| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A Kitadate, S Ikeda, K Teshima, M Ito, I Toyota, N Hasunuma, N Takahashi, T Miyagaki, M Sugaya, H Tagaw. MicroRNA-16 mediates the regulation of a senescence-apoptosis switch in cutaneous T-cell and other non-Hodgkin lymphomas. Oncogene. vol 35. issue 28. 2017-09-13. PMID:26640145. |
alternatively, in ctcl cells lacking functional p53, mir-16 induced compensatory apoptosis. |
2017-09-13 |
2023-08-13 |
Not clear |
| A Kitadate, S Ikeda, K Teshima, M Ito, I Toyota, N Hasunuma, N Takahashi, T Miyagaki, M Sugaya, H Tagaw. MicroRNA-16 mediates the regulation of a senescence-apoptosis switch in cutaneous T-cell and other non-Hodgkin lymphomas. Oncogene. vol 35. issue 28. 2017-09-13. PMID:26640145. |
furthermore, we found that the histone deacetylase inhibitor suberoylanilide hydroxamic acid (saha) restored the expression of mir-16 and its essential targets, induced senescence in ctcl cells expressing wild-type p53 and promoted apoptosis in cells with nonfunctional p53. |
2017-09-13 |
2023-08-13 |
Not clear |
| Na Cao, Jia-Kai Li, Yu-Qing Rao, Huijuan Liu, Ji Wu, Baojie Li, Peiquan Zhao, Li Zeng, Jing L. A potential role for protein palmitoylation and zDHHC16 in DNA damage response. BMC molecular biology. vol 17. issue 1. 2017-09-13. PMID:27159997. |
cells respond to dna damage by activating the phosphatidylinositol-3 kinase-related kinases, p53 and other pathways to promote cell cycle arrest, apoptosis, and/or dna repair. |
2017-09-13 |
2023-08-13 |
Not clear |
| Seung Hee Lee, Jing Du, Jeremiah Stitham, Gourg Atteya, Suho Lee, Yaozu Xiang, Dandan Wang, Yu Jin, Kristen L Leslie, Geralyn Spollett, Anup Srivastava, Praveen Mannam, Allison Ostriker, Kathleen A Martin, Wai Ho Tang, John Hw. Inducing mitophagy in diabetic platelets protects against severe oxidative stress. EMBO molecular medicine. vol 8. issue 7. 2017-09-13. PMID:27221050. |
by removing damaged mitochondria (mitophagy), phosphorylated p53 is reduced, preventing progression to apoptosis, and preserving platelet function. |
2017-09-13 |
2023-08-13 |
human |
| Anup Kumar Singh, Shikha S Chauhan, Sudhir Kumar Singh, Ved Vrat Verma, Akhilesh Singh, Rakesh Kumar Arya, Shrankhla Maheshwari, Md Sohail Akhtar, Jayanta Sarkar, Vivek M Rangnekar, Prem M S Chauhan, Dipak Datt. Dual targeting of MDM2 with a novel small-molecule inhibitor overcomes TRAIL resistance in cancer. Carcinogenesis. vol 37. issue 11. 2017-09-12. PMID:27543608. |
cpi-7c-induced p53 directly recruited to the promoters of dr4 and dr5 genes and enhanced their expression, resulting in sensitization of tnf-related apoptosis-inducing ligand (trail)-resistant cancer cells toward trail-induced apoptosis. |
2017-09-12 |
2023-08-13 |
mouse |
| Karan Singh Saini, Hamidullah, Raghib Ashraf, Dhanaraju Mandalapu, Sharmistha Das, Mohd Quadir Siddiqui, Sonam Dwivedi, Jayanta Sarkar, Vishnu Lal Sharma, Rituraj Konwa. New orally active DNA minor groove binding small molecule CT-1 acts against breast cancer by targeting tumor DNA damage leading to p53-dependent apoptosis. Molecular carcinogenesis. vol 56. issue 4. 2017-09-12. PMID:27813185. |
ct-1 treated mammary tumor shows enhancement in dna damage, p53 upregulation, and apoptosis. |
2017-09-12 |
2023-08-13 |
rat |
| Keiko Omori, Eiji Kobayashi, Jeffrey Rawson, Masafumi Takahashi, Yoko Mulle. Mechanisms of islet damage mediated by pancreas cold ischemia/rewarming. Cryobiology. vol 73. issue 2. 2017-09-11. PMID:27587006. |
