| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Tae-Gyun Woo, Min-Ho Yoon, Shin-Deok Hong, Jiyun Choi, Nam-Chul Ha, Hokeun Sun, Bum-Joon Par. Anti-cancer effect of novel PAK1 inhibitor via induction of PUMA-mediated cell death and p21-mediated cell cycle arrest. Oncotarget. vol 8. issue 14. 2017-10-10. PMID:28423593. |
in previous, we also showed that pak1 is highly activated in the smad4-deficient condition and suppresses puma (p53 upregulated modulator of apoptosis) through direct binding and phosphorylation. |
2017-10-10 |
2023-08-13 |
human |
| Z Li, Y Xion. Cytoplasmic E3 ubiquitin ligase CUL9 controls cell proliferation, senescence, apoptosis and genome integrity through p53. Oncogene. vol 36. issue 36. 2017-10-10. PMID:28481879. |
cytoplasmic e3 ubiquitin ligase cul9 controls cell proliferation, senescence, apoptosis and genome integrity through p53. |
2017-10-10 |
2023-08-13 |
mouse |
| Z Li, Y Xion. Cytoplasmic E3 ubiquitin ligase CUL9 controls cell proliferation, senescence, apoptosis and genome integrity through p53. Oncogene. vol 36. issue 36. 2017-10-10. PMID:28481879. |
cul9 binds to p53 and causes cell apoptosis when ectopically expressed. |
2017-10-10 |
2023-08-13 |
mouse |
| Mohammad Dalla. A synergistic protective effect of selenium and taurine against experimentally induced myocardial infarction in rats. Archives of physiology and biochemistry. vol 123. issue 5. 2017-10-10. PMID:28699791. |
this concomitant treatment acted by increasing the activity of major antioxidant enzymes (sod and gpx), decreasing the levels of inflammatory markers including tnf-α, il-6 as well as levels of bcl-2 and caspase-3 and downregulating mrna levels of bax and p53, markers of apoptosis. |
2017-10-10 |
2023-08-13 |
rat |
| Chengyan Jin, Guangxin Zhang, Yifan Zhang, Peiyan Hua, Ge Song, Mei Sun, Xin Li, Ti Tong, Bingjin Li, Xingyi Zhan. Isoalantolactone induces intrinsic apoptosis through p53 signaling pathway in human lung squamous carcinoma cells. PloS one. vol 12. issue 8. 2017-10-10. PMID:28777796. |
isoalantolactone induces intrinsic apoptosis through p53 signaling pathway in human lung squamous carcinoma cells. |
2017-10-10 |
2023-08-13 |
human |
| Chengyan Jin, Guangxin Zhang, Yifan Zhang, Peiyan Hua, Ge Song, Mei Sun, Xin Li, Ti Tong, Bingjin Li, Xingyi Zhan. Isoalantolactone induces intrinsic apoptosis through p53 signaling pathway in human lung squamous carcinoma cells. PloS one. vol 12. issue 8. 2017-10-10. PMID:28777796. |
it significantly inhibited the growth of sk-mes-1 cells through apoptosis in a dose-dependent manner via activation of p53. |
2017-10-10 |
2023-08-13 |
human |
| Chengyan Jin, Guangxin Zhang, Yifan Zhang, Peiyan Hua, Ge Song, Mei Sun, Xin Li, Ti Tong, Bingjin Li, Xingyi Zhan. Isoalantolactone induces intrinsic apoptosis through p53 signaling pathway in human lung squamous carcinoma cells. PloS one. vol 12. issue 8. 2017-10-10. PMID:28777796. |
our results reveal that isoalantolactone induces intrinsic apoptosis in sk-mes-1 cells through p53 signaling pathway, which suggests that isoalantolactone could be a potential leading compound for future development of anti-lung cancer drugs. |
2017-10-10 |
2023-08-13 |
human |
| Ying He, Guili Lian, Shuyong Lin, Zhiyun Ye, Qinxi L. MDM2 Inhibits Axin-Induced p53 Activation Independently of its E3 Ligase Activity. PloS one. vol 8. issue 6. 2017-10-10. PMID:23826318. |
