| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ruo-Can Qian, Jian Lv, Hao-Wen Li, Yi-Tao Lon. Sugar-Coated Nanobullet: Growth Inhibition of Cancer Cells Induced by Metformin-Loaded Glyconanoparticles. ChemMedChem. vol 12. issue 22. 2017-12-12. PMID:28967197. |
furthermore, inactivation of mitochondria and activation of p53 protein are observed during mgnp treatment, which provides evidence for metformin-induced cell apoptosis pathways. |
2017-12-12 |
2023-08-13 |
Not clear |
| Ryota Koyama, Miyuki Tamura, Takafumi Nakagaki, Tomoko Ohashi, Masashi Idogawa, Hiromu Suzuki, Takashi Tokino, Yasushi Sasak. Identification and characterization of a metastatic suppressor BRMS1L as a target gene of p53. Cancer science. vol 108. issue 12. 2017-12-12. PMID:29030916. |
as transcription factors, p53 family proteins regulate a number of genes that are involved in cell cycle arrest, apoptosis, senescence, and maintenance of genomic stability. |
2017-12-12 |
2023-08-13 |
Not clear |
| Lihui Liu, Haiyan Yue, Qinghua Liu, Jiao Yuan, Jing Li, Guifeng Wei, Xiaomin Chen, Youyong Lu, Mingzhou Guo, Jianjun Luo, Runsheng Che. LncRNA MT1JP functions as a tumor suppressor by interacting with TIAR to modulate the p53 pathway. Oncotarget. vol 7. issue 13. 2017-12-12. PMID:26909858. |
by associating with the rna-binding protein tiar, mt1jp enhanced the translation of the master transcription factor p53, thereby regulating a series of pathways involving p53, such as the cell cycle, apoptosis and proliferation. |
2017-12-12 |
2023-08-13 |
Not clear |
| Chen Qiao, Na Lu, Yuxin Zhou, Ting Ni, Yuanyuan Dai, Zhiyu Li, Qinglong Guo, Libin We. Oroxylin A modulates mitochondrial function and apoptosis in human colon cancer cells by inducing mitochondrial translocation of wild-type p53. Oncotarget. vol 7. issue 13. 2017-12-12. PMID:26958937. |
oroxylin a modulates mitochondrial function and apoptosis in human colon cancer cells by inducing mitochondrial translocation of wild-type p53. |
2017-12-12 |
2023-08-13 |
human |
| Chen Qiao, Na Lu, Yuxin Zhou, Ting Ni, Yuanyuan Dai, Zhiyu Li, Qinglong Guo, Libin We. Oroxylin A modulates mitochondrial function and apoptosis in human colon cancer cells by inducing mitochondrial translocation of wild-type p53. Oncotarget. vol 7. issue 13. 2017-12-12. PMID:26958937. |
finally, we showed that oroxylin a triggers cytosolic p53 activation, thereby promoting apoptosis. |
2017-12-12 |
2023-08-13 |
human |
| Eva Baquedano, Emma Burgos-Ramos, Sandra Canelles, Agueda González-Rodríguez, Julie A Chowen, Jesús Argente, Vicente Barrios, Angela M Valverde, Laura M Frag. Increased oxidative stress and apoptosis in the hypothalamus of diabetic male mice in the insulin receptor substrate-2 knockout model. Disease models & mechanisms. vol 9. issue 5. 2017-12-12. PMID:27013528. |
regulators of apoptosis such as fadd, bcl-2, bcl-xl and p53 were also increased, whereas p-iκb and c-flipl were decreased. |
2017-12-12 |
2023-08-13 |
mouse |
| Guangtong Zhou, Xinrui Liu, Yunqian Li, Songbai Xu, Chengyuan Ma, Xinmin Wu, Ye Cheng, Zhiyun Yu, Gang Zhao, Yong Che. Telomere targeting with a novel G-quadruplex-interactive ligand BRACO-19 induces T-loop disassembly and telomerase displacement in human glioblastoma cells. Oncotarget. vol 7. issue 12. 2017-12-11. PMID:26908447. |
