| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ji Ma, Shaofeng Shui, Xinwei Han, Dong Guo, Tengfei Li, Lei Ya. microRNA-200a silencing protects neural stem cells against cerebral ischemia/reperfusion injury. PloS one. vol 12. issue 2. 2017-08-21. PMID:28222148. |
mir-200a silencing alleviated ogd/r-induced the decrease of cell viability and migration (p < 0.01); meanwhile, alleviated ogd/r-induced apoptosis via reducing bax/bcl-2 ratio and down-regulating p53 and cytochrome c (p < 0.01 or p < 0.001). |
2017-08-21 |
2023-08-13 |
Not clear |
| b' Janusz Godlewski, Bartlomiej E Krazinski, Anna E Kowalczyk, Jolanta Kiewisz, Jacek Kiezun, Przemyslaw Kwiatkowski, Agnieszka Sliwi\\xc5\\x84ska-Jewsiewicka, Piotr W Wierzbicki, Zbigniew Kmie\\xc4\\x8. Expression and Prognostic Significance of Anticancer research. vol 37. issue 6. 2017-08-21. PMID:28551630.' |
expression and prognostic significance of histone acetyltransferase e1a-binding protein p300 (ep300), tumor protein p53 (tp53) and b-cell lymphoma-2-associated x protein (bax) contribute to the regulation of the cell cycle and apoptosis, cellular processes that are often impaired in cancer cells. |
2017-08-21 |
2023-08-13 |
Not clear |
| Nikola Arsic, Alexandre Ho-Pun-Cheung, Evelyne Lopez-Crapez, Eric Assenat, Marta Jarlier, Christelle Anguille, Manon Colard, Mikaël Pezet, Pierre Roux, Gilles Gade. The p53 isoform delta133p53ß regulates cancer cell apoptosis in a RhoB-dependent manner. PloS one. vol 12. issue 2. 2017-08-18. PMID:28212429. |
the p53 isoform delta133p53ß regulates cancer cell apoptosis in a rhob-dependent manner. |
2017-08-18 |
2023-08-13 |
Not clear |
| Nikola Arsic, Alexandre Ho-Pun-Cheung, Evelyne Lopez-Crapez, Eric Assenat, Marta Jarlier, Christelle Anguille, Manon Colard, Mikaël Pezet, Pierre Roux, Gilles Gade. The p53 isoform delta133p53ß regulates cancer cell apoptosis in a RhoB-dependent manner. PloS one. vol 12. issue 2. 2017-08-18. PMID:28212429. |
the recent discovery of p53 isoforms that can differentially regulate cell cycle arrest and apoptosis suggests that their expression, rather than p53 mutations, could be a more clinically relevant biomarker in patients with cancer. |
2017-08-18 |
2023-08-13 |
Not clear |
| Harumasa Nakazawa, Kyungho Chang, Shohei Shinozaki, Takashi Yasukawa, Kazuhiro Ishimaru, Shingo Yasuhara, Yong-Ming Yu, J A Jeevendra Martyn, Ronald G Tompkins, Kentaro Shimokado, Masao Kanek. iNOS as a Driver of Inflammation and Apoptosis in Mouse Skeletal Muscle after Burn Injury: Possible Involvement of Sirt1 S-Nitrosylation-Mediated Acetylation of p65 NF-κB and p53. PloS one. vol 12. issue 1. 2017-08-16. PMID:28099528. |
inos as a driver of inflammation and apoptosis in mouse skeletal muscle after burn injury: possible involvement of sirt1 s-nitrosylation-mediated acetylation of p65 nf-κb and p53. |
2017-08-16 |
2023-08-13 |
mouse |
| Harumasa Nakazawa, Kyungho Chang, Shohei Shinozaki, Takashi Yasukawa, Kazuhiro Ishimaru, Shingo Yasuhara, Yong-Ming Yu, J A Jeevendra Martyn, Ronald G Tompkins, Kentaro Shimokado, Masao Kanek. iNOS as a Driver of Inflammation and Apoptosis in Mouse Skeletal Muscle after Burn Injury: Possible Involvement of Sirt1 S-Nitrosylation-Mediated Acetylation of p65 NF-κB and p53. PloS one. vol 12. issue 1. 2017-08-16. PMID:28099528. |
nuclear factor (nf)-κb and p53 are key regulators of inflammation and apoptosis, respectively. |
2017-08-16 |
2023-08-13 |
mouse |
| Yuan Shen, Shanshan Liu, Jiao Fan, Yinghua Jin, Baolei Tian, Xiaofei Zheng, Hanjiang F. Nuclear retention of the lncRNA SNHG1 by doxorubicin attenuates hnRNPC-p53 protein interactions. EMBO reports. vol 18. issue 4. 2017-08-15. PMID:28264987. |
upon doxorubicin treatment, the lncrna snhg1 is retained in the nucleus through its binding with nucleolin and it competes with p53 for hnrnpc binding, which upregulates p53 levels and promotes p53-dependent apoptosis by impairing hnrnpc regulation of p53 activity. |
