| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A D'Brot, P Kurtz, E Regan, B Jakubowski, J M Abram. A platform for interrogating cancer-associated p53 alleles. Oncogene. vol 36. issue 2. 2017-08-31. PMID:26996664. |
like the fly counterpart, human p53 transcriptionally activated a biosensor and induced apoptosis after dna damage. |
2017-08-31 |
2023-08-13 |
human |
| Ana Finzel, Andrea Grybowski, Jette Strasen, Elena Cristiano, Alexander Loewe. Hyperactivation of ATM upon DNA-PKcs inhibition modulates p53 dynamics and cell fate in response to DNA damage. Molecular biology of the cell. vol 27. issue 15. 2017-08-30. PMID:27280387. |
it is mainly coordinated by the kinases atm, atr, and dna-pkcs, which control the repair of broken dna strands and relay the damage signal to the tumor suppressor p53 to induce cell cycle arrest, apoptosis, or senescence. |
2017-08-30 |
2023-08-13 |
Not clear |
| John F Dankert, Gergely Rona, Linda Clijsters, Phillip Geter, Jeffrey R Skaar, Keria Bermudez-Hernandez, Elizabeth Sassani, David Fenyö, Beatrix Ueberheide, Robert Schneider, Michele Pagan. Cyclin F-Mediated Degradation of SLBP Limits H2A.X Accumulation and Apoptosis upon Genotoxic Stress in G2. Molecular cell. vol 64. issue 3. 2017-08-30. PMID:27773672. |
upon genotoxic stress in g2, high levels of h2a.x lead to persistent γh2a.x signaling, high levels of h2a.x phosphorylated on tyr142, high levels of p53, and induction of apoptosis. |
2017-08-30 |
2023-08-13 |
Not clear |
| K T Bieging-Rolett, T M Johnson, C A Brady, V G Beaudry, N Pathak, S Han, L D Attard. p19(Arf) is required for the cellular response to chronic DNA damage. Oncogene. vol 35. issue 33. 2017-08-30. PMID:26725325. |
the p53 tumor suppressor is a stress sensor, driving cell cycle arrest or apoptosis in response to dna damage or oncogenic signals. |
2017-08-30 |
2023-08-13 |
mouse |
| Tomoko Ohashi, Masashi Idogawa, Yasushi Sasaki, Takashi Tokin. p53 mediates the suppression of cancer cell invasion by inducing LIMA1/EPLIN. Cancer letters. vol 390. 2017-08-29. PMID:28093207. |
p53 executes various functions, such as apoptosis induction and cell cycle arrest, by modulating transcriptional regulation. |
2017-08-29 |
2023-08-13 |
human |
| Kit I Tong, Kazushige Ota, Akiyoshi Komuro, Takeshi Ueda, Akihiko Ito, C Anne Koch, Hitoshi Okad. Attenuated DNA damage repair delays therapy-related myeloid neoplasms in a mouse model. Cell death & disease. vol 7. issue 10. 2017-08-28. PMID:27711078. |
simultaneous deficiency of p53 abrogated ir-induced apoptosis and the benefit of impaired dna repair on mortality in irradiated aplf–/– mice. |
2017-08-28 |
2023-08-13 |
mouse |
| Vincent El Ghouzzi, Federico T Bianchi, Ivan Molineris, Bryan C Mounce, Gaia E Berto, Malgorzata Rak, Sophie Lebon, Laetitia Aubry, Chiara Tocco, Marta Gai, Alessandra Ma Chiotto, Francesco Sgrò, Gianmarco Pallavicini, Etienne Simon-Loriere, Sandrine Passemard, Marco Vignuzzi, Pierre Gressens, Ferdinando Di Cunt. ZIKA virus elicits P53 activation and genotoxic stress in human neural progenitors similar to mutations involved in severe forms of genetic microcephaly. Cell death & disease. vol 7. issue 10. 2017-08-28. PMID:27787521. |
in agreement with these observations, we report that zikv infection increases total p53 levels and nuclear accumulation, as well as p53 ser15 phosphorylation, correlated with genotoxic stress and apoptosis induction. |