during the first 6 h of culture following islet isolation, p53 upregulated modulator of apoptosis (puma) and caspase-3 activation were also upregulated. |
2017-09-11 |
2023-08-13 |
rat |
| Patrick Y Lang, Gouri J Nanjangud, Marina Sokolsky-Papkov, Christine Shaw, Duhyeong Hwang, Joel S Parker, Alexander V Kabanov, Timothy R Gersho. ATR maintains chromosomal integrity during postnatal cerebellar neurogenesis and is required for medulloblastoma formation. Development (Cambridge, England). vol 143. issue 21. 2017-09-11. PMID:27803059. |
atr deletion in cerebellar granule neuron progenitors (cgnps) induced proliferation-associated dna damage, p53 activation, apoptosis and cerebellar hypoplasia in mice. |
2017-09-11 |
2023-08-13 |
mouse |
| Patrick Y Lang, Gouri J Nanjangud, Marina Sokolsky-Papkov, Christine Shaw, Duhyeong Hwang, Joel S Parker, Alexander V Kabanov, Timothy R Gersho. ATR maintains chromosomal integrity during postnatal cerebellar neurogenesis and is required for medulloblastoma formation. Development (Cambridge, England). vol 143. issue 21. 2017-09-11. PMID:27803059. |
co-deletions of either p53 or bax and bak prevented apoptosis in atr-deleted cgnps, but failed to fully rescue cerebellar growth. |
2017-09-11 |
2023-08-13 |
mouse |
| Patrick Y Lang, Gouri J Nanjangud, Marina Sokolsky-Papkov, Christine Shaw, Duhyeong Hwang, Joel S Parker, Alexander V Kabanov, Timothy R Gersho. ATR maintains chromosomal integrity during postnatal cerebellar neurogenesis and is required for medulloblastoma formation. Development (Cambridge, England). vol 143. issue 21. 2017-09-11. PMID:27803059. |
our data show that p53-driven apoptosis and cell cycle arrest - and, in the absence of p53, non-apoptotic cell death - redundantly limit growth in atr-deficient progenitors. |
2017-09-11 |
2023-08-13 |
mouse |
| Ahmad Najem, Mohammad Krayem, François Salès, Nader Hussein, Bassam Badran, Caroline Robert, Ahmad Awada, Fabrice Journe, Ghanem E Ghane. P53 and MITF/Bcl-2 identified as key pathways in the acquired resistance of NRAS-mutant melanoma to MEK inhibition. European journal of cancer (Oxford, England : 1990). vol 83. 2017-09-11. PMID:28738256. |
therefore, we aimed to further investigate the downstream mitf targets that can explain this anti-apoptotic effect and to evaluate in parallel the effect of p53 reactivation on the promotion of apoptosis under mek inhibition in a panel of |
2017-09-11 |
2023-08-13 |
Not clear |
| L J Valente, S Grabow, C J Vandenberg, A Strasser, A Jani. Combined loss of PUMA and p21 accelerates c-MYC-driven lymphoma development considerably less than loss of one allele of p53. Oncogene. vol 35. issue 29. 2017-09-11. PMID:26640149. |
p53 induces apoptosis via transcriptional induction of the bh3-only proteins puma (p53-upregulated modulator of apoptosis) and noxa, and cell cycle arrest via p21. |
2017-09-11 |
2023-08-13 |
mouse |
| L J Valente, S Grabow, C J Vandenberg, A Strasser, A Jani. Combined loss of PUMA and p21 accelerates c-MYC-driven lymphoma development considerably less than loss of one allele of p53. Oncogene. vol 35. issue 29. 2017-09-11. PMID:26640149. |
these results demonstrate that even in the context of deregulated c-myc expression, p53 must suppress tumor development by activating processes apart from, or in addition to, puma-mediated apoptosis and p21-induced cell cycle arrest. |
2017-09-11 |
2023-08-13 |
mouse |
| Venkaiah Betapudi, Meenal Shukla, Ravi Alluri, Sergei Merkulov, Keith R McCra. Novel role for p56/Lck in regulation of endothelial cell survival and angiogenesis. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 30. issue 10. 2017-09-08. PMID:27402674. |