2017-08-15 |
2023-08-13 |
Not clear |
| Yuan Shen, Shanshan Liu, Jiao Fan, Yinghua Jin, Baolei Tian, Xiaofei Zheng, Hanjiang F. Nuclear retention of the lncRNA SNHG1 by doxorubicin attenuates hnRNPC-p53 protein interactions. EMBO reports. vol 18. issue 4. 2017-08-15. PMID:28264987. |
our results indicate that a balance between lncrna snhg1 and hnrnpc regulates p53 activity and p53-dependent apoptosis upon doxorubicin treatment, and further indicate that a change in lncrna subcellular localization under specific circumstances is biologically significant. |
2017-08-15 |
2023-08-13 |
Not clear |
| Teru Hideshima, Francesca Cottini, Yoshihisa Nozawa, Hyuk-Soo Seo, Hiroto Ohguchi, Mehmet K Samur, Diana Cirstea, Naoya Mimura, Yoshikazu Iwasawa, Paul G Richardson, Nikhil C Munshi, Dharminder Chauhan, Walter Massefski, Teruhiro Utsugi, Sirano Dhe-Paganon, Kenneth C Anderso. p53-related protein kinase confers poor prognosis and represents a novel therapeutic target in multiple myeloma. Blood. vol 129. issue 10. 2017-08-14. PMID:28082445. |
here we show that tp53rk confers poor prognosis in multiple myeloma (mm) patients, and, conversely, that tp53rk knockdown inhibits p53 phosphorylation and triggers mm cell apoptosis, associated with downregulation of c-myc and e2f-1-mediated upregulation of pro-apoptotic bim. |
2017-08-14 |
2023-08-13 |
Not clear |
| Jesvin Samuel, Sandrine Jayne, Yixiang Chen, Aneela Majid, Alice Wignall, Timothy Wormull, Hishyar Najeeb, Jin-Li Luo, George D D Jones, Salvador Macip, Martin J S Dye. Posttranscriptional Upregulation of p53 by Reactive Oxygen Species in Chronic Lymphocytic Leukemia. Cancer research. vol 76. issue 21. 2017-08-11. PMID:27634759. |
using this system, we observed a 30- to 40-fold induction of wild-type p53 protein in 50 distinct human cll specimens tested, without the induction of either cell-cycle arrest or apoptosis. |
2017-08-11 |
2023-08-13 |
human |
| Jesvin Samuel, Sandrine Jayne, Yixiang Chen, Aneela Majid, Alice Wignall, Timothy Wormull, Hishyar Najeeb, Jin-Li Luo, George D D Jones, Salvador Macip, Martin J S Dye. Posttranscriptional Upregulation of p53 by Reactive Oxygen Species in Chronic Lymphocytic Leukemia. Cancer research. vol 76. issue 21. 2017-08-11. PMID:27634759. |
the addition of a dna-damaging agent further upregulated p53 protein levels, which led to apoptosis. |
2017-08-11 |
2023-08-13 |
human |
| Jesvin Samuel, Sandrine Jayne, Yixiang Chen, Aneela Majid, Alice Wignall, Timothy Wormull, Hishyar Najeeb, Jin-Li Luo, George D D Jones, Salvador Macip, Martin J S Dye. Posttranscriptional Upregulation of p53 by Reactive Oxygen Species in Chronic Lymphocytic Leukemia. Cancer research. vol 76. issue 21. 2017-08-11. PMID:27634759. |
we propose that chronic oxidative stress is a characteristic of the microenvironment in b-cell "proliferation centers" in cll that are capable of elevating the basal expression of p53, but to levels below the threshold needed to induce arrest or apoptosis. |
2017-08-11 |
2023-08-13 |
human |
| Ana A Baburamani, Kristina S Sobotka, Regina Vontell, Carina Mallard, Veena G Supramaniam, Claire Thornton, Henrik Hagber. Effect of Trp53 gene deficiency on brain injury after neonatal hypoxia-ischemia. Oncotarget. vol 8. issue 7. 2017-08-11. PMID:28076846. |
in response to cellular stressors such as hypoxia, tumor suppressor protein p53 is activated, potently initiating apoptosis and promoting bax-dependent mitochondrial outer membrane permeabilization. |
2017-08-11 |
2023-08-13 |
mouse |
| Ali Aydın, Sengul Aslan Korkmaz, Veysel Demir, Saban Teki. Anticancer and Cytotoxic Activities of [Cu(C6H16N2O2)2][Ni(CN)4] and [Cu(C6H16N2O2)Pd(CN)4] Cyanidometallate Compounds on HT29, HeLa, C6 and Vero Cell Lines. Anti-cancer agents in medicinal chemistry. vol 17. issue 6. 2017-08-10. PMID:28044934. |
