| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Qinqin Gao, Xiaolin Zhu, Jie Chen, Caiping Mao, Lubo Zhang, Zhice X. Upregulation of P53 promoted G1 arrest and apoptosis in human umbilical cord vein endothelial cells from preeclampsia. Journal of hypertension. vol 34. issue 7. 2017-08-08. PMID:27115339. |
upregulation of p53 promoted g1 arrest and apoptosis in human umbilical cord vein endothelial cells from preeclampsia. |
2017-08-08 |
2023-08-13 |
human |
| Rodrigo Esaki Tamura, Rafael Bento da Silva Soares, Eugenia Costanzi-Strauss, Bryan E Straus. Autoregulated expression of p53 from an adenoviral vector confers superior tumor inhibition in a model of prostate carcinoma gene therapy. Cancer biology & therapy. vol 17. issue 12. 2017-08-07. PMID:27646031. |
adpgp53 conferred greatly enhanced levels of p53 protein and induction of the p53 target gene, p21, as well as superior cell killing by a mechanism consistent with apoptosis. |
2017-08-07 |
2023-08-13 |
human |
| Pramod Darvin, Youn Hee Joung, Dong Young Kang, Nipin Sp, Hyo Joo Byun, Tae Sook Hwang, Hema Sasidharakurup, Chi Ho Lee, Kwang Hyun Cho, Kyung Do Park, Hak Kyo Lee, Young Mok Yan. Tannic acid inhibits EGFR/STAT1/3 and enhances p38/STAT1 signalling axis in breast cancer cells. Journal of cellular and molecular medicine. vol 21. issue 4. 2017-08-07. PMID:27862996. |
regardless of the p53 status and membrane receptors, ta induced g1-arrest and apoptosis in breast cancer cells. |
2017-08-07 |
2023-08-13 |
Not clear |
| Armin Wiegering, Niels Matthes, Bettina Mühling, Monika Koospal, Anne Quenzer, Stephanie Peter, Christoph-Thomas Germer, Michael Linnebacher, Christoph Ott. Reactivating p53 and Inducing Tumor Apoptosis (RITA) Enhances the Response of RITA-Sensitive Colorectal Cancer Cells to Chemotherapeutic Agents 5-Fluorouracil and Oxaliplatin. Neoplasia (New York, N.Y.). vol 19. issue 4. 2017-08-07. PMID:28284059. |
reactivating p53 and inducing tumor apoptosis (rita) enhances the response of rita-sensitive colorectal cancer cells to chemotherapeutic agents 5-fluorouracil and oxaliplatin. |
2017-08-07 |
2023-08-13 |
human |
| Armin Wiegering, Niels Matthes, Bettina Mühling, Monika Koospal, Anne Quenzer, Stephanie Peter, Christoph-Thomas Germer, Michael Linnebacher, Christoph Ott. Reactivating p53 and Inducing Tumor Apoptosis (RITA) Enhances the Response of RITA-Sensitive Colorectal Cancer Cells to Chemotherapeutic Agents 5-Fluorouracil and Oxaliplatin. Neoplasia (New York, N.Y.). vol 19. issue 4. 2017-08-07. PMID:28284059. |
the small molecule reactivating p53 and inducing tumor apoptosis (rita) is described as an activator of wild-type and reactivator of mutant p53 function, resulting in elevated levels of p53 protein, cell growth arrest, and cell death. |
2017-08-07 |
2023-08-13 |
human |
| Rebecca A Jackson, Mai Linh Nguyen, Angela N Barrett, Yuan Yee Tan, Mahesh A Choolani, Ee Sin Che. Synthetic combinations of missense polymorphic genetic changes underlying Down syndrome susceptibility. Cellular and molecular life sciences : CMLS. vol 73. issue 21. 2017-08-04. PMID:27245382. |
we also describe recent links between snps in p53 and its related pathway proteins and down syndrome, as well as highlight several proteins that help to associate apoptosis and p53 signaling with the down syndrome phenotype. |
2017-08-04 |
2023-08-13 |
Not clear |
| Xin Cao, Ying Lu, Xianyu Zhang, Damian Kovalovsk. Zbtb1 Safeguards Genome Integrity and Prevents p53-Mediated Apoptosis in Proliferating Lymphoid Progenitors. Journal of immunology (Baltimore, Md. : 1950). vol 197. issue 4. 2017-08-02. PMID:27402700. |