here we show that mdm2 can inhibit axin-stimulated p53-dependent apoptosis by suppressing p53 phosphorylation at ser 46 and apoptosis-related p53 transactivational activity. |
2017-10-10 |
2023-08-12 |
Not clear |
| Kai Shen, Yuan Zhang, Xuan Lv, Xufeng Chen, Rongbin Zhou, Lan K Nguyen, Xiaodong Wu, Honghong Ya. Molecular Mechanisms Involving Sigma-1 Receptor in Cell Apoptosis of BV-2 Microglial Cells Induced by Methamphetamine. CNS & neurological disorders drug targets. vol 15. issue 7. 2017-10-10. PMID:27189473. |
exposure of bv-2 cells to methamphetamine induces cell apoptosis through its cognate receptor σ-1r, followed by activation of the mitogen-activated protein kinases, phosphatidylinositol-3' kinase/akt as well as the downstream transcription factor p53 pathways. |
2017-10-10 |
2023-08-13 |
Not clear |
| W Lu, F Cheng, W Yan, X Li, X Yao, W Song, M Liu, X Shen, H Jiang, J Chen, J Li, J Huan. Selective targeting p53 Oncogene. vol 36. issue 33. 2017-10-09. PMID:28394340. |
herein, we identify a novel cyclophilin a (cypa) small molecule inhibitor (hl001) that induces non-small cell lung cancer (nsclc) cell cycle arrest and apoptosis via restoring p53 expression. |
2017-10-09 |
2023-08-13 |
mouse |
| Ashraf Yusuf Rangrez, Jost Pott, Annika Kluge, Robert Frauen, Katharina Stiebeling, Phillip Hoppe, Samuel Sossalla, Norbert Frey, Derk Fran. Myeloid leukemia factor-1 is a novel modulator of neonatal rat cardiomyocyte proliferation. Biochimica et biophysica acta. Molecular cell research. vol 1864. issue 4. 2017-10-06. PMID:28087342. |
the observed accelerated apoptosis is attributed to the activation of caspase-3/-7/parp-dependent apoptotic signaling and upregulation of p53. |
2017-10-06 |
2023-08-13 |
mouse |
| Ana Ludke, Gauri Akolkar, Prathapan Ayyappan, Anita K Sharma, Pawan K Singa. Time course of changes in oxidative stress and stress-induced proteins in cardiomyocytes exposed to doxorubicin and prevention by vitamin C. PloS one. vol 12. issue 7. 2017-10-06. PMID:28678856. |
dox administration to cardiomyocytes increased the levels of ros in a time-dependent manner that followed the activation of stress-induced proteins p53, p38 and jnk mapks, culminating in an increase in autophagy and apoptosis markers. |
2017-10-06 |
2023-08-13 |
rat |
| Ana Ludke, Gauri Akolkar, Prathapan Ayyappan, Anita K Sharma, Pawan K Singa. Time course of changes in oxidative stress and stress-induced proteins in cardiomyocytes exposed to doxorubicin and prevention by vitamin C. PloS one. vol 12. issue 7. 2017-10-06. PMID:28678856. |
protective effect of vit c against the activation of stress induced proteins, autophagy and apoptosis was mainly attributed to its antioxidant properties even though blockage of p38, jnk and p53 by pharmacological inhibitors also suppressed dox-induced apoptosis. |
2017-10-06 |
2023-08-13 |
rat |
| Yanhong Zhang, Wensheng Yan, Yong Sam Jung, Xinbin Che. PUMA Cooperates with p21 to Regulate Mammary Epithelial Morphogenesis and Epithelial-To-Mesenchymal Transition. PloS one. vol 8. issue 6. 2017-10-06. PMID:23805223. |
previously, we showed that knockdown of p53 or p73 leads to aberrant mammary acinus formation accompanied with decreased expression of p53 family targets puma and p21, suggesting that puma, an inducer of apoptosis, and p21, an inducer of cell cycle arrest, directly regulate mammary morphogenesis. |
2017-10-06 |
2023-08-12 |
Not clear |
