| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Liyang Jiang, Weili Zhang, Wei Li, Chunhua Ling, Min Jian. Anti-inflammatory drug, leflunomide and its metabolite teriflunomide inhibit NSCLC proliferation in vivo and in vitro. Toxicology letters. vol 282. 2017-12-01. PMID:29050931. |
in addition, to comprehensively clarify the mechanisms of teriflunomide in nsclc, we explored a genome-wide transcriptomic analysis, and found that teriflunomide was involved in multiple signaling pathways and cellular processes, such as cell cycle, apoptosis, mapk and p53 signaling pathway. |
2017-12-01 |
2023-08-13 |
mouse |
| Tatyana A Grigoreva, Daria S Novikova, Alexey V Petukhov, Maxim A Gureev, Alexander V Garabadzhiu, Gerry Melino, Nickolai A Barlev, Vyacheslav G Tribulovic. Proapoptotic modification of substituted isoindolinones as MDM2-p53 inhibitors. Bioorganic & medicinal chemistry letters. vol 27. issue 23. 2017-12-01. PMID:29089230. |
synthesized molecules were evaluated for their ability to induce apoptosis in two cancer cell lines and their derivatives with different status of p53 (colorectal hct116 and osteosarcoma u2os cells) by annexin v staining. |
2017-12-01 |
2023-08-13 |
Not clear |
| Kacie A Gardella, Israel Muro, Gloria Fang, Krishnakali Sarkar, Omayra Mendez, Casey W Wrigh. Aryl hydrocarbon receptor nuclear translocator (ARNT) isoforms control lymphoid cancer cell proliferation through differentially regulating tumor suppressor p53 activity. Oncotarget. vol 7. issue 10. 2017-11-30. PMID:26909609. |
furthermore, co-suppression of relb or p53 with arnt isoform 1 prevented cell cycle arrest and blocked doxorubicin induced apoptosis. |
2017-11-30 |
2023-08-13 |
human |
| Ke He, Hu Qu, Li-Nan Xu, Jun Gao, Fu-Yi Cheng, Peng Xiang, Can-Quan Zho. Epigenetics changes caused by the fusion of human embryonic stem cell and ovarian cancer cells. Bioscience reports. vol 36. issue 5. 2017-11-29. PMID:27377320. |
the hescs can inhibit the growth of ovcar-3 cells in vitro by suppressing p53 and pten expression to suppress the growth of tumour that may be achieved by inducing apoptosis of ovcar-3 cells. |
2017-11-29 |
2023-08-13 |
mouse |
| b' Marek Petr, Robert Helma, Alena Pol\\xc3\\xa1\\xc5\\xa1kov\\xc3\\xa1, Aneta Krej\\xc4\\x8d\\xc3\\xad, Zuzana Dvo\\xc5\\x99\\xc3\\xa1kov\\xc3\\xa1, Iva Kejnovsk\\xc3\\xa1, Lucie Navr\\xc3\\xa1tilov\\xc3\\xa1, Matej Ad\\xc3\\xa1mik, Michaela Vorl\\xc3\\xad\\xc4\\x8dkov\\xc3\\xa1, Marie Br\\xc3\\xa1zdov\\xc3\\xa. Wild-type p53 binds to MYC promoter G-quadruplex. Bioscience reports. vol 36. issue 5. 2017-11-29. PMID:27634752.' |
tumour suppressor p53 plays a critical role in regulatory pathways leading to cell cycle arrest, dna repair and apoptosis. |
2017-11-29 |
2023-08-13 |
Not clear |
| Vamsidhar Velcheti, Tomas Radivoyevitch, Yogen Saunthararaja. Higher-Level Pathway Objectives of Epigenetic Therapy: A Solution to the p53 Problem in Cancer. American Society of Clinical Oncology educational book. American Society of Clinical Oncology. Annual Meeting. vol 37. 2017-11-29. PMID:28561650. |
outside of this core, apoptosis and differentiation programs, which dominantly antagonize myc to terminate cell division, necessarily differ between cancer and normal cells, as apoptosis is suppressed by biallelic inactivation of the master regulator of apoptosis, p53, or its cofactor p16/cdkn2a in approximately 80% of cancers. |
2017-11-29 |
2023-08-13 |
Not clear |
| Vamsidhar Velcheti, Tomas Radivoyevitch, Yogen Saunthararaja. Higher-Level Pathway Objectives of Epigenetic Therapy: A Solution to the p53 Problem in Cancer. American Society of Clinical Oncology educational book. American Society of Clinical Oncology. Annual Meeting. vol 37. 2017-11-29. PMID:28561650. |
these genetic alterations impact therapy: conventional oncotherapy applies stress upstream of p53 to upregulate it and causes apoptosis (cytotoxicity)-a toxic, futile intent when it is absent or nonfunctional. |
