| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xingwen Wang, Yiwei Cheng, YiFu Zhu, Huayi Li, Wenjie Ge, Xiaoliang Wu, Kunming Zhao, Jinyang Yuan, Zhenglin Li, Shijian Jiang, Zhengbin Han, Qinghua Jiang, Qiong Wu, Tao Liu, Cheng Zhang, Miao Yu, Ying H. Epigenetic silencing of ASPP1 confers 5-FU resistance in clear cell renal cell carcinoma by preventing p53 activation. International journal of cancer. vol 141. issue 7. 2017-09-27. PMID:28656647. |
in contrast, aspp1 knockdown promoted cell growth and prevent 5-fu-induced p53 activation and apoptosis. |
2017-09-27 |
2023-08-13 |
human |
| Yang Kong, Lufei Zhang, Yu Huang, Tianyu He, Linshi Zhang, Xinyi Zhao, Xiaohu Zhou, Dongkai Zhou, Yingcai Yan, Jiarong Zhou, Haiyang Xie, Lin Zhou, Shusen Zheng, Weilin Wan. Pseudogene PDIA3P1 promotes cell proliferation, migration and invasion, and suppresses apoptosis in hepatocellular carcinoma by regulating the p53 pathway. Cancer letters. vol 407. 2017-09-27. PMID:28823960. |
pseudogene pdia3p1 promotes cell proliferation, migration and invasion, and suppresses apoptosis in hepatocellular carcinoma by regulating the p53 pathway. |
2017-09-27 |
2023-08-13 |
Not clear |
| Yang Kong, Lufei Zhang, Yu Huang, Tianyu He, Linshi Zhang, Xinyi Zhao, Xiaohu Zhou, Dongkai Zhou, Yingcai Yan, Jiarong Zhou, Haiyang Xie, Lin Zhou, Shusen Zheng, Weilin Wan. Pseudogene PDIA3P1 promotes cell proliferation, migration and invasion, and suppresses apoptosis in hepatocellular carcinoma by regulating the p53 pathway. Cancer letters. vol 407. 2017-09-27. PMID:28823960. |
we performed a genechip assay to investigate the underlying mechanism of pdia3p1 action on biological function, and our results suggested that pdia3p1 may promote proliferation and inhibit apoptosis of liver cancer cells by inhibiting the p53 pathway. |
2017-09-27 |
2023-08-13 |
Not clear |
| Oh-Joon Kwon, Li Zhang, Jianghua Wang, Qingtai Su, Qin Feng, Xiang H F Zhang, Sendurai A Mani, Robia Paulter, Chad J Creighton, Michael M Ittmann, Li Xi. Notch promotes tumor metastasis in a prostate-specific Pten-null mouse model. The Journal of clinical investigation. vol 126. issue 7. 2017-09-26. PMID:27294523. |
the increase in cellular apoptosis was linked to dna damage-induced p53 activation. |
2017-09-26 |
2023-08-13 |
mouse |
| Wei Qiang, Fang Sui, Jingjing Ma, Xinru Li, Xiaojuan Ren, Yuan Shao, Jiazhe Liu, Haixia Guan, Bingyin Shi, Peng Ho. Proteasome inhibitor MG132 induces thyroid cancer cell apoptosis by modulating the activity of transcription factor FOXO3a. Endocrine. vol 56. issue 1. 2017-09-26. PMID:28220348. |
however, apoptosis can also be found in cancer cells with mutant-type p53, suggesting the involvement of p53-independent mechanism. |
2017-09-26 |
2023-08-13 |
Not clear |
| Wei Qiang, Fang Sui, Jingjing Ma, Xinru Li, Xiaojuan Ren, Yuan Shao, Jiazhe Liu, Haixia Guan, Bingyin Shi, Peng Ho. Proteasome inhibitor MG132 induces thyroid cancer cell apoptosis by modulating the activity of transcription factor FOXO3a. Endocrine. vol 56. issue 1. 2017-09-26. PMID:28220348. |
the resulted showed that mg132 induced significant apoptosis, and caused the accumulation of p53 protein in both p53 wild-type and mutant-type thyroid cancer cell lines, whereas the proapoptotic targets of p53 were transcriptionally upregulated only in the p53 wild-type cells. |
2017-09-26 |
2023-08-13 |
Not clear |