increased p53-mediated apoptosis affected not only lymphoid but also myeloid development in competitive bone marrow chimeras, and prevention of apoptosis by transgenic bcl2 expression and p53 deficiency rescued lymphoid as well as myeloid development from zbtb1-mutant progenitors. |
2017-08-02 |
2023-08-13 |
Not clear |
| Eun-Young Won, Sang-Ok Lee, Dong-Hwa Lee, Daeyoup Lee, Kwang-Hee Bae, Sang Chul Lee, Seung Jun Kim, Seung-Wook Ch. Structural Insight into the Critical Role of the N-Terminal Region in the Catalytic Activity of Dual-Specificity Phosphatase 26. PloS one. vol 11. issue 9. 2017-08-02. PMID:27583453. |
human dual-specificity phosphatase 26 (dusp26) is a novel target for anticancer therapy because its dephosphorylation of the p53 tumor suppressor regulates the apoptosis of cancer cells. |
2017-08-02 |
2023-08-13 |
human |
| Hoai J Ly, Tetsuro Ikegam. Rift Valley fever virus NSs protein functions and the similarity to other bunyavirus NSs proteins. Virology journal. vol 13. 2017-08-01. PMID:27368371. |
the presence of nss filaments in the nucleus induces dna damage responses and causes cell-cycle arrest, p53 activation, and apoptosis. |
2017-08-01 |
2023-08-13 |
Not clear |
| Santosh Kumar Singh, Saswati Banerjee, Edward P Acosta, James W Lillard, Rajesh Sing. Resveratrol induces cell cycle arrest and apoptosis with docetaxel in prostate cancer cells via a p53/ p21WAF1/CIP1 and p27KIP1 pathway. Oncotarget. vol 8. issue 10. 2017-08-01. PMID:28212547. |
the current study demonstrates that combination treatment blocks the cell cycle arrest by modulation of key regulators and promotes apoptosis via p53 dependent and independent mechanism in pca. |
2017-08-01 |
2023-08-13 |
Not clear |
| Xiaorong Wang, Xiansheng Zhang, Guishuan Wang, Lu Wang, Yu Lin, Fei Su. Hsa-miR-513b-5p suppresses cell proliferation and promotes P53 expression by targeting IRF2 in testicular embryonal carcinoma cells. Gene. vol 626. 2017-08-01. PMID:28512062. |
moreover, overexpression of hsa-mir-513b-5p in the absence of p53 could also induce cell apoptosis. |
2017-08-01 |
2023-08-13 |
Not clear |
| Xiao-Feng Tian, Fu-Jian Ji, Hong-Liang Zang, Hong Ca. Activation of the miR-34a/SIRT1/p53 Signaling Pathway Contributes to the Progress of Liver Fibrosis via Inducing Apoptosis in Hepatocytes but Not in HSCs. PloS one. vol 11. issue 7. 2017-07-31. PMID:27387128. |
the mir-34a/sirt1/p53 signaling pathway thus forms a positive feedback loop wherein p53 induces mir-34a and mir-34a activates p53 by inhibiting sirt1, playing an important role in cell proliferation and apoptosis. |
2017-07-31 |
2023-08-13 |
human |
| Xin Gu, Bingjie Gu, Xianhui Lv, Zhenzhen Yu, Rong Wang, Xiaoli Zhou, Wanxin Qiao, Zhiyuan Mao, Guoping Zuo, Qing Li, Dengshun Miao, Jianliang Ji. 1, 25-dihydroxy-vitamin D3 with tumor necrosis factor-alpha protects against rheumatoid arthritis by promoting p53 acetylation-mediated apoptosis via Sirt1 in synoviocytes. Cell death & disease. vol 7. issue 10. 2017-07-31. PMID:27763638. |
1, 25-dihydroxy-vitamin d3 with tumor necrosis factor-alpha protects against rheumatoid arthritis by promoting p53 acetylation-mediated apoptosis via sirt1 in synoviocytes. |
2017-07-31 |
2023-08-13 |
Not clear |
| Juri Bergmann, Miryam Müller, Niklas Baumann, Manuel Reichert, Carola Heneweer, Julia Bolik, Karsten Lücke, Sabine Gruber, Antonella Carambia, Susanne Boretius, Ivo Leuschner, Thomas Becker, Björn Rabe, Johannes Herkel, F Thomas Wunderlich, Hans-Willi Mittrücker, Stefan Rose-John, Dirk Schmidt-Arra. IL-6 trans-signaling is essential for the development of hepatocellular carcinoma in mice. Hepatology (Baltimore, Md.). vol 65. issue 1. 2017-07-31. PMID:27770462. |
