| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Minglan Guo, Jingguang Wei, Yongcan Zhou, Qiwei Qi. c-Jun N-terminal kinases 3 (JNK3) from orange-spotted grouper, Epinephelus coioides, inhibiting the replication of Singapore grouper iridovirus (SGIV) and SGIV-induced apoptosis. Developmental and comparative immunology. vol 65. 2017-11-13. PMID:27422159. |
to achieve the antiviral and anti-apoptosis activities, jnk3 promoted the activation of genes isre and type i ifn in the antiviral ifn signaling pathway, and inhibited the activation of transcription factors nf-κb and p53 relating to apoptosis, respectively. |
2017-11-13 |
2023-08-13 |
Not clear |
| Hanbing He, Cheng Wang, Qian Dai, Fengtian Li, Johann Bergholz, Zhonghan Li, Qintong Li, Zhi-Xiong Xia. p53 and p73 Regulate Apoptosis but Not Cell-Cycle Progression in Mouse Embryonic Stem Cells upon DNA Damage and Differentiation. Stem cell reports. vol 7. issue 6. 2017-11-13. PMID:27866875. |
p53 and p73 regulate apoptosis but not cell-cycle progression in mouse embryonic stem cells upon dna damage and differentiation. |
2017-11-13 |
2023-08-13 |
mouse |
| Hanbing He, Cheng Wang, Qian Dai, Fengtian Li, Johann Bergholz, Zhonghan Li, Qintong Li, Zhi-Xiong Xia. p53 and p73 Regulate Apoptosis but Not Cell-Cycle Progression in Mouse Embryonic Stem Cells upon DNA Damage and Differentiation. Stem cell reports. vol 7. issue 6. 2017-11-13. PMID:27866875. |
in somatic cells, it is well documented that p53 is rapidly activated upon dna damage to arrest the cell cycle and induce apoptosis. |
2017-11-13 |
2023-08-13 |
mouse |
| Hanbing He, Cheng Wang, Qian Dai, Fengtian Li, Johann Bergholz, Zhonghan Li, Qintong Li, Zhi-Xiong Xia. p53 and p73 Regulate Apoptosis but Not Cell-Cycle Progression in Mouse Embryonic Stem Cells upon DNA Damage and Differentiation. Stem cell reports. vol 7. issue 6. 2017-11-13. PMID:27866875. |
instead, p53 and p73 were fully responsible for apoptosis. |
2017-11-13 |
2023-08-13 |
mouse |
| Hanbing He, Cheng Wang, Qian Dai, Fengtian Li, Johann Bergholz, Zhonghan Li, Qintong Li, Zhi-Xiong Xia. p53 and p73 Regulate Apoptosis but Not Cell-Cycle Progression in Mouse Embryonic Stem Cells upon DNA Damage and Differentiation. Stem cell reports. vol 7. issue 6. 2017-11-13. PMID:27866875. |
p53 and p73 were also required for differentiation-induced apoptosis in mouse escs. |
2017-11-13 |
2023-08-13 |
mouse |
| Hanbing He, Cheng Wang, Qian Dai, Fengtian Li, Johann Bergholz, Zhonghan Li, Qintong Li, Zhi-Xiong Xia. p53 and p73 Regulate Apoptosis but Not Cell-Cycle Progression in Mouse Embryonic Stem Cells upon DNA Damage and Differentiation. Stem cell reports. vol 7. issue 6. 2017-11-13. PMID:27866875. |
therefore, both p53 and p73 are critical in apoptosis induced by dna damage and differentiation. |
2017-11-13 |
2023-08-13 |
mouse |
| Wei Zhang, Maria A Sartori, Taras Makhnevych, Kelly E Federowicz, Xiaohui Dong, Li Liu, Satra Nim, Aiping Dong, Jingsong Yang, Yanjun Li, Dania Haddad, Andreas Ernst, Dirk Heerding, Yufeng Tong, Jason Moffat, Sachdev S Sidh. Generation and Validation of Intracellular Ubiquitin Variant Inhibitors for USP7 and USP10. Journal of molecular biology. vol 429. issue 22. 2017-11-13. PMID:28587923. |
post-translational modification of the p53 signaling pathway plays an important role in cell cycle progression and stress-induced apoptosis. |
2017-11-13 |
2023-08-13 |
Not clear |
