| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yan-Wei Hu, Shao-Guo Wu, Jing-Jing Zhao, Xin Ma, Jing-Bo Lu, Jian-Cheng Xiu, Yuan Zhang, Chuan Huang, Yu-Rong Qiu, Yan-Hua Sha, Ji-Juan Gao, Yan-Chao Wang, Shu-Fen Li, Jia-Yi Zhao, Lei Zheng, Qian Wan. VNN1 promotes atherosclerosis progression in apoE-/- mice fed a high-fat/high-cholesterol diet. Journal of lipid research. vol 57. issue 8. 2017-09-05. PMID:27281478. |
in addition, vnn1 attenuated ox-ldl-induced apoptosis through upregulation of expression of p53 by 59.15% and downregulation of expression of b-cell lymphoma-2 127.13% in thp-1 macrophage (p < 0.05). |
2017-09-05 |
2023-08-13 |
mouse |
| Ming-Hsien Chien, Tzong-Huei Lee, Wei-Jiunn Lee, Yen-Hsiu Yeh, Tsai-Kun Li, Po-Chuan Wang, Jih-Jung Chen, Jyh-Ming Chow, Yung-Wei Lin, Michael Hsiao, Shih-Wei Wang, Kuo-Tai Hu. Trichodermin induces c-Jun N-terminal kinase-dependent apoptosis caused by mitotic arrest and DNA damage in human p53-mutated pancreatic cancer cells and xenografts. Cancer letters. vol 388. 2017-09-05. PMID:27965041. |
trichodermin triggered dna damage stress to activate p53 function for executing apoptosis in p53-mutated cells. |
2017-09-05 |
2023-08-13 |
human |
| Hyun-Wook Ryu, Dong-Hee Shin, Dong Hoon Lee, Junjeong Choi, Gyoonhee Han, Kang Young Lee, So Hee Kwo. HDAC6 deacetylates p53 at lysines 381/382 and differentially coordinates p53-induced apoptosis. Cancer letters. vol 391. 2017-09-05. PMID:28153791. |
hdac6 deacetylates p53 at lysines 381/382 and differentially coordinates p53-induced apoptosis. |
2017-09-05 |
2023-08-13 |
Not clear |
| Yonglong Wei, Jin Xu, Wenqing Zhang, Zilong Wen, Feng Li. RNA polymerase III component Rpc9 regulates hematopoietic stem and progenitor cell maintenance in zebrafish. Development (Cambridge, England). vol 143. issue 12. 2017-09-05. PMID:27151951. |
excessive apoptosis is observed in the caudal hematopoietic tissue (cht; the equivalent of fetal liver in mammals) of rpc9(-/-) embryos and the hematopoietic defects in these embryos can be fully rescued by suppression of p53 thus, our work illustrates that rpc9, a component of pol iii, plays an important tissue-specific role in hspc maintenance during zebrafish embryogenesis and might be conserved across vertebrates, including mammals. |
2017-09-05 |
2023-08-13 |
zebrafish |
| Maya Miller, Ori Braitbard, Jacob Hochman, Edit Y Tshuv. Insights into molecular mechanism of action of salan titanium(IV) complex with in vitro and in vivo anticancer activity. Journal of inorganic biochemistry. vol 163. 2017-09-04. PMID:27090292. |
both cell lines responded in vitro (but to a different extent) by upregulation of p53 with no apparent effect on p21 followed by cell cycle arrest, apoptosis and necrosis as demonstrated by sub-g1 cell accumulation and staining by annexin-v and propidium iodide. |
2017-09-04 |
2023-08-13 |
mouse |
| T Liu, J Xiong, S Yi, H Zhang, S Zhou, L Gu, M Zho. FKBP12 enhances sensitivity to chemotherapy-induced cancer cell apoptosis by inhibiting MDM2. Oncogene. vol 36. issue 12. 2017-09-01. PMID:27617579. |
the fkbp12-mediated downregulation of mdm2 in response to doxorubicin or nutlin-3 results in continuing and constitutive activation of p53, inhibition of xiap and sensitization of cancer cells to apoptosis. |
2017-09-01 |
2023-08-13 |
Not clear |