2017-11-29 |
2023-08-13 |
Not clear |
| Shang-Jui Wang, Dawei Li, Yang Ou, Le Jiang, Yue Chen, Yingming Zhao, Wei G. Acetylation Is Crucial for p53-Mediated Ferroptosis and Tumor Suppression. Cell reports. vol 17. issue 2. 2017-11-28. PMID:27705786. |
although previous studies indicate that loss of p53-mediated cell cycle arrest, apoptosis, and senescence does not completely abrogate its tumor suppression function, it is unclear how the remaining activities of p53 are regulated. |
2017-11-28 |
2023-08-13 |
mouse |
| Mei-Mei Gu, Jing-Rong Kong, Di-Huang, Ting Peng, Chen-Ying Xie, Kai-Yuan Yang, Yuan Liu, Wei-Na Wan. Molecular characterization and function of the Prohibitin2 gene in Litopenaeus vannamei responses to Vibrio alginolyticus. Developmental and comparative immunology. vol 67. 2017-11-28. PMID:27756688. |
luciferase reporter assays showed that over-expression of lvphb2 could activate the p53 pathway, indicating that it might participate in apoptosis regulation. |
2017-11-28 |
2023-08-13 |
Not clear |
| Ok Ran Choi, Min Sook Ryu, In Kyoung Li. Shifting p53-induced senescence to cell death by TIS21(/BTG2/Pc3) gene through posttranslational modification of p53 protein. Cellular signalling. vol 28. issue 9. 2017-11-28. PMID:27208501. |
cellular senescence and apoptosis can be regulated by p53 activity, although the underlying mechanism of the switch between the two events remains largely unknown. |
2017-11-28 |
2023-08-13 |
Not clear |
| Ok Ran Choi, Min Sook Ryu, In Kyoung Li. Shifting p53-induced senescence to cell death by TIS21(/BTG2/Pc3) gene through posttranslational modification of p53 protein. Cellular signalling. vol 28. issue 9. 2017-11-28. PMID:27208501. |
by employing adenoviral transduction of p53 or tis21 genes, we observed shifting of p53 induced-senescence to apoptosis in ej bladder cancer cells, which express h-rasv12 and mutant p53; transduction of p53 increased h-rasv12 expression along with senescence phenotypes, whereas coexpression with tis21 (p53+tis21) induced cell death rather than senescence. |
2017-11-28 |
2023-08-13 |
Not clear |
| Ok Ran Choi, Min Sook Ryu, In Kyoung Li. Shifting p53-induced senescence to cell death by TIS21(/BTG2/Pc3) gene through posttranslational modification of p53 protein. Cellular signalling. vol 28. issue 9. 2017-11-28. PMID:27208501. |
the tis21-mediated switch of senescence to apoptosis was accompanied by nuclear translocation of p53 protein and its modifications on ser-15 and ser-46 phosphorylation and acetylations on lys-120, -320, -373 and -382 residues. |
2017-11-28 |
2023-08-13 |
Not clear |
| Xiao-Yan He, Xiao-Li Feng, Xin-Pei Song, Huan-Chao Zeng, Zhong-Xu Cao, Wei-Wei Xiao, Bao Zhang, Qing-Hua W. [RITA combined with temozolomide inhibits the proliferation of human glioblastoma U87 cells]. Nan fang yi ke da xue xue bao = Journal of Southern Medical University. vol 36. issue 10. 2017-11-27. PMID:27777210. |
to observe the effect of rita, a small molecule that targets p53, combined with temozolomide (tmz) on proliferation, colony formation and apoptosis of human glioblastoma u87 cells and explore the underlying mechanism. |
2017-11-27 |
2023-08-13 |
human |
| Laura J Phalen, Bernd Köllner, Natacha S Hogan, Michael R van den Heuve. Transcriptional response in rainbow trout (Oncorhynchus mykiss) B cells and thrombocytes following in vivo exposure to benzo[a]pyrene. Environmental toxicology and pharmacology. vol 53. 2017-11-27. PMID:28662488. |
the mrna expression of five cytochrome p450 (cyp) enzymes, the aryl hydrocarbon receptor (ahr), and an intrinsic pathway apoptosis checkpoint (p53) in b cells and thrombocytes were examined. |
2017-11-27 |
2023-08-13 |
Not clear |