| Sharon Pok, Harpreet Vohra, Charbel Wehbe, Vanessa A Barn, Evi Arfianti, Yock-Young Dan, Geoffrey C Farrell, Narci C Teo. Deriving and testing of dysplastic murine hepatocytes: A new platform in liver cancer research. Experimental cell research. vol 356. issue 1. 2017-09-26. PMID:28408319. |
to establish utility of dh, we studied pathways of p53 turnover, apoptosis and cell proliferation using pfithrin-α (pft) and nutlin-3. |
2017-09-26 |
2023-08-13 |
mouse |
| Kwon Jeong, Seong-Jin Kim, Yoojung Oh, Hunsung Kim, Young-Seok Lee, Byung-Su Kwon, Sanghyun Park, Key-Chung Park, Kyung-Sik Yoon, Sung Soo Kim, Joohun Ha, Insug Kang, Wonchae Cho. p53 negatively regulates Pin1 expression under ER stress. Biochemical and biophysical research communications. vol 454. issue 4. 2017-09-26. PMID:25451271. |
a previous study indicated that the apoptotic regulator p53 is significantly increased in response to er stress and participates in er stress-induced apoptosis. |
2017-09-26 |
2023-08-13 |
Not clear |
| Lin Fang, Qian Cheng, Wenshun Liu, Jie Zhang, Yan Ge, Qi Zhang, Liantao Li, Junjie Liu, Junnian Zhen. Selective effects of a fiber chimeric conditionally replicative adenovirus armed with hep27 gene on renal cancer cell. Cancer biology & therapy. vol 17. issue 6. 2017-09-26. PMID:27195521. |
further, hep27 mediated p53 and cleaved-parp upregulation and mdm2 downregulation was involved and caused increased apoptosis. |
2017-09-26 |
2023-08-13 |
human |
| Lin Fang, Qian Cheng, Wenshun Liu, Jie Zhang, Yan Ge, Qi Zhang, Liantao Li, Junjie Liu, Junnian Zhen. Selective effects of a fiber chimeric conditionally replicative adenovirus armed with hep27 gene on renal cancer cell. Cancer biology & therapy. vol 17. issue 6. 2017-09-26. PMID:27195521. |
our data demonstrated that 5/35 fiber-modified adenovirus f5/35-zd55-hep27 transferred into renal cancers efficiently and increased p53 to induce cancer cell apoptosis. |
2017-09-26 |
2023-08-13 |
human |
| Nesrine Benkafadar, Julien Menardo, Jérôme Bourien, Régis Nouvian, Florence François, Didier Decaudin, Domenico Maiorano, Jean-Luc Puel, Jing Wan. Reversible p53 inhibition prevents cisplatin ototoxicity without blocking chemotherapeutic efficacy. EMBO molecular medicine. vol 9. issue 1. 2017-09-25. PMID:27794029. |
encouragingly, however, genetic or pharmacological ablation of p53 substantially attenuated cochlear cell apoptosis, thus preserving hearing. |
2017-09-25 |
2023-08-13 |
mouse |
| Liyun Miao, Yue Yuan, Feng Cheng, Junshun Fang, Fang Zhou, Weirui Ma, Yan Jiang, Xiahe Huang, Yingchun Wang, Lingjuan Shan, Dahua Chen, Jian Zhan. Translation repression by maternal RNA binding protein Zar1 is essential for early oogenesis in zebrafish. Development (Cambridge, England). vol 144. issue 1. 2017-09-25. PMID:27913641. |
loss of p53 suppresses the apoptosis in zar1 mutants and restores oocyte development. |
2017-09-25 |
2023-08-13 |
zebrafish |
| Muhammad Haseeb, Shumaila Azam, A I Bhatti, Rizwan Azam, Mukhtar Ullah, Sahar Faza. On p53 revival using system oriented drug dosage design. Journal of theoretical biology. vol 415. 2017-09-25. PMID:27979498. |
the p53 pathway is the focus of researchers for the last thirty years for its pivotal role as a frontline cancer suppressant protein due to its effect on cell cycle checkpoints and cell apoptosis in response to a dna strand break. |
2017-09-25 |
2023-08-13 |
human |
