| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Upasana Sahu, Himakshi Sidhar, Pankaj S Ghate, Gopal M Advirao, Sathees C Raghavan, Ranjit K Gir. A Novel Anticancer Agent, 8-Methoxypyrimido[4',5':4,5]thieno(2,3-b) Quinoline-4(3H)-One Induces Neuro 2a Neuroblastoma Cell Death through p53-Dependent, Caspase-Dependent and -Independent Apoptotic Pathways. PloS one. vol 8. issue 6. 2017-10-23. PMID:23824039. |
collectively, mptq-induced neuro 2a cell death is mediated by atm and p53 activation, and bax-mediated activation of caspase-dependent and caspase-independent mitochondrial apoptosis pathways. |
2017-10-23 |
2023-08-12 |
mouse |
| Daniel Coutandin, Christian Osterburg, Ratnesh Kumar Srivastav, Manuela Sumyk, Sebastian Kehrloesser, Jakob Gebel, Marcel Tuppi, Jens Hannewald, Birgit Schäfer, Eidarus Salah, Sebastian Mathea, Uta Müller-Kuller, James Doutch, Manuel Grez, Stefan Knapp, Volker Dötsc. Quality control in oocytes by p63 is based on a spring-loaded activation mechanism on the molecular and cellular level. eLife. vol 5. 2017-10-23. PMID:27021569. |
mammalian oocytes are arrested in the dictyate stage of meiotic prophase i for long periods of time, during which the high concentration of the p53 family member tap63α sensitizes them to dna damage-induced apoptosis. |
2017-10-23 |
2023-08-13 |
Not clear |
| Zhantao Deng, Xiaozhou Liu, Jiewen Jin, Haidong Xu, Qian Gao, Yong Wang, Jianning Zha. Histone Deacetylase Inhibitor Trichostatin a Promotes the Apoptosis of Osteosarcoma Cells through p53 Signaling Pathway Activation. International journal of biological sciences. vol 12. issue 11. 2017-10-20. PMID:27877082. |
histone deacetylase inhibitor trichostatin a promotes the apoptosis of osteosarcoma cells through p53 signaling pathway activation. |
2017-10-20 |
2023-08-13 |
Not clear |
| Niharika Sinha, Prashanta K Panda, Prajna P Naik, Durgesh N Das, Subhadip Mukhopadhyay, Tapas K Maiti, Muthu K Shanmugam, Arunachalam Chinnathambi, M E Zayed, Sulaiman A Alharbi, Gautam Sethi, Rajesh Agarwal, Sujit K Bhuti. Abrus agglutinin promotes irreparable DNA damage by triggering ROS generation followed by ATM-p73 mediated apoptosis in oral squamous cell carcinoma. Molecular carcinogenesis. vol 56. issue 11. 2017-10-20. PMID:28543759. |
in oral cancer p53 is mutated, thus we focused on p73; agg resulted in p73 upregulation and knock down of p73 caused a decrease in agg-induced apoptosis. |
2017-10-20 |
2023-08-13 |
mouse |
| Niharika Sinha, Prashanta K Panda, Prajna P Naik, Durgesh N Das, Subhadip Mukhopadhyay, Tapas K Maiti, Muthu K Shanmugam, Arunachalam Chinnathambi, M E Zayed, Sulaiman A Alharbi, Gautam Sethi, Rajesh Agarwal, Sujit K Bhuti. Abrus agglutinin promotes irreparable DNA damage by triggering ROS generation followed by ATM-p73 mediated apoptosis in oral squamous cell carcinoma. Molecular carcinogenesis. vol 56. issue 11. 2017-10-20. PMID:28543759. |
in conclusion, we established a connection among ros, atm and p73 in agg-induced apoptosis, which might be useful in enhancing the therapeutic targeting of p53 deficient oral squamous cell carcinoma. |
2017-10-20 |
2023-08-13 |
mouse |
| Danijela Stanisavljevic, Isidora Petrovic, Vladanka Vukovic, Marija Schwirtlich, Marija Gredic, Milena Stevanovic, Jelena Popovi. SOX14 activates the p53 signaling pathway and induces apoptosis in a cervical carcinoma cell line. PloS one. vol 12. issue 9. 2017-10-20. PMID:28926586. |
sox14 activates the p53 signaling pathway and induces apoptosis in a cervical carcinoma cell line. |
2017-10-20 |
2023-08-13 |
Not clear |
