| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Daxiang Chen, Mingjian Long, Bin Xiao, Yufeng Xiong, Huiqin Chen, Yu Chen, Zhenzhan Kuang, Ming Li, Yingsong Wu, Daniel L Rock, Daoyuan Gong, Yong Wang, Haijian He, Fang Liu, Shuhong Luo, Wenbo Ha. Transcriptomic profiles of human foreskin fibroblast cells in response to orf virus. Oncotarget. vol 8. issue 35. 2017-09-25. PMID:28938587. |
the p53 signaling pathway was activated to induce apoptosis at the same time. |
2017-09-25 |
2023-08-13 |
human |
| Yoko Yoshihisa, Mati Ur Rehman, Takashi Kondo, Tadamichi Shimiz. Role of macrophage migration inhibitory factor in heat-induced apoptosis in keratinocytes. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 30. issue 11. 2017-09-21. PMID:27528627. |
these results showed that the activation of jnk (p-jnk and p-bad) and p53 may be involved in ht-induced apoptosis in keratinocytes and that enhanced endogenous mif expression suppressed apoptosis.-yoshihisa, y., rehman, m. u., kondo, t., shimizu, t. role of macrophage migration inhibitory factor in heat-induced apoptosis in keratinocytes. |
2017-09-21 |
2023-08-13 |
mouse |
| Uddin Md Nazim, Mohammad Rasheduzzaman, You-Jin Lee, Dai-Wu Seol, Sang-Youel Par. Enhancement of TRAIL-induced apoptosis by 5-fluorouracil requires activating Bax and p53 pathways in TRAIL-resistant lung cancers. Oncotarget. vol 8. issue 11. 2017-09-20. PMID:28178647. |
enhancement of trail-induced apoptosis by 5-fluorouracil requires activating bax and p53 pathways in trail-resistant lung cancers. |
2017-09-20 |
2023-08-13 |
human |
| Uddin Md Nazim, Mohammad Rasheduzzaman, You-Jin Lee, Dai-Wu Seol, Sang-Youel Par. Enhancement of TRAIL-induced apoptosis by 5-fluorouracil requires activating Bax and p53 pathways in TRAIL-resistant lung cancers. Oncotarget. vol 8. issue 11. 2017-09-20. PMID:28178647. |
taken together, the present study demonstrated that 5-fluorouracil enhances trail-induced apoptosis in trail-resistant lung adenocarcinoma cells by activating bax and p53, and also suggest that trail and 5-fluorouracil cotreatment can be used as an adequate therapeutic strategy for trail-resistant human cancers. |
2017-09-20 |
2023-08-13 |
human |
| Xue Jiang, Weiwei Li. Long Noncoding RNA Highly Upregulated in Liver Cancer Activates p53-p21 Pathway and Promotes Nasopharyngeal Carcinoma Cell Growth. DNA and cell biology. vol 36. issue 7. 2017-09-20. PMID:28445086. |
downregulation of hulc activated p53 and induced the increased expression of p21, which finally caused cell cycle arrest and cell apoptosis. |
2017-09-20 |
2023-08-13 |
Not clear |
| Masashi Idogawa, Tomoko Ohashi, Yasushi Sasaki, Hiroshi Nakase, Takashi Tokin. Long non-coding RNA NEAT1 is a transcriptional target of p53 and modulates p53-induced transactivation and tumor-suppressor function. International journal of cancer. vol 140. issue 12. 2017-09-18. PMID:28295289. |
our previous study revealed that several long non-coding rnas (lncrnas) are direct transcriptional targets of p53, and knockdown of specific lncrnas modulates p53-induced apoptosis. |
2017-09-18 |
2023-08-13 |
Not clear |
| Jun Yang, Xinyu Zhao, Mei Tang, Lei Li, Yi Lei, Ping Cheng, Wenhao Guo, Yu Zheng, Wei Wang, Na Luo, Yong Peng, Aiping Tong, Yuquan Wei, Chunlai Nie, Zhu Yua. The role of ROS and subsequent DNA-damage response in PUMA-induced apoptosis of ovarian cancer cells. Oncotarget. vol 8. issue 14. 2017-09-18. PMID:28423586. |