the resulting dysfunctional telomere ultimately provokes p53 and p21-mediated cell cycle arrest, apoptosis and senescence. |
2017-12-11 |
2023-08-13 |
human |
| Tongyuan Li, Xiangyu Liu, Le Jiang, James Manfredi, Shan Zha, Wei G. Loss of p53-mediated cell-cycle arrest, senescence and apoptosis promotes genomic instability and premature aging. Oncotarget. vol 7. issue 11. 2017-12-11. PMID:26943586. |
although p53-mediated cell cycle arrest, senescence and apoptosis are well accepted as major tumor suppression mechanisms, the loss of these functions does not directly lead to tumorigenesis, suggesting that the precise roles of these canonical activities of p53 need to be redefined. |
2017-12-11 |
2023-08-13 |
mouse |
| Guang Chen, Jin-Ye Xu, Jie Chen, Jian-Xin Zhang, Jun Zhou, Yong Liang, Xiao-Fei Din. Loss of PIG3 increases HIF-1α level by promoting protein synthesis via mTOR pathway in renal cell carcinoma cells. Oncotarget. vol 7. issue 19. 2017-12-11. PMID:27029070. |
pig3 is a target of the tumor suppressor p53 and is thought to be involved in p53-mediated cell apoptosis. |
2017-12-11 |
2023-08-13 |
human |
| M Aggarwal, R Saxena, E Sinclair, Y Fu, A Jacobs, M Dyba, X Wang, I Cruz, D Berry, B Kallakury, S C Mueller, S D Agostino, G Blandino, M L Avantaggiati, F-L Chun. Reactivation of mutant p53 by a dietary-related compound phenethyl isothiocyanate inhibits tumor growth. Cell death and differentiation. vol 23. issue 10. 2017-12-11. PMID:27258787. |
mechanistic studies revealed that peitc induces apoptosis in a p53(r175) mutant-dependent manner by restoring p53 wt conformation and transactivation functions. |
2017-12-11 |
2023-08-13 |
mouse |
| M Aggarwal, R Saxena, E Sinclair, Y Fu, A Jacobs, M Dyba, X Wang, I Cruz, D Berry, B Kallakury, S C Mueller, S D Agostino, G Blandino, M L Avantaggiati, F-L Chun. Reactivation of mutant p53 by a dietary-related compound phenethyl isothiocyanate inhibits tumor growth. Cell death and differentiation. vol 23. issue 10. 2017-12-11. PMID:27258787. |
accordingly, in peitc-treated cells the reactivated p53(r175) mutant induces apoptosis by activating canonical wt p53 targets, inducing a delay in s and g2/m phase, and by phosphorylating atm/chk2. |
2017-12-11 |
2023-08-13 |
mouse |
| Margaret E Katz, Katharyn S Braunberger, Joan M Kell. Role of HxkC, a mitochondrial hexokinase-like protein, in fungal programmed cell death. Fungal genetics and biology : FG & B. vol 97. 2017-12-08. PMID:27836782. |
though apoptotic-like pcd also occurs in plants and fungi, genes encoding several of the key players in mammalian apoptosis (p53 and bh-domain proteins) have not been identified in these kingdoms. |
2017-12-08 |
2023-08-13 |
Not clear |
| L M Zhao, A X Pan. Iodine-131 treatment of thyroid cancer cells leads to suppression of cell proliferation followed by induction of cell apoptosis and cell cycle arrest by regulation of B-cell translocation gene 2-mediated JNK/NF-κB pathways. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. vol 50. issue 1. 2017-12-08. PMID:28099584. |
they were then assessed for 131i uptake, cell viability, apoptosis, cell cycle arrest, p53 expression, and btg2 gene expression. |
2017-12-08 |
2023-08-13 |
human |
| Yumi Jang, Juhae Kim, Je Won Ko, Young Hye Kwo. Homocysteine induces PUMA-mediated mitochondrial apoptosis in SH-SY5Y cells. Amino acids. vol 48. issue 11. 2017-12-07. PMID:27339788. |