| Laure Bidou, Olivier Bugaud, Valery Belakhov, Timor Baasov, Olivier Nam. Characterization of new-generation aminoglycoside promoting premature termination codon readthrough in cancer cells. RNA biology. vol 14. issue 3. 2017-10-19. PMID:28145797. |
both ptc suppression and mrna stabilization contributed to the production of a full-length p53 protein capable of activating p53-dependent genes, thereby specifically promoting high levels of apoptosis. |
2017-10-19 |
2023-08-13 |
human |
| Zhixian Yu, Dana L Ruter, Erich J Kushner, Victoria L Bautc. Excess centrosomes induce p53-dependent senescence without DNA damage in endothelial cells. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 31. issue 10. 2017-10-19. PMID:28626028. |
excess centrosomes in ecs were associated with p53 phosphorylation at ser33, increased p21 levels, and decreased cell proliferation and expression of senescence markers, but independent of dna damage and apoptosis. |
2017-10-19 |
2023-08-13 |
mouse |
| H B Xia, H W Cui, L Su, Z H Zhang, X Y Yang, S Q Ning, X L S. Clinical significance and expression of PUMA, MCL-1, and p53 in human renal cell carcinoma and para-carcinoma tissues. Genetics and molecular research : GMR. vol 16. issue 3. 2017-10-19. PMID:28692117. |
we investigated the expression level of p53 upregulated modulator of apoptosis (puma), myeloid cell leukemia-i (mcl-1), and p53 in renal cell carcinoma (rcc) and para-carcinoma tissues, as well as their clinical significance. |
2017-10-19 |
2023-08-13 |
human |
| Yang Wang, Qi Ding, Tao Xu, Chang-Yao Li, Dan-Dan Zhou, Lei Zhan. HZ-6d targeted HERC5 to regulate p53 ISGylation in human hepatocellular carcinoma. Toxicology and applied pharmacology. vol 334. 2017-10-17. PMID:28919514. |
knockdown of herc5 significantly induced the expression of p53, p21 and bax/bcl-2 in hcc cells, resulting in apoptosis augment. |
2017-10-17 |
2023-08-13 |
mouse |
| Ruibing Chen, Yun Liu, Hao Zhuang, Baicai Yang, Kaiwen Hei, Mingming Xiao, Chunyu Hou, Huajun Gao, Xinran Zhang, Chenxi Jia, Lingjun Li, Yongmei Li, Ning Zhan. Quantitative proteomics reveals that long non-coding RNA MALAT1 interacts with DBC1 to regulate p53 acetylation. Nucleic acids research. vol 45. issue 17. 2017-10-17. PMID:28973437. |
consequently, the deacetylation of p53 reduces the transcription of a spectrum of its downstream target genes, promotes cell proliferation and inhibits cell apoptosis. |
2017-10-17 |
2023-08-13 |
Not clear |
| Se-Lim Kim, Seong Hun Kim, Young Ran Park, Yu-Chuan Liu, Eun-Mi Kim, Hwan-Jeong Jeong, Yo Na Kim, Seung Young Seo, In Hee Kim, Seung Ok Lee, Soo Teik Lee, Sang-Wook Ki. Combined Parthenolide and Balsalazide Have Enhanced Antitumor Efficacy Through Blockade of NF-κB Activation. Molecular cancer research : MCR. vol 15. issue 2. 2017-10-16. PMID:28108625. |
apoptosis via nf-κb signaling was confirmed by detecting expression of caspases, p53 and parp. |
2017-10-16 |
2023-08-13 |
mouse |
| Maike Busch, Jan Große-Kreul, Janina Jasmin Wirtz, Manfred Beier, Harald Stephan, Brigitte Royer-Pokora, Klaus Metz, Nicole Dünke. Reduction of the tumorigenic potential of human retinoblastoma cell lines by TFF1 overexpression involves p53/caspase signaling and miR-18a regulation. International journal of cancer. vol 141. issue 3. 2017-10-13. PMID:28481041. |
results from pg13-luciferase reporter assays and western blot analyses indicate that tff1-induced apoptosis is mediated through transcriptional activity of p53 with concurrently downregulated mir-18a expression. |
2017-10-13 |
2023-08-13 |
human |
| Lei Bi, Xiaojing Yan, Weiping Chen, Jing Gao, Lei Qian, Shuang Qi. Antihepatocellular Carcinoma Potential of Tetramethylpyrazine Induces Cell Cycle Modulation and Mitochondrial-Dependent Apoptosis: Regulation of p53 Signaling Pathway in HepG2 Cells In Vitro. Integrative cancer therapies. vol 15. issue 2. 2017-10-12. PMID:27179035. |