here, we show that il-6 trans-signaling, but not il-6 classic signaling, is essential to promote hepatocellular carcinogenesis by two mechanisms: first, it prevents dna-damage-induced hepatocyte apoptosis through suppression of p53 and enhances β-catenin activation and tumor proliferation. |
2017-07-31 |
2023-08-13 |
mouse |
| Bijesh Puthusseri, Amarnath Marudamuthu, Nivedita Tiwari, Jian Fu, Steven Idell, Sreerama Shett. Regulation of p53-mediated changes in the uPA-fibrinolytic system and in lung injury by loss of surfactant protein C expression in alveolar epithelial cells. American journal of physiology. Lung cellular and molecular physiology. vol 312. issue 6. 2017-07-31. PMID:28385810. |
it is unclear whether loss of sp-c contributes to the increased p53 and urokinase-type plasminogen activator (upa) system cross-talk and apoptosis of aecs. |
2017-07-31 |
2023-08-13 |
mouse |
| Bijesh Puthusseri, Amarnath Marudamuthu, Nivedita Tiwari, Jian Fu, Steven Idell, Sreerama Shett. Regulation of p53-mediated changes in the uPA-fibrinolytic system and in lung injury by loss of surfactant protein C expression in alveolar epithelial cells. American journal of physiology. Lung cellular and molecular physiology. vol 312. issue 6. 2017-07-31. PMID:28385810. |
inhibition of sp-c expression in aecs induced p53 and activated caspase-3, indicating aec apoptosis. |
2017-07-31 |
2023-08-13 |
mouse |
| Bijesh Puthusseri, Amarnath Marudamuthu, Nivedita Tiwari, Jian Fu, Steven Idell, Sreerama Shett. Regulation of p53-mediated changes in the uPA-fibrinolytic system and in lung injury by loss of surfactant protein C expression in alveolar epithelial cells. American journal of physiology. Lung cellular and molecular physiology. vol 312. issue 6. 2017-07-31. PMID:28385810. |
depletion of sp-c expression by lentiviral sp-c shrna in pai-1-deficient mice failed to induce p53 or apoptosis in aecs, whereas it increased both aec p53 and apoptosis in wild-type and upa-deficient mice. |
2017-07-31 |
2023-08-13 |
mouse |
| Bijesh Puthusseri, Amarnath Marudamuthu, Nivedita Tiwari, Jian Fu, Steven Idell, Sreerama Shett. Regulation of p53-mediated changes in the uPA-fibrinolytic system and in lung injury by loss of surfactant protein C expression in alveolar epithelial cells. American journal of physiology. Lung cellular and molecular physiology. vol 312. issue 6. 2017-07-31. PMID:28385810. |
furthermore, caveolin-1 expression and phosphorylation were increased in aecs, indicating an intricate link between caveolin-1 and src kinase-mediated cell signaling and aec apoptosis due to loss of sp-c expression through p53 and upa system-mediated cross-talk. |
2017-07-31 |
2023-08-13 |
mouse |
| Bijesh Puthusseri, Amarnath Marudamuthu, Nivedita Tiwari, Jian Fu, Steven Idell, Sreerama Shett. Regulation of p53-mediated changes in the uPA-fibrinolytic system and in lung injury by loss of surfactant protein C expression in alveolar epithelial cells. American journal of physiology. Lung cellular and molecular physiology. vol 312. issue 6. 2017-07-31. PMID:28385810. |
the role of upa, pai-1, and p53 in the regulation of aec apoptosis after injury was also determined in knockout mice. |
2017-07-31 |
2023-08-13 |
mouse |
| Yu-Ching Huang, Ming-Shiun Tsai, Pei-Chi Hsieh, Jheng-Hong Shih, Tsu-Shing Wang, Yi-Chun Wang, Ting-Hui Lin, Sue-Hong Wan. Galangin ameliorates cisplatin-induced nephrotoxicity by attenuating oxidative stress, inflammation and cell death in mice through inhibition of ERK and NF-kappaB signaling. Toxicology and applied pharmacology. vol 329. 2017-07-31. PMID:28558962. |
in terms of cell death, galangin administration reduced levels of p53, pro-apoptotic bax and activated caspase-3 to inhibit the cisplatin-induced apoptosis. |
2017-07-31 |
2023-08-13 |
mouse |