| Xian Zhang, Chien-Feng Li, Ling Zhang, Ching-Yuan Wu, Lixia Han, Guoxiang Jin, Abdol Hossein Rezaeian, Fei Han, Chunfang Liu, Chuan Xu, Xiaohong Xu, Chih-Yang Huang, Fuu-Jen Tsai, Chang-Hai Tsai, Kounosuke Watabe, Hui-Kuan Li. TRAF6 Restricts p53 Mitochondrial Translocation, Apoptosis, and Tumor Suppression. Molecular cell. vol 64. issue 4. 2017-09-01. PMID:27818144. |
traf6 restricts p53 mitochondrial translocation, apoptosis, and tumor suppression. |
2017-09-01 |
2023-08-13 |
Not clear |
| Xian Zhang, Chien-Feng Li, Ling Zhang, Ching-Yuan Wu, Lixia Han, Guoxiang Jin, Abdol Hossein Rezaeian, Fei Han, Chunfang Liu, Chuan Xu, Xiaohong Xu, Chih-Yang Huang, Fuu-Jen Tsai, Chang-Hai Tsai, Kounosuke Watabe, Hui-Kuan Li. TRAF6 Restricts p53 Mitochondrial Translocation, Apoptosis, and Tumor Suppression. Molecular cell. vol 64. issue 4. 2017-09-01. PMID:27818144. |
mitochondrial p53 is involved in apoptosis and tumor suppression. |
2017-09-01 |
2023-08-13 |
Not clear |
| Xian Zhang, Chien-Feng Li, Ling Zhang, Ching-Yuan Wu, Lixia Han, Guoxiang Jin, Abdol Hossein Rezaeian, Fei Han, Chunfang Liu, Chuan Xu, Xiaohong Xu, Chih-Yang Huang, Fuu-Jen Tsai, Chang-Hai Tsai, Kounosuke Watabe, Hui-Kuan Li. TRAF6 Restricts p53 Mitochondrial Translocation, Apoptosis, and Tumor Suppression. Molecular cell. vol 64. issue 4. 2017-09-01. PMID:27818144. |
here, we show that traf6 e3 ligase is a crucial factor to restrict mitochondrial translocation of p53 and spontaneous apoptosis by promoting k63-linked ubiquitination of p53 at k24 in cytosol, and such ubiquitination limits the interaction between p53 and mcl-1/bak. |
2017-09-01 |
2023-08-13 |
Not clear |
| Xian Zhang, Chien-Feng Li, Ling Zhang, Ching-Yuan Wu, Lixia Han, Guoxiang Jin, Abdol Hossein Rezaeian, Fei Han, Chunfang Liu, Chuan Xu, Xiaohong Xu, Chih-Yang Huang, Fuu-Jen Tsai, Chang-Hai Tsai, Kounosuke Watabe, Hui-Kuan Li. TRAF6 Restricts p53 Mitochondrial Translocation, Apoptosis, and Tumor Suppression. Molecular cell. vol 64. issue 4. 2017-09-01. PMID:27818144. |
colorectal cancer samples with wt p53 reveal that traf6 overexpression negatively correlates with apoptosis and predicts poor response to chemotherapy and radiotherapy. |
2017-09-01 |
2023-08-13 |
Not clear |
| Jie Yang, Ji-Min Zhu, Song Wu, Jing Li, Ming-Rui Wang, Ting-Ting Wang, Yu-Wei L. Association study between the TP53 Rs1042522G/C polymorphism and susceptibility to systemic lupus erythematosus in a Chinese Han population. Rheumatology international. vol 37. issue 4. 2017-09-01. PMID:28184992. |
tumour suppressor protein 53 (p53) plays a central role in apoptosis, cell proliferation and death. |
2017-09-01 |
2023-08-13 |
Not clear |
| Antonio Pérez-Pérez, Ayelén R Toro, Teresa Vilarino-Garcia, Pilar Guadix, Julieta L Maymó, José L Dueñas, Cecilia L Varone, Víctor Sánchez-Margale. Leptin reduces apoptosis triggered by high temperature in human placental villous explants: The role of the p53 pathway. Placenta. vol 42. 2017-09-01. PMID:27238720. |
leptin reduces apoptosis triggered by high temperature in human placental villous explants: the role of the p53 pathway. |
2017-09-01 |
2023-08-13 |
human |
| Antonio Pérez-Pérez, Ayelén R Toro, Teresa Vilarino-Garcia, Pilar Guadix, Julieta L Maymó, José L Dueñas, Cecilia L Varone, Víctor Sánchez-Margale. Leptin reduces apoptosis triggered by high temperature in human placental villous explants: The role of the p53 pathway. Placenta. vol 42. 2017-09-01. PMID:27238720. |
