| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Li Xue, Xiujuan Han, Rongrong Liu, Ziming Wang, Hecheng Li, Qi Chen, Peng Zhang, Zhenlong Wang, Tie Chon. MDM2 and P53 polymorphisms contribute together to the risk and survival of prostate cancer. Oncotarget. vol 7. issue 22. 2017-12-26. PMID:26025918. |
the p53 gene and mdm2 gene play critical roles in cell cycle arrest and apoptosis together. |
2017-12-26 |
2023-08-13 |
Not clear |
| Zhiqin Deng, Pan Gao, Lianling Yu, Bin Ma, Yuanyuan You, Leung Chan, Chaoming Mei, Tianfeng Che. Ruthenium complexes with phenylterpyridine derivatives target cell membrane and trigger death receptors-mediated apoptosis in cancer cells. Biomaterials. vol 129. 2017-12-25. PMID:28340357. |
at the same time, the residual 2c can translocate into cell nucleus to interact with dna, induce dna damage, activate p53 pathway and enhance apoptosis. |
2017-12-25 |
2023-08-13 |
Not clear |
| Lingling Ou, Shaoqiang Lin, Bin Song, Jia Liu, Renfa Lai, Longquan Sha. The mechanisms of graphene-based materials-induced programmed cell death: a review of apoptosis, autophagy, and programmed necrosis. International journal of nanomedicine. vol 12. 2017-12-25. PMID:28924347. |
though apoptosis, autophagy, and necroptosis are distinguished by some characteristics, their numerous signaling pathways comprise an interconnected network and correlate with each other, such as the tlrs, p53 signaling pathways, and the beclin-1 and bcl-2 interaction. |
2017-12-25 |
2023-08-13 |
human |
| Hesham M Hassan, Michelle L Varney, Nagendra K Chaturvedi, Shantaram S Joshi, Dennis D Weisenburger, Rakesh K Singh, Bhavana J Dav. Modulation of p73 isoforms expression induces anti-proliferative and pro-apoptotic activity in mantle cell lymphoma independent of p53 status. Leukemia & lymphoma. vol 57. issue 12. 2017-12-22. PMID:27074052. |
in this report, we investigated whether modulation of p73 isoforms by diclofenac inhibits cell growth, induces apoptosis and/or cell cycle arrest in mcl relative to p53 status. |
2017-12-22 |
2023-08-13 |
human |
| Ako Azimi, Maryam Majidinia, Vahid Shafiei-Irannejad, Rana Jahanban-Esfahlan, Yasin Ahmadi, Ansar Karimian, Seyed Mostafa Mir, Hadi Karami, Bahman Yousef. Suppression of p53R2 gene expression with specific siRNA sensitizes HepG2 cells to doxorubicin. Gene. vol 642. 2017-12-21. PMID:29126924. |
herein, we examined the effects of p53r2 silencing on hepg2 human hepatocellular carcinoma (hhc) cell line (wild-type p53) viability, apoptosis and cell cycle arrest in the presence and absence of doxorubicin. |
2017-12-21 |
2023-08-13 |
human |
| Jacob Stewart-Ornstein, Galit Laha. p53 dynamics in response to DNA damage vary across cell lines and are shaped by efficiency of DNA repair and activity of the kinase ATM. Science signaling. vol 10. issue 476. 2017-12-20. PMID:28442631. |
we focused on the dynamics of the tumor suppressor protein p53, which regulates cell cycle arrest and apoptosis in response to dna damage. |
2017-12-20 |
2023-08-13 |
Not clear |
| Kamonwan Fish, Richard P Sora, Samantha J Schaller, Richard Longnecker, Masato Iked. EBV latent membrane protein 2A orchestrates p27 Blood. vol 130. issue 23. 2017-12-20. PMID:29074502. |
by studying the roles of lmp2a during lymphoma development in vivo, we found that lmp2a mediates rapid myc-driven lymphoma onset by allowing b cells to bypass myc-induced apoptosis mediated by the p53 pathway in our transgenic mouse model. |
2017-12-20 |
2023-08-13 |
mouse |