we further showed that puma induces mitochondrial dysfunction-mediated apoptosis and ros generation through functional bax in a ros generating enzyme- and caspase-independent manner irrespective of their p53 status, and results in activation of nrf2/ho-1 pathway. |
2017-09-18 |
2023-08-13 |
Not clear |
| Ling Zhang, Daoyuan Xie, Xueping Chen, Maria L R Hughes, Guozheng Jiang, Ziyin Lu, Chunli Xia, Li Li, Jinli Wang, Wei Xu, Yuan Sun, Rui Li, Rui Wang, Feng Qian, Jian Li, Jichang L. p53 Mediates Colistin-Induced Autophagy and Apoptosis in PC-12 Cells. Antimicrobial agents and chemotherapy. vol 60. issue 9. 2017-09-15. PMID:27324771. |
p53 mediates colistin-induced autophagy and apoptosis in pc-12 cells. |
2017-09-15 |
2023-08-13 |
rat |
| Ling Zhang, Daoyuan Xie, Xueping Chen, Maria L R Hughes, Guozheng Jiang, Ziyin Lu, Chunli Xia, Li Li, Jinli Wang, Wei Xu, Yuan Sun, Rui Li, Rui Wang, Feng Qian, Jian Li, Jichang L. p53 Mediates Colistin-Induced Autophagy and Apoptosis in PC-12 Cells. Antimicrobial agents and chemotherapy. vol 60. issue 9. 2017-09-15. PMID:27324771. |
as an important cellular stress sensor, phosphoprotein p53 can trigger cell cycle arrest and apoptosis and regulate autophagy. |
2017-09-15 |
2023-08-13 |
rat |
| Ling Zhang, Daoyuan Xie, Xueping Chen, Maria L R Hughes, Guozheng Jiang, Ziyin Lu, Chunli Xia, Li Li, Jinli Wang, Wei Xu, Yuan Sun, Rui Li, Rui Wang, Feng Qian, Jian Li, Jichang L. p53 Mediates Colistin-Induced Autophagy and Apoptosis in PC-12 Cells. Antimicrobial agents and chemotherapy. vol 60. issue 9. 2017-09-15. PMID:27324771. |
specifically, cells were treated with colistin (125 μg/ml) in the absence and presence of a p53 inhibitor, pifithrin-α (pft-α; 20 nm), for 12 h and 24 h, and the typical hallmarks of autophagy and apoptosis were examined by fluorescence/immunofluorescence microscopy and electron microscopy, real-time pcr, and western blotting. |
2017-09-15 |
2023-08-13 |
rat |
| Ling Zhang, Daoyuan Xie, Xueping Chen, Maria L R Hughes, Guozheng Jiang, Ziyin Lu, Chunli Xia, Li Li, Jinli Wang, Wei Xu, Yuan Sun, Rui Li, Rui Wang, Feng Qian, Jian Li, Jichang L. p53 Mediates Colistin-Induced Autophagy and Apoptosis in PC-12 Cells. Antimicrobial agents and chemotherapy. vol 60. issue 9. 2017-09-15. PMID:27324771. |
the results indicate that colistin had a stimulatory effect on the expression levels of the target genes and proteins involved in autophagy and apoptosis, including lc3-ii/i, p53, dram (damage-regulated autophagy modulator), puma (p53 upregulated modulator of apoptosis), bax, p-ampk (activated form of amp-activated protein kinase), and caspase-3. |
2017-09-15 |
2023-08-13 |
rat |
| Ling Zhang, Daoyuan Xie, Xueping Chen, Maria L R Hughes, Guozheng Jiang, Ziyin Lu, Chunli Xia, Li Li, Jinli Wang, Wei Xu, Yuan Sun, Rui Li, Rui Wang, Feng Qian, Jian Li, Jichang L. p53 Mediates Colistin-Induced Autophagy and Apoptosis in PC-12 Cells. Antimicrobial agents and chemotherapy. vol 60. issue 9. 2017-09-15. PMID:27324771. |
importantly, analysis of the levels of p53 in the cells treated with colistin revealed an increase in nuclear p53 at 12 h and cytoplasmic p53 at 24 h. pretreatment of colistin-treated cells with pft-α inhibited autophagy and promoted colistin-induced apoptosis. |
2017-09-15 |
2023-08-13 |
rat |