since p53 is a critical regulator of apoptosis we hypothesized that increased temperature in placenta produces abnormal expression of proteins in the p53 pathway and finally caspase-3 activation. |
2017-09-01 |
2023-08-13 |
human |
| Antonio Pérez-Pérez, Ayelén R Toro, Teresa Vilarino-Garcia, Pilar Guadix, Julieta L Maymó, José L Dueñas, Cecilia L Varone, Víctor Sánchez-Margale. Leptin reduces apoptosis triggered by high temperature in human placental villous explants: The role of the p53 pathway. Placenta. vol 42. 2017-09-01. PMID:27238720. |
these data illustrate the potential role of leptin for reducing apoptosis in trophoblast explants, including trophoblastic cells, triggered by high temperature, by preventing the activation of p53 signaling. |
2017-09-01 |
2023-08-13 |
human |
| Akash Sabarwal, Rajesh Agarwal, Rana P Sing. Fisetin inhibits cellular proliferation and induces mitochondria-dependent apoptosis in human gastric cancer cells. Molecular carcinogenesis. vol 56. issue 2. 2017-09-01. PMID:27254419. |
fisetin-induced apoptosis was observed to be independent of p53. |
2017-09-01 |
2023-08-13 |
human |
| S Ramadoss, G Guo, C-Y Wan. Lysine demethylase KDM3A regulates breast cancer cell invasion and apoptosis by targeting histone and the non-histone protein p53. Oncogene. vol 36. issue 1. 2017-09-01. PMID:27270439. |
lysine demethylase kdm3a regulates breast cancer cell invasion and apoptosis by targeting histone and the non-histone protein p53. |
2017-09-01 |
2023-08-13 |
human |
| S Ramadoss, G Guo, C-Y Wan. Lysine demethylase KDM3A regulates breast cancer cell invasion and apoptosis by targeting histone and the non-histone protein p53. Oncogene. vol 36. issue 1. 2017-09-01. PMID:27270439. |
here we identified that the lysine-specific demethylase kdm3a played a dual role in breast cancer cell invasion and apoptosis by demethylating histone and the non-histone protein p53, respectively. |
2017-09-01 |
2023-08-13 |
human |
| Liang Wei, Brian J Leibowitz, Xinwei Wang, Michael Epperly, Joel Greenberger, Lin Zhang, Jian Y. Inhibition of CDK4/6 protects against radiation-induced intestinal injury in mice. The Journal of clinical investigation. vol 126. issue 11. 2017-08-31. PMID:27701148. |
pd treatment strongly but reversibly inhibited radiation-induced p53 activation, which blocked p53-upregulated modulator of apoptosis-dependent (puma-dependent) apoptosis without affecting p21-dependent suppression of dna damage accumulation, with a repair bias toward nonhomologous end joining. |
2017-08-31 |
2023-08-13 |
mouse |
| Shuai Meng, Yi Zhu, Jiang-Feng Li, Xiao Wang, Zhen Liang, Shi-Qi Li, Xin Xu, Hong Chen, Ben Liu, Xiang-Yi Zheng, Li-Ping Xi. Apigenin inhibits renal cell carcinoma cell proliferation. Oncotarget. vol 8. issue 12. 2017-08-31. PMID:28423637. |
small interfering rna (sirna)-mediated p53 knockdown showed that apigenin-induced apoptosis was likely p53 dependent. |
2017-08-31 |
2023-08-13 |
mouse |
| Shuai Meng, Yi Zhu, Jiang-Feng Li, Xiao Wang, Zhen Liang, Shi-Qi Li, Xin Xu, Hong Chen, Ben Liu, Xiang-Yi Zheng, Li-Ping Xi. Apigenin inhibits renal cell carcinoma cell proliferation. Oncotarget. vol 8. issue 12. 2017-08-31. PMID:28423637. |
these findings suggest that apigenin exposure induces dna damage, g2/m phase cell cycle arrest, p53 accumulation and apoptosis, which collectively suppress achn rcc cell proliferation in vitro and in vivo. |
2017-08-31 |
2023-08-13 |
mouse |