| Song-Yi Park, Sophors Phorl, Suna Jung, Korm Sovannarith, Se-In Lee, Solhee Noh, Miae Han, Rema Naskar, Jae-Young Kim, Yun-Jaie Choi, Joo-Yong Le. HDAC6 deficiency induces apoptosis in mesenchymal stem cells through p53 K120 acetylation. Biochemical and biophysical research communications. vol 494. issue 1-2. 2017-11-13. PMID:29054408. |
hdac6 deficiency induces apoptosis in mesenchymal stem cells through p53 k120 acetylation. |
2017-11-13 |
2023-08-13 |
Not clear |
| Fatima Abdelmutaal Ahmed Omer, Najihah Binti Mohd Hashim, Mohamed Yousif Ibrahim, Firouzeh Dehghan, Maizatulakmal Yahayu, Hamed Karimian, Landa Zeenelabdin Ali Salim, Syam Moha. Beta-mangostin from Cratoxylum arborescens activates the intrinsic apoptosis pathway through reactive oxygen species with downregulation of the HSP70 gene in the HL60 cells associated with a G Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 39. issue 11. 2017-11-13. PMID:29110583. |
caspase-3 and caspase-9 activities; reactive oxygen species; real-time polymerase chain reaction for bcl-2, bax, caspase-3, and caspase-9 hsp70 genes; and western blot for p53, cytochrome c, and pro- and cleavage-caspase-3 and caspase-9 were assessed to examine the apoptosis mechanism. |
2017-11-13 |
2023-08-13 |
human |
| Xiannan Meng, Ling Zhang, Xiang Chen, Zou Xiang, Dongmei Li, Xiaodong Ha. miR-541 Contributes to Microcystin-LR-Induced Reproductive Toxicity through Regulating the Expression of p15 in Mice. Toxins. vol 8. issue 9. 2017-11-08. PMID:27608041. |
increase in mir-541 led to a reduction of p15 and murine double minute2 (mdm2), promoting the activation of p53 signaling and mc-lr-mediated cell apoptosis. |
2017-11-08 |
2023-08-13 |
mouse |
| Yuta Adachi, Kazuyoshi Watanabe, Kenji Kita, Hidenori Kitai, Hiroshi Kotani, Yuki Sato, Naohiko Inase, Seiji Yano, Hiromichi Eb. Resistance mediated by alternative receptor tyrosine kinases in FGFR1-amplified lung cancer. Carcinogenesis. vol 38. issue 11. 2017-11-08. PMID:28968756. |
combinatorial inhibition of alternative rtks and fgfr1 was required to suppress both akt and extracellular signal-regulated kinase phosphorylation and to induce key pro-apoptotic proteins bim and p53 upregulated modulator of apoptosis (puma). |
2017-11-08 |
2023-08-13 |
Not clear |
| Lieying Fan, Ming Zong, Ruhan Gong, Dongyi He, Niu Li, Li Shan Sun, Qin Ye, Shanshan Y. PADI4 Epigenetically Suppresses p21 Transcription and Inhibits Cell Apoptosis in Fibroblast-like Synoviocytes from Rheumatoid Arthritis Patients. International journal of biological sciences. vol 13. issue 3. 2017-11-07. PMID:28367100. |
the results showed that knockdown of padi4 promoted the apoptosis of ra-flss and the expression of p53 and p21. |
2017-11-07 |
2023-08-13 |
Not clear |
| Lieying Fan, Ming Zong, Ruhan Gong, Dongyi He, Niu Li, Li Shan Sun, Qin Ye, Shanshan Y. PADI4 Epigenetically Suppresses p21 Transcription and Inhibits Cell Apoptosis in Fibroblast-like Synoviocytes from Rheumatoid Arthritis Patients. International journal of biological sciences. vol 13. issue 3. 2017-11-07. PMID:28367100. |
ectopic expression of padi4 inhibited adr-induced apoptosis of ra-flss, and down-regulated the expression of p53 and p21. |
2017-11-07 |
2023-08-13 |
Not clear |
| Yasuaki Enokida, Kimihiro Shimizu, Jun Atsumi, Seiichi Kakegawa, Yoshiaki Takase, Kyoichi Kaira, Hideaki Yashima, Takuya Araki, Seshiru Nakazawa, Yoichi Ohtaki, Toshiteru Nagashima, Lezhava Alexander, Kengo Usui, Toshihisa Ishikawa, Yoshihide Hayashizaki, Izumi Takeyosh. Prognostic potential of the MDM2 309T>G polymorphism in stage I lung adenocarcinoma. Cancer medicine. vol 5. issue 8. 2017-11-07. PMID:27228500. |