| Robin Assfalg, Marius Costel Alupei, Maximilian Wagner, Sylvia Koch, Omar Garcia Gonzalez, Adrian Schelling, Karin Scharffetter-Kochanek, Sebastian Ibe. Cellular sensitivity to UV-irradiation is mediated by RNA polymerase I transcription. PloS one. vol 12. issue 6. 2017-09-15. PMID:28636660. |
apoptosis mediated by highly activated p53 is a typical hallmark of cockayne syndrome cells and transcriptional abnormalities and the following activation of the rp-hdm2-p53 pathway would be a possible explanation. |
2017-09-15 |
2023-08-13 |
Not clear |
| Kishu Ranjan, Chandramani Patha. Expression of cFLIPL Determines the Basal Interaction of Bcl-2 With Beclin-1 and Regulates p53 Dependent Ubiquitination of Beclin-1 During Autophagic Stress. Journal of cellular biochemistry. vol 117. issue 8. 2017-09-15. PMID:26682748. |
the apoptosis associated proteins such as bcl-2 and p53 have a close association with autophagic proteins hmgb1 and beclin-1 to modulate autophagic signaling. |
2017-09-15 |
2023-08-13 |
Not clear |
| Hao Luo, Hairong Liang, Jiajia Chen, Yongchun Xu, Yuting Chen, Longmei Xu, Lin Yun, Jiaxian Liu, Hui Yang, Linhua Liu, Jianming Peng, Zhidong Liu, Lin Tang, Wen Chen, Huanwen Tan. Hydroquinone induces TK6 cell growth arrest and apoptosis through PARP-1/p53 regulatory pathway. Environmental toxicology. vol 32. issue 9. 2017-09-14. PMID:28444915. |
the reduction of parp-1 expression further intensified up-regulation of p53 in tk6-shparp-1 cells, resulting in an increased g1→s phase cell arrest and apoptosis in tk6-shparp-1 cells compared to tk6-shnc cells. |
2017-09-14 |
2023-08-13 |
Not clear |
| Antonietta Arcella, Maria Antonietta Oliva, Massimo Sanchez, Sabrina Staffieri, Vincenzo Esposito, Felice Giangaspero, Giampaolo Cantor. Effects of hispolon on glioblastoma cell growth. Environmental toxicology. vol 32. issue 9. 2017-09-14. PMID:28618133. |
our results indicate that hispolon inhibits the cell viability, induces g2/m cell cycle arrest and apoptosis in glioblastoma u87mg cells, and p53 should play a role in hispolon-mediated antitumor activity. |
2017-09-14 |
2023-08-13 |
human |
| G Yang, Y Gong, Q Wang, L Wang, X Zhan. miR-100 antagonism triggers apoptosis by inhibiting ubiquitination-mediated p53 degradation. Oncogene. vol 36. issue 8. 2017-09-13. PMID:27524417. |
mir-100 antagonism triggers apoptosis by inhibiting ubiquitination-mediated p53 degradation. |
2017-09-13 |
2023-08-13 |
human |
| G Yang, Y Gong, Q Wang, L Wang, X Zhan. miR-100 antagonism triggers apoptosis by inhibiting ubiquitination-mediated p53 degradation. Oncogene. vol 36. issue 8. 2017-09-13. PMID:27524417. |
during tumourigenesis, p53 functions as 'the guardian of the genome' because p53-dependent apoptosis strongly regulates the fate of cancer cells. |
2017-09-13 |
2023-08-13 |
human |
| G Yang, Y Gong, Q Wang, L Wang, X Zhan. miR-100 antagonism triggers apoptosis by inhibiting ubiquitination-mediated p53 degradation. Oncogene. vol 36. issue 8. 2017-09-13. PMID:27524417. |
in the regulation of p53-dependent apoptosis, mir-100 antagonism inhibited ubiquitin-mediated p53 protein degradation by activating rnf144b, an e3 ubiquitination ligase. |
2017-09-13 |
2023-08-13 |
human |
| G Yang, Y Gong, Q Wang, L Wang, X Zhan. miR-100 antagonism triggers apoptosis by inhibiting ubiquitination-mediated p53 degradation. Oncogene. vol 36. issue 8. 2017-09-13. PMID:27524417. |
our findings highlight a novel mechanism of ubiquitin-mediated p53 protein degradation in apoptosis. |
2017-09-13 |
2023-08-13 |
human |