| Rongqing Pan, Vivian Ruvolo, Hong Mu, Joel D Leverson, Gwen Nichols, John C Reed, Marina Konopleva, Michael Andreef. Synthetic Lethality of Combined Bcl-2 Inhibition and p53 Activation in AML: Mechanisms and Superior Antileukemic Efficacy. Cancer cell. vol 32. issue 6. 2017-12-20. PMID:29232553. |
bcl-2 and p53 represent two important nodes in apoptosis signaling pathways. |
2017-12-20 |
2023-08-13 |
mouse |
| Rongqing Pan, Vivian Ruvolo, Hong Mu, Joel D Leverson, Gwen Nichols, John C Reed, Marina Konopleva, Michael Andreef. Synthetic Lethality of Combined Bcl-2 Inhibition and p53 Activation in AML: Mechanisms and Superior Antileukemic Efficacy. Cancer cell. vol 32. issue 6. 2017-12-20. PMID:29232553. |
we find that concomitant p53 activation and bcl-2 inhibition overcome apoptosis resistance and markedly prolong survival in three mouse models of resistant acute myeloid leukemia (aml). |
2017-12-20 |
2023-08-13 |
mouse |
| Rongqing Pan, Vivian Ruvolo, Hong Mu, Joel D Leverson, Gwen Nichols, John C Reed, Marina Konopleva, Michael Andreef. Synthetic Lethality of Combined Bcl-2 Inhibition and p53 Activation in AML: Mechanisms and Superior Antileukemic Efficacy. Cancer cell. vol 32. issue 6. 2017-12-20. PMID:29232553. |
moreover, bcl-2 inhibition reciprocally overcomes apoptosis resistance to p53 activation by switching cellular response from g |
2017-12-20 |
2023-08-13 |
mouse |
| Emna Mahfoudhi, Larissa Lordier, Caroline Marty, Jiajia Pan, Anita Roy, Lydia Roy, Philippe Rameau, Salem Abbes, Najet Debili, Hana Raslova, Yunhua Chang, Laurent Debussche, William Vainchenker, Isabelle Pl. P53 activation inhibits all types of hematopoietic progenitors and all stages of megakaryopoiesis. Oncotarget. vol 7. issue 22. 2017-12-20. PMID:26959882. |
p53 is involved in cell cycle, apoptosis and dna repair mechanisms and is thus tightly controlled by many regulators. |
2017-12-20 |
2023-08-13 |
human |
| Samar Alsafadi, Sophie Tourpin, Nadia Bessoltane, Sophie Salomé-Desnoulez, Gilles Vassal, Fabrice André, Jean-Charles Ahomadegb. Nuclear localization of the caspase-3-cleaved form of p73 in anoikis. Oncotarget. vol 7. issue 11. 2017-12-19. PMID:26575022. |
unlike p53, p73 is rarely mutated or lost in cancers and it is found to replace defective p53 inducing apoptosis. |
2017-12-19 |
2023-08-13 |
Not clear |
| Ahmed Bulldan, Mazen Shihan, Sandra Goericke-Pesch, Georgios Scheiner-Bobi. Signaling events associated with gonadotropin releasing hormone-agonist-induced hormonal castration and its reversal in canines. Molecular reproduction and development. vol 83. issue 12. 2017-12-15. PMID:27764533. |
phosphorylation of p53 occurred at ser15, consistent with activation of the c-raf-erk1/2-p53 signaling cascade that triggers growth arrest or apoptosis. |
2017-12-15 |
2023-08-13 |
Not clear |
| Wenjun Zhang, Haixia Wu, Meng Yang, Shiguang Ye, Liang Li, Hong Zhang, Jiong Hu, Xuguang Wang, Jun Xu, Aibin Lian. SIRT1 inhibition impairs non-homologous end joining DNA damage repair by increasing Ku70 acetylation in chronic myeloid leukemia cells. Oncotarget. vol 7. issue 12. 2017-12-15. PMID:26646449. |
furthermore, sirt1 knockdown resulted in cell cycle arrest, induction of apoptosis and reduction of k562 cell proliferation accompanied by enhanced p53 and foxo1 acetylation in k562 cells after etoposide treatment. |
2017-12-15 |
2023-08-13 |
mouse |