the mdm2 protein plays an important role in the regulation of cell proliferation and apoptosis via ubiquitination and proteasome-mediated degradation of p53. |
2017-11-07 |
2023-08-13 |
Not clear |
| K Matsuura, K Canfield, W Feng, M Kurokaw. Metabolic Regulation of Apoptosis in Cancer. International review of cell and molecular biology. vol 327. 2017-11-06. PMID:27692180. |
in turn, p53, a regulator of apoptosis, also controls metabolism by limiting glycolysis and facilitating mitochondrial respiration. |
2017-11-06 |
2023-08-13 |
human |
| Franco Bisceglie, Rossella Alinovi, Silvana Pinelli, Maricla Galetti, Marianna Pioli, Pieralberto Tarasconi, Antonio Mutti, Matteo Goldoni, Giorgio Pelos. Autophagy and apoptosis: studies on the effects of bisthiosemicarbazone copper(ii) complexes on p53 and p53-null tumour cell lines. Metallomics : integrated biometal science. vol 8. issue 12. 2017-11-03. PMID:27841435. |
autophagy and apoptosis: studies on the effects of bisthiosemicarbazone copper(ii) complexes on p53 and p53-null tumour cell lines. |
2017-11-03 |
2023-08-13 |
Not clear |
| Franco Bisceglie, Rossella Alinovi, Silvana Pinelli, Maricla Galetti, Marianna Pioli, Pieralberto Tarasconi, Antonio Mutti, Matteo Goldoni, Giorgio Pelos. Autophagy and apoptosis: studies on the effects of bisthiosemicarbazone copper(ii) complexes on p53 and p53-null tumour cell lines. Metallomics : integrated biometal science. vol 8. issue 12. 2017-11-03. PMID:27841435. |
the study includes cell viability, cell cycle, morphological changes, assessment of apoptosis, analysis of autophagy, measurement of reactive oxygen species (ros) and of lipid peroxidation, protein determination, assessment of the expression of p53 and cellular uptake of metal complexes. |
2017-11-03 |
2023-08-13 |
Not clear |
| Xuepeng Chen, Songying Li, Zhaobin Zeng, Zexu Gu, Yanfang Yu, Feifei Zheng, Yi Zhou, Huiming Wan. Notch1 signalling inhibits apoptosis of human dental follicle stem cells via both the cytoplasmic mitochondrial pathway and nuclear transcription regulation. The international journal of biochemistry & cell biology. vol 82. 2017-11-03. PMID:27888063. |
the expression of p53 was also inhibited in notch1-overexpressing dfscs, while the ectopic expression of p53 promoted apoptosis even when notch1 was overexpressed. |
2017-11-03 |
2023-08-13 |
human |
| Bu-Nam Jeon, Jae-Hyeon Yoon, Dohyun Han, Min-Kyeong Kim, Youngsoo Kim, Seo-Hyun Choi, Jiyang Song, Kyung-Sup Kim, Kunhong Kim, Man-Wook Hu. ZNF509S1 downregulates PUMA by inhibiting p53K382 acetylation and p53-DNA binding. Biochimica et biophysica acta. Gene regulatory mechanisms. vol 1860. issue 9. 2017-11-03. PMID:28757384. |
when cells are exposed to severe dna damage, p53 activates puma (p53-upregulated modulator of apoptosis) transcription. |
2017-11-03 |
2023-08-13 |
Not clear |
| Bu-Nam Jeon, Jae-Hyeon Yoon, Dohyun Han, Min-Kyeong Kim, Youngsoo Kim, Seo-Hyun Choi, Jiyang Song, Kyung-Sup Kim, Kunhong Kim, Man-Wook Hu. ZNF509S1 downregulates PUMA by inhibiting p53K382 acetylation and p53-DNA binding. Biochimica et biophysica acta. Gene regulatory mechanisms. vol 1860. issue 9. 2017-11-03. PMID:28757384. |
interestingly, apoptosis due to transcriptional activation of puma by p53 is attenuated by znf509s1. |
2017-11-03 |
2023-08-13 |
Not clear |