homocysteine significantly increased mrna levels of chop and p53, resulting in the upregulation of their downstream target gene, p53 up-regulated modulator of apoptosis (puma). |
2017-12-07 |
2023-08-13 |
human |
| Xiaobo Cui, Laixiao Song, Yunfei Bai, Yaping Wang, Boqian Wang, Wei Wan. Stromal interaction molecule 1 regulates growth, cell cycle, and apoptosis of human tongue squamous carcinoma cells. Bioscience reports. vol 37. issue 2. 2017-12-07. PMID:28108672. |
furthermore, we performed microarray and bioinformatics analysis and found that stim1 was associated with p53 and mapk pathways, which may contribute to the effects of stim1 on cell growth, cell cycle, and apoptosis. |
2017-12-07 |
2023-08-13 |
human |
| Morgan A Sammons, Jiajun Zhu, Shelley L Berge. A Chromatin-Focused siRNA Screen for Regulators of p53-Dependent Transcription. G3 (Bethesda, Md.). vol 6. issue 8. 2017-12-06. PMID:27334938. |
the protein product of the homo sapiens tp53 gene is a transcription factor (p53) that regulates the expression of genes critical for the response to dna damage and tumor suppression, including genes involved in cell cycle arrest, apoptosis, dna repair, metabolism, and a number of other tumorigenesis-related pathways. |
2017-12-06 |
2023-08-13 |
Not clear |
| Alexandra Schütze, Christian Vogeley, Tobias Gorges, Sören Twarock, Jonas Butschan, Anna Babayan, Diana Klein, Shirley K Knauer, Eric Metzen, Volkmar Müller, Verena Jendrossek, Klaus Pantel, Karin Milde-Langosch, Jens W Fischer, Katharina Röc. RHAMM splice variants confer radiosensitivity in human breast cancer cell lines. Oncotarget. vol 7. issue 16. 2017-12-04. PMID:26870892. |
high expression of rhammv1/v2 in p53 wild type cells (mcf-7) induced cellular apoptosis in response to ionizing radiation. |
2017-12-04 |
2023-08-13 |
human |
| Alexandra Schütze, Christian Vogeley, Tobias Gorges, Sören Twarock, Jonas Butschan, Anna Babayan, Diana Klein, Shirley K Knauer, Eric Metzen, Volkmar Müller, Verena Jendrossek, Klaus Pantel, Karin Milde-Langosch, Jens W Fischer, Katharina Röc. RHAMM splice variants confer radiosensitivity in human breast cancer cell lines. Oncotarget. vol 7. issue 16. 2017-12-04. PMID:26870892. |
in comparison, in p53 mutated cells (mda-mb-231) rhammv1/v2 was expressed sparsely resulting in resistance towards irradiation induced apoptosis. |
2017-12-04 |
2023-08-13 |
human |
| You-Cheng Hseu, Varadharajan Thiyagarajan, Hsiao-Tung Tsou, Kai-Yuan Lin, Hui-Jye Chen, Chung-Ming Lin, Jiuun-Wang Liao, Hsin-Ling Yan. In vitro and in vivo anti-tumor activity of CoQ0 against melanoma cells: inhibition of metastasis and induction of cell-cycle arrest and apoptosis through modulation of Wnt/β-catenin signaling pathways. Oncotarget. vol 7. issue 16. 2017-12-04. PMID:26968952. |
furthermore, coq0 treatment induced apoptosis through caspase-9/-3 activation, parp degradation, bcl-2/bax dysregulation, and p53 expression. |
2017-12-04 |
2023-08-13 |
mouse |
| Yung-Lung Chang, Li-Chun Huang, Ying-Chuan Chen, Yi-Wen Wang, Dueng-Yuan Hueng, Shih-Ming Huan. The synergistic effects of valproic acid and fluvastatin on apoptosis induction in glioblastoma multiforme cell lines. The international journal of biochemistry & cell biology. vol 92. 2017-12-01. PMID:29017950. |
however, partial silencing of p53 had no effect on apoptosis. |
2017-12-01 |
2023-08-13 |
Not clear |