| Augusto Faria Andrade, Kleiton Silva Borges, Veridiana Kiill Suazo, Lenisa Geron, Carolina Alves Pereira Corrêa, Angel Mauricio Castro-Gamero, Elton José Rosas de Vasconcelos, Ricardo Santos de Oliveira, Luciano Neder, José Andres Yunes, Simone Dos Santos Aguiar, Carlos Alberto Scrideli, Luiz Gonzaga Ton. The DNA methyltransferase inhibitor zebularine exerts antitumor effects and reveals BATF2 as a poor prognostic marker for childhood medulloblastoma. Investigational new drugs. vol 35. issue 1. 2017-12-14. PMID:27785591. |
the treatment inhibited proliferation and clonogenicity, increased the apoptosis rate and the number of cells in the s phase (p < 0.05), as well as the expression of p53, p21, and bax, and decreased cyclin a, survivin and bcl-2 proteins. |
2017-12-14 |
2023-08-13 |
Not clear |
| Kamal Razavi-Azarkhiavi, Milad Iranshahy, Amirhossein Sahebkar, Kobra Shirani, Gholamreza Karim. The Protective Role of Phenolic Compounds Against Doxorubicin-induced Cardiotoxicity: A Comprehensive Review. Nutrition and cancer. vol 68. issue 6. 2017-12-13. PMID:27341037. |
the cardioprotective effects of phenolic compounds are exerted via multiple mechanisms including inhibition of reactive oxygen species generation, apoptosis, nf-κb, p53, mitochondrial dysfunction, and dna damage. |
2017-12-13 |
2023-08-13 |
Not clear |
| Mozhgan Moshrefi, Adel Spotin, Hossein Samadi Kafil, Mahmoud Mahami-Oskouei, Behzad Baradaran, Ehsan Ahmadpour, Behzad Mansoor. Tumor suppressor p53 induces apoptosis of host lymphocytes experimentally infected by Leishmania major, by activation of Bax and caspase-3: a possible survival mechanism for the parasite. Parasitology research. vol 116. issue 8. 2017-12-12. PMID:28560572. |
tumor suppressor p53 induces apoptosis of host lymphocytes experimentally infected by leishmania major, by activation of bax and caspase-3: a possible survival mechanism for the parasite. |
2017-12-12 |
2023-08-13 |
Not clear |
| Mozhgan Moshrefi, Adel Spotin, Hossein Samadi Kafil, Mahmoud Mahami-Oskouei, Behzad Baradaran, Ehsan Ahmadpour, Behzad Mansoor. Tumor suppressor p53 induces apoptosis of host lymphocytes experimentally infected by Leishmania major, by activation of Bax and caspase-3: a possible survival mechanism for the parasite. Parasitology research. vol 116. issue 8. 2017-12-12. PMID:28560572. |
however, there is no eligible data about whether tumor suppressor p53 could induce the apoptosis of host lymphocytes-treated leishmania major via the mitochondrial intrinsic pathway. |
2017-12-12 |
2023-08-13 |
Not clear |
| Sihem Ben Abid, Mouna Sahnoun, Ines Yacoubi-Hadj Amor, Salma Abdelmoula-Souissi, Hajer Hassairi, Raja Mokdad-Gargouri, Ali Gargour. New Phage Display-Isolated Heptapeptide Recognizing the Regulatory Carboxy-Terminal Domain of Human Tumour Protein p53. The protein journal. vol 36. issue 5. 2017-12-12. PMID:28710679. |
the transcription factor tumor protein p53 (p53) controls a variety of genes most involved in cell cycle and is at the origin of apoptosis when dna is irreparably damaged. |
2017-12-12 |
2023-08-13 |
human |
| Xinxin Du, Bo Wang, Xiumei Liu, Xiaobing Liu, Yan He, Quanqi Zhang, Xubo Wan. Comparative transcriptome analysis of ovary and testis reveals potential sex-related genes and pathways in spotted knifejaw Oplegnathus punctatus. Gene. vol 637. 2017-12-12. PMID:28962924. |
interestingly, p53, apoptosis, jak-stat and neuroactive ligand-receptor interaction pathways were found to be pivotal in regulating gonadal development and gametogenesis of spotted knifejaw in various aspects. |
2017-12-12 |
2023-08-13 |
Not clear |