi, Mariam Ben Hamad, Bochra Ben Rhouma, Slim Tounsi, Abdellatif Maalej, Hassen Kamoun, Leila Keskes-Ammar, Mohamed Abid, Mouna Mnif, Faiza Fakhfak. Association study of apoptosis gene polymorphisms in mitochondrial diabetes: A potential role in the pathogenicity of MD. Gene. vol 639. 2017-12-27. PMID:28987347. |
we found 10 selected polymorphisms (p53 (rs1042522 and rs17878362), bcl2 (rs2279115), bax (rs1805419), bak1 (rs210132 and rs2227925), casp3 (rs1405937), casp7 (rs2227310), casp8 (rs1045485) and casp10 (rs13006529)) with a potential apoptosis effect in md patients compared to control population. |
2017-12-27 |
2023-08-13 |
Not clear |
| Mouna Tabebi, Bodour Khabou, Hanen Boukadi, Mariam Ben Hamad, Bochra Ben Rhouma, Slim Tounsi, Abdellatif Maalej, Hassen Kamoun, Leila Keskes-Ammar, Mohamed Abid, Mouna Mnif, Faiza Fakhfak. Association study of apoptosis gene polymorphisms in mitochondrial diabetes: A potential role in the pathogenicity of MD. Gene. vol 639. 2017-12-27. PMID:28987347. |
specifically, snps involved in the intrinsic pathway (p53, bcl2, bak1 and casp3) presented the highest risk of apoptosis. |
2017-12-27 |
2023-08-13 |
Not clear |
| Bhawna Chandravanshi, Ramesh Ramchandra Bhond. Shielding Engineered Islets With Mesenchymal Stem Cells Enhance Survival Under Hypoxia. Journal of cellular biochemistry. vol 118. issue 9. 2017-12-26. PMID:28098405. |
this was further accompanied by reduction in total reactive oxygen species, nitric oxide, and super oxide ions and down regulation of caspase3, caspase8, p53, and up regulation of bcl2 confirming prevention of apoptosis in icas. |
2017-12-26 |
2023-08-13 |
Not clear |
| Wilson X Mai, Laura Gosa, Veerle W Daniels, Lisa Ta, Jonathan E Tsang, Brian Higgins, W Blake Gilmore, Nicholas A Bayley, Mitra Dehghan Harati, Jason T Lee, William H Yong, Harley I Kornblum, Steven J Bensinger, Paul S Mischel, P Nagesh Rao, Peter M Clark, Timothy F Cloughesy, Anthony Letai, David A Nathanso. Cytoplasmic p53 couples oncogene-driven glucose metabolism to apoptosis and is a therapeutic target in glioblastoma. Nature medicine. vol 23. issue 11. 2017-12-26. PMID:29035366. |
cytoplasmic p53 couples oncogene-driven glucose metabolism to apoptosis and is a therapeutic target in glioblastoma. |
2017-12-26 |
2023-08-13 |
Not clear |
| Wilson X Mai, Laura Gosa, Veerle W Daniels, Lisa Ta, Jonathan E Tsang, Brian Higgins, W Blake Gilmore, Nicholas A Bayley, Mitra Dehghan Harati, Jason T Lee, William H Yong, Harley I Kornblum, Steven J Bensinger, Paul S Mischel, P Nagesh Rao, Peter M Clark, Timothy F Cloughesy, Anthony Letai, David A Nathanso. Cytoplasmic p53 couples oncogene-driven glucose metabolism to apoptosis and is a therapeutic target in glioblastoma. Nature medicine. vol 23. issue 11. 2017-12-26. PMID:29035366. |
mechanistic studies revealed that after attenuated glucose consumption, bcl-xl blocks cytoplasmic p53 from triggering intrinsic apoptosis. |
2017-12-26 |
2023-08-13 |
Not clear |