2017-08-28 |
2023-08-13 |
mouse |
| Vincent El Ghouzzi, Federico T Bianchi, Ivan Molineris, Bryan C Mounce, Gaia E Berto, Malgorzata Rak, Sophie Lebon, Laetitia Aubry, Chiara Tocco, Marta Gai, Alessandra Ma Chiotto, Francesco Sgrò, Gianmarco Pallavicini, Etienne Simon-Loriere, Sandrine Passemard, Marco Vignuzzi, Pierre Gressens, Ferdinando Di Cunt. ZIKA virus elicits P53 activation and genotoxic stress in human neural progenitors similar to mutations involved in severe forms of genetic microcephaly. Cell death & disease. vol 7. issue 10. 2017-08-28. PMID:27787521. |
interestingly, increased p53 activation and apoptosis are induced not only in cells expressing high levels of viral antigens but also in cells showing low or undetectable levels of the same proteins. |
2017-08-28 |
2023-08-13 |
mouse |
| b' Hadia Moindjie, Esther Dos Santos, Rita-Josiane Gouesse, Nelly Swierkowski-Blanchard, Val\\xc3\\xa9rie Serazin, Eytan R Barnea, Fran\\xc3\\xa7ois Vialard, Marie-No\\xc3\\xablle Dieudonn\\xc3\\xa. Preimplantation factor is an anti-apoptotic effector in human trophoblasts involving p53 signaling pathway. Cell death & disease. vol 7. issue 12. 2017-08-28. PMID:27906186.' |
functional assays revealed that spif acts through the p53 pathway to reduce both early and late trophoblast apoptosis. |
2017-08-28 |
2023-08-13 |
human |
| Masato Kitazawa, Shigeaki Hida, Chifumi Fujii, Shun'ichiro Taniguchi, Kensuke Ito, Tomio Matsumura, Nagisa Okada, Takashi Sakaizawa, Akira Kobayashi, Michiko Takeoka, Shin-Ichi Miyagaw. ASC Induces Apoptosis via Activation of Caspase-9 by Enhancing Gap Junction-Mediated Intercellular Communication. PloS one. vol 12. issue 1. 2017-08-28. PMID:28056049. |
asc-dependent apoptosis was mediated not by p21, p53, or caspase-1, but rather by cleavage of caspase-9 as well as by suppression of the nf-κb-related x-linked inhibitor-of-apoptosis protein. |
2017-08-28 |
2023-08-13 |
Not clear |
| Huei-Yu Chen, Hsiao-Ling Cheng, Yi-Hui Lee, Tien-Ming Yuan, Shi-Wen Chen, You-Yu Lin, Pin Ju Chue. Tumor-associated NADH oxidase (tNOX)-NAD+-sirtuin 1 axis contributes to oxaliplatin-induced apoptosis of gastric cancer cells. Oncotarget. vol 8. issue 9. 2017-08-28. PMID:28122359. |
in ags cells, we found that the oxaliplatin-inhibited tnox effectively attenuated the nad+/nadh ratio and reduced the deacetylase activity of an nad+-dependent sirtuin 1, thereby enhancing p53 acetylation and apoptosis. |
2017-08-28 |
2023-08-13 |
Not clear |
| E Salas, S Roy, T Marsh, B Rubin, J Debnat. Oxidative pentose phosphate pathway inhibition is a key determinant of antimalarial induced cancer cell death. Oncogene. vol 35. issue 22. 2017-08-28. PMID:26434592. |
simultaneous genetic targeting of the oxppp and autophagy is sufficient to trigger apoptosis in lung cancer cells, including cells lacking p53. |
2017-08-28 |
2023-08-13 |
Not clear |
| Karine Z Oben, Beth W Gachuki, Sara S Alhakeem, Mary K McKenna, Ying Liang, Daret K St Clair, Vivek M Rangnekar, Subbarao Bondad. Radiation Induced Apoptosis of Murine Bone Marrow Cells Is Independent of Early Growth Response 1 (EGR1). PloS one. vol 12. issue 1. 2017-08-24. PMID:28081176. |
radiation induced apoptosis of bone marrow cells by double strand dna breaks induced p53 activation. |
2017-08-24 |
2023-08-13 |
Not clear |