| Xiang Zhou, Bo Cao, Hua L. Negative auto-regulators trap p53 in their web. Journal of molecular cell biology. vol 9. issue 1. 2017-09-25. PMID:28069666. |
the transcriptional factor p53 activates the expression of a myriad of target genes involving a complicated signalling network, resulting in various cellular outcomes, such as growth arrest, senescence, apoptosis, and metabolic changes, and leading to consequent suppression of tumour growth and progression. |
2017-09-25 |
2023-08-13 |
Not clear |
| Nicole R Tackmann, Yanping Zhan. Mouse modelling of the MDM2/MDMX-p53 signalling axis. Journal of molecular cell biology. vol 9. issue 1. 2017-09-25. PMID:28096294. |
it is evident that p53 activity is critical for tumour prevention and stress response through its transcriptional activation of genes affecting cellular senescence, apoptosis, cellular metabolism, and dna repair. |
2017-09-25 |
2023-08-13 |
mouse |
| Ji-Young Seo, Do-Yeon Kim, Seong-Hoon Kim, Hyo-Jin Kim, Hye Guk Ryu, Juhyun Lee, Kyung-Ha Lee, Kyong-Tai Ki. Heterogeneous nuclear ribonucleoprotein (hnRNP) L promotes DNA damage-induced cell apoptosis by enhancing the translation of p53. Oncotarget. vol 8. issue 31. 2017-09-25. PMID:28881634. |
heterogeneous nuclear ribonucleoprotein (hnrnp) l promotes dna damage-induced cell apoptosis by enhancing the translation of p53. |
2017-09-25 |
2023-08-13 |
Not clear |
| Ji-Young Seo, Do-Yeon Kim, Seong-Hoon Kim, Hyo-Jin Kim, Hye Guk Ryu, Juhyun Lee, Kyung-Ha Lee, Kyong-Tai Ki. Heterogeneous nuclear ribonucleoprotein (hnRNP) L promotes DNA damage-induced cell apoptosis by enhancing the translation of p53. Oncotarget. vol 8. issue 31. 2017-09-25. PMID:28881634. |
the tumor suppressor p53 is an essential gene in the induction of cell cycle arrest, dna repair, and apoptosis. |
2017-09-25 |
2023-08-13 |
Not clear |
| Ji-Young Seo, Do-Yeon Kim, Seong-Hoon Kim, Hyo-Jin Kim, Hye Guk Ryu, Juhyun Lee, Kyung-Ha Lee, Kyong-Tai Ki. Heterogeneous nuclear ribonucleoprotein (hnRNP) L promotes DNA damage-induced cell apoptosis by enhancing the translation of p53. Oncotarget. vol 8. issue 31. 2017-09-25. PMID:28881634. |
conversely, p53 protein levels were decreased following hnrnp l knock-down, rendering them resistant to apoptosis and arrest in the g2/m phase after dna damage. |
2017-09-25 |
2023-08-13 |
Not clear |
| Ji-Young Seo, Do-Yeon Kim, Seong-Hoon Kim, Hyo-Jin Kim, Hye Guk Ryu, Juhyun Lee, Kyung-Ha Lee, Kyong-Tai Ki. Heterogeneous nuclear ribonucleoprotein (hnRNP) L promotes DNA damage-induced cell apoptosis by enhancing the translation of p53. Oncotarget. vol 8. issue 31. 2017-09-25. PMID:28881634. |
thus, our findings suggest that hnrnp l functions as a positive regulator of p53 translation and promotes cell cycle arrest and apoptosis. |
2017-09-25 |
2023-08-13 |
Not clear |
| Jiyuan Liu, Zhen Tian, Nan Zhou, Xueying Liu, Chenyi Liao, Beilei Lei, Jianing Li, Shengyong Zhang, Hui Che. Targeting the apoptotic Mcl-1-PUMA interface with a dual-acting compound. Oncotarget. vol 8. issue 33. 2017-09-25. PMID:28903337. |
the interface of two apoptotic proteins, myeloid cell leukemia-1 (mcl-1) and p53 upregulated modulator of apoptosis (puma), has been recently affirmed as a target for treating cancers, as the disruption of mcl-1-puma binding can reduce cancer cell survival and protect normal cells from apoptosis. |
2017-09-25 |
2023-08-13 |
Not clear |