sirna knockdown of p56/lck promoted endothelial proliferation and blocked hka-induced apoptosis and activation of p53, bax, and bak. |
2017-09-08 |
2023-08-13 |
human |
| Ons Zakraoui, Cezary Marcinkiewicz, Zohra Aloui, Houcemeddine Othman, Renaud Grépin, Meriam Haoues, Makram Essafi, Najet Srairi-Abid, Ammar Gasmi, Habib Karoui, Gilles Pagès, Khadija Essafi-Benkhadi. Lebein, a snake venom disintegrin, suppresses human colon cancer cells proliferation and tumor-induced angiogenesis through cell cycle arrest, apoptosis induction and inhibition of VEGF expression. Molecular carcinogenesis. vol 56. issue 1. 2017-09-08. PMID:26824338. |
interestingly, lebein-induced apoptosis of colon cancer cells was dependent on their p53 status. |
2017-09-08 |
2023-08-13 |
mouse |
| Amna Parveen, Muhammad Sajid Hamid Akash, Kanwal Rehman, Whang Wan Kyun. Anticancer Activities of Medicinal Plants: Modulation of p53 Expression and Induction of Apoptosis. Critical reviews in eukaryotic gene expression. vol 26. issue 3. 2017-09-07. PMID:27650989. |
anticancer activities of medicinal plants: modulation of p53 expression and induction of apoptosis. |
2017-09-07 |
2023-08-13 |
Not clear |
| Amna Parveen, Muhammad Sajid Hamid Akash, Kanwal Rehman, Whang Wan Kyun. Anticancer Activities of Medicinal Plants: Modulation of p53 Expression and Induction of Apoptosis. Critical reviews in eukaryotic gene expression. vol 26. issue 3. 2017-09-07. PMID:27650989. |
in this article, we briefly summarize the recent progress in exploring the anticancer properties of various medicinal plants reported to modulate the expression of p53 and the induction of apoptosis. |
2017-09-07 |
2023-08-13 |
Not clear |
| Y Xue, A Raharja, W Sim, E S M Wong, S A B Rahmat, D P Lan. The hot-spot p53R172H mutant promotes formation of giant spermatogonia triggered by DNA damage. Oncogene. vol 36. issue 14. 2017-09-07. PMID:27869164. |
the formation of gsg does not translate to higher efficacy of testicular tumorigenesis arising from mutant p53 cells, which might be due to the presence of delayed-onset of p53-independent apoptosis. |
2017-09-07 |
2023-08-13 |
mouse |
| Assala Lamaa, Morgane Le Bras, Nicolas Skuli, Sébastien Britton, Philippe Frit, Patrick Calsou, Hervé Prats, Anne Cammas, Stefania Millevo. A novel cytoprotective function for the DNA repair protein Ku in regulating p53 mRNA translation and function. EMBO reports. vol 17. issue 4. 2017-09-07. PMID:26964895. |
we show that ku represses p53 protein synthesis and p53-mediated apoptosis by binding to a bulged stem-loop structure within the p53 5' utr however, ku-mediated translational repression of the p53 mrna is relieved after genotoxic stress. |
2017-09-07 |
2023-08-13 |
Not clear |
| Westley J Friesen, Christopher R Trotta, Yuki Tomizawa, Jin Zhuo, Briana Johnson, Jairo Sierra, Bijoyita Roy, Marla Weetall, Jean Hedrick, Josephine Sheedy, James Takasugi, Young-Choon Moon, Suresh Babu, Ramil Baiazitov, John D Leszyk, Thomas W Davis, Joseph M Colacino, Stuart W Peltz, Ellen M Welc. The nucleoside analog clitocine is a potent and efficacious readthrough agent. RNA (New York, N.Y.). vol 23. issue 4. 2017-09-06. PMID:28096517. |
in these cells, clitocine restored production of full-length and functional p53 as evidenced by induced transcriptional activation of downstream p53 target genes, progression of cells into apoptosis, and impeded growth of nonsense-containing human ovarian cancer tumors in xenograft tumor models. |
2017-09-06 |
2023-08-13 |
human |