| Xing-Hua Liao, Yuan Xiang, Cheng-Xi Yu, Jia-Peng Li, Hui Li, Qi Nie, Peng Hu, Jun Zhou, Tong-Cun Zhan. STAT3 is required for MiR-17-5p-mediated sensitization to chemotherapy-induced apoptosis in breast cancer cells. Oncotarget. vol 8. issue 9. 2017-08-24. PMID:28178652. |
finally, mir-17-5p promoted apoptosis by increasing p53 expression, which was inhibited by stat3. |
2017-08-24 |
2023-08-13 |
Not clear |
| Xing-Hua Liao, Yuan Xiang, Cheng-Xi Yu, Jia-Peng Li, Hui Li, Qi Nie, Peng Hu, Jun Zhou, Tong-Cun Zhan. STAT3 is required for MiR-17-5p-mediated sensitization to chemotherapy-induced apoptosis in breast cancer cells. Oncotarget. vol 8. issue 9. 2017-08-24. PMID:28178652. |
these results demonstrate a novel pathway via which mir-17-5p inhibits stat3 and increases p53 expression to promote apoptosis in breast cancer cells. |
2017-08-24 |
2023-08-13 |
Not clear |
| Jing Guo, Nam-Hyung Kim, Xiang-Shun Cu. Inhibition of Fatty Acid Synthase Reduces Blastocyst Hatching through Regulation of the AKT Pathway in Pigs. PloS one. vol 12. issue 1. 2017-08-23. PMID:28107461. |
this inhibition of fasn resulted in the down-regulation of the akt pathway, thereby triggering apoptosis through the activation of the p53 pathway. |
2017-08-23 |
2023-08-13 |
Not clear |
| Chunmei Li, Yoonhwa Jeong, Misook Ki. Mammea longifolia Planch. and Triana Fruit Extract Induces Cell Death in the Human Colon Cancer Cell Line, SW480, via Mitochondria-Related Apoptosis and Activation of p53. Journal of medicinal food. vol 20. issue 5. 2017-08-22. PMID:28504908. |
and triana fruit extract induces cell death in the human colon cancer cell line, sw480, via mitochondria-related apoptosis and activation of p53. |
2017-08-22 |
2023-08-13 |
human |
| Yue Zhao, Chuanlong Guo, Lijun Wang, Shuaiyu Wang, Xiangqian Li, Bo Jiang, Ning Wu, Shuju Guo, Renshuai Zhang, Kun Liu, Dayong Sh. A novel fluorinated thiosemicarbazone derivative- 2-(3,4-difluorobenzylidene) hydrazinecarbothioamide induces apoptosis in human A549 lung cancer cells via ROS-mediated mitochondria-dependent pathway. Biochemical and biophysical research communications. vol 491. issue 1. 2017-08-22. PMID:28698138. |
moreover, compound 1 markedly induced apoptosis on a549 cells, and the ratio of bcl-2/bax was decreased while the amount of p53, cleaved-caspase 3 and cleaved-parp expression were increased significantly. |
2017-08-22 |
2023-08-13 |
human |
| Barbara D Boyan, Sharon L Hyzy, Qingfen Pan, Kayla M Scott, Richard D Coutts, Robert Healey, Zvi Schwart. 24R,25-Dihydroxyvitamin D3 Protects against Articular Cartilage Damage following Anterior Cruciate Ligament Transection in Male Rats. PloS one. vol 11. issue 8. 2017-08-21. PMID:27575371. |
previously, we showed that 24r,25(oh)2d3 blocks chondrocyte apoptosis via phospholipase d and p53, suggesting a role for 24r,25(oh)2d3 in maintaining cartilage health. |
2017-08-21 |
2023-08-13 |
rat |
| Lubing Gu, Hailong Zhang, Tao Liu, Sheng Zhou, Yuhong Du, Jing Xiong, Sha Yi, Cheng-Kui Qu, Haian Fu, Muxiang Zho. Discovery of Dual Inhibitors of MDM2 and XIAP for Cancer Treatment. Cancer cell. vol 30. issue 4. 2017-08-21. PMID:27666947. |
the compound-induced mdm2 downregulation resulted not only in inhibition of xiap expression, but also in activation of p53, which contributed to cancer cell apoptosis in vitro and inhibition of cancer cell proliferation in vivo. |
2017-08-21 |
2023-08-13 |
human |