in cancer, apoptosis relevant proteins-such as cam kinase, bcl-2 or p53, topoisomerase i, cell migration feature and dna/bsa-macromolecules represent significant targets for current chemotherapeutics. |
2017-08-10 |
2023-08-13 |
Not clear |
| Lin Wang, Xiao-Cong Pang, Zi-Ru Yu, Sheng-Qian Yang, Ai-Lin Liu, Jin-Hua Wang, Guan-Hua D. Actinomycin D synergistically enhances the cytotoxicity of CDDP on KB cells by activating P53 via decreasing P53-MDM2 complex. Journal of Asian natural products research. vol 19. issue 6. 2017-08-09. PMID:28440085. |
significant increase of the apoptotic activity by the combination therapy in kb cells is p53 upregulated modulator of apoptosis (puma) dependent. |
2017-08-09 |
2023-08-13 |
mouse |
| Jipei Du, Yufang Wang, Degao Chen, Guangyu Ji, Qizhao Ma, Shiping Liao, Yanjiang Zheng, Ji Zhang, Yiping Ho. BAY61-3606 potentiates the anti-tumor effects of TRAIL against colon cancer through up-regulating DR4 and down-regulating NF-κB. Cancer letters. vol 383. issue 2. 2017-08-08. PMID:27721019. |
knockout of p53 decreased bay61-3606-induced dr4 expression and inhibited the effect of bay61-3606 on trail-induced apoptosis. |
2017-08-08 |
2023-08-13 |
human |
| Yiwen Bu, Guoshuai Cai, Yi Shen, Chenfei Huang, Xi Zeng, Yu Cao, Chuan Cai, Yuhong Wang, Dan Huang, Duan-Fang Liao, Deliang Ca. Targeting NF-κB RelA/p65 phosphorylation overcomes RITA resistance. Cancer letters. vol 383. issue 2. 2017-08-08. PMID:27721021. |
rita is a promising anticancer small molecule that dissociates p53-mdm2 interaction, reactivates p53 and induces exclusive apoptosis in cancer cells, but acquired rita resistance remains a major drawback. |
2017-08-08 |
2023-08-13 |
mouse |
| Juan Huertas-Martínez, Franck Court, Santiago Rello-Varona, David Herrero-Martín, Olga Almacellas-Rabaiget, Miguel Sáinz-Jaspeado, Silvia Garcia-Monclús, Laura Lagares-Tena, Raquel Buj, Lourdes Hontecillas-Prieto, Ana Sastre, Daniel Azorin, Xavier Sanjuan, Roser López-Alemany, Sebastian Moran, Josep Roma, Soledad Gallego, Jaume Mora, Xavier García Del Muro, Paloma H Giangrande, Miquel A Peinado, Javier Alonso, Enrique de Alava, Dave Monk, Manel Esteller, Oscar M Tirad. DNA methylation profiling identifies PTRF/Cavin-1 as a novel tumor suppressor in Ewing sarcoma when co-expressed with caveolin-1. Cancer letters. vol 386. 2017-08-08. PMID:27894957. |
restoration of caveolae in the membrane of ewing sarcoma cells, by exogenously reintroducing ptrf, disrupts the mdm2/p53 complex, which consequently results in the activation of p53 and the induction of apoptosis. |
2017-08-08 |
2023-08-13 |
human |
| Lucian Beer, Lucas Nemec, Tanja Wagner, Robin Ristl, Lukas M Altenburger, Hendrik Jan Ankersmit, Michael Mildne. Ionizing radiation regulates long non-coding RNAs in human peripheral blood mononuclear cells. Journal of radiation research. vol 58. issue 2. 2017-08-08. PMID:27974506. |
exposure of pbmcs to ir dose-dependently activated p53 and its downstream target p21, ultimately leading to cell-cycle arrest and/or apoptosis. |
2017-08-08 |
2023-08-13 |
human |
| Gabriela Bottaro Gelaleti, Thaiz Ferraz Borin, Larissa Bazela Maschio-Signorini, Marina Gobbe Moschetta, Bruna Victorasso Jardim-Perassi, Guilherme Berto Calvinho, Mariana Castilho Facchini, Alicia M Viloria-Petit, Debora Aparecida Pires de Campos Zuccar. Efficacy of melatonin, IL-25 and siIL-17B in tumorigenesis-associated properties of breast cancer cell lines. Life sciences. vol 183. 2017-08-08. PMID:28624391. |
semi-quantitative analysis of apoptosis pathway proteins showed an increase of cyto-c, dr6, igfbp-3, igfbp-5, igfpb-6, igf-1, igf-1r, livin, p21, p53, tnfrii, xiap and htra proteins and reduction of caspase-3 (p<0.05) after melatonin treatment. |
2017-08-08 |
2023-08-13 |
Not clear |