| Robert Nakayama, Yi-Xiang Zhang, Jeffrey T Czaplinski, Alex J Anatone, Ewa T Sicinska, Jonathan A Fletcher, George D Demetri, Andrew J Wagne. Preclinical activity of selinexor, an inhibitor of XPO1, in sarcoma. Oncotarget. vol 7. issue 13. 2017-11-27. PMID:26918731. |
in lps cell lines with mdm2 and cdk4 amplification, selinexor induced g1-arrest and apoptosis irrespective of p53 expression or mutation and irrespective of rb expression. |
2017-11-27 |
2023-08-13 |
Not clear |
| Somanshu Banerjee, Chandra Mohini Chaturved. Apoptotic mechanism behind the testicular atrophy in photorefractory and scotosensitive quail: Involvement of GnIH induced p-53 dependent Bax-Caspase-3 mediated pathway. Journal of photochemistry and photobiology. B, Biology. vol 176. 2017-11-22. PMID:28992606. |
testicular apoptosis in the quail of different photoperiodic conditions was assessed by monitoring the alterations in the local testicular expression of gnrh-i, gnih, pro-apoptotic proteins (p53 and bax), inactive caspase (pro-caspase-3), executioner active-caspase-3 and inactive/uncleaved parp-1 (dna repair enzyme) and tunel analysis. |
2017-11-22 |
2023-08-13 |
Not clear |
| Stefania Trino, Ilaria Iacobucci, Daniela Erriquez, Ilaria Laurenzana, Luciana De Luca, Anna Ferrari, Andrea Ghelli Luserna Di Rorà, Cristina Papayannidis, Enrico Derenzini, Giorgia Simonetti, Annalisa Lonetti, Claudia Venturi, Federica Cattina, Emanuela Ottaviani, Maria Chiara Abbenante, Domenico Russo, Giovanni Perini, Pellegrino Musto, Giovanni Martinell. Targeting the p53-MDM2 interaction by the small-molecule MDM2 antagonist Nutlin-3a: a new challenged target therapy in adult Philadelphia positive acute lymphoblastic leukemia patients. Oncotarget. vol 7. issue 11. 2017-11-21. PMID:26887044. |
we demonstrated that nutlin-3a treatment reduced viability and induced p53-mediated apoptosis in all cells with wild-type p53 protein, in a time and dose-dependent manner, resulting in the increased expression of pro-apoptotic proteins and key regulators of cell cycle arrest. |
2017-11-21 |
2023-08-13 |
Not clear |
| Xiang Zhou, Qian Hao, Peng Liao, Shiwen Luo, Minhong Zhang, Guohui Hu, Hongbing Liu, Yiwei Zhang, Bo Cao, Melody Baddoo, Erik K Flemington, Shelya X Zeng, Hua L. Nerve growth factor receptor negates the tumor suppressor p53 as a feedback regulator. eLife. vol 5. 2017-11-20. PMID:27282385. |
inversely, ngfr ablation activates p53, consequently inducing apoptosis, attenuating survival, and reducing clonogenic capability of cancer cells, as well as sensitizing human cancer cells to chemotherapeutic agents that induce p53 and suppressing mouse xenograft tumor growth. |
2017-11-20 |
2023-08-13 |
mouse |
| Isabel Morgado-Palacin, Amanda Day, Matilde Murga, Vanesa Lafarga, Marta Elena Anton, Anthony Tubbs, Hua Tang Chen, Aysegul Ergan, Rhonda Anderson, Avinash Bhandoola, Kurt G Pike, Bernard Barlaam, Elaine Cadogan, Xi Wang, Andrew J Pierce, Chad Hubbard, Scott A Armstrong, André Nussenzweig, Oscar Fernandez-Capetill. Targeting the kinase activities of ATR and ATM exhibits antitumoral activity in mouse models of MLL-rearranged AML. Science signaling. vol 9. issue 445. 2017-11-20. PMID:27625305. |
aml-mll tumor cells are resistant to current genotoxic therapies because of an attenuated response by p53, a protein that induces cell cycle arrest and apoptosis in response to dna damage. |
2017-11-20 |
2023-08-13 |
mouse |
| Ava Safaroghli-Azar, Davood Bashash, Parisa Sadreazami, Majid Momeny, Seyed H Ghaffar. PI3K-δ inhibition using CAL-101 exerts apoptotic effects and increases doxorubicin-induced cell death in pre-B-acute lymphoblastic leukemia cells. Anti-cancer drugs. vol 28. issue 4. 2017-11-16. PMID:28125433. |
cal-101 also leads to induction of caspase-dependent apoptosis probably through reactive oxygen species-dependent upregulation of foxo3a and subsequent induction of the proapoptotic target genes of p53. |
2017-11-16 |
2023-08-13 |
Not clear |