antihepatocellular carcinoma potential of tetramethylpyrazine induces cell cycle modulation and mitochondrial-dependent apoptosis: regulation of p53 signaling pathway in hepg2 cells in vitro. |
2017-10-12 |
2023-08-13 |
Not clear |
| Lei Bi, Xiaojing Yan, Weiping Chen, Jing Gao, Lei Qian, Shuang Qi. Antihepatocellular Carcinoma Potential of Tetramethylpyrazine Induces Cell Cycle Modulation and Mitochondrial-Dependent Apoptosis: Regulation of p53 Signaling Pathway in HepG2 Cells In Vitro. Integrative cancer therapies. vol 15. issue 2. 2017-10-12. PMID:27179035. |
moreover, tmp altered expression of p53 and the bcl-2/bax protein ratio, which revealed that tmp induced cell cycle arrest and caspase-dependent mitochondrial apoptosis in hepg2 cells in vitro. |
2017-10-12 |
2023-08-13 |
Not clear |
| Ming J Poi, Junan Li, Douglas W Sborov, Zachary VanGundy, Yu Kyoung Cho, Misty Lamprecht, Flavia Pichiorri, Mitch A Phelps, Craig C Hofmeiste. Polymorphism in ANRIL is associated with relapse in patients with multiple myeloma after autologous stem cell transplant. Molecular carcinogenesis. vol 56. issue 7. 2017-10-11. PMID:28150872. |
our results indicate that anril may be involved in melphalan-mediated apoptosis via down-regulating p14arf and subsequent p53, and that the rs2151280 polymorphism may be a potential prognostic biomarker for relapse in melphalan-treated mm patients. |
2017-10-11 |
2023-08-13 |
Not clear |
| Mahsa Jafari Gi. Exposure to Amphetamines Leads to Development of Amphetamine Type Stimulants Associated Cardiomyopathy (ATSAC). Cardiovascular toxicology. vol 17. issue 1. 2017-10-10. PMID:27663745. |
oxidative stress, accelerated apoptosis, increased p53 activity, cardiomyocyte necrosis, perfusion defects, fatty acid toxicity, altered gene expression, abnormal cardiac protein synthesis and function in addition to defects in intracellular calcium hemostasis present themselves as likely mechanisms of cardiotoxicity in atsac. |
2017-10-10 |
2023-08-13 |
Not clear |
| Dan Xu, Qian Du, Cong Han, Zengguo Wang, Xiujuan Zhang, Tongtong Wang, Xiaomin Zhao, Yong Huang, Dewen Ton. p53 signaling modulation of cell cycle arrest and viral replication in porcine circovirus type 2 infection cells. Veterinary research. vol 47. issue 1. 2017-10-10. PMID:27899159. |
previous studies have shown that pcv2 infection induces host cell apoptosis through up-regulation of p53. |
2017-10-10 |
2023-08-13 |
Not clear |
| Katja Kiseljak-Vassiliades, Taylor S Mills, Yu Zhang, Mei Xu, Kevin O Lillehei, B K Kleinschmidt-DeMasters, Margaret E Wierma. Elucidating the Role of the Desmosome Protein p53 Apoptosis Effector Related to PMP-22 in Growth Hormone Tumors. Endocrinology. vol 158. issue 5. 2017-10-10. PMID:28323918. |
elucidating the role of the desmosome protein p53 apoptosis effector related to pmp-22 in growth hormone tumors. |
2017-10-10 |
2023-08-13 |
human |
| Katja Kiseljak-Vassiliades, Taylor S Mills, Yu Zhang, Mei Xu, Kevin O Lillehei, B K Kleinschmidt-DeMasters, Margaret E Wierma. Elucidating the Role of the Desmosome Protein p53 Apoptosis Effector Related to PMP-22 in Growth Hormone Tumors. Endocrinology. vol 158. issue 5. 2017-10-10. PMID:28323918. |
there was a consistent downregulation of transcripts involved in the structure and function of the desmosome, including desmoplakin (eightfold), desmoglein 2 (sixfold), plakophilin 2 (sevenfold), and p53 apoptosis effector related to pmp-22 (perp; sixfold) in sg tumors compared with normal pituitary. |
2017-10-10 |
2023-08-13 |
human |