| Xing Li, Yin Zhao, Qian Xia, Lu Zheng, Lu Liu, Baoming Zhao, Jing Sh. Nuclear translocation of annexin 1 following oxygen-glucose deprivation-reperfusion induces apoptosis by regulating Bid expression via p53 binding. Cell death & disease. vol 7. issue 9. 2017-10-04. PMID:27584794. |
nuclear translocation of annexin 1 following oxygen-glucose deprivation-reperfusion induces apoptosis by regulating bid expression via p53 binding. |
2017-10-04 |
2023-08-13 |
Not clear |
| Patrick Vianna Garcia, Fábio Rodrigues Ferreira Seiva, Amanda Pocol Carniato, Wilson de Mello Júnior, Nelson Duran, Alda Maria Macedo, Alexandre Gabarra de Oliveira, Rok Romih, Iseu da Silva Nunes, Odilon da Silva Nunes, Wagner José Fávar. Increased toll-like receptors and p53 levels regulate apoptosis and angiogenesis in non-muscle invasive bladder cancer: mechanism of action of P-MAPA biological response modifier. BMC cancer. vol 16. 2017-10-03. PMID:27389279. |
increased toll-like receptors and p53 levels regulate apoptosis and angiogenesis in non-muscle invasive bladder cancer: mechanism of action of p-mapa biological response modifier. |
2017-10-03 |
2023-08-13 |
Not clear |
| Patrick Vianna Garcia, Fábio Rodrigues Ferreira Seiva, Amanda Pocol Carniato, Wilson de Mello Júnior, Nelson Duran, Alda Maria Macedo, Alexandre Gabarra de Oliveira, Rok Romih, Iseu da Silva Nunes, Odilon da Silva Nunes, Wagner José Fávar. Increased toll-like receptors and p53 levels regulate apoptosis and angiogenesis in non-muscle invasive bladder cancer: mechanism of action of P-MAPA biological response modifier. BMC cancer. vol 16. 2017-10-03. PMID:27389279. |
this study detailed and characterized the mechanisms of action of p-mapa based on activation of mediators of toll-like receptors (tlrs) 2 and 4 signaling pathways and p53 in regulating angiogenesis and apoptosis in an animal model of nmibc, as well as, compared these mechanisms with bcg treatment. |
2017-10-03 |
2023-08-13 |
Not clear |
| Wafa Mihoubi, Emna Sahli, Ali Gargouri, Caroline Amie. FTIR spectroscopy of whole cells for the monitoring of yeast apoptosis mediated by p53 over-expression and its suppression by Nigella sativa extracts. PloS one. vol 12. issue 7. 2017-10-03. PMID:28704406. |
ftir spectroscopy of whole cells for the monitoring of yeast apoptosis mediated by p53 over-expression and its suppression by nigella sativa extracts. |
2017-10-03 |
2023-08-13 |
Not clear |
| Wafa Mihoubi, Emna Sahli, Ali Gargouri, Caroline Amie. FTIR spectroscopy of whole cells for the monitoring of yeast apoptosis mediated by p53 over-expression and its suppression by Nigella sativa extracts. PloS one. vol 12. issue 7. 2017-10-03. PMID:28704406. |
p53 over expression in yeast results in cell death with typical markers of apoptosis such as dna fragmentation and phosphatidylserine externalization. |
2017-10-03 |
2023-08-13 |
Not clear |
| Wafa Mihoubi, Emna Sahli, Ali Gargouri, Caroline Amie. FTIR spectroscopy of whole cells for the monitoring of yeast apoptosis mediated by p53 over-expression and its suppression by Nigella sativa extracts. PloS one. vol 12. issue 7. 2017-10-03. PMID:28704406. |
we aimed to substitute/supplement classical fluorescent techniques (tunel, annexin v, ros detection) usually used to detect biochemical changes occurring during yeast apoptosis mediated by p53 over expression and the effect of anti-apoptotic purified molecules from nigel (nigella sativa) extracts on these same yeasts by the label free technique of ftir spectroscopy. |
2017-10-03 |
2023-08-13 |
Not clear |